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Q5UQR3

- UBPL1_MIMIV

UniProt

Q5UQR3 - UBPL1_MIMIV

Protein

Probable ubiquitin carboxyl-terminal hydrolase R319

Gene

MIMI_R319

Organism
Acanthamoeba polyphaga mimivirus (APMV)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 50 (01 Oct 2014)
      Sequence version 1 (07 Dec 2004)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei51 – 511NucleophilePROSITE-ProRule annotation
    Active sitei420 – 4201Proton acceptorPROSITE-ProRule annotation

    GO - Molecular functioni

    1. cysteine-type peptidase activity Source: UniProtKB-KW
    2. ubiquitinyl hydrolase activity Source: InterPro

    GO - Biological processi

    1. ubiquitin-dependent protein catabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Protease, Thiol protease

    Keywords - Biological processi

    Ubl conjugation pathway

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable ubiquitin carboxyl-terminal hydrolase R319 (EC:3.4.19.12)
    Alternative name(s):
    Deubiquitinating enzyme R319
    Ubiquitin thioesterase R319
    Ubiquitin-specific-processing protease R319
    Gene namesi
    Ordered Locus Names:MIMI_R319
    OrganismiAcanthamoeba polyphaga mimivirus (APMV)
    Taxonomic identifieri212035 [NCBI]
    Taxonomic lineageiVirusesdsDNA viruses, no RNA stageMimiviridaeMimivirus
    Virus hostiAcanthamoeba polyphaga (Amoeba) [TaxID: 5757]
    ProteomesiUP000001134: Genome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 468468Probable ubiquitin carboxyl-terminal hydrolase R319PRO_0000080700Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ5UQR3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini42 – 462421USPAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase C19 family.Curated
    Contains 1 USP domain.Curated

    Family and domain databases

    InterProiIPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR028889. UCH/PAN2.
    [Graphical view]
    PfamiPF00443. UCH. 1 hit.
    [Graphical view]
    PROSITEiPS00972. USP_1. 1 hit.
    PS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5UQR3-1 [UniParc]FASTAAdd to Basket

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    MQNMMNTSQS FQNDSVLIGD KNTLQSINKS VDNGSKNTHG ITGIMNLGNT    50
    CYMNSALQAL SHNYLLINYL FMNKKQIIRT LLTNARKIFK DCDNFKIEST 100
    ISPIPLELRK KIQSENYHLS MLTVEDVNIL LNNTITAQII RLFECMWKNN 150
    CVVVPTSFRK VFGEVRDKFF FGYEQHDAEE AYSCIIQKMQ EELAEKRTIR 200
    FKTTRHSVGE YIKYMNDVKE KVSCLPNGKE KDIVMNKFKQ IKKQMPRESL 250
    TAESFREMKK YYEQGYSYIT EIFSGYVHSS ICCPNTSCGF TNDRFDAFTH 300
    LSLSIPVKNM YEQLNVYDCL REYFSQETLD ADNLWNCEGC HEKVQAIKKT 350
    KLWTTPYVLV IQFKRFGMTR IAKDNRFINY PMDELDVSSV ICSQQFEDSV 400
    QTKYKLQCVI NHHGGLNNGH YFTYSKIENT GEWYEFNDTY TGKVTDNHIV 450
    NQNAYILFYI RSDLFRSQ 468
    Length:468
    Mass (Da):54,760
    Last modified:December 7, 2004 - v1
    Checksum:i3BFE646E5BDF206A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY653733 Genomic DNA. Translation: AAV50588.1.
    RefSeqiYP_003986822.1. NC_014649.1.

    Genome annotation databases

    GeneIDi9924936.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY653733 Genomic DNA. Translation: AAV50588.1 .
    RefSeqi YP_003986822.1. NC_014649.1.

    3D structure databases

    ProteinModelPortali Q5UQR3.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 9924936.

    Family and domain databases

    InterProi IPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR028889. UCH/PAN2.
    [Graphical view ]
    Pfami PF00443. UCH. 1 hit.
    [Graphical view ]
    PROSITEi PS00972. USP_1. 1 hit.
    PS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Rowbotham-Bradford.

    Entry informationi

    Entry nameiUBPL1_MIMIV
    AccessioniPrimary (citable) accession number: Q5UQR3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 13, 2005
    Last sequence update: December 7, 2004
    Last modified: October 1, 2014
    This is version 50 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3