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Q5UQ88

- UBC3_MIMIV

UniProt

Q5UQ88 - UBC3_MIMIV

Protein

Probable ubiquitin-conjugating enzyme E2 R521

Gene

MIMI_R521

Organism
Acanthamoeba polyphaga mimivirus (APMV)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 63 (01 Oct 2014)
      Sequence version 1 (07 Dec 2004)
      Previous versions | rss
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    Functioni

    Catalyzes the covalent attachment of ubiquitin to other proteins.PROSITE-ProRule annotation

    Catalytic activityi

    ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.PROSITE-ProRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei1306 – 13061Glycyl thioester intermediatePROSITE-ProRule annotation

    GO - Molecular functioni

    1. acid-amino acid ligase activity Source: InterPro
    2. ATP binding Source: UniProtKB-KW

    GO - Biological processi

    1. DNA protection Source: InterPro
    2. protein ubiquitination Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Ubl conjugation pathway

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    UniPathwayiUPA00143.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable ubiquitin-conjugating enzyme E2 R521 (EC:6.3.2.19)
    Alternative name(s):
    Ubiquitin carrier protein
    Ubiquitin-protein ligase
    Gene namesi
    Ordered Locus Names:MIMI_R521
    OrganismiAcanthamoeba polyphaga mimivirus (APMV)
    Taxonomic identifieri212035 [NCBI]
    Taxonomic lineageiVirusesdsDNA viruses, no RNA stageMimiviridaeMimivirus
    Virus hostiAcanthamoeba polyphaga (Amoeba) [TaxID: 5757]
    ProteomesiUP000001134: Genome

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 14411441Probable ubiquitin-conjugating enzyme E2 R521PRO_0000243982Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ5UQ88.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei20 – 4021HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili63 – 8927Sequence AnalysisAdd
    BLAST
    Coiled coili340 – 36829Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the ubiquitin-conjugating enzyme family.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil, Transmembrane, Transmembrane helix

    Family and domain databases

    Gene3Di3.10.110.10. 2 hits.
    InterProiIPR008674. MC1.
    IPR000608. UBQ-conjugat_E2.
    IPR016135. UBQ-conjugating_enzyme/RWD.
    [Graphical view]
    PfamiPF00179. UQ_con. 1 hit.
    [Graphical view]
    SUPFAMiSSF102875. SSF102875. 1 hit.
    SSF54495. SSF54495. 2 hits.
    PROSITEiPS50127. UBIQUITIN_CONJUGAT_2. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5UQ88-1 [UniParc]FASTAAdd to Basket

    « Hide

    MHDYLGSFYN PLTLQKKLKY IHHIIINYIT NSILYFFLIM QSKNNPKHNS     50
    MKFKEQTESP ILNQSKLVNT LDIIKDEINK WEEKNTDKDI KIVSIDNGKI 100
    VLSMVYGKQH IIEILCPKDY PNVKSGFSCK EIKTVNTIPL SFISQANNQL 150
    KSKKNLSVHR IISHLSTTFQ NYKKALKSKV SKDKMKDKSE SNSEHEQESK 200
    SVVSNEIPSE VSIDSKLTKD INFINDLIKE ANKCSNDVPS DSDETHQEVD 250
    DRPLTEEVVV PDPTRIVRRR NSKLQTGSTK IKIFGKSKNS GPSSSKTSIS 300
    SMSKVEELED KNPYLQEQDI MSIIQDEWNK VQESKSICPT TNEDNNDLDN 350
    LINEVERLVQ ETKDQETKDQ ETKDQKEIWA SSLTIEEPNG ENFEEFSWEV 400
    PNETSQITVV EPVQEATEEP VQNVTEELIQ LVADEPVQET VKDSVQEVAE 450
    ESVQETTVEA VQEIAEESVQ QVVEESVQET TVEPVQEVAE EAVQQVVEES 500
    VQETTVEPVQ EVAEEPVQQE VAEEPVQQEV AEEPVQQEVA EEPVQEVAEE 550
    PVQKATEELV QQEVAEDIVK LDVTVQNDFS DHSDSPEPSD SSDSEEEITN 600
    SNNLGRYFKI YDPTTGKTTG VYVGKTPTQA ANKAFIKTFS NDNTGNKKEF 650
    YLQEYTGNKP GKIYKYEGTR QKLNQPQKIS IPLYGDGQYK TITYNYKNTV 700
    VKKNVPDSIK NPPKTIKKSI KPVKKSIKPV KKLSTTKLDS QTNSVKEKSE 750
    NKDIINYNDT GDKYGLYIDF GKFFKNSKIP FDLEKLRDNA LKLSNQENQD 800
    DNYSTMKLRN FKNNNAVNLM INDFTKLYND GVKNGYNIEP VNNNIYDLDI 850
    LLSSNFLDKD SVLYQDMINL KIDHIKINIK INHKMYPFYP PQVSLIRPTI 900
    ENNVAAIIAT IDYLFANKWN PMISIVNIVN DIRNILNKYG ALDEKKYQNN 950
    LDPIFHDLVE LSLLTGTQCS MYQSDQKVID LSNNSTNEKQ SKYWKKGTGF 1000
    GHSGLSDWDF NQTKENIKNR ELKIYQCLRK IVVKLTKIIL GKNQVDVINI 1050
    LKESCFIPYL KLVFIDGSLF DLVKDLSYFE LVLNSMRILT KEYLPLFLHK 1100
    YNDKSLLEVL DQFNKDCHSY LNTLKNIKES DCQNEIDIIE NFMSFYKRLS 1150
    TSIEKFNEIT ESNNKEEVIS NDVKDLYKIT LGNEVFQEYN LDLNKFANML 1200
    TNDTKKEGLI HKDALKAISR ELLSHSKNLP VEYGSSIYYR YSPENIRYHE 1250
    FIITGPEDSP YDSGCFHFRM YNPSAYPNTS PFVSMTTTGH GSVRFNPNLY 1300
    ADGKVCLSIL GTWRGQAGES WIPGVSSMLQ VMISIQSLVL ISEPYFNEPG 1350
    YESSRGTDKG NKLSTEYNQK VRFNCMKWAM IDVIKNPVPG FESMIKKHFS 1400
    IKAPHIKQVC QTWINEAPDN NKSEYQKLYD ELIGLLDSLV A 1441
    Length:1,441
    Mass (Da):165,046
    Last modified:December 7, 2004 - v1
    Checksum:i0F605583124D4F0A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY653733 Genomic DNA. Translation: AAV50785.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY653733 Genomic DNA. Translation: AAV50785.1 .

    3D structure databases

    ProteinModelPortali Q5UQ88.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    UniPathwayi UPA00143 .

    Family and domain databases

    Gene3Di 3.10.110.10. 2 hits.
    InterProi IPR008674. MC1.
    IPR000608. UBQ-conjugat_E2.
    IPR016135. UBQ-conjugating_enzyme/RWD.
    [Graphical view ]
    Pfami PF00179. UQ_con. 1 hit.
    [Graphical view ]
    SUPFAMi SSF102875. SSF102875. 1 hit.
    SSF54495. SSF54495. 2 hits.
    PROSITEi PS50127. UBIQUITIN_CONJUGAT_2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Rowbotham-Bradford.

    Entry informationi

    Entry nameiUBC3_MIMIV
    AccessioniPrimary (citable) accession number: Q5UQ88
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 27, 2006
    Last sequence update: December 7, 2004
    Last modified: October 1, 2014
    This is version 63 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3