Q5UPW7 (UBPL2_MIMIV) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative ubiquitin carboxyl-terminal hydrolase L293
EC=3.4.19.12

Alternative name(s):
Deubiquitinating enzyme L293
Ubiquitin thioesterase L293
Ubiquitin-specific-processing protease L293

Gene names

Ordered Locus Names:

MIMI_L293

Organism

Acanthamoeba polyphaga mimivirus (APMV) [Reference proteome]

Taxonomic identifier

212035 [NCBI]

Taxonomic lineage

Viruses › dsDNA viruses, no RNA stage › Mimiviridae › Mimivirus

Virus host

Acanthamoeba polyphaga (Amoeba) [TaxID: 5757]

Protein attributes

Sequence length	445 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Catalytic activity	Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
Subcellular location	Virion.
Sequence similarities	Belongs to the peptidase C19 family.

Ontologies

Keywords
Biological process	Ubl conjugation pathway
Cellular component	Virion
Molecular function	Hydrolase Protease Thiol protease
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	ubiquitin-dependent protein catabolic process Inferred from electronic annotation. Source: InterPro
Cellular_component	virion Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	cysteine-type peptidase activity Inferred from electronic annotation. Source: UniProtKB-KW ubiquitin thiolesterase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 445	445	Putative ubiquitin carboxyl-terminal hydrolase L293		PRO_0000251133
Sites
	Active site	142	1	Nucleophile By similarity
	Active site	384	1	Proton acceptor By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5UPW7 [UniParc]. Last modified December 7, 2004. Version 1. Checksum: E5C2D9653139DCE4	FASTA	445	50,458
	10 20 30 40 50 60 MCVEMKNKTN TTIPSQPQIP IQPSILPTQQ TISPIPQIIP PTQPTLPKLQ LDPILGSNGI 70 80 90 100 110 120 PIANQEWSGT EYVRTNDPTK FIVITKTLDP KIARFLPTFK KPVITDIINK TSNSTLDMNK 130 140 150 160 170 180 IITTNNFNVE NAKALANFGN SCYFGTSMQL LFVMFHVRNF IVKNSNFTET GISIDLKNAY 190 200 210 220 230 240 DSIKNLFITM NTAPKNDPIK SFPDYPNVKK QIMKEPDPVQ MLEEDAEEFI TQFMSDLDPK 250 260 270 280 290 300 ARNLALIKGN EYIYDVSNAQ LNRQQSFSNI FNLIPLDIIK SNPTDTLENI LSKTYTMVEL 310 320 330 340 350 360 REGVNTIQNP ITSDYEFTYF VNQPTILPEY FLVRLNMVDP TSTNKLRHNI QINTTLVLTI 370 380 390 400 410 420 NGQTTTYFAL AIIVHRGNSI RTGHYTCLVF DNQTGSQFQY IFYDDSLSSL VSIPTNSKII 430 440 PSNLYLKNIT DSAYIILYGD ITKLR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The 1.2-megabase genome sequence of Mimivirus." Raoult D., Audic S., Robert C., Abergel C., Renesto P., Ogata H., La Scola B., Susan M., Claverie J.-M. Science 306:1344-1350(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: Rowbotham-Bradford.
[2]	"Mimivirus giant particles incorporate a large fraction of anonymous and unique gene products." Renesto P., Abergel C., Decloquement P., Moinier D., Azza S., Ogata H., Fourquet P., Gorvel J.-P., Claverie J.-M., Raoult D. J. Virol. 80:11678-11685(2006) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], SUBCELLULAR LOCATION.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY653733 Genomic DNA. Translation: AAV50565.1.
RefSeq	YP_003986795.1. NC_014649.1.
3D structure databases
ProteinModelPortal	Q5UPW7.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	9924908.
Family and domain databases
InterPro	IPR001394. Peptidase_C19. [Graphical view]
Pfam	PF00443. UCH. 1 hit. [Graphical view]
PROSITE	PS00972. UCH_2_1. False negative. PS00973. UCH_2_2. False negative. PS50235. UCH_2_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

UBPL2_MIMIV

Accession

Primary (citable) accession number: Q5UPW7

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 3, 2006
Last sequence update:	December 7, 2004
Last modified:	July 11, 2012
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program