SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q5UQR0

- DPOL_MIMIV

UniProt

Q5UQR0 - DPOL_MIMIV

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

DNA polymerase

Gene
POLB, MIMI_R322
Organism
Acanthamoeba polyphaga mimivirus (APMV)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. DNA-directed DNA polymerase activity Source: UniProtKB-KW
  3. endonuclease activity Source: InterPro
  4. nucleotide binding Source: InterPro

GO - Biological processi

  1. intein-mediated protein splicing Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

DNA-directed DNA polymerase, Nucleotidyltransferase, Transferase

Keywords - Biological processi

DNA replication

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA polymerase (EC:2.7.7.7)
Cleaved into the following chain:
Gene namesi
Name:POLB
Ordered Locus Names:MIMI_R322
OrganismiAcanthamoeba polyphaga mimivirus (APMV)
Taxonomic identifieri212035 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageMimiviridaeMimivirus
Virus hostiAcanthamoeba polyphaga (Amoeba) [TaxID: 5757]
ProteomesiUP000001134: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10521052DNA polymerase, 1st part Reviewed predictionPRO_0000041777Add
BLAST
Chaini1053 – 1403351Mimv polB intein Reviewed predictionPRO_0000041778Add
BLAST
Chaini1404 – 1740337DNA polymerase, 2nd part Reviewed predictionPRO_0000041779Add
BLAST

Post-translational modificationi

This protein undergoes a protein self splicing that involves a post-translational excision of the intervening region (intein) followed by peptide ligation Reviewed prediction.

Keywords - PTMi

Autocatalytic cleavage, Protein splicing

Structurei

3D structure databases

ProteinModelPortaliQ5UQR0.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1189 – 1334146DOD-type homing endonucleaseAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Repeat

Family and domain databases

Gene3Di2.170.16.10. 2 hits.
3.10.28.10. 1 hit.
3.30.420.10. 3 hits.
InterProiIPR006172. DNA-dir_DNA_pol_B.
IPR006133. DNA-dir_DNA_pol_B_exonuc.
IPR006134. DNA-dir_DNA_pol_B_multi_dom.
IPR028992. Hedgehog/Intein_dom.
IPR027434. Homing_endonucl.
IPR004042. Intein_endonuc.
IPR006141. Intein_splice_site.
IPR012337. RNaseH-like_dom.
[Graphical view]
PfamiPF00136. DNA_pol_B. 2 hits.
PF03104. DNA_pol_B_exo1. 1 hit.
[Graphical view]
SMARTiSM00486. POLBc. 1 hit.
[Graphical view]
SUPFAMiSSF51294. SSF51294. 2 hits.
SSF53098. SSF53098. 3 hits.
SSF55608. SSF55608. 1 hit.
PROSITEiPS50818. INTEIN_C_TER. 1 hit.
PS50819. INTEIN_ENDONUCLEASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5UQR0-1 [UniParc]FASTAAdd to Basket

« Hide

MPSETIDSTK QFEFQISDWN SYHELDQEEE EKYVIQLFGR TEDDHDVCLK     50
VTGYTPFFYV EIPKQWKQRQ VDKFVEILKN KVQYHCKKNL DEDFDLSKSL 100
IKYAMVKKHK FYNFRNKQLY NFLLLVFKSH TAMKEFSSIL ARPLEAKGLT 150
NKPMLYQRYE SNIEPHIRFM HINNLSSCGW ASIDKDKLKK IPEYSNCDYS 200
FSVNWKDVKP SNNDDRMAPF KIMGYDIECV SCDQNFPQAE RPSDKIIQIG 250
ITMYRYGSMK CYEQHILTLK KCAPIEGVNV ECYKKEKGLL RGFAKKIAEL 300
RPDFKTGYNN FGFDDKYIYD RILRIDKREG KKQGVNINAL KNKFMDEILR 350
TIGKVNNNYL IENEGLDRIP IYTTVKDKKI SSKASRFIQI RGGTYVENGN 400
NLKYVQSPGI TYFEVKNLSS SALGDNELKF IQIPGVLSID MMKVIQRDHR 450
LIGYKLDNVS ANFITEKADK IIEMPHNQED SDSEKEDEDT DDKTYDVNIY 500
TKSTKALEKD SYIQIMVNDG YSSSPLSEGA KYKVYDIQTI TEKKLNEKTN 550
KEEIFVYQAI KTKICQKDIQ QLRETIKNPL LGISWTFAKD DMHHTKINEY 600
FEEGDPKKIR QIAKYCLKDC KLVNLLLAKL EIIVNSVGMA KVCHVPLSYL 650
FLRGQGVKIF SLVSKKCREK NFLIPVLRRK SKDNEGDEDE TYEGATVITP 700
KPNVYLSPIG VLDYSSLYPN SMRERNLSQE CYVDDSKYDN LPGYIYHDVE 750
IILKDKKGKI LRNIDGTPQK EYHRFAQEII TDEQINRELK DIFDKINTVF 800
ENNVAIIQNQ KYFTEKNISE LIDKHKNISD SKIEDIEFDE SLSDKRKNKL 850
VDAEKDSLDK NIGFYQKIKS QIDKIKLDSK IEIDNLSKNL NEEEKSKQIN 900
KMELNTKNLI SKVFSKYLIT EQQREELIVL EKERAKRSVN AEKAKVYNTV 950
DGITVRYGIL PEILTELLNK RKETNGKLAN EKDPFVKAIL NALQLAFKVT 1000
ANSLYGQTGA PTSPLYFIAI AACTTAIGRE RLHYAKKTVE DNFPGSEVIY 1050
GDSVTGDTPI ITRHQNGDIN ITTIEELGSK WKPYEIFKAH EKNSNRKFKQ 1100
QSQYPTDSEV WTAKGWAKIK RVIRHKTVKK IYRVLTHTGC IDVTEDHSLL 1150
DPNQNIIKPI NCQIGTELLH GFPESNNVYD NISEQEAYVW GFFMGDGSCG 1200
SYQTKNGIKY SWALNNQDLD VLNKCKKYLE ETENIQFKIL DTMKSSSVYK 1250
LVPIRKIKYM VNKYRKIFYD NKKYKLVPKE ILNSTKDIKN SFLEGYYAAD 1300
GSRKETENMG CRRCDIKGKI SAQCLFYLLK SLGYNVSINI RSDKNQIYRL 1350
TFSNKKQRKN PIAIKKIQLM NETSNDHDGD YVYDLETESG SFHAGVGEMI 1400
VKNTDSIFIN FHIKDENGEE KTDKEALMKT IAKCQRAAKL INQNVPKPQS 1450
IVYEKTLHPF ILVAKKKYVG LLFEKSPDKY FLKSMGIVLK RRDNAPIVKI 1500
VVGGIIDNIL KNRDIDKAIE YTKIVLDKLM NGEYPMDKFI ISKTLKSRYK 1550
KPSTIAHKVL ADRMAVRDPG NKPQINDRIP FVYIVKDMGK KKKKDILQGD 1600
LIEHPEYVIA NNLKIDYLYY LEHQIINPAS QILELMMDTK DVQKFFNKYI 1650
IDEQNKRKGA QSLTKWMDFS KLPKESGSKT AKKPYQSQKL QKTKSSNKSQ 1700
IDPKYINLIK NKSRKHECQN MNKWISSTDK CTDDWEPIVE 1740
Length:1,740
Mass (Da):201,945
Last modified:December 7, 2004 - v1
Checksum:iDC8B2AFF4EEE7724
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY606804 Genomic DNA. Translation: AAU11330.1.
AY653733 Genomic DNA. Translation: AAV50591.1.
RefSeqiYP_003986825.1. NC_014649.1.

Genome annotation databases

GeneIDi9924939.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY606804 Genomic DNA. Translation: AAU11330.1 .
AY653733 Genomic DNA. Translation: AAV50591.1 .
RefSeqi YP_003986825.1. NC_014649.1.

3D structure databases

ProteinModelPortali Q5UQR0.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 9924939.

Family and domain databases

Gene3Di 2.170.16.10. 2 hits.
3.10.28.10. 1 hit.
3.30.420.10. 3 hits.
InterProi IPR006172. DNA-dir_DNA_pol_B.
IPR006133. DNA-dir_DNA_pol_B_exonuc.
IPR006134. DNA-dir_DNA_pol_B_multi_dom.
IPR028992. Hedgehog/Intein_dom.
IPR027434. Homing_endonucl.
IPR004042. Intein_endonuc.
IPR006141. Intein_splice_site.
IPR012337. RNaseH-like_dom.
[Graphical view ]
Pfami PF00136. DNA_pol_B. 2 hits.
PF03104. DNA_pol_B_exo1. 1 hit.
[Graphical view ]
SMARTi SM00486. POLBc. 1 hit.
[Graphical view ]
SUPFAMi SSF51294. SSF51294. 2 hits.
SSF53098. SSF53098. 3 hits.
SSF55608. SSF55608. 1 hit.
PROSITEi PS50818. INTEIN_C_TER. 1 hit.
PS50819. INTEIN_ENDONUCLEASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A new example of viral intein in Mimivirus."
    Ogata H., Raoult D., Claverie J.-M.
    Virol. J. 2:8-8(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], DISCUSSION OF SEQUENCE.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Rowbotham-Bradford.

Entry informationi

Entry nameiDPOL_MIMIV
AccessioniPrimary (citable) accession number: Q5UQR0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: December 7, 2004
Last modified: June 11, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Intein-containing proteins
    List of intein-containing protein entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi