Reviewed,
UniProtKB/Swiss-Prot Q5UQG3 (DRTS_MIMIV)
Last modified
November 25, 2008.
Version 24.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Bifunctional dihydrofolate reductase-thymidylate synthase Short name=DHFR-TS Including the following 2 domains: 1- Recommended name: Dihydrofolate reductase EC=1.5.1.3 2- Recommended name: Thymidylate synthase EC=2.1.1.45 | ||
| Gene names |
| ||
| Organism | Acanthamoeba polyphaga mimivirus (APMV) [Complete proteome] | ||
| Taxonomic identifier | 212035 [NCBI] | ||
| Taxonomic lineage | Viruses › dsDNA viruses, no RNA stage › Mimiviridae › Mimivirus | ||
| Virus host | Acanthamoeba polyphaga (Amoeba) [TaxID: 5757] |
Protein attributes
| Sequence length | 563 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Catalytic activity | 5,6,7,8-tetrahydrofolate + NADP(+) = 7,8-dihydrofolate + NADPH. 5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP. |
| Pathway | Cofactor biosynthesis; tetrahydrofolate biosynthesis; tetrahydrofolate from dihydrofolate: step 1/1. |
| Miscellaneous | The reaction catalyzed by this enzyme represents an essential step for de novo glycine and purine synthesis, DNA precursor synthesis, and for the conversion of dUMP to dTMP. |
| Sequence similarities | In the N-terminal section; belongs to the dihydrofolate reductase family. In the C-terminal section; belongs to the thymidylate synthase family. Contains 1 DHFR (dihydrofolate reductase) domain. |
Ontologies
Keywords | |
|---|---|
| Biological process | Nucleotide biosynthesis One-carbon metabolism |
| Ligand | NADP |
| Molecular function | Methyltransferase Oxidoreductase Transferase |
| Technical term | Complete proteome Multifunctional enzyme |
Gene Ontology (GO) | |
| Biological process | dTMP biosynthetic process Inferred from electronic annotation. Source: InterPro glycine biosynthetic processInferred from electronic annotation. Source: InterPro one-carbon compound metabolic processInferred from electronic annotation. Source: UniProtKB-KW oxidation reductionInferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | dihydrofolate reductase activity Inferred from electronic annotation. Source: InterPro thymidylate synthase activityInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
Sequences
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References
| [1] | "The 1.2-megabase genome sequence of Mimivirus." Raoult D., Audic S., Robert C., Abergel C., Renesto P., Ogata H., La Scola B., Susan M., Claverie J.-M. Science 306:1344-1350(2004) [PubMed: 15486256] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Rowbotham-Bradford. |
Cross-references
Sequence databases | |
|---|---|
| AY653733 Genomic DNA. Translation: AAV50762.1. | |
| RefSeq | YP_142851.1. |
3D structure databases | |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 3162308. |
Family and domain databases | |
| InterPro | IPR001796. DHFR_reg. IPR000398. Thymidylat_synth_C. [Graphical view] |
| Gene3D | G3DSA:3.30.572.10. Thymidylat_synth_C. 1 hit. |
| PANTHER | PTHR11549:SF2. Thymidylat_synth_C. 1 hit. |
| Pfam | PF00186. DHFR_1. 1 hit. PF00303. Thymidylat_synt. 1 hit. [Graphical view] |
| PRINTS | PR00070. DHFR. PR00108. THYMDSNTHASE. |
| ProDom | PD001180. Thymidylat_synth. 1 hit. [Graphical view] [Entries sharing at least one domain] |
| TIGRFAMs | TIGR03284. thym_sym. 1 hit. |
| PROSITE | PS00075. DHFR_1. False negative. PS51330. DHFR_2. 1 hit. PS00091. THYMIDYLATE_SYNTHASE. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | DRTS_MIMIV | ||||||||
| Accession | Primary (citable) accession number: Q5UQG3 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | Virus (Virus annotation project) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


