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Protein

Arginine--tRNA ligase

Gene

RARS

Organism
Acanthamoeba polyphaga mimivirus (APMV)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg).

GO - Molecular functioni

  1. arginine-tRNA ligase activity Source: UniProtKB-EC
  2. ATP binding Source: UniProtKB-KW

GO - Biological processi

  1. arginyl-tRNA aminoacylation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Arginine--tRNA ligase (EC:6.1.1.19)
Alternative name(s):
Arginyl-tRNA synthetase
Short name:
ArgRS
Gene namesi
Name:RARS
Ordered Locus Names:MIMI_R663
OrganismiAcanthamoeba polyphaga mimivirus (APMV)
Taxonomic identifieri212035 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageMimiviridaeMimivirus
Virus hostiAcanthamoeba polyphaga (Amoeba) [TaxID: 5757]
ProteomesiUP000001134: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 600600Arginine--tRNA ligasePRO_0000151665Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ5UQ59.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi152 – 16211"HIGH" regionAdd
BLAST

Sequence similaritiesi

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 1 hit.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR001278. Arg-tRNA-ligase.
IPR008909. DALR_anticod-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view]
PANTHERiPTHR11956. PTHR11956. 1 hit.
PfamiPF05746. DALR_1. 1 hit.
PF00750. tRNA-synt_1d. 1 hit.
[Graphical view]
PRINTSiPR01038. TRNASYNTHARG.
SMARTiSM00836. DALR_1. 1 hit.
[Graphical view]
SUPFAMiSSF47323. SSF47323. 1 hit.
TIGRFAMsiTIGR00456. argS. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5UQ59-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQDNLIYLAN CFLNEAIKTT LQNLNKVNII DTPELYSFVK GINTDYQFNK
60 70 80 90 100
STKLANDCNL DKEKIVNELI TQLKSNSFFE NISSVELEQN KSVKINGKKT
110 120 130 140 150
NTVIKQIMIT LNISKLYLSN RINLLYKRIL SGSSIYVPNT ITKKIIVDYS
160 170 180 190 200
SPNIAKEMHI GHLRSTIIGE SICRVLEMCG HDVYRINHVG DWGTQFGMLI
210 220 230 240 250
AYIKNNQIES YTISELMNIY KESRKLFESS IDFKNQSRLE TVSLQNGNIE
260 270 280 290 300
SITIWQKIHK ISMNSFHEIY SLLGINNLIT KGESFYQDQM TELVNSLTSD
310 320 330 340 350
NKITVENDMK LMFVEGISKP FILQKSDGGF TYDTSDLTAL KYRLFIEKAD
360 370 380 390 400
HIIYVVDSSQ QEHFSQMFQI AEKLDWIKNQ QLQHIGFGLV LGSDGSKLKT
410 420 430 440 450
RSGETIKLQD VIDNVVSHAS NITRELIKQK NLDWNDDDIL TISKKIAINC
460 470 480 490 500
IKYSDLNNPR LNNYKFDINK MLNSKGNTAV YLMYGLARCK SILRKVPNNT
510 520 530 540 550
VLNGDIIIEN ENSRNLLLHV LKYVEVIDQT VETMCPHYLC IYLYDLIGSL
560 570 580 590 600
TKFYTTNRCL EYDNDNLIGY NANNLRIVNM VKIIISKIFE LIGLEEIEQL
Length:600
Mass (Da):68,994
Last modified:December 7, 2004 - v1
Checksum:i8B35DBD6794CCE0E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY653733 Genomic DNA. Translation: AAV50924.1.
RefSeqiYP_003987185.1. NC_014649.1.

Genome annotation databases

GeneIDi9925309.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY653733 Genomic DNA. Translation: AAV50924.1.
RefSeqiYP_003987185.1. NC_014649.1.

3D structure databases

ProteinModelPortaliQ5UQ59.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi9925309.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 1 hit.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR001278. Arg-tRNA-ligase.
IPR008909. DALR_anticod-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view]
PANTHERiPTHR11956. PTHR11956. 1 hit.
PfamiPF05746. DALR_1. 1 hit.
PF00750. tRNA-synt_1d. 1 hit.
[Graphical view]
PRINTSiPR01038. TRNASYNTHARG.
SMARTiSM00836. DALR_1. 1 hit.
[Graphical view]
SUPFAMiSSF47323. SSF47323. 1 hit.
TIGRFAMsiTIGR00456. argS. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Rowbotham-Bradford.

Entry informationi

Entry nameiSYR_MIMIV
AccessioniPrimary (citable) accession number: Q5UQ59
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: December 7, 2004
Last modified: January 7, 2015
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.