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Q5UPW7 (UBPL2_MIMIV) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 43. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Putative ubiquitin carboxyl-terminal hydrolase L293

EC=3.4.19.12
Alternative name(s):
Deubiquitinating enzyme L293
Ubiquitin thioesterase L293
Ubiquitin-specific-processing protease L293
Gene names
Ordered Locus Names:MIMI_L293
OrganismAcanthamoeba polyphaga mimivirus (APMV) [Reference proteome]
Taxonomic identifier212035 [NCBI]
Taxonomic lineageVirusesdsDNA viruses, no RNA stageMimiviridaeMimivirus
Virus hostAcanthamoeba polyphaga (Amoeba) [TaxID: 5757]

Protein attributes

Sequence length445 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Subcellular location

Virion.

Sequence similarities

Belongs to the peptidase C19 family.

Contains 1 USP domain.

Ontologies

Keywords
   Biological processUbl conjugation pathway
   Cellular componentVirion
   Molecular functionHydrolase
Protease
Thiol protease
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processubiquitin-dependent protein catabolic process

Inferred from electronic annotation. Source: InterPro

   Cellular_componentvirion

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functioncysteine-type peptidase activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 445445Putative ubiquitin carboxyl-terminal hydrolase L293
PRO_0000251133

Regions

Domain133 – 441309USP

Sites

Active site1421Nucleophile By similarity
Active site3841Proton acceptor By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5UPW7 [UniParc].

Last modified December 7, 2004. Version 1.
Checksum: E5C2D9653139DCE4

FASTA44550,458
        10         20         30         40         50         60 
MCVEMKNKTN TTIPSQPQIP IQPSILPTQQ TISPIPQIIP PTQPTLPKLQ LDPILGSNGI 

        70         80         90        100        110        120 
PIANQEWSGT EYVRTNDPTK FIVITKTLDP KIARFLPTFK KPVITDIINK TSNSTLDMNK 

       130        140        150        160        170        180 
IITTNNFNVE NAKALANFGN SCYFGTSMQL LFVMFHVRNF IVKNSNFTET GISIDLKNAY 

       190        200        210        220        230        240 
DSIKNLFITM NTAPKNDPIK SFPDYPNVKK QIMKEPDPVQ MLEEDAEEFI TQFMSDLDPK 

       250        260        270        280        290        300 
ARNLALIKGN EYIYDVSNAQ LNRQQSFSNI FNLIPLDIIK SNPTDTLENI LSKTYTMVEL 

       310        320        330        340        350        360 
REGVNTIQNP ITSDYEFTYF VNQPTILPEY FLVRLNMVDP TSTNKLRHNI QINTTLVLTI 

       370        380        390        400        410        420 
NGQTTTYFAL AIIVHRGNSI RTGHYTCLVF DNQTGSQFQY IFYDDSLSSL VSIPTNSKII 

       430        440 
PSNLYLKNIT DSAYIILYGD ITKLR 

« Hide

References

« Hide 'large scale' references
[1]"The 1.2-megabase genome sequence of Mimivirus."
Raoult D., Audic S., Robert C., Abergel C., Renesto P., Ogata H., La Scola B., Susan M., Claverie J.-M.
Science 306:1344-1350(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: Rowbotham-Bradford.
[2]"Mimivirus giant particles incorporate a large fraction of anonymous and unique gene products."
Renesto P., Abergel C., Decloquement P., Moinier D., Azza S., Ogata H., Fourquet P., Gorvel J.-P., Claverie J.-M., Raoult D.
J. Virol. 80:11678-11685(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], SUBCELLULAR LOCATION.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY653733 Genomic DNA. Translation: AAV50565.1.
RefSeqYP_003986795.1. NC_014649.1.

3D structure databases

ProteinModelPortalQ5UPW7.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID9924908.

Family and domain databases

InterProIPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
[Graphical view]
PfamPF00443. UCH. 1 hit.
[Graphical view]
PROSITEPS50235. USP_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameUBPL2_MIMIV
AccessionPrimary (citable) accession number: Q5UPW7
Entry history
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: December 7, 2004
Last modified: April 16, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries