Reviewed, UniProtKB/Swiss-Prot Q5UQV6 (YR368_MIMIV)

Names and origin

Protein names

Recommended name:
    Probable FAD-linked sulfhydryl oxidase R368
    EC=1.8.3.2

Gene names

Ordered Locus Names:

MIMI_R368

Organism

Acanthamoeba polyphaga mimivirus (APMV) [Complete proteome]

Taxonomic identifier

212035 [NCBI]

Taxonomic lineage

Viruses › dsDNA viruses, no RNA stage › Mimiviridae › Mimivirus

Virus host

Acanthamoeba polyphaga (Amoeba) [TaxID: 5757]

Protein attributes

Sequence length	143 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	FAD-dependent sulfhydryl oxidase that catalyzes disulfide bond formation By similarity.
Catalytic activity	4 R'C(R)SH + O2 = 2 R'C(R)S-S(R)CR' + 2 H2O.
Cofactor	FAD By similarity.
Subcellular location	Membrane; Single-pass membrane protein Potential.
Sequence similarities	Contains 1 ERV/ALR sulfhydryl oxidase domain.

Ontologies

Keywords
Cellular component	Membrane
Domain	Transmembrane
Ligand	FAD Flavoprotein
Molecular function	Oxidoreductase
PTM	Disulfide bond
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	thiol oxidase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 143	143	Probable FAD-linked sulfhydryl oxidase R368		PRO_0000309199
Regions
	Transmembrane	117 – 137	21	Potential
	Domain	10 – 104	95	ERV/ALR sulfhydryl oxidase
Amino acid modifications
	Disulfide bond	46 ↔ 49		Redox-active Potential

Sequences

	Sequence		Length	Mass (Da)
	Q5UQV6-1 [UniParc]. Last modified December 7, 2004. Version 1. Checksum: CA9BCD24A6933889	FASTA	143	16,981
	10 20 30 40 50 60 MSPEQWGIYG WTFSHAVALG YPINPTEEDK LRYYTFFNSY RYVLPCGKCR INYADHLNKY 70 80 90 100 110 120 PLTDEVLSSR ENLVKWTIDI HNVVNYYTGK KMLTYPEAIE AIEKTLTPKK KSSYNWFFII 130 140 LIIIGIIVII YLMYIVFKKK LNK

References

[1]	"The 1.2-megabase genome sequence of Mimivirus." Raoult D., Audic S., Robert C., Abergel C., Renesto P., Ogata H., La Scola B., Susan M., Claverie J.-M. Science 306:1344-1350(2004) [PubMed: 15486256] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Rowbotham-Bradford.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY653733 Genomic DNA. Translation: AAV50637.1.
RefSeq	YP_142722.1.
3D structure databases
HSSP	HSSP built from PDB template 1JR8 based on UniProtKB Q12284.
ModBase	Search...
Genome annotation databases
GeneID	3162232.
Enzyme and pathway databases
BRENDA	1.8.3.2. 281366.
Family and domain databases
InterPro	IPR017905. ERV/ALR_sulphydryl_oxidase. IPR006863. Evr1_Alr. [Graphical view]
Gene3D	G3DSA:1.20.120.310. Evr1_Alr. 1 hit.
Pfam	PF04777. Evr1_Alr. 1 hit. [Graphical view]
PROSITE	PS51324. ERV_ALR. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

YR368_MIMIV

Accession

Primary (citable) accession number: Q5UQV6

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 13, 2007
Last sequence update:	December 7, 2004
Last modified:	November 24, 2009
This is version 26 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Virus (Virus annotation project)