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Protein

GTP cyclohydrolase MptA

Gene

mptA

Organism
Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) (Halobacterium marismortui)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin.UniRule annotation

Catalytic activityi

GTP + H2O = formate + 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate + diphosphate.UniRule annotation

Cofactori

Fe2+UniRule annotationNote: Binds 1 Fe2+ ion per subunit.UniRule annotation

Pathwayi: 5,6,7,8-tetrahydromethanopterin biosynthesis

This protein is involved in the pathway 5,6,7,8-tetrahydromethanopterin biosynthesis, which is part of Cofactor biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway 5,6,7,8-tetrahydromethanopterin biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei157 – 1571May be catalytically importantUniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

BioCyciHMAR272569:GJDH-2971-MONOMER.
UniPathwayiUPA00065.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase MptAUniRule annotation (EC:3.5.4.39UniRule annotation)
Alternative name(s):
GTP cyclohydrolase IVUniRule annotation
Gene namesi
Name:mptAUniRule annotation
Ordered Locus Names:rrnAC3309
OrganismiHaloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) (Halobacterium marismortui)
Taxonomic identifieri272569 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHaloarcula
Proteomesi
  • UP000001169 Componenti: Chromosome I

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 309309GTP cyclohydrolase MptAPRO_0000147740Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi272569.rrnAC3309.

Structurei

3D structure databases

ProteinModelPortaliQ5UXK3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GTP cyclohydrolase IV family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG04301. Archaea.
COG1469. LUCA.
HOGENOMiHOG000280680.
KOiK17488.
OMAiPCSQGMS.

Family and domain databases

HAMAPiMF_01527_A. GTP_cyclohydrol_A. 1 hit.
InterProiIPR003801. GTP_cyclohydrolase_FolE2/MptA.
IPR022840. GTP_cyclohydrolase_MptA.
[Graphical view]
PfamiPF02649. GCHY-1. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00294. TIGR00294. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5UXK3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQQLPDVQA SSPDVTVGLN RVGVTGVEKL VKLGRRDRDP IVLMAEFEVF
60 70 80 90 100
VDLPSWRKGA DMSRNMEVID ETLETAVSEE AYRVEDVCGD AAELLLEKHD
110 120 130 140 150
YTTKAEVRME AEYVTHESTP ASEMATQSTA DIIASATATE DGTSEEIGAR
160 170 180 190 200
VTGMTVCPCS QGMSASRARE TLKQLNVEDD VIEEFLETNP QAGHSQRGHA
210 220 230 240 250
TLTVQSDGAP EVDLNELIEV ARDSMSARIY NLAKRPDEDH MTYEAHKDAK
260 270 280 290 300
FVEDCVRALA EGVVNTFPDL PDDAVVTMKQ SNDESIHQHN AHAERVAQLD

DLRQEVSED
Length:309
Mass (Da):34,036
Last modified:December 7, 2004 - v1
Checksum:i11D58A7DF0E1D5EF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY596297 Genomic DNA. Translation: AAV48000.1.
RefSeqiWP_004964088.1. NC_006396.1.

Genome annotation databases

EnsemblBacteriaiAAV48000; AAV48000; rrnAC3309.
GeneIDi3128362.
KEGGihma:rrnAC3309.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY596297 Genomic DNA. Translation: AAV48000.1.
RefSeqiWP_004964088.1. NC_006396.1.

3D structure databases

ProteinModelPortaliQ5UXK3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272569.rrnAC3309.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAV48000; AAV48000; rrnAC3309.
GeneIDi3128362.
KEGGihma:rrnAC3309.

Phylogenomic databases

eggNOGiarCOG04301. Archaea.
COG1469. LUCA.
HOGENOMiHOG000280680.
KOiK17488.
OMAiPCSQGMS.

Enzyme and pathway databases

UniPathwayiUPA00065.
BioCyciHMAR272569:GJDH-2971-MONOMER.

Family and domain databases

HAMAPiMF_01527_A. GTP_cyclohydrol_A. 1 hit.
InterProiIPR003801. GTP_cyclohydrolase_FolE2/MptA.
IPR022840. GTP_cyclohydrolase_MptA.
[Graphical view]
PfamiPF02649. GCHY-1. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00294. TIGR00294. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMPTA_HALMA
AccessioniPrimary (citable) accession number: Q5UXK3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: December 7, 2004
Last modified: December 9, 2015
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.