Reviewed, UniProtKB/Swiss-Prot Q5UQ57 (UBC2_MIMIV)

Names and origin

Protein names

Recommended name:
    Probable ubiquitin-conjugating enzyme E2 L709
    EC=6.3.2.19
Alternative name(s):
    Ubiquitin-protein ligase
    Ubiquitin carrier protein

Gene names

Ordered Locus Names:

MIMI_L709

Organism

Acanthamoeba polyphaga mimivirus (APMV) [Complete proteome]

Taxonomic identifier

212035 [NCBI]

Taxonomic lineage

Viruses › dsDNA viruses, no RNA stage › Mimiviridae › Mimivirus

Virus host

Acanthamoeba polyphaga (Amoeba) [TaxID: 5757]

Protein attributes

Sequence length	388 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the covalent attachment of ubiquitin to other proteins By similarity.
Catalytic activity	ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.
Pathway	Protein modification; protein ubiquitination.
Sequence similarities	Belongs to the ubiquitin-conjugating enzyme family.

Ontologies

Keywords
Biological process	Ubl conjugation pathway
Molecular function	Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	post-translational protein modification Inferred from electronic annotation. Source: InterPro regulation of protein metabolic process Inferred from electronic annotation. Source: InterPro ubiquitin-dependent protein catabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ubiquitin-protein ligase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 388	388	Probable ubiquitin-conjugating enzyme E2 L709		PRO_0000243981
Sites
	Active site	95	1	Glycyl thioester intermediate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5UQ57-1 [UniParc]. Last modified December 7, 2004. Version 1. Checksum: 9329EB6E7F020B78	FASTA	388	42,724
	10 20 30 40 50 60 MQNVHKRVIK DINDGMKNLK QEFGIYLAPE EDDFYKVHFI LQGPEGTPFE GGLYHGMIRL 70 80 90 100 110 120 NNDHPFRPPN LHMITPSGRF EAEKYPISPN SRGICTTATS FHPESWTSMN NLETVLKGFV 130 140 150 160 170 180 SLMCDPYDGG VGAVKSTDTQ VKKLAQDSLT HIGNDLMVQK LFPDLYKAVN NGTFKPVKLA 190 200 210 220 230 240 ELSKIVYKEP TKPIVEEKSA KTSKSSTKTS VKSKKNQKSD SEEEENSDDD NTDSDSESDD 250 260 270 280 290 300 FRDLDDVVDD SDQESDDESD SSSESENESG GSDDESDDGS DDESDDETSE SDSESEEEKP 310 320 330 340 350 360 VKKSTRKISK TTTKSSSTKP VKSIKSSKST TTKPTKPTKS TKTTKSTKST KSTKSTKPTE 370 380 STKSSRSVKT TESSKSSKSS KSSKTGKK

References

[1]	"The 1.2-megabase genome sequence of Mimivirus." Raoult D., Audic S., Robert C., Abergel C., Renesto P., Ogata H., La Scola B., Susan M., Claverie J.-M. Science 306:1344-1350(2004) [PubMed: 15486256] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Rowbotham-Bradford.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AY653733 Genomic DNA. Translation: AAV50969.1.
RefSeq	YP_143063.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3162972.
Family and domain databases
InterPro	IPR016135. UBQ-conjugat/RWD-like. IPR000608. UBQ-conjugat_E2. [Graphical view]
Gene3D	G3DSA:3.10.110.10. UBQ-conjugat_E2. 1 hit.
PANTHER	PTHR11621. UBQ-conjugat_E2. 1 hit.
Pfam	PF00179. UQ_con. 1 hit. [Graphical view]
ProDom	PD000461. UBQ_conjugat. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00212. UBCc. 1 hit. [Graphical view]
PROSITE	PS50127. UBIQUITIN_CONJUGAT_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

UBC2_MIMIV

Accession

Primary (citable) accession number: Q5UQ57

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 27, 2006
Last sequence update:	December 7, 2004
Last modified:	November 25, 2008
This is version 31 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Virus (Virus annotation project)