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Q5UQI4

- DHCR7_MIMIV

UniProt

Q5UQI4 - DHCR7_MIMIV

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Protein

Probable 7-dehydrocholesterol reductase

Gene

DHCR7

Organism
Acanthamoeba polyphaga mimivirus (APMV)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Production of cholesterol by reduction of C7-C8 double bond of 7-dehydrocholesterol (7-DHC).By similarity

Catalytic activityi

Cholesterol + NADP+ = cholesta-5,7-dien-3-beta-ol + NADPH.

Pathwayi

GO - Molecular functioni

  1. 7-dehydrocholesterol reductase activity Source: UniProtKB-EC

GO - Biological processi

  1. cholesterol biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Cholesterol biosynthesis, Cholesterol metabolism, Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis, Steroid metabolism, Sterol biosynthesis, Sterol metabolism

Keywords - Ligandi

NADP

Enzyme and pathway databases

UniPathwayiUPA00063.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable 7-dehydrocholesterol reductase (EC:1.3.1.21)
Short name:
7-DHC reductase
Alternative name(s):
Sterol Delta(7)-reductase
Gene namesi
Name:DHCR7
Ordered Locus Names:MIMI_R807
OrganismiAcanthamoeba polyphaga mimivirus (APMV)
Taxonomic identifieri212035 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageMimiviridaeMimivirus
Virus hostiAcanthamoeba polyphaga (Amoeba) [TaxID: 5757]
ProteomesiUP000001134: Genome

Subcellular locationi

Membrane By similarity; Multi-pass membrane protein By similarity

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 447447Probable 7-dehydrocholesterol reductasePRO_0000207508Add
BLAST

Structurei

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei24 – 4421HelicalSequence AnalysisAdd
BLAST
Transmembranei71 – 9121HelicalSequence AnalysisAdd
BLAST
Transmembranei102 – 12423HelicalSequence AnalysisAdd
BLAST
Transmembranei133 – 15321HelicalSequence AnalysisAdd
BLAST
Transmembranei157 – 17721HelicalSequence AnalysisAdd
BLAST
Transmembranei244 – 26421HelicalSequence AnalysisAdd
BLAST
Transmembranei281 – 30121HelicalSequence AnalysisAdd
BLAST
Transmembranei309 – 32921HelicalSequence AnalysisAdd
BLAST
Transmembranei393 – 41321HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the ERG4/ERG24 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

InterProiIPR001171. Ergosterol_biosynth_ERG4_ERG24.
[Graphical view]
PfamiPF01222. ERG4_ERG24. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5UQI4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNSYQTNTAT SWGRNHIPTL LDNLTTAAMF MFCPFIILVF YLITYGEYLG
60 70 80 90 100
SIGDFYLDII NGDWQTIWSN IPSFKINVLG ACLLWIVFQL ILSKLPDTIH
110 120 130 140 150
RFVPHYVGGI KAGHITPAGN LVYYNINGLQ AFIITHVLVI MSCYYGLFSP
160 170 180 190 200
TIIMDNWGSI FWSVNIIGYL ITFLAYFKAL TFSSHPSDNK FTGKLFYDIV
210 220 230 240 250
MGIEFNPEIF GTDLKLFFNG RPGIIAWNLI NLSCAMKQYE NFGYVSNSMI
260 270 280 290 300
LVIILQLIYI VDFFYNENWY VHTVDIAHDH FGWMLAWGDT VWLPFGYTLQ
310 320 330 340 350
AGYLMNNPID LSTGFFNLVF VMGIIGYIIF RTANYQKDKY RSNTQGVKYI
360 370 380 390 400
PCTYQTADGL NRASKLIYSG LWGVSRHMNY TGDIILSTAY CLACGFSHFI
410 420 430 440
PYFYCVYMTI LLVTRCLRDE QRCSRKYGKY WKMYTKRVPY RFIPGIY
Length:447
Mass (Da):51,692
Last modified:December 7, 2004 - v1
Checksum:iF338970A8F7AA48D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY653733 Genomic DNA. Translation: AAV51067.1.
RefSeqiYP_003987339.1. NC_014649.1.

Genome annotation databases

GeneIDi9925469.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY653733 Genomic DNA. Translation: AAV51067.1 .
RefSeqi YP_003987339.1. NC_014649.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 9925469.

Enzyme and pathway databases

UniPathwayi UPA00063 .

Family and domain databases

InterProi IPR001171. Ergosterol_biosynth_ERG4_ERG24.
[Graphical view ]
Pfami PF01222. ERG4_ERG24. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Rowbotham-Bradford.

Entry informationi

Entry nameiDHCR7_MIMIV
AccessioniPrimary (citable) accession number: Q5UQI4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: December 7, 2004
Last modified: October 1, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3