Probable cholinesterase precursor - Acanthamoeba polyphaga mimivirus (APMV)

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Q5UR02 (CHLE_MIMIV) Reviewed, UniProtKB/Swiss-Prot

Last modified July 11, 2012. Version 43. History...

Clusters with 100%, 90%, 50% identity |

Documents (1) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Probable cholinesterase
EC=3.1.1.8

Alternative name(s):
Acylcholine acylhydrolase

Gene names

Ordered Locus Names:

MIMI_L906

Organism

Acanthamoeba polyphaga mimivirus (APMV) [Reference proteome]

Taxonomic identifier

Taxonomic lineage

Viruses › dsDNA viruses, no RNA stage › Mimiviridae › Mimivirus

Virus host

Acanthamoeba polyphaga (Amoeba) [TaxID: 5757]

Protein attributes

Sequence length	579 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Function	May be involved in the disruption of the host membrane.
Catalytic activity	An acylcholine + H₂O = choline + a carboxylate.
Sequence similarities	Belongs to the type-B carboxylesterase/lipase family.

Ontologies

Keywords
Domain	Signal
Molecular function	Hydrolase Serine esterase
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular_function	carboxylesterase activity Inferred from electronic annotation. Source: UniProtKB-KW cholinesterase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

19

Potential

Chain

560

Probable cholinesterase

PRO_0000041775

Sites

Active site

1

Acyl-ester intermediate By similarity

Active site

1

Charge relay system By similarity

Active site

1

Charge relay system By similarity

Amino acid modifications

Glycosylation

1

N-linked (GlcNAc...); by host Potential

Glycosylation

1

N-linked (GlcNAc...); by host Potential

Glycosylation

1

N-linked (GlcNAc...); by host Potential

Glycosylation

1

N-linked (GlcNAc...); by host Potential

Glycosylation

1

N-linked (GlcNAc...); by host Potential

Glycosylation

1

N-linked (GlcNAc...); by host Potential

Glycosylation

1

N-linked (GlcNAc...); by host Potential

Glycosylation

1

N-linked (GlcNAc...); by host Potential

Sequences

Sequence

Length

Mass (Da)

Tools

Q5UR02 [UniParc].

Last modified December 7, 2004. Version 1.
Checksum: 1DD9D68940B8B9E6
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579

64,868

        10         20         30         40         50         60 
MTDHKIIMLL LLGIYCIQAT QFTQVNIDNG PIKGTLQYVE GRAIRVFKGI PFAEPPVNNL 

        70         80         90        100        110        120 
RWKAPVPYTK KWHNPLNTTE YKPKCPQYVA PGTVPEPRGI SEDCLYTNVW APVPEYHGET 

       130        140        150        160        170        180 
FPVMVWIHGG AFISGSPEDF GVGNFSILAV TKRIIIVAAS YRVNAFGFFS SELLGKSQLE 

       190        200        210        220        230        240 
ARGVYGLLDQ RLGLKWVKNN IAAFGGKSKD ITIYGQSAGG ISVCLQAVTP LNDLPGEKLF 

       250        260        270        280        290        300 
TRVIGSSGYC DILPMTNNSA DAGLVQKLNC TTKECLYALP WQNITNAVGP GFLSFQPTVG 

       310        320        330        340        350        360 
INKFLPDQPI SLLADRTNPR SKNFVPDIYM QGFTANEGTF VLYNYFPQTY DNPNTPGFPT 

       370        380        390        400        410        420 
QQMADALSIA SGNYSAEFYY NDLAPLYSTE YNSNVTYPGQ GFISRVDDIM ACNTRRNMIY 

       430        440        450        460        470        480 
WQQSKKTKAH SWYFDSAPDT HIYPSWTKVF HESDVFYVAR RCDGLWCTNL TCQQDNLGKT 

       490        500        510        520        530        540 
MNIYWNSAIR AASLTPKNKM DNLRDVPVWP QYGKNEVVMH FTAVGENKGP QTSVLFSSII 

       550        560        570 
SADGDYQYLQ RCKILDRVRA EYYNIPALDP ETYLNACSK

References

[1]

"The 1.2-megabase genome sequence of Mimivirus."
Raoult D., Audic S., Robert C., Abergel C., Renesto P., Ogata H., La Scola B., Susan M., Claverie J.-M.
Science 306:1344-1350(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Rowbotham-Bradford.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY653733 Genomic DNA. Translation: AAV51163.1.
RefSeq	YP_003987440.1. NC_014649.1.
3D structure databases
ProteinModelPortal	Q5UR02.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	9925575.
Family and domain databases
InterPro	IPR002018. CarbesteraseB. IPR019826. Carboxylesterase_B_AS. IPR019819. Carboxylesterase_B_CS. [Graphical view]
Pfam	PF00135. COesterase. 1 hit. [Graphical view]
PROSITE	PS00122. CARBOXYLESTERASE_B_1. 1 hit. PS00941. CARBOXYLESTERASE_B_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CHLE_MIMIV

Accession

Primary (citable) accession number: Q5UR02

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 13, 2005
Last sequence update:	December 7, 2004
Last modified:	July 11, 2012
This is version 43 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents