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Q5UQ88

- UBC3_MIMIV

UniProt

Q5UQ88 - UBC3_MIMIV

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Protein

Probable ubiquitin-conjugating enzyme E2 R521

Gene
MIMI_R521
Organism
Acanthamoeba polyphaga mimivirus (APMV)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the covalent attachment of ubiquitin to other proteins By similarity.

Catalytic activityi

ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei1306 – 13061Glycyl thioester intermediate By similarity

GO - Molecular functioni

  1. acid-amino acid ligase activity Source: InterPro
  2. ATP binding Source: UniProtKB-KW

GO - Biological processi

  1. DNA protection Source: InterPro
  2. protein ubiquitination Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Ubl conjugation pathway

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable ubiquitin-conjugating enzyme E2 R521 (EC:6.3.2.19)
Alternative name(s):
Ubiquitin carrier protein
Ubiquitin-protein ligase
Gene namesi
Ordered Locus Names:MIMI_R521
OrganismiAcanthamoeba polyphaga mimivirus (APMV)
Taxonomic identifieri212035 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageMimiviridaeMimivirus
Virus hostiAcanthamoeba polyphaga (Amoeba) [TaxID: 5757]
ProteomesiUP000001134: Genome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei20 – 4021Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 14411441Probable ubiquitin-conjugating enzyme E2 R521PRO_0000243982Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ5UQ88.

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili63 – 8927 Reviewed predictionAdd
BLAST
Coiled coili340 – 36829 Reviewed predictionAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di3.10.110.10. 2 hits.
InterProiIPR008674. MC1.
IPR000608. UBQ-conjugat_E2.
IPR016135. UBQ-conjugating_enzyme/RWD.
[Graphical view]
PfamiPF00179. UQ_con. 1 hit.
[Graphical view]
SUPFAMiSSF102875. SSF102875. 1 hit.
SSF54495. SSF54495. 2 hits.
PROSITEiPS50127. UBIQUITIN_CONJUGAT_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5UQ88-1 [UniParc]FASTAAdd to Basket

« Hide

MHDYLGSFYN PLTLQKKLKY IHHIIINYIT NSILYFFLIM QSKNNPKHNS     50
MKFKEQTESP ILNQSKLVNT LDIIKDEINK WEEKNTDKDI KIVSIDNGKI 100
VLSMVYGKQH IIEILCPKDY PNVKSGFSCK EIKTVNTIPL SFISQANNQL 150
KSKKNLSVHR IISHLSTTFQ NYKKALKSKV SKDKMKDKSE SNSEHEQESK 200
SVVSNEIPSE VSIDSKLTKD INFINDLIKE ANKCSNDVPS DSDETHQEVD 250
DRPLTEEVVV PDPTRIVRRR NSKLQTGSTK IKIFGKSKNS GPSSSKTSIS 300
SMSKVEELED KNPYLQEQDI MSIIQDEWNK VQESKSICPT TNEDNNDLDN 350
LINEVERLVQ ETKDQETKDQ ETKDQKEIWA SSLTIEEPNG ENFEEFSWEV 400
PNETSQITVV EPVQEATEEP VQNVTEELIQ LVADEPVQET VKDSVQEVAE 450
ESVQETTVEA VQEIAEESVQ QVVEESVQET TVEPVQEVAE EAVQQVVEES 500
VQETTVEPVQ EVAEEPVQQE VAEEPVQQEV AEEPVQQEVA EEPVQEVAEE 550
PVQKATEELV QQEVAEDIVK LDVTVQNDFS DHSDSPEPSD SSDSEEEITN 600
SNNLGRYFKI YDPTTGKTTG VYVGKTPTQA ANKAFIKTFS NDNTGNKKEF 650
YLQEYTGNKP GKIYKYEGTR QKLNQPQKIS IPLYGDGQYK TITYNYKNTV 700
VKKNVPDSIK NPPKTIKKSI KPVKKSIKPV KKLSTTKLDS QTNSVKEKSE 750
NKDIINYNDT GDKYGLYIDF GKFFKNSKIP FDLEKLRDNA LKLSNQENQD 800
DNYSTMKLRN FKNNNAVNLM INDFTKLYND GVKNGYNIEP VNNNIYDLDI 850
LLSSNFLDKD SVLYQDMINL KIDHIKINIK INHKMYPFYP PQVSLIRPTI 900
ENNVAAIIAT IDYLFANKWN PMISIVNIVN DIRNILNKYG ALDEKKYQNN 950
LDPIFHDLVE LSLLTGTQCS MYQSDQKVID LSNNSTNEKQ SKYWKKGTGF 1000
GHSGLSDWDF NQTKENIKNR ELKIYQCLRK IVVKLTKIIL GKNQVDVINI 1050
LKESCFIPYL KLVFIDGSLF DLVKDLSYFE LVLNSMRILT KEYLPLFLHK 1100
YNDKSLLEVL DQFNKDCHSY LNTLKNIKES DCQNEIDIIE NFMSFYKRLS 1150
TSIEKFNEIT ESNNKEEVIS NDVKDLYKIT LGNEVFQEYN LDLNKFANML 1200
TNDTKKEGLI HKDALKAISR ELLSHSKNLP VEYGSSIYYR YSPENIRYHE 1250
FIITGPEDSP YDSGCFHFRM YNPSAYPNTS PFVSMTTTGH GSVRFNPNLY 1300
ADGKVCLSIL GTWRGQAGES WIPGVSSMLQ VMISIQSLVL ISEPYFNEPG 1350
YESSRGTDKG NKLSTEYNQK VRFNCMKWAM IDVIKNPVPG FESMIKKHFS 1400
IKAPHIKQVC QTWINEAPDN NKSEYQKLYD ELIGLLDSLV A 1441
Length:1,441
Mass (Da):165,046
Last modified:December 7, 2004 - v1
Checksum:i0F605583124D4F0A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY653733 Genomic DNA. Translation: AAV50785.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY653733 Genomic DNA. Translation: AAV50785.1 .

3D structure databases

ProteinModelPortali Q5UQ88.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00143 .

Family and domain databases

Gene3Di 3.10.110.10. 2 hits.
InterProi IPR008674. MC1.
IPR000608. UBQ-conjugat_E2.
IPR016135. UBQ-conjugating_enzyme/RWD.
[Graphical view ]
Pfami PF00179. UQ_con. 1 hit.
[Graphical view ]
SUPFAMi SSF102875. SSF102875. 1 hit.
SSF54495. SSF54495. 2 hits.
PROSITEi PS50127. UBIQUITIN_CONJUGAT_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Rowbotham-Bradford.

Entry informationi

Entry nameiUBC3_MIMIV
AccessioniPrimary (citable) accession number: Q5UQ88
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: December 7, 2004
Last modified: September 3, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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