Q5UZA4 (Q5UZA4_HALMA) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Delta-aminolevulinic acid dehydratase EMBL AAV47399.1
EC=4.2.1.24 EMBL AAV47399.1

Gene names

Name:	hemB EMBL AAV47399.1
Ordered Locus Names:	rrnAC2610

Organism

Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) (Halobacterium marismortui) [Complete proteome] [HAMAP] EMBL AAV47399.1

Taxonomic identifier

272569 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Halobacteria › Halobacteriales › Halobacteriaceae › Haloarcula

Protein attributes

Sequence length	326 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Subunit structure

Homooctamer By similarity. PIRSR PIRSR001415-3

Ontologies

Keywords
Ligand	Magnesium PIRSR PIRSR001415-5 Metal-binding PIRSR PIRSR001415-3 Zinc PIRSR PIRSR001415-3
Molecular function	Lyase EMBL AAV47399.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	porphyrin-containing compound biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW porphobilinogen synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	199	1	Schiff-base intermediate with substrate By similarity PIRSR PIRSR001415-1
	Active site	252	1	Schiff-base intermediate with substrate By similarity PIRSR PIRSR001415-1
	Metal binding	117	1	Zinc; catalytic By similarity PIRSR PIRSR001415-3
	Metal binding	119	1	Zinc; catalytic By similarity PIRSR PIRSR001415-3
	Metal binding	127	1	Zinc; catalytic By similarity PIRSR PIRSR001415-3
	Metal binding	237	1	Magnesium By similarity PIRSR PIRSR001415-5
	Binding site	209	1	Substrate 1 By similarity PIRSR PIRSR001415-2
	Binding site	221	1	Substrate 1 By similarity PIRSR PIRSR001415-2
	Binding site	278	1	Substrate 2 By similarity PIRSR PIRSR001415-2
	Binding site	317	1	Substrate 2 By similarity PIRSR PIRSR001415-2

Sequences

	Sequence		Length	Mass (Da)
	Q5UZA4 [UniParc]. Last modified December 7, 2004. Version 1. Checksum: 5515A701511C5E43	FASTA	326	35,537
	10 20 30 40 50 60 MNLTQRPRRL RTDGVRPLVR ETELTASDLI APVFVDATTD ERVPIETMPG HERVPIEEAV 70 80 90 100 110 120 DRVEEVLETG VEAVMLFGIP ESKDERGSRA WAEDGVVQEA TRRISGETDA YVITDVCLCE 130 140 150 160 170 180 YTDHGHCGVL EDGAAENPRL TVRNDETLDL LGKIAASHAA AGADMVAPSG MIDGMVGAIR 190 200 210 220 230 240 TALDADGFDD VAIMSYAAKY ESAFYGPFRD AADGAPAFGD RRHYQMDPAN AREASREVDL 250 260 270 280 290 300 DVEQGADVLM VKPALPYLDI VKEVRESYDH PVAAYNVSGE YAMLHAAAEK GWLDLEAVAY 310 320 ESLLSIKRAG ADLILTYFAE DLADEL

References

[1]

"Genome sequence of Haloarcula marismortui: a halophilic archaeon from the Dead Sea." Baliga N.S., Bonneau R., Facciotti M.T., Pan M., Glusman G., Deutsch E.W., Shannon P., Chiu Y., Weng R.S., Gan R.R., Hung P., Date S.V., Marcotte E., Hood L., Ng W.V. Genome Res. 14:2221-2234(2004) [PubMed: 15520287] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY596297 Genomic DNA. Translation: AAV47399.1.
RefSeq	YP_137105.1. NC_006396.1.
3D structure databases
ProteinModelPortal	Q5UZA4.
SMR	Q5UZA4. Positions 2-325.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3128436.
GenomeReviews	Gene locus rrnAC2610 in contig AY596297_GR.
KEGG	hma:rrnAC2610.
NMPDR	fig|272569.1.peg.2385.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG285270.
OMA	ADLCFCE.
PhylomeDB	Q5UZA4.
ProtClustDB	PRK09283.
Family and domain databases
InterPro	IPR013785. Aldolase_TIM. IPR001731. Porphobilinogen_synth. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KO	K01698.
PANTHER	PTHR11458. AlaD_dehydratase. 1 hit.
Pfam	PF00490. ALAD. 1 hit. [Graphical view]
PIRSF	PIRSF001415. Porphbilin_synth. 1 hit.
PRINTS	PR00144. DALDHYDRTASE.
SMART	SM01004. ALAD. 1 hit. [Graphical view]
PROSITE	PS00169. D_ALA_DEHYDRATASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q5UZA4_HALMA

Accession

Primary (citable) accession number: Q5UZA4

Entry history

Integrated into UniProtKB/TrEMBL:	December 7, 2004
Last sequence update:	December 7, 2004
Last modified:	January 25, 2012
This is version 52 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)