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Q5UQI4

- DHCR7_MIMIV

UniProt

Q5UQI4 - DHCR7_MIMIV

Protein

Probable 7-dehydrocholesterol reductase

Gene

DHCR7

Organism
Acanthamoeba polyphaga mimivirus (APMV)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 47 (01 Oct 2014)
      Sequence version 1 (07 Dec 2004)
      Previous versions | rss
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    Functioni

    Production of cholesterol by reduction of C7-C8 double bond of 7-dehydrocholesterol (7-DHC).By similarity

    Catalytic activityi

    Cholesterol + NADP+ = cholesta-5,7-dien-3-beta-ol + NADPH.

    Pathwayi

    GO - Molecular functioni

    1. 7-dehydrocholesterol reductase activity Source: UniProtKB-EC

    GO - Biological processi

    1. cholesterol biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Cholesterol biosynthesis, Cholesterol metabolism, Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis, Steroid metabolism, Sterol biosynthesis, Sterol metabolism

    Keywords - Ligandi

    NADP

    Enzyme and pathway databases

    UniPathwayiUPA00063.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable 7-dehydrocholesterol reductase (EC:1.3.1.21)
    Short name:
    7-DHC reductase
    Alternative name(s):
    Sterol Delta(7)-reductase
    Gene namesi
    Name:DHCR7
    Ordered Locus Names:MIMI_R807
    OrganismiAcanthamoeba polyphaga mimivirus (APMV)
    Taxonomic identifieri212035 [NCBI]
    Taxonomic lineageiVirusesdsDNA viruses, no RNA stageMimiviridaeMimivirus
    Virus hostiAcanthamoeba polyphaga (Amoeba) [TaxID: 5757]
    ProteomesiUP000001134: Genome

    Subcellular locationi

    Membrane By similarity; Multi-pass membrane protein By similarity

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 447447Probable 7-dehydrocholesterol reductasePRO_0000207508Add
    BLAST

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei24 – 4421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei71 – 9121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei102 – 12423HelicalSequence AnalysisAdd
    BLAST
    Transmembranei133 – 15321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei157 – 17721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei244 – 26421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei281 – 30121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei309 – 32921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei393 – 41321HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ERG4/ERG24 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Family and domain databases

    InterProiIPR001171. Ergosterol_biosynth_ERG4_ERG24.
    [Graphical view]
    PfamiPF01222. ERG4_ERG24. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5UQI4-1 [UniParc]FASTAAdd to Basket

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    MNSYQTNTAT SWGRNHIPTL LDNLTTAAMF MFCPFIILVF YLITYGEYLG    50
    SIGDFYLDII NGDWQTIWSN IPSFKINVLG ACLLWIVFQL ILSKLPDTIH 100
    RFVPHYVGGI KAGHITPAGN LVYYNINGLQ AFIITHVLVI MSCYYGLFSP 150
    TIIMDNWGSI FWSVNIIGYL ITFLAYFKAL TFSSHPSDNK FTGKLFYDIV 200
    MGIEFNPEIF GTDLKLFFNG RPGIIAWNLI NLSCAMKQYE NFGYVSNSMI 250
    LVIILQLIYI VDFFYNENWY VHTVDIAHDH FGWMLAWGDT VWLPFGYTLQ 300
    AGYLMNNPID LSTGFFNLVF VMGIIGYIIF RTANYQKDKY RSNTQGVKYI 350
    PCTYQTADGL NRASKLIYSG LWGVSRHMNY TGDIILSTAY CLACGFSHFI 400
    PYFYCVYMTI LLVTRCLRDE QRCSRKYGKY WKMYTKRVPY RFIPGIY 447
    Length:447
    Mass (Da):51,692
    Last modified:December 7, 2004 - v1
    Checksum:iF338970A8F7AA48D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY653733 Genomic DNA. Translation: AAV51067.1.
    RefSeqiYP_003987339.1. NC_014649.1.

    Genome annotation databases

    GeneIDi9925469.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY653733 Genomic DNA. Translation: AAV51067.1 .
    RefSeqi YP_003987339.1. NC_014649.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 9925469.

    Enzyme and pathway databases

    UniPathwayi UPA00063 .

    Family and domain databases

    InterProi IPR001171. Ergosterol_biosynth_ERG4_ERG24.
    [Graphical view ]
    Pfami PF01222. ERG4_ERG24. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Rowbotham-Bradford.

    Entry informationi

    Entry nameiDHCR7_MIMIV
    AccessioniPrimary (citable) accession number: Q5UQI4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 13, 2005
    Last sequence update: December 7, 2004
    Last modified: October 1, 2014
    This is version 47 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3