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Q5UQR3

- UBPL1_MIMIV

UniProt

Q5UQR3 - UBPL1_MIMIV

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Protein

Probable ubiquitin carboxyl-terminal hydrolase R319

Gene

MIMI_R319

Organism
Acanthamoeba polyphaga mimivirus (APMV)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei51 – 511NucleophilePROSITE-ProRule annotation
Active sitei420 – 4201Proton acceptorPROSITE-ProRule annotation

GO - Molecular functioni

  1. cysteine-type peptidase activity Source: UniProtKB-KW
  2. ubiquitinyl hydrolase activity Source: InterPro

GO - Biological processi

  1. ubiquitin-dependent protein catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Ubl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Probable ubiquitin carboxyl-terminal hydrolase R319 (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme R319
Ubiquitin thioesterase R319
Ubiquitin-specific-processing protease R319
Gene namesi
Ordered Locus Names:MIMI_R319
OrganismiAcanthamoeba polyphaga mimivirus (APMV)
Taxonomic identifieri212035 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageMimiviridaeMimivirus
Virus hostiAcanthamoeba polyphaga (Amoeba) [TaxID: 5757]
ProteomesiUP000001134: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 468468Probable ubiquitin carboxyl-terminal hydrolase R319PRO_0000080700Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ5UQR3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini42 – 462421USPAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase C19 family.Curated
Contains 1 USP domain.Curated

Family and domain databases

InterProiIPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
[Graphical view]
PfamiPF00443. UCH. 1 hit.
[Graphical view]
PROSITEiPS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5UQR3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQNMMNTSQS FQNDSVLIGD KNTLQSINKS VDNGSKNTHG ITGIMNLGNT
60 70 80 90 100
CYMNSALQAL SHNYLLINYL FMNKKQIIRT LLTNARKIFK DCDNFKIEST
110 120 130 140 150
ISPIPLELRK KIQSENYHLS MLTVEDVNIL LNNTITAQII RLFECMWKNN
160 170 180 190 200
CVVVPTSFRK VFGEVRDKFF FGYEQHDAEE AYSCIIQKMQ EELAEKRTIR
210 220 230 240 250
FKTTRHSVGE YIKYMNDVKE KVSCLPNGKE KDIVMNKFKQ IKKQMPRESL
260 270 280 290 300
TAESFREMKK YYEQGYSYIT EIFSGYVHSS ICCPNTSCGF TNDRFDAFTH
310 320 330 340 350
LSLSIPVKNM YEQLNVYDCL REYFSQETLD ADNLWNCEGC HEKVQAIKKT
360 370 380 390 400
KLWTTPYVLV IQFKRFGMTR IAKDNRFINY PMDELDVSSV ICSQQFEDSV
410 420 430 440 450
QTKYKLQCVI NHHGGLNNGH YFTYSKIENT GEWYEFNDTY TGKVTDNHIV
460
NQNAYILFYI RSDLFRSQ
Length:468
Mass (Da):54,760
Last modified:December 7, 2004 - v1
Checksum:i3BFE646E5BDF206A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY653733 Genomic DNA. Translation: AAV50588.1.
RefSeqiYP_003986822.1. NC_014649.1.

Genome annotation databases

GeneIDi9924936.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY653733 Genomic DNA. Translation: AAV50588.1 .
RefSeqi YP_003986822.1. NC_014649.1.

3D structure databases

ProteinModelPortali Q5UQR3.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 9924936.

Family and domain databases

InterProi IPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
[Graphical view ]
Pfami PF00443. UCH. 1 hit.
[Graphical view ]
PROSITEi PS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Rowbotham-Bradford.

Entry informationi

Entry nameiUBPL1_MIMIV
AccessioniPrimary (citable) accession number: Q5UQR3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: December 7, 2004
Last modified: October 1, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3