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Protein

Probable ubiquitin-conjugating enzyme E2 L709

Gene

MIMI_L709

Organism
Acanthamoeba polyphaga mimivirus (APMV)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the covalent attachment of ubiquitin to other proteins.PROSITE-ProRule annotation

Catalytic activityi

S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.PROSITE-ProRule annotation

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.PROSITE-ProRule annotation
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei95Glycyl thioester intermediatePROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processUbl conjugation pathway
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable ubiquitin-conjugating enzyme E2 L709 (EC:2.3.2.23)
Alternative name(s):
E2 ubiquitin-conjugating enzyme L709
Ubiquitin carrier protein
Ubiquitin-protein ligase
Gene namesi
Ordered Locus Names:MIMI_L709
OrganismiAcanthamoeba polyphaga mimivirus (APMV)
Taxonomic identifieri212035 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageMimiviridaeMimivirus
Virus hostiAcanthamoeba polyphaga (Amoeba) [TaxID: 5757]
Proteomesi
  • UP000001134 Componenti: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002439811 – 388Probable ubiquitin-conjugating enzyme E2 L709Add BLAST388

Structurei

3D structure databases

ProteinModelPortaliQ5UQ57.
SMRiQ5UQ57.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ubiquitin-conjugating enzyme family.PROSITE-ProRule annotation

Phylogenomic databases

OrthoDBiVOG09000091.

Family and domain databases

Gene3Di3.10.110.10. 1 hit.
InterProiView protein in InterPro
IPR000608. UBQ-conjugat_E2.
IPR016135. UBQ-conjugating_enzyme/RWD.
PfamiView protein in Pfam
PF00179. UQ_con. 1 hit.
SUPFAMiSSF54495. SSF54495. 1 hit.
PROSITEiView protein in PROSITE
PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5UQ57-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQNVHKRVIK DINDGMKNLK QEFGIYLAPE EDDFYKVHFI LQGPEGTPFE
60 70 80 90 100
GGLYHGMIRL NNDHPFRPPN LHMITPSGRF EAEKYPISPN SRGICTTATS
110 120 130 140 150
FHPESWTSMN NLETVLKGFV SLMCDPYDGG VGAVKSTDTQ VKKLAQDSLT
160 170 180 190 200
HIGNDLMVQK LFPDLYKAVN NGTFKPVKLA ELSKIVYKEP TKPIVEEKSA
210 220 230 240 250
KTSKSSTKTS VKSKKNQKSD SEEEENSDDD NTDSDSESDD FRDLDDVVDD
260 270 280 290 300
SDQESDDESD SSSESENESG GSDDESDDGS DDESDDETSE SDSESEEEKP
310 320 330 340 350
VKKSTRKISK TTTKSSSTKP VKSIKSSKST TTKPTKPTKS TKTTKSTKST
360 370 380
KSTKSTKPTE STKSSRSVKT TESSKSSKSS KSSKTGKK
Length:388
Mass (Da):42,724
Last modified:December 7, 2004 - v1
Checksum:i9329EB6E7F020B78
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY653733 Genomic DNA. Translation: AAV50969.1.
RefSeqiYP_003987237.1. NC_014649.1.

Genome annotation databases

GeneIDi9925362.
KEGGivg:9925362.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiUBC2_MIMIV
AccessioniPrimary (citable) accession number: Q5UQ57
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: December 7, 2004
Last modified: April 12, 2017
This is version 66 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families