Q5UQT7 (RNC_MIMIV) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable ribonuclease 3
EC=3.1.26.3

Alternative name(s):
Ribonuclease III
Short name=RNase III

Gene names

Ordered Locus Names:

MIMI_R343

Organism

Acanthamoeba polyphaga mimivirus (APMV) [Reference proteome]

Taxonomic identifier

212035 [NCBI]

Taxonomic lineage

Viruses › dsDNA viruses, no RNA stage › Mimiviridae › Mimivirus

Virus host

Acanthamoeba polyphaga (Amoeba) [TaxID: 5757]

Protein attributes

Sequence length	538 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Digests double-stranded RNA By similarity.
Catalytic activity	Endonucleolytic cleavage to 5'-phosphomonoester.
Sequence similarities	Contains 1 DRBM (double-stranded RNA-binding) domain. Contains 2 RNase III domains.

Ontologies

Keywords
Domain	Repeat
Ligand	RNA-binding
Molecular function	Endonuclease Hydrolase Nuclease
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	RNA processing Inferred from electronic annotation. Source: InterPro nucleic acid phosphodiester bond hydrolysis Inferred from electronic annotation. Source: GOC rRNA catabolic process Inferred from electronic annotation. Source: InterPro
Molecular_function	double-stranded RNA binding Inferred from electronic annotation. Source: InterPro ribonuclease III activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 538	538	Probable ribonuclease 3		PRO_0000243980
Regions
	Domain	24 – 149	126	RNase III 1
	Domain	238 – 381	144	RNase III 2
	Domain	408 – 477	70	DRBM

Sequences

	Sequence		Length	Mass (Da)
	Q5UQT7 [UniParc]. Last modified December 7, 2004. Version 1. Checksum: BDC3AD6D0CB4E904	FASTA	538	63,058
	10 20 30 40 50 60 MSKFQNYYNN DDNVINYPYI DYIIKSYIPE YYVDTNRRKY VDMHIFEEAM LHVSTIYEES 70 80 90 100 110 120 DKTYERLEYL GDAIFHMIIT EYFYHRYNEE NEGFLTRLRI RIERGDSMVE LSKNLGLNNF 130 140 150 160 170 180 VQIYGISLND HILEDIFESF IGAFYLNFGM KYTRLFIIKL IEKHKNLSEL IAYDDNYKDL 190 200 210 220 230 240 LLRYFHQMKW GHPKYIEEIV IDPKNNQRNK FISKVKNPFD KVIGIGSAST KKKSEQLASQ 250 260 270 280 290 300 MALTNLGVII DGEIDTDWIN KIEKIETEAT QTEIKDKKPM SVFNPNNKLL SKNTIKNLLL 310 320 330 340 350 360 QYNTKLPTID IDLKLFYEAM THRSYLIRKN LPNRDVPKSK SIVRLQKKSN ERLQFLGDAV 370 380 390 400 410 420 IHFIIGEYLF NKYADSGEGY LTRLRCKLEN SESLFFLAKQ SDISSYLLIS QNIEVLHGRE 430 440 450 460 470 480 NVNIIGGGLE AFVGALYLNI GLGTVKQFLL EIMRIELDIN QIAENETNYK DLILQLYNKN 490 500 510 520 530 KWGHPVYKIL KEEGPDHCKI FTMGLYLGNK LMGIGKASSK KKAEQIASKK MYQNYINN

References

[1]	"The 1.2-megabase genome sequence of Mimivirus." Raoult D., Audic S., Robert C., Abergel C., Renesto P., Ogata H., La Scola B., Susan M., Claverie J.-M. Science 306:1344-1350(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Rowbotham-Bradford.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY653733 Genomic DNA. Translation: AAV50612.1.
RefSeq	YP_003986845.1. NC_014649.1.
3D structure databases
ProteinModelPortal	Q5UQT7.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	9924960.
Family and domain databases
Gene3D	1.10.1520.10. 2 hits. 3.30.160.20. 2 hits.
InterPro	IPR001159. Ds-RNA-bd. IPR014720. dsRNA-bd-like_dom. IPR011907. RNase_III. IPR000999. RNase_III_dom. [Graphical view]
PANTHER	PTHR11207. PTHR11207. 1 hit.
Pfam	PF00035. dsrm. 2 hits. PF00636. Ribonuclease_3. 2 hits. [Graphical view]
SMART	SM00358. DSRM. 2 hits. SM00535. RIBOc. 2 hits. [Graphical view]
SUPFAM	SSF69065. RNase_III. 2 hits.
PROSITE	PS50137. DS_RBD. 1 hit. PS00517. RNASE_3_1. 1 hit. PS50142. RNASE_3_2. 2 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

RNC_MIMIV

Accession

Primary (citable) accession number: Q5UQT7

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 27, 2006
Last sequence update:	December 7, 2004
Last modified:	May 1, 2013
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program