Q5UQ57 (UBC2_MIMIV) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable ubiquitin-conjugating enzyme E2 L709
EC=6.3.2.19

Alternative name(s):
Ubiquitin carrier protein
Ubiquitin-protein ligase

Gene names

Ordered Locus Names:

MIMI_L709

Organism

Acanthamoeba polyphaga mimivirus (APMV)

Taxonomic identifier

212035 [NCBI]

Taxonomic lineage

Viruses › dsDNA viruses, no RNA stage › Mimiviridae › Mimivirus

Virus host

Acanthamoeba polyphaga (Amoeba) [TaxID: 5757]

Protein attributes

Sequence length	388 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the covalent attachment of ubiquitin to other proteins By similarity.
Catalytic activity	ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.
Pathway	Protein modification; protein ubiquitination.
Sequence similarities	Belongs to the ubiquitin-conjugating enzyme family.

Ontologies

Keywords
Biological process	Ubl conjugation pathway
Ligand	ATP-binding Nucleotide-binding
Molecular function	Ligase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ubiquitin-protein ligase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 388	388	Probable ubiquitin-conjugating enzyme E2 L709		PRO_0000243981
Sites
	Active site	95	1	Glycyl thioester intermediate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5UQ57 [UniParc]. Last modified December 7, 2004. Version 1. Checksum: 9329EB6E7F020B78	FASTA	388	42,724
	10 20 30 40 50 60 MQNVHKRVIK DINDGMKNLK QEFGIYLAPE EDDFYKVHFI LQGPEGTPFE GGLYHGMIRL 70 80 90 100 110 120 NNDHPFRPPN LHMITPSGRF EAEKYPISPN SRGICTTATS FHPESWTSMN NLETVLKGFV 130 140 150 160 170 180 SLMCDPYDGG VGAVKSTDTQ VKKLAQDSLT HIGNDLMVQK LFPDLYKAVN NGTFKPVKLA 190 200 210 220 230 240 ELSKIVYKEP TKPIVEEKSA KTSKSSTKTS VKSKKNQKSD SEEEENSDDD NTDSDSESDD 250 260 270 280 290 300 FRDLDDVVDD SDQESDDESD SSSESENESG GSDDESDDGS DDESDDETSE SDSESEEEKP 310 320 330 340 350 360 VKKSTRKISK TTTKSSSTKP VKSIKSSKST TTKPTKPTKS TKTTKSTKST KSTKSTKPTE 370 380 STKSSRSVKT TESSKSSKSS KSSKTGKK

References

[1]	"The 1.2-megabase genome sequence of Mimivirus." Raoult D., Audic S., Robert C., Abergel C., Renesto P., Ogata H., La Scola B., Susan M., Claverie J.-M. Science 306:1344-1350(2004) [PubMed: 15486256] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Rowbotham-Bradford.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY653733 Genomic DNA. Translation: AAV50969.1.
RefSeq	YP_003987237.1. NC_014649.1.
3D structure databases
ProteinModelPortal	Q5UQ57.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	9925362.
Family and domain databases
InterPro	IPR000608. UBQ-conjugat_E2. IPR016135. UBQ-conjugating_enzyme/RWD. [Graphical view]
Gene3D	G3DSA:3.10.110.10. UBQ-conjugat_E2. 1 hit.
Pfam	PF00179. UQ_con. 1 hit. [Graphical view]
SUPFAM	SSF54495. UBQ-conjugat/RWD-like. 1 hit.
PROSITE	PS50127. UBIQUITIN_CONJUGAT_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

UBC2_MIMIV

Accession

Primary (citable) accession number: Q5UQ57

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 27, 2006
Last sequence update:	December 7, 2004
Last modified:	September 21, 2011
This is version 49 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program