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Q5UPW7

- UBPL2_MIMIV

UniProt

Q5UPW7 - UBPL2_MIMIV

Protein

Putative ubiquitin carboxyl-terminal hydrolase L293

Gene

MIMI_L293

Organism
Acanthamoeba polyphaga mimivirus (APMV)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 45 (01 Oct 2014)
      Sequence version 1 (07 Dec 2004)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei142 – 1421NucleophileBy similarity
    Active sitei384 – 3841Proton acceptorBy similarity

    GO - Molecular functioni

    1. cysteine-type peptidase activity Source: UniProtKB-KW
    2. ubiquitinyl hydrolase activity Source: InterPro

    GO - Biological processi

    1. ubiquitin-dependent protein catabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Protease, Thiol protease

    Keywords - Biological processi

    Ubl conjugation pathway

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative ubiquitin carboxyl-terminal hydrolase L293 (EC:3.4.19.12)
    Alternative name(s):
    Deubiquitinating enzyme L293
    Ubiquitin thioesterase L293
    Ubiquitin-specific-processing protease L293
    Gene namesi
    Ordered Locus Names:MIMI_L293
    OrganismiAcanthamoeba polyphaga mimivirus (APMV)
    Taxonomic identifieri212035 [NCBI]
    Taxonomic lineageiVirusesdsDNA viruses, no RNA stageMimiviridaeMimivirus
    Virus hostiAcanthamoeba polyphaga (Amoeba) [TaxID: 5757]
    ProteomesiUP000001134: Genome

    Subcellular locationi

    Virion 1 Publication

    GO - Cellular componenti

    1. virion Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Virion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 445445Putative ubiquitin carboxyl-terminal hydrolase L293PRO_0000251133Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ5UPW7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini133 – 441309USPAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase C19 family.Curated
    Contains 1 USP domain.Curated

    Family and domain databases

    InterProiIPR001394. Peptidase_C19_UCH.
    IPR028889. UCH/PAN2.
    [Graphical view]
    PfamiPF00443. UCH. 1 hit.
    [Graphical view]
    PROSITEiPS50235. USP_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5UPW7-1 [UniParc]FASTAAdd to Basket

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    MCVEMKNKTN TTIPSQPQIP IQPSILPTQQ TISPIPQIIP PTQPTLPKLQ    50
    LDPILGSNGI PIANQEWSGT EYVRTNDPTK FIVITKTLDP KIARFLPTFK 100
    KPVITDIINK TSNSTLDMNK IITTNNFNVE NAKALANFGN SCYFGTSMQL 150
    LFVMFHVRNF IVKNSNFTET GISIDLKNAY DSIKNLFITM NTAPKNDPIK 200
    SFPDYPNVKK QIMKEPDPVQ MLEEDAEEFI TQFMSDLDPK ARNLALIKGN 250
    EYIYDVSNAQ LNRQQSFSNI FNLIPLDIIK SNPTDTLENI LSKTYTMVEL 300
    REGVNTIQNP ITSDYEFTYF VNQPTILPEY FLVRLNMVDP TSTNKLRHNI 350
    QINTTLVLTI NGQTTTYFAL AIIVHRGNSI RTGHYTCLVF DNQTGSQFQY 400
    IFYDDSLSSL VSIPTNSKII PSNLYLKNIT DSAYIILYGD ITKLR 445
    Length:445
    Mass (Da):50,458
    Last modified:December 7, 2004 - v1
    Checksum:iE5C2D9653139DCE4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY653733 Genomic DNA. Translation: AAV50565.1.
    RefSeqiYP_003986795.1. NC_014649.1.

    Genome annotation databases

    GeneIDi9924908.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY653733 Genomic DNA. Translation: AAV50565.1 .
    RefSeqi YP_003986795.1. NC_014649.1.

    3D structure databases

    ProteinModelPortali Q5UPW7.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 9924908.

    Family and domain databases

    InterProi IPR001394. Peptidase_C19_UCH.
    IPR028889. UCH/PAN2.
    [Graphical view ]
    Pfami PF00443. UCH. 1 hit.
    [Graphical view ]
    PROSITEi PS50235. USP_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: Rowbotham-Bradford.
    2. "Mimivirus giant particles incorporate a large fraction of anonymous and unique gene products."
      Renesto P., Abergel C., Decloquement P., Moinier D., Azza S., Ogata H., Fourquet P., Gorvel J.-P., Claverie J.-M., Raoult D.
      J. Virol. 80:11678-11685(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiUBPL2_MIMIV
    AccessioniPrimary (citable) accession number: Q5UPW7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 3, 2006
    Last sequence update: December 7, 2004
    Last modified: October 1, 2014
    This is version 45 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3