Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q5UQR3 (UBPL1_MIMIV) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 48. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable ubiquitin carboxyl-terminal hydrolase R319

EC=3.4.19.12
Alternative name(s):
Deubiquitinating enzyme R319
Ubiquitin thioesterase R319
Ubiquitin-specific-processing protease R319
Gene names
Ordered Locus Names:MIMI_R319
OrganismAcanthamoeba polyphaga mimivirus (APMV) [Reference proteome]
Taxonomic identifier212035 [NCBI]
Taxonomic lineageVirusesdsDNA viruses, no RNA stageMimiviridaeMimivirus
Virus hostAcanthamoeba polyphaga (Amoeba) [TaxID: 5757]

Protein attributes

Sequence length468 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sequence similarities

Belongs to the peptidase C19 family.

Contains 1 USP domain.

Ontologies

Keywords
   Biological processUbl conjugation pathway
   Molecular functionHydrolase
Protease
Thiol protease
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processubiquitin-dependent protein catabolic process

Inferred from electronic annotation. Source: InterPro

   Molecular_functioncysteine-type peptidase activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 468468Probable ubiquitin carboxyl-terminal hydrolase R319
PRO_0000080700

Regions

Domain42 – 462421USP

Sites

Active site511Nucleophile By similarity
Active site4201Proton acceptor By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5UQR3 [UniParc].

Last modified December 7, 2004. Version 1.
Checksum: 3BFE646E5BDF206A

FASTA46854,760
        10         20         30         40         50         60 
MQNMMNTSQS FQNDSVLIGD KNTLQSINKS VDNGSKNTHG ITGIMNLGNT CYMNSALQAL 

        70         80         90        100        110        120 
SHNYLLINYL FMNKKQIIRT LLTNARKIFK DCDNFKIEST ISPIPLELRK KIQSENYHLS 

       130        140        150        160        170        180 
MLTVEDVNIL LNNTITAQII RLFECMWKNN CVVVPTSFRK VFGEVRDKFF FGYEQHDAEE 

       190        200        210        220        230        240 
AYSCIIQKMQ EELAEKRTIR FKTTRHSVGE YIKYMNDVKE KVSCLPNGKE KDIVMNKFKQ 

       250        260        270        280        290        300 
IKKQMPRESL TAESFREMKK YYEQGYSYIT EIFSGYVHSS ICCPNTSCGF TNDRFDAFTH 

       310        320        330        340        350        360 
LSLSIPVKNM YEQLNVYDCL REYFSQETLD ADNLWNCEGC HEKVQAIKKT KLWTTPYVLV 

       370        380        390        400        410        420 
IQFKRFGMTR IAKDNRFINY PMDELDVSSV ICSQQFEDSV QTKYKLQCVI NHHGGLNNGH 

       430        440        450        460 
YFTYSKIENT GEWYEFNDTY TGKVTDNHIV NQNAYILFYI RSDLFRSQ 

« Hide

References

[1]"The 1.2-megabase genome sequence of Mimivirus."
Raoult D., Audic S., Robert C., Abergel C., Renesto P., Ogata H., La Scola B., Susan M., Claverie J.-M.
Science 306:1344-1350(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Rowbotham-Bradford.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY653733 Genomic DNA. Translation: AAV50588.1.
RefSeqYP_003986822.1. NC_014649.1.

3D structure databases

ProteinModelPortalQ5UQR3.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID9924936.

Family and domain databases

InterProIPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
[Graphical view]
PfamPF00443. UCH. 1 hit.
[Graphical view]
PROSITEPS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameUBPL1_MIMIV
AccessionPrimary (citable) accession number: Q5UQR3
Entry history
Integrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: December 7, 2004
Last modified: April 16, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries