Q5UQR3 (UBPL1_MIMIV) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable ubiquitin carboxyl-terminal hydrolase R319
EC=3.4.19.12

Alternative name(s):
Deubiquitinating enzyme R319
Ubiquitin thioesterase R319
Ubiquitin-specific-processing protease R319

Gene names

Ordered Locus Names:

MIMI_R319

Organism

Acanthamoeba polyphaga mimivirus (APMV) [Reference proteome]

Taxonomic identifier

212035 [NCBI]

Taxonomic lineage

Viruses › dsDNA viruses, no RNA stage › Mimiviridae › Mimivirus

Virus host

Acanthamoeba polyphaga (Amoeba) [TaxID: 5757]

Protein attributes

Sequence length	468 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
Sequence similarities	Belongs to the peptidase C19 family.

Ontologies

Keywords
Biological process	Ubl conjugation pathway
Molecular function	Hydrolase Protease Thiol protease
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	ubiquitin-dependent protein catabolic process Inferred from electronic annotation. Source: InterPro
Molecular_function	cysteine-type peptidase activity Inferred from electronic annotation. Source: UniProtKB-KW ubiquitin thiolesterase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 468	468	Probable ubiquitin carboxyl-terminal hydrolase R319		PRO_0000080700
Sites
	Active site	51	1	Nucleophile By similarity
	Active site	420	1	Proton acceptor By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5UQR3 [UniParc]. Last modified December 7, 2004. Version 1. Checksum: 3BFE646E5BDF206A	FASTA	468	54,760
	10 20 30 40 50 60 MQNMMNTSQS FQNDSVLIGD KNTLQSINKS VDNGSKNTHG ITGIMNLGNT CYMNSALQAL 70 80 90 100 110 120 SHNYLLINYL FMNKKQIIRT LLTNARKIFK DCDNFKIEST ISPIPLELRK KIQSENYHLS 130 140 150 160 170 180 MLTVEDVNIL LNNTITAQII RLFECMWKNN CVVVPTSFRK VFGEVRDKFF FGYEQHDAEE 190 200 210 220 230 240 AYSCIIQKMQ EELAEKRTIR FKTTRHSVGE YIKYMNDVKE KVSCLPNGKE KDIVMNKFKQ 250 260 270 280 290 300 IKKQMPRESL TAESFREMKK YYEQGYSYIT EIFSGYVHSS ICCPNTSCGF TNDRFDAFTH 310 320 330 340 350 360 LSLSIPVKNM YEQLNVYDCL REYFSQETLD ADNLWNCEGC HEKVQAIKKT KLWTTPYVLV 370 380 390 400 410 420 IQFKRFGMTR IAKDNRFINY PMDELDVSSV ICSQQFEDSV QTKYKLQCVI NHHGGLNNGH 430 440 450 460 YFTYSKIENT GEWYEFNDTY TGKVTDNHIV NQNAYILFYI RSDLFRSQ

References

[1]	"The 1.2-megabase genome sequence of Mimivirus." Raoult D., Audic S., Robert C., Abergel C., Renesto P., Ogata H., La Scola B., Susan M., Claverie J.-M. Science 306:1344-1350(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Rowbotham-Bradford.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY653733 Genomic DNA. Translation: AAV50588.1.
RefSeq	YP_003986822.1. NC_014649.1.
3D structure databases
ProteinModelPortal	Q5UQR3.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	9924936.
Family and domain databases
InterPro	IPR018200. Pept_C19ubi-hydrolase_C_CS. IPR001394. Peptidase_C19. [Graphical view]
Pfam	PF00443. UCH. 1 hit. [Graphical view]
PROSITE	PS00972. UCH_2_1. 1 hit. PS00973. UCH_2_2. 1 hit. PS50235. UCH_2_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

UBPL1_MIMIV

Accession

Primary (citable) accession number: Q5UQR3

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 13, 2005
Last sequence update:	December 7, 2004
Last modified:	July 11, 2012
This is version 45 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program