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Q5UQR3

- UBPL1_MIMIV

UniProt

Q5UQR3 - UBPL1_MIMIV

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Protein
Probable ubiquitin carboxyl-terminal hydrolase R319
Gene
MIMI_R319
Organism
Acanthamoeba polyphaga mimivirus (APMV)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei51 – 511Nucleophile By similarity
Active sitei420 – 4201Proton acceptor By similarity

GO - Molecular functioni

  1. cysteine-type peptidase activity Source: UniProtKB-KW
  2. ubiquitinyl hydrolase activity Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. ubiquitin-dependent protein catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Ubl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Probable ubiquitin carboxyl-terminal hydrolase R319 (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme R319
Ubiquitin thioesterase R319
Ubiquitin-specific-processing protease R319
Gene namesi
Ordered Locus Names:MIMI_R319
OrganismiAcanthamoeba polyphaga mimivirus (APMV)
Taxonomic identifieri212035 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageMimiviridaeMimivirus
Virus hostiAcanthamoeba polyphaga (Amoeba) [TaxID: 5757]
ProteomesiUP000001134: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 468468Probable ubiquitin carboxyl-terminal hydrolase R319
PRO_0000080700Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ5UQR3.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini42 – 462421USP
Add
BLAST

Sequence similaritiesi

Belongs to the peptidase C19 family.
Contains 1 USP domain.

Family and domain databases

InterProiIPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
[Graphical view]
PfamiPF00443. UCH. 1 hit.
[Graphical view]
PROSITEiPS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5UQR3-1 [UniParc]FASTAAdd to Basket

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MQNMMNTSQS FQNDSVLIGD KNTLQSINKS VDNGSKNTHG ITGIMNLGNT    50
CYMNSALQAL SHNYLLINYL FMNKKQIIRT LLTNARKIFK DCDNFKIEST 100
ISPIPLELRK KIQSENYHLS MLTVEDVNIL LNNTITAQII RLFECMWKNN 150
CVVVPTSFRK VFGEVRDKFF FGYEQHDAEE AYSCIIQKMQ EELAEKRTIR 200
FKTTRHSVGE YIKYMNDVKE KVSCLPNGKE KDIVMNKFKQ IKKQMPRESL 250
TAESFREMKK YYEQGYSYIT EIFSGYVHSS ICCPNTSCGF TNDRFDAFTH 300
LSLSIPVKNM YEQLNVYDCL REYFSQETLD ADNLWNCEGC HEKVQAIKKT 350
KLWTTPYVLV IQFKRFGMTR IAKDNRFINY PMDELDVSSV ICSQQFEDSV 400
QTKYKLQCVI NHHGGLNNGH YFTYSKIENT GEWYEFNDTY TGKVTDNHIV 450
NQNAYILFYI RSDLFRSQ 468
Length:468
Mass (Da):54,760
Last modified:December 7, 2004 - v1
Checksum:i3BFE646E5BDF206A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY653733 Genomic DNA. Translation: AAV50588.1.
RefSeqiYP_003986822.1. NC_014649.1.

Genome annotation databases

GeneIDi9924936.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY653733 Genomic DNA. Translation: AAV50588.1 .
RefSeqi YP_003986822.1. NC_014649.1.

3D structure databases

ProteinModelPortali Q5UQR3.
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 9924936.

Family and domain databases

InterProi IPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
[Graphical view ]
Pfami PF00443. UCH. 1 hit.
[Graphical view ]
PROSITEi PS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Rowbotham-Bradford.

Entry informationi

Entry nameiUBPL1_MIMIV
AccessioniPrimary (citable) accession number: Q5UQR3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: December 7, 2004
Last modified: September 3, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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