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Q5UQT7 (RNC_MIMIV) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 51. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable ribonuclease 3

EC=3.1.26.3
Alternative name(s):
Ribonuclease III
Short name=RNase III
Gene names
Ordered Locus Names:MIMI_R343
OrganismAcanthamoeba polyphaga mimivirus (APMV) [Reference proteome]
Taxonomic identifier212035 [NCBI]
Taxonomic lineageVirusesdsDNA viruses, no RNA stageMimiviridaeMimivirus
Virus hostAcanthamoeba polyphaga (Amoeba) [TaxID: 5757]

Protein attributes

Sequence length538 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Digests double-stranded RNA By similarity. HAMAP-Rule MF_00104

Catalytic activity

Endonucleolytic cleavage to 5'-phosphomonoester. HAMAP-Rule MF_00104

Sequence similarities

Contains 1 DRBM (double-stranded RNA-binding) domain.

Contains 2 RNase III domains.

Ontologies

Keywords
   DomainRepeat
   LigandRNA-binding
   Molecular functionEndonuclease
Hydrolase
Nuclease
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processRNA processing

Inferred from electronic annotation. Source: InterPro

rRNA catabolic process

Inferred from electronic annotation. Source: InterPro

   Molecular_functionRNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

ribonuclease III activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 538538Probable ribonuclease 3 HAMAP-Rule MF_00104
PRO_0000243980

Regions

Domain24 – 149126RNase III 1
Domain238 – 381144RNase III 2
Domain408 – 47770DRBM

Sequences

Sequence LengthMass (Da)Tools
Q5UQT7 [UniParc].

Last modified December 7, 2004. Version 1.
Checksum: BDC3AD6D0CB4E904

FASTA53863,058
        10         20         30         40         50         60 
MSKFQNYYNN DDNVINYPYI DYIIKSYIPE YYVDTNRRKY VDMHIFEEAM LHVSTIYEES 

        70         80         90        100        110        120 
DKTYERLEYL GDAIFHMIIT EYFYHRYNEE NEGFLTRLRI RIERGDSMVE LSKNLGLNNF 

       130        140        150        160        170        180 
VQIYGISLND HILEDIFESF IGAFYLNFGM KYTRLFIIKL IEKHKNLSEL IAYDDNYKDL 

       190        200        210        220        230        240 
LLRYFHQMKW GHPKYIEEIV IDPKNNQRNK FISKVKNPFD KVIGIGSAST KKKSEQLASQ 

       250        260        270        280        290        300 
MALTNLGVII DGEIDTDWIN KIEKIETEAT QTEIKDKKPM SVFNPNNKLL SKNTIKNLLL 

       310        320        330        340        350        360 
QYNTKLPTID IDLKLFYEAM THRSYLIRKN LPNRDVPKSK SIVRLQKKSN ERLQFLGDAV 

       370        380        390        400        410        420 
IHFIIGEYLF NKYADSGEGY LTRLRCKLEN SESLFFLAKQ SDISSYLLIS QNIEVLHGRE 

       430        440        450        460        470        480 
NVNIIGGGLE AFVGALYLNI GLGTVKQFLL EIMRIELDIN QIAENETNYK DLILQLYNKN 

       490        500        510        520        530 
KWGHPVYKIL KEEGPDHCKI FTMGLYLGNK LMGIGKASSK KKAEQIASKK MYQNYINN 

« Hide

References

[1]"The 1.2-megabase genome sequence of Mimivirus."
Raoult D., Audic S., Robert C., Abergel C., Renesto P., Ogata H., La Scola B., Susan M., Claverie J.-M.
Science 306:1344-1350(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Rowbotham-Bradford.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY653733 Genomic DNA. Translation: AAV50612.1.
RefSeqYP_003986845.1. NC_014649.1.

3D structure databases

ProteinModelPortalQ5UQT7.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID9924960.

Family and domain databases

Gene3D1.10.1520.10. 2 hits.
3.30.160.20. 2 hits.
HAMAPMF_00104. RNase_III.
InterProIPR014720. dsRNA-bd_dom.
IPR011907. RNase_III.
IPR000999. RNase_III_dom.
[Graphical view]
PANTHERPTHR11207. PTHR11207. 1 hit.
PfamPF00035. dsrm. 2 hits.
PF00636. Ribonuclease_3. 2 hits.
[Graphical view]
SMARTSM00358. DSRM. 2 hits.
SM00535. RIBOc. 2 hits.
[Graphical view]
SUPFAMSSF69065. SSF69065. 2 hits.
PROSITEPS50137. DS_RBD. 1 hit.
PS00517. RNASE_3_1. 1 hit.
PS50142. RNASE_3_2. 2 hits.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameRNC_MIMIV
AccessionPrimary (citable) accession number: Q5UQT7
Entry history
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: December 7, 2004
Last modified: April 16, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families