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Q5UXU0 (G6PI_HALMA) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 53. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable glucose-6-phosphate isomerase

Short name=GPI
EC=5.3.1.9
Alternative name(s):
Phosphoglucose isomerase
Short name=PGI
Phosphohexose isomerase
Short name=PHI
Gene names
Name:pgi
Ordered Locus Names:rrnAC3210
OrganismHaloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) (Halobacterium marismortui) [Complete proteome] [HAMAP]
Taxonomic identifier272569 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHaloarcula

Protein attributes

Sequence length436 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

D-glucose 6-phosphate = D-fructose 6-phosphate. HAMAP-Rule MF_00473

Pathway

Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4. HAMAP-Rule MF_00473

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00473.

Sequence similarities

Belongs to the GPI family.

Sequence caution

The sequence AAV47913.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processGluconeogenesis
Glycolysis
   Cellular componentCytoplasm
   Molecular functionIsomerase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processgluconeogenesis

Inferred from electronic annotation. Source: UniProtKB-HAMAP

glycolytic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionglucose-6-phosphate isomerase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 436436Probable glucose-6-phosphate isomerase HAMAP-Rule MF_00473
PRO_0000180778

Sites

Active site2721Proton donor By similarity
Active site2931 By similarity
Active site4041 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5UXU0 [UniParc].

Last modified November 8, 2005. Version 2.
Checksum: 94D7F534A87BAB18

FASTA43646,180
        10         20         30         40         50         60 
MHVDIGAALA SAADPGVERA TLDDLDEQVA VAHERIEQGR NKGEFGYASL NLLEATDAET 

        70         80         90        100        110        120 
IHDAVAPVAD AESVITVGIG GSALGAKTIT EALAEDPGSH VVLDNVDPEH VRRTLDGLSL 

       130        140        150        160        170        180 
ADTAINVVSR SGTTAETLAN FLVVREAYED RGVDWTERIV VTTGESGPLR ALADQHDLPT 

       190        200        210        220        230        240 
LPVPEGVPGR FSALSAVGLV PPAILGIDIE GLLAGGQQAA DDLAPSLYDS PAYAYGAMAY 

       250        260        270        280        290        300 
ALEEAGATVN AVMPYAERLE SFGEWFAQLW AESLGKDGRG QTPARALGAT DQHSQLQLYR 

       310        320        330        340        350        360 
AGHRDKVVTF VRPRERADVS IPDPDHEDLS YLAGTDLGGL IDAEYEATVA SLPAADRPAL 

       370        380        390        400        410        420 
EVEIDRLDAE SVGELLYAME AACVLVGELA DVETFTQPAV EWGKNATRAL IRGEATDETA 

       430 
VIDERERLRI GETESL 

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References

[1]"Genome sequence of Haloarcula marismortui: a halophilic archaeon from the Dead Sea."
Baliga N.S., Bonneau R., Facciotti M.T., Pan M., Glusman G., Deutsch E.W., Shannon P., Chiu Y., Weng R.S., Gan R.R., Hung P., Date S.V., Marcotte E., Hood L., Ng W.V.
Genome Res. 14:2221-2234(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY596297 Genomic DNA. Translation: AAV47913.1. Different initiation.
RefSeqYP_137619.1. NC_006396.1.

3D structure databases

ProteinModelPortalQ5UXU0.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272569.rrnAC3210.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAV47913; AAV47913; rrnAC3210.
GeneID3129274.
KEGGhma:rrnAC3210.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0166.
HOGENOMHOG000100402.
KOK01810.

Enzyme and pathway databases

BioCycHMAR272569:GJDH-2882-MONOMER.
UniPathwayUPA00109; UER00181.

Family and domain databases

HAMAPMF_00473. G6P_isomerase.
InterProIPR001672. G6P_Isomerase.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERPTHR11469. PTHR11469. 1 hit.
PfamPF00342. PGI. 1 hit.
[Graphical view]
PRINTSPR00662. G6PISOMERASE.
PROSITEPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameG6PI_HALMA
AccessionPrimary (citable) accession number: Q5UXU0
Entry history
Integrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: November 8, 2005
Last modified: June 11, 2014
This is version 53 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways