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Q5UR02 (CHLE_MIMIV) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 48. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable cholinesterase

EC=3.1.1.8
Alternative name(s):
Acylcholine acylhydrolase
Gene names
Ordered Locus Names:MIMI_L906
OrganismAcanthamoeba polyphaga mimivirus (APMV) [Reference proteome]
Taxonomic identifier212035 [NCBI]
Taxonomic lineageVirusesdsDNA viruses, no RNA stageMimiviridaeMimivirus
Virus hostAcanthamoeba polyphaga (Amoeba) [TaxID: 5757]

Protein attributes

Sequence length579 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

May be involved in the disruption of the host membrane.

Catalytic activity

An acylcholine + H2O = choline + a carboxylate.

Sequence similarities

Belongs to the type-B carboxylesterase/lipase family.

Ontologies

Keywords
   DomainSignal
   Molecular functionHydrolase
Serine esterase
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Molecular_functioncholinesterase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 Potential
Chain20 – 579560Probable cholinesterase
PRO_0000041775

Sites

Active site2171Acyl-ester intermediate By similarity
Active site3371Charge relay system By similarity
Active site4511Charge relay system By similarity

Amino acid modifications

Glycosylation771N-linked (GlcNAc...); by host Potential
Glycosylation1441N-linked (GlcNAc...); by host Potential
Glycosylation2571N-linked (GlcNAc...); by host Potential
Glycosylation2691N-linked (GlcNAc...); by host Potential
Glycosylation2831N-linked (GlcNAc...); by host Potential
Glycosylation3731N-linked (GlcNAc...); by host Potential
Glycosylation3941N-linked (GlcNAc...); by host Potential
Glycosylation4691N-linked (GlcNAc...); by host Potential

Sequences

Sequence LengthMass (Da)Tools
Q5UR02 [UniParc].

Last modified December 7, 2004. Version 1.
Checksum: 1DD9D68940B8B9E6

FASTA57964,868
        10         20         30         40         50         60 
MTDHKIIMLL LLGIYCIQAT QFTQVNIDNG PIKGTLQYVE GRAIRVFKGI PFAEPPVNNL 

        70         80         90        100        110        120 
RWKAPVPYTK KWHNPLNTTE YKPKCPQYVA PGTVPEPRGI SEDCLYTNVW APVPEYHGET 

       130        140        150        160        170        180 
FPVMVWIHGG AFISGSPEDF GVGNFSILAV TKRIIIVAAS YRVNAFGFFS SELLGKSQLE 

       190        200        210        220        230        240 
ARGVYGLLDQ RLGLKWVKNN IAAFGGKSKD ITIYGQSAGG ISVCLQAVTP LNDLPGEKLF 

       250        260        270        280        290        300 
TRVIGSSGYC DILPMTNNSA DAGLVQKLNC TTKECLYALP WQNITNAVGP GFLSFQPTVG 

       310        320        330        340        350        360 
INKFLPDQPI SLLADRTNPR SKNFVPDIYM QGFTANEGTF VLYNYFPQTY DNPNTPGFPT 

       370        380        390        400        410        420 
QQMADALSIA SGNYSAEFYY NDLAPLYSTE YNSNVTYPGQ GFISRVDDIM ACNTRRNMIY 

       430        440        450        460        470        480 
WQQSKKTKAH SWYFDSAPDT HIYPSWTKVF HESDVFYVAR RCDGLWCTNL TCQQDNLGKT 

       490        500        510        520        530        540 
MNIYWNSAIR AASLTPKNKM DNLRDVPVWP QYGKNEVVMH FTAVGENKGP QTSVLFSSII 

       550        560        570 
SADGDYQYLQ RCKILDRVRA EYYNIPALDP ETYLNACSK 

« Hide

References

[1]"The 1.2-megabase genome sequence of Mimivirus."
Raoult D., Audic S., Robert C., Abergel C., Renesto P., Ogata H., La Scola B., Susan M., Claverie J.-M.
Science 306:1344-1350(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Rowbotham-Bradford.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY653733 Genomic DNA. Translation: AAV51163.1.
RefSeqYP_003987440.1. NC_014649.1.

3D structure databases

ProteinModelPortalQ5UR02.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID9925575.

Family and domain databases

Gene3D3.40.50.1820. 1 hit.
InterProIPR029058. AB_hydrolase.
IPR002018. CarbesteraseB.
IPR019826. Carboxylesterase_B_AS.
IPR019819. Carboxylesterase_B_CS.
[Graphical view]
PfamPF00135. COesterase. 1 hit.
[Graphical view]
SUPFAMSSF53474. SSF53474. 1 hit.
PROSITEPS00122. CARBOXYLESTERASE_B_1. 1 hit.
PS00941. CARBOXYLESTERASE_B_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCHLE_MIMIV
AccessionPrimary (citable) accession number: Q5UR02
Entry history
Integrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: December 7, 2004
Last modified: June 11, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families