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Q5UZ40

- DP2L_HALMA

UniProt

Q5UZ40 - DP2L_HALMA

Protein

DNA polymerase II large subunit

Gene

polC

Organism
Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) (Halobacterium marismortui)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 59 (01 Oct 2014)
      Sequence version 1 (07 Dec 2004)
      Previous versions | rss
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    Functioni

    Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase By similarity.By similarity

    Catalytic activityi

    Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).UniRule annotation
    Degradation of single-stranded DNA. It acts progressively in a 3'- to 5'-direction, releasing nucleoside 5'-phosphates.UniRule annotation

    GO - Molecular functioni

    1. 3'-5' exonuclease activity Source: UniProtKB-HAMAP
    2. DNA binding Source: UniProtKB-HAMAP
    3. DNA-directed DNA polymerase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. DNA catabolic process, exonucleolytic Source: UniProtKB-HAMAP
    2. intein-mediated protein splicing Source: InterPro

    Keywords - Molecular functioni

    DNA-directed DNA polymerase, Exonuclease, Hydrolase, Nuclease, Nucleotidyltransferase, Transferase

    Keywords - Biological processi

    DNA replication

    Keywords - Ligandi

    DNA-binding

    Enzyme and pathway databases

    BioCyciHMAR272569:GJDH-2420-MONOMER.

    Protein family/group databases

    MEROPSiN10.006.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DNA polymerase II large subunitUniRule annotation (EC:2.7.7.7UniRule annotation)
    Short name:
    Pol IIUniRule annotation
    Cleaved into the following chain:
    Alternative name(s):
    Hma pol II intein
    Gene namesi
    Name:polCUniRule annotation
    Synonyms:polA2
    Ordered Locus Names:rrnAC2691
    OrganismiHaloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) (Halobacterium marismortui)
    Taxonomic identifieri272569 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHaloarcula
    ProteomesiUP000001169: Chromosome I

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 965965DNA polymerase II large subunit, 1st partSequence AnalysisPRO_0000294677Add
    BLAST
    Chaini966 – 1145180Hma polC inteinSequence AnalysisPRO_0000294678Add
    BLAST
    Chaini1146 – 1395250DNA polymerase II large subunit, 2nd partSequence AnalysisPRO_0000294679Add
    BLAST

    Post-translational modificationi

    This protein undergoes a protein self splicing that involves a post-translational excision of the intervening region (intein) followed by peptide ligation.Curated

    Keywords - PTMi

    Autocatalytic cleavage, Protein splicing

    Interactioni

    Subunit structurei

    Heterodimer of a large subunit and a small subunit.UniRule annotation

    Protein-protein interaction databases

    STRINGi272569.rrnAC2691.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5UZ40.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the archaeal DNA polymerase II family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1933.
    HOGENOMiHOG000286435.
    KOiK02322.
    OMAiRNCDGDE.

    Family and domain databases

    Gene3Di2.170.16.10. 1 hit.
    HAMAPiMF_00324. DNApol_II_L_arch.
    InterProiIPR028992. Hedgehog/Intein_dom.
    IPR006141. Intein_splice_site.
    IPR004475. PolC_DP2.
    IPR016033. PolC_DP2_N.
    [Graphical view]
    PfamiPF03833. PolC_DP2. 1 hit.
    [Graphical view]
    SUPFAMiSSF51294. SSF51294. 1 hit.
    TIGRFAMsiTIGR01445. intein_Nterm. 1 hit.
    TIGR00354. polC. 1 hit.
    PROSITEiPS50817. INTEIN_N_TER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q5UZ40-1 [UniParc]FASTAAdd to Basket

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    MREADEQYFE TLETQLEAAF DVAERAKERG GDPKPEVEIP TARDMADRVE     50
    NILGIDGVAE RVRELEGQMS REEAALELVE DFVEGTVGDY DSREGKVEGA 100
    VRTAVALLTE GVVAAPIEGI DRVELLENDD GTEFINVYYA GPIRSAGGTA 150
    QALSVLVADY ARALLGIDQY KAREEEIGRY AEEIDLYDKD TGLQYSPKEK 200
    ETKFIAEHMP IMLDGEATGD EEVSGYRDLE RVDSNSPRGG MCLVLAEGIA 250
    LKAPKIQRYT RNLDEVDWPW LQDLIDGTIG KDEADEGDSA EDANGDDAGE 300
    GADDDGGDEA DEQAGPPRVE PADKYLRDLI AGRPVFSHPS KSGGFRLRYG 350
    RSRNHGFATA GVHPATMHLV DDFLATGTQI KTERPGKAAG VVPVDTIEGP 400
    TVRLANGDVR RIDDAEEALA VRNGVEKILD LGEYLVNYGE FVENNHPLAP 450
    ASYTVEWWEQ DLAAAGADVQ AMQDSPHIDL ADPSAEEAIE WATEYDAPLH 500
    PKYTYLWHDV SIEQVCALAD AVEDAQVAQA DGAYADPEMD GTAGDAHSDD 550
    GALVLPRSDA VQQTLEHLLI GHTQDEETIT VTDWVPLVRT LGFSRSLERD 600
    WTREDLSEHA RTYGESESLD AIGVAEDAER EDGQNAIKAI NEVAPFQVRE 650
    RAPTRIGNRM GRPEKSERRD LSPAVHTLSP IGEAGGAQRD VAKATKHADD 700
    MSDTPGQVEV EVARRRCPDC GTETHQANCA ECSGTTEPVY VCPDCEAEVE 750
    RDESGRAECG RCETLASPTQ YKVLDLQEAY RDALQNVGER ETAFEQLKAV 800
    KGLTSEEKVP EPMEKGILRA KHDVSAFKDG TVRYDMTDLP VTAVRASELD 850
    VSAERLRGLG YTEDIHGDPL THEDQLVELK VQDIVLSDGA AEHMLQTARF 900
    VDDLLEQYYG LERFYEFDDR EDLVGELVFG MAPHTSAATV GRVVGFTSAA 950
    VGYAHPYFHA AKRRNCFHPD TRLWYEDEND DWEYGTIEEL VESRLDDPQE 1000
    DDFGTLVQEL DGDLTVSSLG ENGPCRQPVD AVSKHPAPDH LVEVAVGDRT 1050
    LRVTPDHTML RAGPDGIEEV PASDLAAGDD LPAYDGGETT TMTARGEAST 1100
    AATDGAAPTD TVEAVEYVES DVDHVYCLTV ADTHRVAVEG TYVGQCDGDE 1150
    DCVMLLMDGL LNFSKSYLPN QRGGQMDAPL VMSSRIDPSE IDDEAHNMDI 1200
    MDAYPREFYE ATREMKDPTE VEDVMKIAEE TLGTDREYTE FRHTHDTANI 1250
    AAGPDLSAYK TLGSMEDKMD AQLEISRKLR AVVESDVAER IIEYHFLPDL 1300
    IGNLRAFSRQ EVRCLDCGES FRRAPLTGDC RECGGRVNLT VHEGSVNKYI 1350
    DTAIRVADEF GARDYTKQRL KILERKIESV FENDHNKQSG IADFM 1395
    Length:1,395
    Mass (Da):153,633
    Last modified:December 7, 2004 - v1
    Checksum:i99996EC3A54B3F07
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY596297 Genomic DNA. Translation: AAV47463.1.
    RefSeqiWP_011224375.1. NC_006396.1.
    YP_137169.1. NC_006396.1.

    Genome annotation databases

    EnsemblBacteriaiAAV47463; AAV47463; rrnAC2691.
    GeneIDi3128603.
    KEGGihma:rrnAC2691.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY596297 Genomic DNA. Translation: AAV47463.1 .
    RefSeqi WP_011224375.1. NC_006396.1.
    YP_137169.1. NC_006396.1.

    3D structure databases

    ProteinModelPortali Q5UZ40.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272569.rrnAC2691.

    Protein family/group databases

    MEROPSi N10.006.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAV47463 ; AAV47463 ; rrnAC2691 .
    GeneIDi 3128603.
    KEGGi hma:rrnAC2691.

    Phylogenomic databases

    eggNOGi COG1933.
    HOGENOMi HOG000286435.
    KOi K02322.
    OMAi RNCDGDE.

    Enzyme and pathway databases

    BioCyci HMAR272569:GJDH-2420-MONOMER.

    Family and domain databases

    Gene3Di 2.170.16.10. 1 hit.
    HAMAPi MF_00324. DNApol_II_L_arch.
    InterProi IPR028992. Hedgehog/Intein_dom.
    IPR006141. Intein_splice_site.
    IPR004475. PolC_DP2.
    IPR016033. PolC_DP2_N.
    [Graphical view ]
    Pfami PF03833. PolC_DP2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51294. SSF51294. 1 hit.
    TIGRFAMsi TIGR01445. intein_Nterm. 1 hit.
    TIGR00354. polC. 1 hit.
    PROSITEi PS50817. INTEIN_N_TER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.

    Entry informationi

    Entry nameiDP2L_HALMA
    AccessioniPrimary (citable) accession number: Q5UZ40
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 10, 2007
    Last sequence update: December 7, 2004
    Last modified: October 1, 2014
    This is version 59 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Multifunctional enzyme, Reference proteome

    Documents

    1. Intein-containing proteins
      List of intein-containing protein entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3