HEXB

Functionⁱ

GO - Molecular functionⁱ

hydrolase activity, hydrolyzing O-glycosyl compounds Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

carbohydrate metabolic process Source: InterPro

View the complete GO annotation on QuickGO ...

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: Beta-hexosaminidase subunit betaImported Submitted name: ENC-1ASImported Submitted name: Epididymis luminal protein 248Imported Submitted name: Epididymis secretory protein Li 111Imported
Gene namesⁱ	Name:HEXBImported Synonyms:HEL-248Imported, HEL-S-111Imported
Organismⁱ	Homo sapiens (Human)Imported
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 5

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000049860.13.
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:4879. HEXB.

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000049860.

OpenTargetsⁱ

ENSG00000049860.

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000049860.

Bgeeⁱ

ENSG00000049860.

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	1 – 291	Glyco_hydro_20InterPro annotationAdd BLAST		291

Phylogenomic databases

eggNOGⁱ	KOG2499. Eukaryota. COG3525. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000008107.
HOGENOMⁱ	HOG000157972.
HOVERGENⁱ	HBG005961.

Family and domain databases

InterProⁱ	View protein in InterPro IPR015883. Glyco_hydro_20_cat. IPR017853. Glycoside_hydrolase_SF.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00728. Glyco_hydro_20. 1 hit.
SUPFAMⁱ	SSF51445. SSF51445. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

Q5URX0-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAFNKFNVLH WHIVDDQSFP YQSITFPELS NKGSYSLSHV YTPNDVRMVI 
        60         70         80         90        100
EYARLRGIRV LPEFDTPGHT LSWGKGQKDL LTPCYSRQNK LDSFGPINPT 
       110        120        130        140        150
LNTTYSFLTT FFKEISEVFP DQFIHLGGDE VEFKCWESNP KIQDFMRQKG 
       160        170        180        190        200
FGTDFKKLES FYIQKVLDII ATINKGSIVW QEVFDDKAKL APGTIVEVWK 
       210        220        230        240        250
DSAYPEELSR VTASGFPVIL SAPWYLDLIS YGQDWRKYYK VEPLDFGGTQ 
       260        270        280        290        300
KQKQLFIGGE ACLWGEYVDA TNLTPRLWPR ASAVGERLWS SKDVRDMDDA 
       310        320        330 
YDRLTRHRCR MVERGIAAQP LYAGYCNHEN M

Length:331

Mass (Da):38,258

Last modified:December 7, 2004 - v1

Checksum:ⁱ53040064142332FD

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC026405 Genomic DNA. No translation available. AC093214 Genomic DNA. No translation available. KC877004 Genomic DNA. No translation available. AY643499 mRNA. Translation: AAV48875.1. FJ224336 mRNA. Translation: ACI46028.1. GQ472222 mRNA. Translation: ACV87197.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_001278933.1. NM_001292004.1.
UniGeneⁱ	Hs.69293.

Genome annotation databases

Ensemblⁱ	ENST00000511181; ENSP00000426285; ENSG00000049860.
GeneIDⁱ	3074.
UCSC genome browser More...UCSCⁱ	uc003kdd.3. human.

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q5URX0	P07686 A0A024RAJ6 D6REQ8 UPI0000185C76 UPI00001E2D3F UPI000B9503CF UPI000B9503B4 UPI000B9503CA	Homo sapiens (Human)	556	UniRef100_P07686	Cluster: Beta-hexosaminidase subunit beta	9

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q5URX0	P07686 A0A024RAJ6 D6REQ8 UPI0000185C76 UPI00001E2D3F UPI000B9503CF UPI000B9503B4 UPI000B9503CA A0A2J8VTD3 UPI0002743BF7 +15	Homo sapiens (Human) Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) Pan paniscus (Pygmy chimpanzee) (Bonobo) Pan troglodytes (Chimpanzee) Callithrix jacchus (White-tufted-ear marmoset) Cebus capucinus imitator Saimiri boliviensis boliviensis (Bolivian squirrel monkey) Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys) Aotus nancymaae (Ma's night monkey)	556	UniRef90_P07686	Cluster: Beta-hexosaminidase subunit beta	26

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q5URX0	P07686 A0A024RAJ6 D6REQ8 UPI0000185C76 UPI00001E2D3F UPI000B9503CF UPI000B9503B4 UPI000B9503CA UPI0002743BF7 A0A2J8VTD3 +51	Homo sapiens (Human) Pan paniscus (Pygmy chimpanzee) (Bonobo) Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) Pan troglodytes (Chimpanzee) Callithrix jacchus (White-tufted-ear marmoset) Saimiri boliviensis boliviensis (Bolivian squirrel monkey) Cebus capucinus imitator Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys) Aotus nancymaae (Ma's night monkey) Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys) And more	556	UniRef50_P07686	Cluster: Beta-hexosaminidase subunit beta	62

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC026405 Genomic DNA. No translation available. AC093214 Genomic DNA. No translation available. KC877004 Genomic DNA. No translation available. AY643499 mRNA. Translation: AAV48875.1. FJ224336 mRNA. Translation: ACI46028.1. GQ472222 mRNA. Translation: ACV87197.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_001278933.1. NM_001292004.1.
UniGeneⁱ	Hs.69293.

3D structure databases

ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000511181; ENSP00000426285; ENSG00000049860.
GeneIDⁱ	3074.
UCSC genome browser More...UCSCⁱ	uc003kdd.3. human.

Organism-specific databases

CTDⁱ	3074.
EuPathDBⁱ	HostDB:ENSG00000049860.13.
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:4879. HEXB.
Open Targets More...OpenTargetsⁱ	ENSG00000049860.
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG2499. Eukaryota. COG3525. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000008107.
HOGENOMⁱ	HOG000157972.
HOVERGENⁱ	HBG005961.

Miscellaneous databases

ChiTaRSⁱ	HEXB. human.
GenomeRNAiⁱ	3074.

Gene expression databases

Bgeeⁱ	ENSG00000049860.

Bgeeⁱ

ENSG00000049860.

Family and domain databases

InterProⁱ	View protein in InterPro IPR015883. Glyco_hydro_20_cat. IPR017853. Glycoside_hydrolase_SF.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00728. Glyco_hydro_20. 1 hit.
SUPFAMⁱ	SSF51445. SSF51445. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	Q5URX0_HUMAN
Accessionⁱ	Q5URX0Primary (citable) accession number: Q5URX0
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	December 7, 2004
	Last sequence update:	December 7, 2004
	Last modified:	March 28, 2018
	This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

UniProtKB - Q5URX0 (Q5URX0_HUMAN)

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Beta-hexosaminidase subunit beta

Select a section on the left to see content.

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Organism-specific databases

Pathology & Biotechⁱ

Organism-specific databases

Expressionⁱ

Gene expression databases

Family & Domainsⁱ

Domains and Repeats

Phylogenomic databases

Family and domain databases

Sequenceⁱ

Sequence databases

Genome annotation databases

Similar proteinsⁱ

Cross-referencesⁱ

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q5URX0 (Q5URX0_HUMAN)

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Beta-hexosaminidase subunit beta

HEXB

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Pathology & Biotechⁱ

Expressionⁱ

Family & Domainsⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ