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Q5UQ88

- UBC3_MIMIV

UniProt

Q5UQ88 - UBC3_MIMIV

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Protein

Probable ubiquitin-conjugating enzyme E2 R521

Gene

MIMI_R521

Organism
Acanthamoeba polyphaga mimivirus (APMV)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the covalent attachment of ubiquitin to other proteins.PROSITE-ProRule annotation

Catalytic activityi

ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.PROSITE-ProRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei1306 – 13061Glycyl thioester intermediatePROSITE-ProRule annotation

GO - Molecular functioni

  1. acid-amino acid ligase activity Source: InterPro
  2. ATP binding Source: UniProtKB-KW

GO - Biological processi

  1. DNA protection Source: InterPro
  2. protein ubiquitination Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Ubl conjugation pathway

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable ubiquitin-conjugating enzyme E2 R521 (EC:6.3.2.19)
Alternative name(s):
Ubiquitin carrier protein
Ubiquitin-protein ligase
Gene namesi
Ordered Locus Names:MIMI_R521
OrganismiAcanthamoeba polyphaga mimivirus (APMV)
Taxonomic identifieri212035 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageMimiviridaeMimivirus
Virus hostiAcanthamoeba polyphaga (Amoeba) [TaxID: 5757]
ProteomesiUP000001134: Genome

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 14411441Probable ubiquitin-conjugating enzyme E2 R521PRO_0000243982Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ5UQ88.
ModBaseiSearch...
MobiDBiSearch...

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei20 – 4021HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili63 – 8927Sequence AnalysisAdd
BLAST
Coiled coili340 – 36829Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the ubiquitin-conjugating enzyme family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di3.10.110.10. 2 hits.
InterProiIPR008674. MC1.
IPR000608. UBQ-conjugat_E2.
IPR016135. UBQ-conjugating_enzyme/RWD.
[Graphical view]
PfamiPF00179. UQ_con. 1 hit.
[Graphical view]
SUPFAMiSSF102875. SSF102875. 1 hit.
SSF54495. SSF54495. 2 hits.
PROSITEiPS50127. UBIQUITIN_CONJUGAT_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5UQ88 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MHDYLGSFYN PLTLQKKLKY IHHIIINYIT NSILYFFLIM QSKNNPKHNS
60 70 80 90 100
MKFKEQTESP ILNQSKLVNT LDIIKDEINK WEEKNTDKDI KIVSIDNGKI
110 120 130 140 150
VLSMVYGKQH IIEILCPKDY PNVKSGFSCK EIKTVNTIPL SFISQANNQL
160 170 180 190 200
KSKKNLSVHR IISHLSTTFQ NYKKALKSKV SKDKMKDKSE SNSEHEQESK
210 220 230 240 250
SVVSNEIPSE VSIDSKLTKD INFINDLIKE ANKCSNDVPS DSDETHQEVD
260 270 280 290 300
DRPLTEEVVV PDPTRIVRRR NSKLQTGSTK IKIFGKSKNS GPSSSKTSIS
310 320 330 340 350
SMSKVEELED KNPYLQEQDI MSIIQDEWNK VQESKSICPT TNEDNNDLDN
360 370 380 390 400
LINEVERLVQ ETKDQETKDQ ETKDQKEIWA SSLTIEEPNG ENFEEFSWEV
410 420 430 440 450
PNETSQITVV EPVQEATEEP VQNVTEELIQ LVADEPVQET VKDSVQEVAE
460 470 480 490 500
ESVQETTVEA VQEIAEESVQ QVVEESVQET TVEPVQEVAE EAVQQVVEES
510 520 530 540 550
VQETTVEPVQ EVAEEPVQQE VAEEPVQQEV AEEPVQQEVA EEPVQEVAEE
560 570 580 590 600
PVQKATEELV QQEVAEDIVK LDVTVQNDFS DHSDSPEPSD SSDSEEEITN
610 620 630 640 650
SNNLGRYFKI YDPTTGKTTG VYVGKTPTQA ANKAFIKTFS NDNTGNKKEF
660 670 680 690 700
YLQEYTGNKP GKIYKYEGTR QKLNQPQKIS IPLYGDGQYK TITYNYKNTV
710 720 730 740 750
VKKNVPDSIK NPPKTIKKSI KPVKKSIKPV KKLSTTKLDS QTNSVKEKSE
760 770 780 790 800
NKDIINYNDT GDKYGLYIDF GKFFKNSKIP FDLEKLRDNA LKLSNQENQD
810 820 830 840 850
DNYSTMKLRN FKNNNAVNLM INDFTKLYND GVKNGYNIEP VNNNIYDLDI
860 870 880 890 900
LLSSNFLDKD SVLYQDMINL KIDHIKINIK INHKMYPFYP PQVSLIRPTI
910 920 930 940 950
ENNVAAIIAT IDYLFANKWN PMISIVNIVN DIRNILNKYG ALDEKKYQNN
960 970 980 990 1000
LDPIFHDLVE LSLLTGTQCS MYQSDQKVID LSNNSTNEKQ SKYWKKGTGF
1010 1020 1030 1040 1050
GHSGLSDWDF NQTKENIKNR ELKIYQCLRK IVVKLTKIIL GKNQVDVINI
1060 1070 1080 1090 1100
LKESCFIPYL KLVFIDGSLF DLVKDLSYFE LVLNSMRILT KEYLPLFLHK
1110 1120 1130 1140 1150
YNDKSLLEVL DQFNKDCHSY LNTLKNIKES DCQNEIDIIE NFMSFYKRLS
1160 1170 1180 1190 1200
TSIEKFNEIT ESNNKEEVIS NDVKDLYKIT LGNEVFQEYN LDLNKFANML
1210 1220 1230 1240 1250
TNDTKKEGLI HKDALKAISR ELLSHSKNLP VEYGSSIYYR YSPENIRYHE
1260 1270 1280 1290 1300
FIITGPEDSP YDSGCFHFRM YNPSAYPNTS PFVSMTTTGH GSVRFNPNLY
1310 1320 1330 1340 1350
ADGKVCLSIL GTWRGQAGES WIPGVSSMLQ VMISIQSLVL ISEPYFNEPG
1360 1370 1380 1390 1400
YESSRGTDKG NKLSTEYNQK VRFNCMKWAM IDVIKNPVPG FESMIKKHFS
1410 1420 1430 1440
IKAPHIKQVC QTWINEAPDN NKSEYQKLYD ELIGLLDSLV A
Length:1,441
Mass (Da):165,046
Last modified:December 7, 2004 - v1
Checksum:i0F605583124D4F0A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY653733 Genomic DNA. Translation: AAV50785.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY653733 Genomic DNA. Translation: AAV50785.1 .

3D structure databases

ProteinModelPortali Q5UQ88.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00143 .

Family and domain databases

Gene3Di 3.10.110.10. 2 hits.
InterProi IPR008674. MC1.
IPR000608. UBQ-conjugat_E2.
IPR016135. UBQ-conjugating_enzyme/RWD.
[Graphical view ]
Pfami PF00179. UQ_con. 1 hit.
[Graphical view ]
SUPFAMi SSF102875. SSF102875. 1 hit.
SSF54495. SSF54495. 2 hits.
PROSITEi PS50127. UBIQUITIN_CONJUGAT_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Rowbotham-Bradford.

Entry informationi

Entry nameiUBC3_MIMIV
AccessioniPrimary (citable) accession number: Q5UQ88
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: December 7, 2004
Last modified: October 1, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3