Reviewed,
UniProtKB/Swiss-Prot Q5UQI3 (CP51_MIMIV)
Last modified
November 25, 2008.
Version 25.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Probable cytochrome P450 51 EC=1.14.13.70 Alternative name(s): CYPLI P450-LIA1 Sterol 14-alpha demethylase Lanosterol 14-alpha demethylase P450-14DM | ||
| Gene names |
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| Organism | Acanthamoeba polyphaga mimivirus (APMV) [Complete proteome] | ||
| Taxonomic identifier | 212035 [NCBI] | ||
| Taxonomic lineage | Viruses › dsDNA viruses, no RNA stage › Mimiviridae › Mimivirus | ||
| Virus host | Acanthamoeba polyphaga (Amoeba) [TaxID: 5757] |
Protein attributes
| Sequence length | 709 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | Catalyzes the 14-alpha demethylation of obtusifoliol to 4 alpha-methyl-5 alpha-ergosta-8,14,24(28)-trien-3 beta-ol By similarity. |
| Catalytic activity | Obtusifoliol + 3 O(2) + 3 NADPH = 4-alpha-methyl-5-alpha-ergosta-8,14,24(28)-trien-3-beta-ol + formate + 3 NADP(+) + 4 H(2)O. |
| Cofactor | Heme group By similarity. |
| Pathway | Steroid biosynthesis; zymosterol biosynthesis; zymosterol from lanosterol: step 1/6. |
| Subcellular location | MembranePotential. |
| Sequence similarities | Belongs to the cytochrome P450 family. |
Ontologies
Keywords | |
|---|---|
| Biological process | Lipid synthesis Steroid biosynthesis Sterol biosynthesis |
| Cellular component | Membrane |
| Ligand | Heme Iron Metal-binding NADP |
| Molecular function | Methyltransferase Monooxygenase Oxidoreductase Transferase |
| Technical term | Complete proteome |
Gene Ontology (GO) | |
| Biological process | oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW sterol biosynthetic processInferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | membrane Inferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | electron carrier activity Inferred from electronic annotation. Source: InterPro heme bindingInferred from electronic annotation. Source: InterPro iron ion bindingInferred from electronic annotation. Source: InterPro methyltransferase activityInferred from electronic annotation. Source: UniProtKB-KW sterol 14-demethylase activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
Sequences
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References
| [1] | "The 1.2-megabase genome sequence of Mimivirus." Raoult D., Audic S., Robert C., Abergel C., Renesto P., Ogata H., La Scola B., Susan M., Claverie J.-M. Science 306:1344-1350(2004) [PubMed: 15486256] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Rowbotham-Bradford. |
Cross-references
Sequence databases | |
|---|---|
| AY653733 Genomic DNA. Translation: AAV51068.1. | |
| RefSeq | YP_143162.1. |
3D structure databases | |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 3162320. |
Family and domain databases | |
| InterPro | IPR001128. Cyt_P450. IPR002403. Cyt_P450_E_grp-IV. [Graphical view] |
| Gene3D | G3DSA:1.10.630.10. Cyt_P450. 1 hit. |
| PANTHER | PTHR19383. Cyt_P450. 1 hit. |
| Pfam | PF00067. p450. 1 hit. [Graphical view] |
| PRINTS | PR00465. EP450IV. |
| PROSITE | PS00086. CYTOCHROME_P450. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | CP51_MIMIV | ||||||||
| Accession | Primary (citable) accession number: Q5UQI3 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | Virus (Virus annotation project) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


