Q5UPT2 (UNG_MIMIV) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable uracil-DNA glycosylase
Short name=UDG
EC=3.2.2.-

Gene names

Name:	UNG
Ordered Locus Names:	MIMI_L249

Organism

Acanthamoeba polyphaga mimivirus (APMV) [Reference proteome]

Taxonomic identifier

212035 [NCBI]

Taxonomic lineage

Viruses › dsDNA viruses, no RNA stage › Mimiviridae › Mimivirus

Virus host

Acanthamoeba polyphaga (Amoeba) [TaxID: 5757]

Protein attributes

Sequence length	370 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine By similarity.
Sequence similarities	Belongs to the uracil-DNA glycosylase family.

Ontologies

Keywords
Biological process	DNA damage DNA repair
Molecular function	Glycosidase Hydrolase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	base-excision repair Inferred from electronic annotation. Source: InterPro
Molecular_function	uracil DNA N-glycosylase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 370	370	Probable uracil-DNA glycosylase		PRO_0000176176
Sites
	Active site	191	1	Proton acceptor By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5UPT2 [UniParc]. Last modified December 7, 2004. Version 1. Checksum: 15D0E0CF1DB11A26	FASTA	370	42,218
	10 20 30 40 50 60 MSKKNVDPFS DSDSSSEPPS IFSSDNEENS DVDNSVIIND KNTKSDEADI KYMDEDESSD 70 80 90 100 110 120 SESESESKKK SKKSKKSKKS KKSVTKKKNN LLVGNRIITE YILIDANNYH FKSWIECFPD 130 140 150 160 170 180 CKVNLKLLLF RPEWFDFFKY VESKTYFPQL ESKLSSYLEK RQRIVPYPEL LFNTMNVLPP 190 200 210 220 230 240 GKIKVVILGQ DPYPGSCISG VPYAMGCSFS VPLNCPVPKS LANIYTNLIK FNHMRKAPKH 250 260 270 280 290 300 GCLASWILQG TFMINSAFTT VLNESGVHAR TWESFTADLI DYLTDNYDDL IFVAWGAHAH 310 320 330 340 350 360 KLCQRVDPKK HYIITSSHPS PYSVSNTMTS MSYGPNPKKV TYPSFNSVDH FGKINEHLKS 370 RNKKPIFWDL

References

[1]	"The 1.2-megabase genome sequence of Mimivirus." Raoult D., Audic S., Robert C., Abergel C., Renesto P., Ogata H., La Scola B., Susan M., Claverie J.-M. Science 306:1344-1350(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Rowbotham-Bradford.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY653733 Genomic DNA. Translation: AAV50521.1.
RefSeq	YP_003986745.1. NC_014649.1.
3D structure databases
ProteinModelPortal	Q5UPT2.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	9924856.
Family and domain databases
Gene3D	3.40.470.10. 1 hit.
InterPro	IPR018085. Ura-DNA_Glyclase_AS. IPR002043. Ura_DNA_glycsylse. IPR005122. Uracil-DNA_glycosylase-like. [Graphical view]
PANTHER	PTHR11264. PTHR11264. 1 hit.
Pfam	PF03167. UDG. 1 hit. [Graphical view]
SMART	SM00986. UDG. 1 hit. [Graphical view]
SUPFAM	SSF52141. UDNA_glycsylseSF. 1 hit.
PROSITE	PS00130. U_DNA_GLYCOSYLASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

UNG_MIMIV

Accession

Primary (citable) accession number: Q5UPT2

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 13, 2005
Last sequence update:	December 7, 2004
Last modified:	March 6, 2013
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program