SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q5UZ40

- DP2L_HALMA

UniProt

Q5UZ40 - DP2L_HALMA

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
DNA polymerase II large subunit
Gene
polC, polA2, rrnAC2691
Organism
Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) (Halobacterium marismortui)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase By similarity.UniRule annotation

Catalytic activityi

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).UniRule annotation
Degradation of single-stranded DNA. It acts progressively in a 3'- to 5'-direction, releasing nucleoside 5'-phosphates.UniRule annotation

GO - Molecular functioni

  1. 3'-5' exonuclease activity Source: UniProtKB-HAMAP
  2. DNA binding Source: UniProtKB-HAMAP
  3. DNA-directed DNA polymerase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. DNA catabolic process, exonucleolytic Source: UniProtKB-HAMAP
  2. intein-mediated protein splicing Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

DNA-directed DNA polymerase, Exonuclease, Hydrolase, Nuclease, Nucleotidyltransferase, Transferase

Keywords - Biological processi

DNA replication

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciHMAR272569:GJDH-2420-MONOMER.

Protein family/group databases

MEROPSiN10.006.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA polymerase II large subunit (EC:2.7.7.7)
Short name:
Pol II
Cleaved into the following chain:
Alternative name(s):
Hma pol II intein
Gene namesi
Name:polC
Synonyms:polA2
Ordered Locus Names:rrnAC2691
OrganismiHaloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) (Halobacterium marismortui)
Taxonomic identifieri272569 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHaloarcula
ProteomesiUP000001169: Chromosome I

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 965965DNA polymerase II large subunit, 1st part Reviewed prediction
PRO_0000294677Add
BLAST
Chaini966 – 1145180Hma polC intein Reviewed prediction
PRO_0000294678Add
BLAST
Chaini1146 – 1395250DNA polymerase II large subunit, 2nd part Reviewed prediction
PRO_0000294679Add
BLAST

Post-translational modificationi

This protein undergoes a protein self splicing that involves a post-translational excision of the intervening region (intein) followed by peptide ligation Reviewed prediction.UniRule annotation

Keywords - PTMi

Autocatalytic cleavage, Protein splicing

Interactioni

Subunit structurei

Heterodimer of a large subunit and a small subunit By similarity.

Protein-protein interaction databases

STRINGi272569.rrnAC2691.

Structurei

3D structure databases

ProteinModelPortaliQ5UZ40.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1933.
HOGENOMiHOG000286435.
KOiK02322.
OMAiRNCDGDE.

Family and domain databases

Gene3Di2.170.16.10. 1 hit.
HAMAPiMF_00324. DNApol_II_L_arch.
InterProiIPR028992. Hedgehog/Intein_dom.
IPR006141. Intein_splice_site.
IPR004475. PolC_DP2.
IPR016033. PolC_DP2_N.
[Graphical view]
PfamiPF03833. PolC_DP2. 1 hit.
[Graphical view]
SUPFAMiSSF51294. SSF51294. 1 hit.
TIGRFAMsiTIGR01445. intein_Nterm. 1 hit.
TIGR00354. polC. 1 hit.
PROSITEiPS50817. INTEIN_N_TER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5UZ40-1 [UniParc]FASTAAdd to Basket

« Hide

MREADEQYFE TLETQLEAAF DVAERAKERG GDPKPEVEIP TARDMADRVE     50
NILGIDGVAE RVRELEGQMS REEAALELVE DFVEGTVGDY DSREGKVEGA 100
VRTAVALLTE GVVAAPIEGI DRVELLENDD GTEFINVYYA GPIRSAGGTA 150
QALSVLVADY ARALLGIDQY KAREEEIGRY AEEIDLYDKD TGLQYSPKEK 200
ETKFIAEHMP IMLDGEATGD EEVSGYRDLE RVDSNSPRGG MCLVLAEGIA 250
LKAPKIQRYT RNLDEVDWPW LQDLIDGTIG KDEADEGDSA EDANGDDAGE 300
GADDDGGDEA DEQAGPPRVE PADKYLRDLI AGRPVFSHPS KSGGFRLRYG 350
RSRNHGFATA GVHPATMHLV DDFLATGTQI KTERPGKAAG VVPVDTIEGP 400
TVRLANGDVR RIDDAEEALA VRNGVEKILD LGEYLVNYGE FVENNHPLAP 450
ASYTVEWWEQ DLAAAGADVQ AMQDSPHIDL ADPSAEEAIE WATEYDAPLH 500
PKYTYLWHDV SIEQVCALAD AVEDAQVAQA DGAYADPEMD GTAGDAHSDD 550
GALVLPRSDA VQQTLEHLLI GHTQDEETIT VTDWVPLVRT LGFSRSLERD 600
WTREDLSEHA RTYGESESLD AIGVAEDAER EDGQNAIKAI NEVAPFQVRE 650
RAPTRIGNRM GRPEKSERRD LSPAVHTLSP IGEAGGAQRD VAKATKHADD 700
MSDTPGQVEV EVARRRCPDC GTETHQANCA ECSGTTEPVY VCPDCEAEVE 750
RDESGRAECG RCETLASPTQ YKVLDLQEAY RDALQNVGER ETAFEQLKAV 800
KGLTSEEKVP EPMEKGILRA KHDVSAFKDG TVRYDMTDLP VTAVRASELD 850
VSAERLRGLG YTEDIHGDPL THEDQLVELK VQDIVLSDGA AEHMLQTARF 900
VDDLLEQYYG LERFYEFDDR EDLVGELVFG MAPHTSAATV GRVVGFTSAA 950
VGYAHPYFHA AKRRNCFHPD TRLWYEDEND DWEYGTIEEL VESRLDDPQE 1000
DDFGTLVQEL DGDLTVSSLG ENGPCRQPVD AVSKHPAPDH LVEVAVGDRT 1050
LRVTPDHTML RAGPDGIEEV PASDLAAGDD LPAYDGGETT TMTARGEAST 1100
AATDGAAPTD TVEAVEYVES DVDHVYCLTV ADTHRVAVEG TYVGQCDGDE 1150
DCVMLLMDGL LNFSKSYLPN QRGGQMDAPL VMSSRIDPSE IDDEAHNMDI 1200
MDAYPREFYE ATREMKDPTE VEDVMKIAEE TLGTDREYTE FRHTHDTANI 1250
AAGPDLSAYK TLGSMEDKMD AQLEISRKLR AVVESDVAER IIEYHFLPDL 1300
IGNLRAFSRQ EVRCLDCGES FRRAPLTGDC RECGGRVNLT VHEGSVNKYI 1350
DTAIRVADEF GARDYTKQRL KILERKIESV FENDHNKQSG IADFM 1395
Length:1,395
Mass (Da):153,633
Last modified:December 7, 2004 - v1
Checksum:i99996EC3A54B3F07
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY596297 Genomic DNA. Translation: AAV47463.1.
RefSeqiWP_011224375.1. NC_006396.1.
YP_137169.1. NC_006396.1.

Genome annotation databases

EnsemblBacteriaiAAV47463; AAV47463; rrnAC2691.
GeneIDi3128603.
KEGGihma:rrnAC2691.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY596297 Genomic DNA. Translation: AAV47463.1 .
RefSeqi WP_011224375.1. NC_006396.1.
YP_137169.1. NC_006396.1.

3D structure databases

ProteinModelPortali Q5UZ40.
ModBasei Search...

Protein-protein interaction databases

STRINGi 272569.rrnAC2691.

Protein family/group databases

MEROPSi N10.006.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAV47463 ; AAV47463 ; rrnAC2691 .
GeneIDi 3128603.
KEGGi hma:rrnAC2691.

Phylogenomic databases

eggNOGi COG1933.
HOGENOMi HOG000286435.
KOi K02322.
OMAi RNCDGDE.

Enzyme and pathway databases

BioCyci HMAR272569:GJDH-2420-MONOMER.

Family and domain databases

Gene3Di 2.170.16.10. 1 hit.
HAMAPi MF_00324. DNApol_II_L_arch.
InterProi IPR028992. Hedgehog/Intein_dom.
IPR006141. Intein_splice_site.
IPR004475. PolC_DP2.
IPR016033. PolC_DP2_N.
[Graphical view ]
Pfami PF03833. PolC_DP2. 1 hit.
[Graphical view ]
SUPFAMi SSF51294. SSF51294. 1 hit.
TIGRFAMsi TIGR01445. intein_Nterm. 1 hit.
TIGR00354. polC. 1 hit.
PROSITEi PS50817. INTEIN_N_TER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.

Entry informationi

Entry nameiDP2L_HALMA
AccessioniPrimary (citable) accession number: Q5UZ40
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: December 7, 2004
Last modified: September 3, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme

Documents

  1. Intein-containing proteins
    List of intein-containing protein entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi