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Q5UQI4 (DHCR7_MIMIV) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 46. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable 7-dehydrocholesterol reductase

Short name=7-DHC reductase
EC=1.3.1.21
Alternative name(s):
Sterol Delta(7)-reductase
Gene names
Name:DHCR7
Ordered Locus Names:MIMI_R807
OrganismAcanthamoeba polyphaga mimivirus (APMV) [Reference proteome]
Taxonomic identifier212035 [NCBI]
Taxonomic lineageVirusesdsDNA viruses, no RNA stageMimiviridaeMimivirus
Virus hostAcanthamoeba polyphaga (Amoeba) [TaxID: 5757]

Protein attributes

Sequence length447 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Production of cholesterol by reduction of C7-C8 double bond of 7-dehydrocholesterol (7-DHC) By similarity.

Catalytic activity

Cholesterol + NADP+ = cholesta-5,7-dien-3-beta-ol + NADPH.

Pathway

Steroid biosynthesis; cholesterol biosynthesis.

Subcellular location

Membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the ERG4/ERG24 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 447447Probable 7-dehydrocholesterol reductase
PRO_0000207508

Regions

Transmembrane24 – 4421Helical; Potential
Transmembrane71 – 9121Helical; Potential
Transmembrane102 – 12423Helical; Potential
Transmembrane133 – 15321Helical; Potential
Transmembrane157 – 17721Helical; Potential
Transmembrane244 – 26421Helical; Potential
Transmembrane281 – 30121Helical; Potential
Transmembrane309 – 32921Helical; Potential
Transmembrane393 – 41321Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
Q5UQI4 [UniParc].

Last modified December 7, 2004. Version 1.
Checksum: F338970A8F7AA48D

FASTA44751,692
        10         20         30         40         50         60 
MNSYQTNTAT SWGRNHIPTL LDNLTTAAMF MFCPFIILVF YLITYGEYLG SIGDFYLDII 

        70         80         90        100        110        120 
NGDWQTIWSN IPSFKINVLG ACLLWIVFQL ILSKLPDTIH RFVPHYVGGI KAGHITPAGN 

       130        140        150        160        170        180 
LVYYNINGLQ AFIITHVLVI MSCYYGLFSP TIIMDNWGSI FWSVNIIGYL ITFLAYFKAL 

       190        200        210        220        230        240 
TFSSHPSDNK FTGKLFYDIV MGIEFNPEIF GTDLKLFFNG RPGIIAWNLI NLSCAMKQYE 

       250        260        270        280        290        300 
NFGYVSNSMI LVIILQLIYI VDFFYNENWY VHTVDIAHDH FGWMLAWGDT VWLPFGYTLQ 

       310        320        330        340        350        360 
AGYLMNNPID LSTGFFNLVF VMGIIGYIIF RTANYQKDKY RSNTQGVKYI PCTYQTADGL 

       370        380        390        400        410        420 
NRASKLIYSG LWGVSRHMNY TGDIILSTAY CLACGFSHFI PYFYCVYMTI LLVTRCLRDE 

       430        440 
QRCSRKYGKY WKMYTKRVPY RFIPGIY 

« Hide

References

[1]"The 1.2-megabase genome sequence of Mimivirus."
Raoult D., Audic S., Robert C., Abergel C., Renesto P., Ogata H., La Scola B., Susan M., Claverie J.-M.
Science 306:1344-1350(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Rowbotham-Bradford.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY653733 Genomic DNA. Translation: AAV51067.1.
RefSeqYP_003987339.1. NC_014649.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID9925469.

Enzyme and pathway databases

UniPathwayUPA00063.

Family and domain databases

InterProIPR001171. Ergosterol_biosynth_ERG4_ERG24.
[Graphical view]
PfamPF01222. ERG4_ERG24. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDHCR7_MIMIV
AccessionPrimary (citable) accession number: Q5UQI4
Entry history
Integrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: December 7, 2004
Last modified: February 19, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways