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Protein

Probable ubiquitin carboxyl-terminal hydrolase R319

Gene

MIMI_R319

Organism
Acanthamoeba polyphaga mimivirus (APMV)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei51 – 511NucleophilePROSITE-ProRule annotation
Active sitei420 – 4201Proton acceptorPROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Ubl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Probable ubiquitin carboxyl-terminal hydrolase R319 (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme R319
Ubiquitin thioesterase R319
Ubiquitin-specific-processing protease R319
Gene namesi
Ordered Locus Names:MIMI_R319
OrganismiAcanthamoeba polyphaga mimivirus (APMV)
Taxonomic identifieri212035 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageMimiviridaeMimivirus
Virus hostiAcanthamoeba polyphaga (Amoeba) [TaxID: 5757]
ProteomesiUP000001134 Componenti: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 468468Probable ubiquitin carboxyl-terminal hydrolase R319PRO_0000080700Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ5UQR3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini42 – 462421USPAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase C19 family.Curated
Contains 1 USP domain.Curated

Phylogenomic databases

KOiK11833.

Family and domain databases

InterProiIPR001394. Peptidase_C19_UCH.
IPR018200. USP_CS.
IPR028889. USP_dom.
[Graphical view]
PfamiPF00443. UCH. 1 hit.
[Graphical view]
PROSITEiPS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5UQR3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQNMMNTSQS FQNDSVLIGD KNTLQSINKS VDNGSKNTHG ITGIMNLGNT
60 70 80 90 100
CYMNSALQAL SHNYLLINYL FMNKKQIIRT LLTNARKIFK DCDNFKIEST
110 120 130 140 150
ISPIPLELRK KIQSENYHLS MLTVEDVNIL LNNTITAQII RLFECMWKNN
160 170 180 190 200
CVVVPTSFRK VFGEVRDKFF FGYEQHDAEE AYSCIIQKMQ EELAEKRTIR
210 220 230 240 250
FKTTRHSVGE YIKYMNDVKE KVSCLPNGKE KDIVMNKFKQ IKKQMPRESL
260 270 280 290 300
TAESFREMKK YYEQGYSYIT EIFSGYVHSS ICCPNTSCGF TNDRFDAFTH
310 320 330 340 350
LSLSIPVKNM YEQLNVYDCL REYFSQETLD ADNLWNCEGC HEKVQAIKKT
360 370 380 390 400
KLWTTPYVLV IQFKRFGMTR IAKDNRFINY PMDELDVSSV ICSQQFEDSV
410 420 430 440 450
QTKYKLQCVI NHHGGLNNGH YFTYSKIENT GEWYEFNDTY TGKVTDNHIV
460
NQNAYILFYI RSDLFRSQ
Length:468
Mass (Da):54,760
Last modified:December 7, 2004 - v1
Checksum:i3BFE646E5BDF206A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY653733 Genomic DNA. Translation: AAV50588.1.
RefSeqiYP_003986822.1. NC_014649.1.

Genome annotation databases

GeneIDi9924936.
KEGGivg:9924936.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY653733 Genomic DNA. Translation: AAV50588.1.
RefSeqiYP_003986822.1. NC_014649.1.

3D structure databases

ProteinModelPortaliQ5UQR3.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi9924936.
KEGGivg:9924936.

Phylogenomic databases

KOiK11833.

Family and domain databases

InterProiIPR001394. Peptidase_C19_UCH.
IPR018200. USP_CS.
IPR028889. USP_dom.
[Graphical view]
PfamiPF00443. UCH. 1 hit.
[Graphical view]
PROSITEiPS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Rowbotham-Bradford.

Entry informationi

Entry nameiUBPL1_MIMIV
AccessioniPrimary (citable) accession number: Q5UQR3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: December 7, 2004
Last modified: April 1, 2015
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.