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Protein

Putative ubiquitin carboxyl-terminal hydrolase L293

Gene

MIMI_L293

Organism
Acanthamoeba polyphaga mimivirus (APMV)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei142 – 1421NucleophileBy similarity
Active sitei384 – 3841Proton acceptorBy similarity

GO - Molecular functioni

  1. cysteine-type peptidase activity Source: UniProtKB-KW
  2. ubiquitinyl hydrolase activity Source: InterPro

GO - Biological processi

  1. ubiquitin-dependent protein catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Ubl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Putative ubiquitin carboxyl-terminal hydrolase L293 (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme L293
Ubiquitin thioesterase L293
Ubiquitin-specific-processing protease L293
Gene namesi
Ordered Locus Names:MIMI_L293
OrganismiAcanthamoeba polyphaga mimivirus (APMV)
Taxonomic identifieri212035 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageMimiviridaeMimivirus
Virus hostiAcanthamoeba polyphaga (Amoeba) [TaxID: 5757]
ProteomesiUP000001134 Componenti: Genome

Subcellular locationi

Virion 1 Publication

GO - Cellular componenti

  1. virion Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 445445Putative ubiquitin carboxyl-terminal hydrolase L293PRO_0000251133Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ5UPW7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini133 – 441309USPAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase C19 family.Curated
Contains 1 USP domain.Curated

Family and domain databases

InterProiIPR001394. Peptidase_C19_UCH.
IPR028889. USP_dom.
[Graphical view]
PfamiPF00443. UCH. 1 hit.
[Graphical view]
PROSITEiPS50235. USP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5UPW7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCVEMKNKTN TTIPSQPQIP IQPSILPTQQ TISPIPQIIP PTQPTLPKLQ
60 70 80 90 100
LDPILGSNGI PIANQEWSGT EYVRTNDPTK FIVITKTLDP KIARFLPTFK
110 120 130 140 150
KPVITDIINK TSNSTLDMNK IITTNNFNVE NAKALANFGN SCYFGTSMQL
160 170 180 190 200
LFVMFHVRNF IVKNSNFTET GISIDLKNAY DSIKNLFITM NTAPKNDPIK
210 220 230 240 250
SFPDYPNVKK QIMKEPDPVQ MLEEDAEEFI TQFMSDLDPK ARNLALIKGN
260 270 280 290 300
EYIYDVSNAQ LNRQQSFSNI FNLIPLDIIK SNPTDTLENI LSKTYTMVEL
310 320 330 340 350
REGVNTIQNP ITSDYEFTYF VNQPTILPEY FLVRLNMVDP TSTNKLRHNI
360 370 380 390 400
QINTTLVLTI NGQTTTYFAL AIIVHRGNSI RTGHYTCLVF DNQTGSQFQY
410 420 430 440
IFYDDSLSSL VSIPTNSKII PSNLYLKNIT DSAYIILYGD ITKLR
Length:445
Mass (Da):50,458
Last modified:December 6, 2004 - v1
Checksum:iE5C2D9653139DCE4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY653733 Genomic DNA. Translation: AAV50565.1.
RefSeqiYP_003986795.1. NC_014649.1.

Genome annotation databases

GeneIDi9924908.
KEGGivg:9924908.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY653733 Genomic DNA. Translation: AAV50565.1.
RefSeqiYP_003986795.1. NC_014649.1.

3D structure databases

ProteinModelPortaliQ5UPW7.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi9924908.
KEGGivg:9924908.

Family and domain databases

InterProiIPR001394. Peptidase_C19_UCH.
IPR028889. USP_dom.
[Graphical view]
PfamiPF00443. UCH. 1 hit.
[Graphical view]
PROSITEiPS50235. USP_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Rowbotham-Bradford.
  2. "Mimivirus giant particles incorporate a large fraction of anonymous and unique gene products."
    Renesto P., Abergel C., Decloquement P., Moinier D., Azza S., Ogata H., Fourquet P., Gorvel J.-P., Claverie J.-M., Raoult D.
    J. Virol. 80:11678-11685(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], SUBCELLULAR LOCATION.

Entry informationi

Entry nameiUBPL2_MIMIV
AccessioniPrimary (citable) accession number: Q5UPW7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2006
Last sequence update: December 6, 2004
Last modified: March 31, 2015
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.