Q5UR64 (NMT_MIMIV) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative glycylpeptide N-tetradecanoyltransferase
EC=2.3.1.97

Alternative name(s):
Myristoyl-CoA:protein N-myristoyltransferase
Short name=NMT
Peptide N-myristoyltransferase

Gene names

Ordered Locus Names:

MIMI_L621

Organism

Acanthamoeba polyphaga mimivirus (APMV)

Taxonomic identifier

212035 [NCBI]

Taxonomic lineage

Viruses › dsDNA viruses, no RNA stage › Mimiviridae › Mimivirus

Virus host

Acanthamoeba polyphaga (Amoeba) [TaxID: 5757]

Protein attributes

Sequence length	358 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Adds a myristoyl group to the N-terminal glycine residue of certain proteins Potential.
Catalytic activity	Tetradecanoyl-CoA + glycylpeptide = CoA + N-tetradecanoylglycylpeptide.
Sequence similarities	Belongs to the NMT family.

Ontologies

Keywords
Molecular function	Acyltransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	N-terminal protein myristoylation Inferred from electronic annotation. Source: InterPro
Molecular function	glycylpeptide N-tetradecanoyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 358	358	Putative glycylpeptide N-tetradecanoyltransferase		PRO_0000064251

Sequences

	Sequence		Length	Mass (Da)
	Q5UR64 [UniParc]. Last modified December 7, 2004. Version 1. Checksum: F6D9DC09399B6C81	FASTA	358	41,997
	10 20 30 40 50 60 MSNLNLFETN QNKSISIMTQ DITKLLDPLT EKFDGFSIKT LNVKHVDEIH ELLNKHYIED 70 80 90 100 110 120 NDHIIRIIYS RDFLYWYLKY VPNNFTIGLM YKNKLVGLIT ALFVDMIMYD NKIKIPYINF 130 140 150 160 170 180 FCIQNKIRKF GLSNILIEEL KSRLLKIGVA YSLFTRMNCQ NSLDKHFTST IDFAIPINCP 190 200 210 220 230 240 KLKSVGFIPD DEKLMNWKIE NNPLSLMVKT DILSVTSKLN VHLQHLSVRP YLTEDSVHHF 250 260 270 280 290 300 ILPKKNIVYT FVKRDSRGYV TDMVSVYKHY AYILETGKII SNAQLSFYYN ETMDLTQLIL 310 320 330 340 350 LLLDKLINYG FDQLIFRNFY DNGKINITRF ETNGELNYYA GNISMPITCP NNMFMIPI

References

[1]	"The 1.2-megabase genome sequence of Mimivirus." Raoult D., Audic S., Robert C., Abergel C., Renesto P., Ogata H., La Scola B., Susan M., Claverie J.-M. Science 306:1344-1350(2004) [PubMed: 15486256] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Rowbotham-Bradford.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY653733 Genomic DNA. Translation: AAV50882.1.
RefSeq	YP_003987138.1. NC_014649.1.
3D structure databases
ProteinModelPortal	Q5UR64.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	9925262.
Family and domain databases
InterPro	IPR016181. Acyl_CoA_acyltransferase. IPR000903. MyristoylCoA_TrFase. IPR022677. MyristoylCoA_TrFase_C. IPR022676. MyristoylCoA_TrFase_N. [Graphical view]
Gene3D	G3DSA:3.40.630.30. Acyl_CoA_acyltransferase. 2 hits.
PANTHER	PTHR11377. Myristoyl_trans. 1 hit.
Pfam	PF01233. NMT. 1 hit. PF02799. NMT_C. 1 hit. [Graphical view]
SUPFAM	SSF55729. Acyl_CoA_acyltransferase. 2 hits.
PROSITE	PS00975. NMT_1. False negative. PS00976. NMT_2. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

NMT_MIMIV

Accession

Primary (citable) accession number: Q5UR64

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 13, 2005
Last sequence update:	December 7, 2004
Last modified:	September 21, 2011
This is version 34 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program