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Protein

GTP cyclohydrolase MptA

Gene

mptA

Organism
Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) (Halobacterium marismortui)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin.UniRule annotation

Catalytic activityi

GTP + H2O = formate + 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate + diphosphate.UniRule annotation

Cofactori

Fe2+UniRule annotationNote: Binds 1 Fe2+ ion per subunit.UniRule annotation

Pathwayi: 5,6,7,8-tetrahydromethanopterin biosynthesis

This protein is involved in the pathway 5,6,7,8-tetrahydromethanopterin biosynthesis, which is part of Cofactor biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway 5,6,7,8-tetrahydromethanopterin biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei157May be catalytically importantUniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase
LigandIron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00065

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase MptAUniRule annotation (EC:3.5.4.39UniRule annotation)
Alternative name(s):
GTP cyclohydrolase IVUniRule annotation
Gene namesi
Name:mptAUniRule annotation
Ordered Locus Names:rrnAC3309
OrganismiHaloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) (Halobacterium marismortui)
Taxonomic identifieri272569 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHaloarculaceaeHaloarcula
Proteomesi
  • UP000001169 Componenti: Chromosome I

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001477401 – 309GTP cyclohydrolase MptAAdd BLAST309

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi272569.rrnAC3309

Structurei

3D structure databases

ProteinModelPortaliQ5UXK3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GTP cyclohydrolase IV family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG04301 Archaea
COG1469 LUCA
HOGENOMiHOG000280680
KOiK17488
OMAiHNQRGRG
OrthoDBiPOG093Z06SZ

Family and domain databases

HAMAPiMF_01527_A GTP_cyclohydrol_A, 1 hit
InterProiView protein in InterPro
IPR003801 GTP_cyclohydrolase_FolE2/MptA
IPR022840 GTP_cyclohydrolase_MptA
PANTHERiPTHR36445 PTHR36445, 1 hit
PfamiView protein in Pfam
PF02649 GCHY-1, 1 hit
TIGRFAMsiTIGR00294 TIGR00294, 1 hit

Sequencei

Sequence statusi: Complete.

Q5UXK3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQQLPDVQA SSPDVTVGLN RVGVTGVEKL VKLGRRDRDP IVLMAEFEVF
60 70 80 90 100
VDLPSWRKGA DMSRNMEVID ETLETAVSEE AYRVEDVCGD AAELLLEKHD
110 120 130 140 150
YTTKAEVRME AEYVTHESTP ASEMATQSTA DIIASATATE DGTSEEIGAR
160 170 180 190 200
VTGMTVCPCS QGMSASRARE TLKQLNVEDD VIEEFLETNP QAGHSQRGHA
210 220 230 240 250
TLTVQSDGAP EVDLNELIEV ARDSMSARIY NLAKRPDEDH MTYEAHKDAK
260 270 280 290 300
FVEDCVRALA EGVVNTFPDL PDDAVVTMKQ SNDESIHQHN AHAERVAQLD

DLRQEVSED
Length:309
Mass (Da):34,036
Last modified:December 7, 2004 - v1
Checksum:i11D58A7DF0E1D5EF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY596297 Genomic DNA Translation: AAV48000.1
RefSeqiWP_004964088.1, NC_006396.1

Genome annotation databases

EnsemblBacteriaiAAV48000; AAV48000; rrnAC3309
GeneIDi3128362
KEGGihma:rrnAC3309
PATRICifig|272569.17.peg.3837

Similar proteinsi

Entry informationi

Entry nameiMPTA_HALMA
AccessioniPrimary (citable) accession number: Q5UXK3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: December 7, 2004
Last modified: March 28, 2018
This is version 71 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
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