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Q5UQ40

- UBC4_MIMIV

UniProt

Q5UQ40 - UBC4_MIMIV

Protein

Probable bifunctional E2/E3 enzyme R795

Gene

MIMI_R795

Organism
Acanthamoeba polyphaga mimivirus (APMV)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 73 (01 Oct 2014)
      Sequence version 1 (07 Dec 2004)
      Previous versions | rss
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    Functioni

    Catalyzes the covalent attachment of ubiquitin to other proteins. Also act as a E3 ubiquitin-protein ligase Potential.PROSITE-ProRule annotation

    Catalytic activityi

    ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.PROSITE-ProRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei1217 – 12171Glycyl thioester intermediatePROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri74 – 12855RING-type; atypicalPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. acid-amino acid ligase activity Source: InterPro
    2. ATP binding Source: UniProtKB-KW
    3. ubiquitin-protein transferase activity Source: InterPro
    4. zinc ion binding Source: InterPro

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Ubl conjugation pathway

    Keywords - Ligandi

    ATP-binding, Metal-binding, Nucleotide-binding, Zinc

    Enzyme and pathway databases

    UniPathwayiUPA00143.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable bifunctional E2/E3 enzyme R795
    Including the following 2 domains:
    E3 ubiquitin-protein ligase (EC:6.3.2.-)
    Ubiquitin-conjugating enzyme E2 (EC:6.3.2.19)
    Gene namesi
    Ordered Locus Names:MIMI_R795
    OrganismiAcanthamoeba polyphaga mimivirus (APMV)
    Taxonomic identifieri212035 [NCBI]
    Taxonomic lineageiVirusesdsDNA viruses, no RNA stageMimiviridaeMimivirus
    Virus hostiAcanthamoeba polyphaga (Amoeba) [TaxID: 5757]
    ProteomesiUP000001134: Genome

    Subcellular locationi

    GO - Cellular componenti

    1. ubiquitin ligase complex Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 12971297Probable bifunctional E2/E3 enzyme R795PRO_0000309555Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ5UQ40.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini678 – 75073U-boxAdd
    BLAST
    Domaini899 – 1082184VWFAPROSITE-ProRule annotationAdd
    BLAST

    Domaini

    The RING-type zinc finger domain mediates binding to an E2 ubiquitin-conjugating enzyme.By similarity

    Sequence similaritiesi

    In the C-terminal section; belongs to the ubiquitin-conjugating enzyme family.Curated
    Contains 1 RING-type zinc finger.PROSITE-ProRule annotation
    Contains 1 U-box domain.Curated
    Contains 1 VWFA domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri74 – 12855RING-type; atypicalPROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Zinc-finger

    Family and domain databases

    Gene3Di3.10.110.10. 1 hit.
    3.30.40.10. 2 hits.
    3.40.50.410. 1 hit.
    InterProiIPR029071. Ubiquitin-rel_dom.
    IPR003613. Ubox_domain.
    IPR000608. UBQ-conjugat_E2.
    IPR016135. UBQ-conjugating_enzyme/RWD.
    IPR002035. VWF_A.
    IPR001841. Znf_RING.
    IPR013083. Znf_RING/FYVE/PHD.
    IPR024766. Znf_RING_H2.
    [Graphical view]
    PfamiPF04564. U-box. 1 hit.
    PF00179. UQ_con. 1 hit.
    PF12678. zf-rbx1. 1 hit.
    [Graphical view]
    SMARTiSM00184. RING. 1 hit.
    SM00504. Ubox. 1 hit.
    SM00327. VWA. 1 hit.
    [Graphical view]
    SUPFAMiSSF53300. SSF53300. 1 hit.
    SSF54236. SSF54236. 1 hit.
    SSF54495. SSF54495. 1 hit.
    PROSITEiPS51698. U_BOX. 1 hit.
    PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
    PS50234. VWFA. 1 hit.
    PS50089. ZF_RING_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5UQ40-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEQIVTFGGI TIDNVSPDHI QQLYSVKLNG TSNNEEIPTE FPNIIQSVCS     50
    CDKHVVELTM DVFKLVDTTE NSSCAICRYQ ENEPCIEHKS SESNTKCPIA 100
    QSVSCSHSFH ACCISRWLHT KKTCPLCNIE WQLIGANNDS VVIYFDDKNQ 150
    EFKLSDNLVE DIGRQFGIDM DNYIVCKNKS PVTEYKNSTY ALCTRDRHNS 200
    QNGQTNLKII CEFDSKTENL FIKYSTTIEE LRKLVSQTFD LFKDQVKLIY 250
    NNIEISKDFD NLTVFNIGIK NDSNLAVECY KSFTYDMEIT NNFMVLYVPD 300
    TFNTTNSSNN IQSVVSGSIA WIPQPFIDNV TNKDLRCLLS SLYILVKKVN 350
    LNTELIQSVT DRFEKYMELY GMHYRQIKLA KDSLRCLLEM NHFNNKDRMI 400
    LSCTFYELID RIQRDNNINK NPLLSSNLIC NLILSDKQVN EQTKINWKFL 450
    AKDVRITKVF NIYSPLVLTN SVPPLLTLNK NLDVVVFTGK GKDVSLPIIL 500
    YDTLTNSETD VNAAELGKIV SDKGDLMMVD DRIYEEAIMV CIDTSNSMSK 550
    ASDFDEDIKL KRSSIIETKN RFYEILKTES HSSPQESDIR QLTNTIIWFI 600
    THPNFEDWYR KLYSQELIRS IACFEQKVYP NFAMMLVKYP WFFNKLLTSK 650
    KVVVNNTWYS FIRNESNSNY NETKYSKEPL QEFLCPISHE IMEHPVVAKD 700
    GFTYEKSNIL KWFENKSTSP MTNEKISKKI CDNKVLKSII RDWKENNTVI 750
    EQSDKLSVTI KLPDPWNETV IHYNETDNIW DLIYQIYHIT GLSHDQYKLT 800
    SNYWAIDKSS LIKQISSKIK IHPFEKKMVD VKICDKTYFF GTENTMTVSS 850
    FYTVGNLLYK LKSRKYHRYA VWYGLKDSGD GFQRGTILSP HDKLIDYSEM 900
    TLEIHSSNRY KTPKGNHLSR LDVVKKLFDA YINRSIAYSF NTAIGLMSFS 950
    DKSVLECAIS PFYESFREKV NELDTSGATA LYECLKDSIE NLIEWKNADL 1000
    ENRSKAKLRI ICLTDGKDTG LDKFKNTVKH KSQYHNVTID CILIGSDYDN 1050
    YLGKIGEKTN GYVFNPSTIK YALDIMELET MISSTNRKTI FYHNTIDEKT 1100
    IPPIINPTKK LHAKAISPME IISKTNENTK LSQKLIRVQR EIVDVMKNQH 1150
    PDIDVYINEQ DISFWKIVFK GPDSTPYKNG TWLAYIQFTE EYPNIAPNIR 1200
    FVTPIKHCNI NNYGRVCHSI LDRNYTPNVK ISLILQCIYG LLLNPDVNDP 1250
    LDTNLAMIYY DANGLYEAQI IDYVNKFALK SREEWNQELA KNQFKNW 1297
    Length:1,297
    Mass (Da):150,351
    Last modified:December 7, 2004 - v1
    Checksum:iBE177D02F78F6685
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY653733 Genomic DNA. Translation: AAV51055.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY653733 Genomic DNA. Translation: AAV51055.1 .

    3D structure databases

    ProteinModelPortali Q5UQ40.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    UniPathwayi UPA00143 .

    Family and domain databases

    Gene3Di 3.10.110.10. 1 hit.
    3.30.40.10. 2 hits.
    3.40.50.410. 1 hit.
    InterProi IPR029071. Ubiquitin-rel_dom.
    IPR003613. Ubox_domain.
    IPR000608. UBQ-conjugat_E2.
    IPR016135. UBQ-conjugating_enzyme/RWD.
    IPR002035. VWF_A.
    IPR001841. Znf_RING.
    IPR013083. Znf_RING/FYVE/PHD.
    IPR024766. Znf_RING_H2.
    [Graphical view ]
    Pfami PF04564. U-box. 1 hit.
    PF00179. UQ_con. 1 hit.
    PF12678. zf-rbx1. 1 hit.
    [Graphical view ]
    SMARTi SM00184. RING. 1 hit.
    SM00504. Ubox. 1 hit.
    SM00327. VWA. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53300. SSF53300. 1 hit.
    SSF54236. SSF54236. 1 hit.
    SSF54495. SSF54495. 1 hit.
    PROSITEi PS51698. U_BOX. 1 hit.
    PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
    PS50234. VWFA. 1 hit.
    PS50089. ZF_RING_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Rowbotham-Bradford.

    Entry informationi

    Entry nameiUBC4_MIMIV
    AccessioniPrimary (citable) accession number: Q5UQ40
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 13, 2007
    Last sequence update: December 7, 2004
    Last modified: October 1, 2014
    This is version 73 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3