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Q5UR02

- CHLE_MIMIV

UniProt

Q5UR02 - CHLE_MIMIV

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Protein

Probable cholinesterase

Gene

MIMI_L906

Organism
Acanthamoeba polyphaga mimivirus (APMV)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

May be involved in the disruption of the host membrane.

Catalytic activityi

An acylcholine + H2O = choline + a carboxylate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei217 – 2171Acyl-ester intermediatePROSITE-ProRule annotation
Active sitei337 – 3371Charge relay systemBy similarity
Active sitei451 – 4511Charge relay systemBy similarity

GO - Molecular functioni

  1. cholinesterase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Serine esterase

Names & Taxonomyi

Protein namesi
Recommended name:
Probable cholinesterase (EC:3.1.1.8)
Alternative name(s):
Acylcholine acylhydrolase
Gene namesi
Ordered Locus Names:MIMI_L906
OrganismiAcanthamoeba polyphaga mimivirus (APMV)
Taxonomic identifieri212035 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageMimiviridaeMimivirus
Virus hostiAcanthamoeba polyphaga (Amoeba) [TaxID: 5757]
ProteomesiUP000001134: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence AnalysisAdd
BLAST
Chaini20 – 579560Probable cholinesterasePRO_0000041775Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi77 – 771N-linked (GlcNAc...); by hostSequence Analysis
Glycosylationi144 – 1441N-linked (GlcNAc...); by hostSequence Analysis
Glycosylationi257 – 2571N-linked (GlcNAc...); by hostSequence Analysis
Glycosylationi269 – 2691N-linked (GlcNAc...); by hostSequence Analysis
Glycosylationi283 – 2831N-linked (GlcNAc...); by hostSequence Analysis
Glycosylationi373 – 3731N-linked (GlcNAc...); by hostSequence Analysis
Glycosylationi394 – 3941N-linked (GlcNAc...); by hostSequence Analysis
Glycosylationi469 – 4691N-linked (GlcNAc...); by hostSequence Analysis

Keywords - PTMi

Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliQ5UR02.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR002018. CarbesteraseB.
IPR019826. Carboxylesterase_B_AS.
IPR019819. Carboxylesterase_B_CS.
[Graphical view]
PfamiPF00135. COesterase. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00122. CARBOXYLESTERASE_B_1. 1 hit.
PS00941. CARBOXYLESTERASE_B_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5UR02-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTDHKIIMLL LLGIYCIQAT QFTQVNIDNG PIKGTLQYVE GRAIRVFKGI
60 70 80 90 100
PFAEPPVNNL RWKAPVPYTK KWHNPLNTTE YKPKCPQYVA PGTVPEPRGI
110 120 130 140 150
SEDCLYTNVW APVPEYHGET FPVMVWIHGG AFISGSPEDF GVGNFSILAV
160 170 180 190 200
TKRIIIVAAS YRVNAFGFFS SELLGKSQLE ARGVYGLLDQ RLGLKWVKNN
210 220 230 240 250
IAAFGGKSKD ITIYGQSAGG ISVCLQAVTP LNDLPGEKLF TRVIGSSGYC
260 270 280 290 300
DILPMTNNSA DAGLVQKLNC TTKECLYALP WQNITNAVGP GFLSFQPTVG
310 320 330 340 350
INKFLPDQPI SLLADRTNPR SKNFVPDIYM QGFTANEGTF VLYNYFPQTY
360 370 380 390 400
DNPNTPGFPT QQMADALSIA SGNYSAEFYY NDLAPLYSTE YNSNVTYPGQ
410 420 430 440 450
GFISRVDDIM ACNTRRNMIY WQQSKKTKAH SWYFDSAPDT HIYPSWTKVF
460 470 480 490 500
HESDVFYVAR RCDGLWCTNL TCQQDNLGKT MNIYWNSAIR AASLTPKNKM
510 520 530 540 550
DNLRDVPVWP QYGKNEVVMH FTAVGENKGP QTSVLFSSII SADGDYQYLQ
560 570
RCKILDRVRA EYYNIPALDP ETYLNACSK
Length:579
Mass (Da):64,868
Last modified:December 7, 2004 - v1
Checksum:i1DD9D68940B8B9E6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY653733 Genomic DNA. Translation: AAV51163.1.
RefSeqiYP_003987440.1. NC_014649.1.

Genome annotation databases

GeneIDi9925575.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY653733 Genomic DNA. Translation: AAV51163.1 .
RefSeqi YP_003987440.1. NC_014649.1.

3D structure databases

ProteinModelPortali Q5UR02.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 9925575.

Family and domain databases

Gene3Di 3.40.50.1820. 1 hit.
InterProi IPR029058. AB_hydrolase.
IPR002018. CarbesteraseB.
IPR019826. Carboxylesterase_B_AS.
IPR019819. Carboxylesterase_B_CS.
[Graphical view ]
Pfami PF00135. COesterase. 1 hit.
[Graphical view ]
SUPFAMi SSF53474. SSF53474. 1 hit.
PROSITEi PS00122. CARBOXYLESTERASE_B_1. 1 hit.
PS00941. CARBOXYLESTERASE_B_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Rowbotham-Bradford.

Entry informationi

Entry nameiCHLE_MIMIV
AccessioniPrimary (citable) accession number: Q5UR02
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: December 7, 2004
Last modified: October 1, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3