ID PAP1_MIMIV Reviewed; 584 AA. AC Q5UQS6; DT 17-OCT-2006, integrated into UniProtKB/Swiss-Prot. DT 07-DEC-2004, sequence version 1. DT 27-MAR-2024, entry version 63. DE RecName: Full=Putative poly(A) polymerase catalytic subunit; DE EC=2.7.7.19; GN OrderedLocusNames=MIMI_R341; OS Acanthamoeba polyphaga mimivirus (APMV). OC Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Megaviricetes; OC Imitervirales; Mimiviridae; Megamimivirinae; Mimivirus; OC Mimivirus bradfordmassiliense. OX NCBI_TaxID=212035; OH NCBI_TaxID=5757; Acanthamoeba polyphaga (Amoeba). RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Rowbotham-Bradford; RX PubMed=15486256; DOI=10.1126/science.1101485; RA Raoult D., Audic S., Robert C., Abergel C., Renesto P., Ogata H., RA La Scola B., Susan M., Claverie J.-M.; RT "The 1.2-megabase genome sequence of Mimivirus."; RL Science 306:1344-1350(2004). RN [2] RP SIMILARITY. RA Abergel C.; RL Unpublished observations (SEP-2007). RN [3] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], AND SUBCELLULAR RP LOCATION. RX PubMed=16971431; DOI=10.1128/jvi.00940-06; RA Renesto P., Abergel C., Decloquement P., Moinier D., Azza S., Ogata H., RA Fourquet P., Gorvel J.-P., Claverie J.-M., Raoult D.; RT "Mimivirus giant particles incorporate a large fraction of anonymous and RT unique gene products."; RL J. Virol. 80:11678-11685(2006). CC -!- FUNCTION: Polymerase that creates the 3'-poly(A) tail of mRNA's. CC {ECO:0000305}. CC -!- CATALYTIC ACTIVITY: CC Reaction=ATP + RNA(n) = diphosphate + RNA(n)-3'-adenine ribonucleotide; CC Xref=Rhea:RHEA:11332, Rhea:RHEA-COMP:14527, Rhea:RHEA-COMP:17347, CC ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:140395, CC ChEBI:CHEBI:173115; EC=2.7.7.19; CC -!- SUBCELLULAR LOCATION: Virion {ECO:0000269|PubMed:16971431}. CC -!- SIMILARITY: Belongs to the poxviridae poly(A) polymerase catalytic CC subunit family. Highly divergent. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AY653733; AAV50610.1; -; Genomic_DNA. DR RefSeq; YP_003986843.1; NC_014649.1. DR PDB; 4WSE; X-ray; 2.84 A; A/B=1-584. DR PDBsum; 4WSE; -. DR SMR; Q5UQS6; -. DR GeneID; 9924958; -. DR KEGG; vg:9924958; -. DR OrthoDB; 3863at10239; -. DR Proteomes; UP000001134; Genome. DR GO; GO:0044423; C:virion component; IEA:UniProtKB-KW. DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW. DR GO; GO:1990817; F:poly(A) RNA polymerase activity; IEA:UniProtKB-EC. DR GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW. DR CDD; cd20920; polyA_pol_Mimi; 1. DR InterPro; IPR049463; APMV_polyA_pol_cat_2nd. DR InterPro; IPR045355; PolyA_pol_cat_su. DR Pfam; PF21649; APMV_polyA_pol_cat_2nd; 1. DR Pfam; PF19244; Poly_A_pol_cat; 1. PE 1: Evidence at protein level; KW 3D-structure; ATP-binding; mRNA processing; Nucleotide-binding; KW Reference proteome; Transcription; Transferase; Virion. FT CHAIN 1..584 FT /note="Putative poly(A) polymerase catalytic subunit" FT /id="PRO_0000253421" FT REGION 522..584 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 530..584 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT HELIX 19..41 FT /evidence="ECO:0007829|PDB:4WSE" FT STRAND 42..44 FT /evidence="ECO:0007829|PDB:4WSE" FT HELIX 46..63 FT /evidence="ECO:0007829|PDB:4WSE" FT STRAND 66..68 FT /evidence="ECO:0007829|PDB:4WSE" FT HELIX 69..80 FT /evidence="ECO:0007829|PDB:4WSE" FT HELIX 82..84 FT /evidence="ECO:0007829|PDB:4WSE" FT STRAND 95..101 FT /evidence="ECO:0007829|PDB:4WSE" FT HELIX 102..115 FT /evidence="ECO:0007829|PDB:4WSE" FT STRAND 122..125 FT /evidence="ECO:0007829|PDB:4WSE" FT STRAND 131..138 FT /evidence="ECO:0007829|PDB:4WSE" FT STRAND 140..146 FT /evidence="ECO:0007829|PDB:4WSE" FT HELIX 149..154 FT /evidence="ECO:0007829|PDB:4WSE" FT STRAND 157..160 FT /evidence="ECO:0007829|PDB:4WSE" FT STRAND 163..166 FT /evidence="ECO:0007829|PDB:4WSE" FT HELIX 168..179 FT /evidence="ECO:0007829|PDB:4WSE" FT HELIX 182..203 FT /evidence="ECO:0007829|PDB:4WSE" FT HELIX 220..231 FT /evidence="ECO:0007829|PDB:4WSE" FT TURN 232..235 FT /evidence="ECO:0007829|PDB:4WSE" FT TURN 237..239 FT /evidence="ECO:0007829|PDB:4WSE" FT STRAND 243..246 FT /evidence="ECO:0007829|PDB:4WSE" FT HELIX 247..257 FT /evidence="ECO:0007829|PDB:4WSE" FT TURN 277..280 FT /evidence="ECO:0007829|PDB:4WSE" FT STRAND 286..291 FT /evidence="ECO:0007829|PDB:4WSE" FT HELIX 294..308 FT /evidence="ECO:0007829|PDB:4WSE" FT STRAND 309..311 FT /evidence="ECO:0007829|PDB:4WSE" FT HELIX 312..314 FT /evidence="ECO:0007829|PDB:4WSE" FT STRAND 315..320 FT /evidence="ECO:0007829|PDB:4WSE" FT TURN 324..326 FT /evidence="ECO:0007829|PDB:4WSE" FT STRAND 330..337 FT /evidence="ECO:0007829|PDB:4WSE" FT STRAND 339..345 FT /evidence="ECO:0007829|PDB:4WSE" FT STRAND 351..354 FT /evidence="ECO:0007829|PDB:4WSE" FT HELIX 377..393 FT /evidence="ECO:0007829|PDB:4WSE" FT HELIX 397..421 FT /evidence="ECO:0007829|PDB:4WSE" FT STRAND 427..429 FT /evidence="ECO:0007829|PDB:4WSE" FT STRAND 438..440 FT /evidence="ECO:0007829|PDB:4WSE" FT HELIX 445..459 FT /evidence="ECO:0007829|PDB:4WSE" FT HELIX 469..472 FT /evidence="ECO:0007829|PDB:4WSE" FT HELIX 477..482 FT /evidence="ECO:0007829|PDB:4WSE" FT HELIX 501..503 FT /evidence="ECO:0007829|PDB:4WSE" FT STRAND 505..508 FT /evidence="ECO:0007829|PDB:4WSE" FT STRAND 514..516 FT /evidence="ECO:0007829|PDB:4WSE" FT STRAND 524..526 FT /evidence="ECO:0007829|PDB:4WSE" SQ SEQUENCE 584 AA; 68247 MW; D14A33890DE87406 CRC64; MLKNKTRAEK YQTYYTTNEY QIVKEKLPDI IRDAEIKASE VLEPTIYEKR AIMEVIKDFI RDHQRKVYGG TALNEALKQV NPKDAIYDNY SFSDIEFYSP TPVQDLVDLC NILYRKGYKF VQGKDAQHEE TYSIFVNFQL YCDITYSPTR VFYGIKTIEI DGINYTDPHF MLIDYLRMVN QPLTAAGQRW EKAFERMYRL LKDYPIEDFD KRLDIPEPPE EIQSYISRIK TEFLSDNKLN ESFLISGIEA YNFYIRHAAS SKDEEQMART NRNVVNLNNF IANVPFSELI SVNYREDVKN TYNFLRMIVE DKEKISVDEY FPLFQFTGYS TVIKYDDHPI IRIYEGDGYC IPNVKTVKTV ENDNGTKTKY EYKYVSFQYV LMILYINKFR AHLDKNKPMY FNYGIAISNL VKARNIYLDQ TGKSVLDNTV FKEFRTNCTG NTISFTRMNR LRLLEKRKQG KQTSFVYTPE DFFKKDLETQ AKLDPSKARF KNTSGNKIMV PKYLLFKIDN NGNIEDNIHS EEAEISEKEE TSGGSSISTD KSFEESPNSS PNSSPNNSLN NSIDISTNNY DDRSENSLDS LTSD //