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Q5UXM8 (HTR1_HALMA) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 54. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Sensory rhodopsin I transducer
Alternative name(s):
MCP domain signal transducer 1
Short name=HmHtrI
Gene names
Name:htr1
Ordered Locus Names:rrnAC3281
OrganismHaloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) (Halobacterium marismortui) [Complete proteome] [HAMAP]
Taxonomic identifier272569 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHaloarcula

Protein attributes

Sequence length528 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Transduces signals from the phototaxis receptor sensory rhodopsin I (Sop1). Ref.3

Subunit structure

Interacts with Sop1. Ref.3

Subcellular location

Cell membrane; Multi-pass membrane protein Ref.3.

Induction

Expressed constitutively throughout the growth phases, both in presence and absence of white light. Ref.2

Sequence similarities

Contains 2 HAMP domains.

Contains 1 methyl-accepting transducer domain.

Sequence caution

The sequence AAV47975.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
   Cellular componentCell membrane
Membrane
   DomainRepeat
Transmembrane
Transmembrane helix
   Molecular functionTransducer
   PTMMethylation
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processchemotaxis

Inferred from electronic annotation. Source: InterPro

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionsignal transducer activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 528528Sensory rhodopsin I transducer
PRO_0000428857

Regions

Transmembrane11 – 3121Helical; Potential
Transmembrane35 – 5521Helical; Potential
Domain55 – 10753HAMP 1
Domain142 – 19554HAMP 2
Domain214 – 455242Methyl-accepting transducer
Compositional bias156 – 1594Poly-Ala

Amino acid modifications

Modified residue2591Glutamate methyl ester (Glu) By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5UXM8 [UniParc].

Last modified May 14, 2014. Version 2.
Checksum: EF53B3B6C053C55E

FASTA52855,853
        10         20         30         40         50         60 
MTISSVKQSY GAKLGVGYIA TATLLITVGV VTQDVASTVV AGIAGLLTLG SINAAETVAS 

        70         80         90        100        110        120 
ITELSAQTQR VADGDLDIEI DSTRTDEFGD LADSIEQMRV SLRDRLSEME AARADLEQAQ 

       130        140        150        160        170        180 
TDANEAQAEA EAAEEEAKEL ATAYQDIATE YGTVMAAAAD GDLTQRVDVA TEYDAMETVG 

       190        200        210        220        230        240 
QSFNRMMDEL QETIETVTAV SKRITTETDE ITETSRRVQQ EVDAAVETVA DIQTQATDQQ 

       250        260        270        280        290        300 
TKLESAAVDI QDVSASAEEI AATIDDLADR SSEVEEASSD ARTASETALT EMDQIQADAA 

       310        320        330        340        350        360 
DAVTQVETLQ QRMAEITDIA DIISEIAEQT NMLALNASIE AARAGGQGSG ADGNGFSVVA 

       370        380        390        400        410        420 
DEVKSLAEET QSRADEIATV IAEVSEQTEE VTDSIQATET RVETGTETVE SALSEIATIA 

       430        440        450        460        470        480 
EAVDDISASI EEMRETTSEQ ADTVQATADS IADVTEASAE TATTAEEMST QIRRQRDVVK 

       490        500        510        520 
SISDSLDSFR ETAVDDLESR VRLFTINTDT TAASQTRAVG SPSIGGDD 

« Hide

References

« Hide 'large scale' references
[1]"Genome sequence of Haloarcula marismortui: a halophilic archaeon from the Dead Sea."
Baliga N.S., Bonneau R., Facciotti M.T., Pan M., Glusman G., Deutsch E.W., Shannon P., Chiu Y., Weng R.S., Gan R.R., Hung P., Date S.V., Marcotte E., Hood L., Ng W.V.
Genome Res. 14:2221-2234(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
[2]"A novel six-rhodopsin system in a single archaeon."
Fu H.Y., Lin Y.C., Chang Y.N., Tseng H., Huang C.C., Liu K.C., Huang C.S., Su C.W., Weng R.R., Lee Y.Y., Ng W.V., Yang C.S.
J. Bacteriol. 192:5866-5873(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: INDUCTION, IDENTIFICATION.
[3]"A transducer for microbial sensory rhodopsin that adopts GTG as a start codon is identified in Haloarcula marismortui."
Fu H.Y., Lu Y.H., Yi H.P., Yang C.S.
J. Photochem. Photobiol. B 121:15-22(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION, FUNCTION, INTERACTION WITH SOP1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY596297 Genomic DNA. Translation: AAV47975.1. Different initiation.
RefSeqYP_137681.1. NC_006396.1.

3D structure databases

ProteinModelPortalQ5UXM8.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272569.rrnAC3281.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAV47975; AAV47975; rrnAC3281.
GeneID3128039.
KEGGhma:rrnAC3281.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0840.
HOGENOMHOG000038479.
OMAMASHIAT.

Enzyme and pathway databases

BioCycHMAR272569:GJDH-2945-MONOMER.

Family and domain databases

InterProIPR004090. Chemotax_Me-accpt_rcpt.
IPR003660. HAMP_linker_domain.
IPR004089. MCPsignal_dom.
[Graphical view]
PfamPF00672. HAMP. 1 hit.
PF00015. MCPsignal. 1 hit.
[Graphical view]
PRINTSPR00260. CHEMTRNSDUCR.
SMARTSM00304. HAMP. 3 hits.
SM00283. MA. 1 hit.
[Graphical view]
PROSITEPS50111. CHEMOTAXIS_TRANSDUC_2. 1 hit.
PS50885. HAMP. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHTR1_HALMA
AccessionPrimary (citable) accession number: Q5UXM8
Entry history
Integrated into UniProtKB/Swiss-Prot: May 14, 2014
Last sequence update: May 14, 2014
Last modified: July 9, 2014
This is version 54 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families