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Protein

Probable FAD-linked sulfhydryl oxidase R596

Gene

MIMI_R596

Organism
Acanthamoeba polyphaga mimivirus (APMV)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

FAD-dependent sulfhydryl oxidase that catalyzes disulfide bond formation.PROSITE-ProRule annotation

Catalytic activityi

2 R'C(R)SH + O2 = R'C(R)S-S(R)CR' + H2O2.

Cofactori

FADPROSITE-ProRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

FAD, Flavoprotein

Names & Taxonomyi

Protein namesi
Recommended name:
Probable FAD-linked sulfhydryl oxidase R596 (EC:1.8.3.2)
Gene namesi
Ordered Locus Names:MIMI_R596
OrganismiAcanthamoeba polyphaga mimivirus (APMV)
Taxonomic identifieri212035 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageMimiviridaeMimivirus
Virus hostiAcanthamoeba polyphaga (Amoeba) [TaxID: 5757]
Proteomesi
  • UP000001134 Componenti: Genome

Subcellular locationi

GO - Cellular componenti

  • virion Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002473711 – 292Probable FAD-linked sulfhydryl oxidase R596Add BLAST292

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi80 ↔ 83Redox-activePROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Structurei

Secondary structure

1292
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi37 – 53Combined sources17
Helixi61 – 77Combined sources17
Beta strandi78 – 80Combined sources3
Helixi81 – 90Combined sources10
Helixi94 – 96Combined sources3
Helixi100 – 103Combined sources4
Helixi106 – 123Combined sources18
Helixi132 – 140Combined sources9
Helixi160 – 171Combined sources12
Helixi180 – 183Combined sources4
Helixi184 – 186Combined sources3
Helixi187 – 192Combined sources6
Helixi197 – 200Combined sources4
Helixi201 – 208Combined sources8
Turni209 – 211Combined sources3
Helixi213 – 216Combined sources4
Helixi221 – 238Combined sources18
Turni249 – 252Combined sources4
Helixi256 – 262Combined sources7
Turni263 – 265Combined sources3
Helixi271 – 290Combined sources20

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3GWNX-ray1.78A/B33-145[»]
3TD7X-ray2.21A1-292[»]
ProteinModelPortaliQ5UP54.
SMRiQ5UP54.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ5UP54.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini33 – 139ERV/ALR sulfhydryl oxidasePROSITE-ProRule annotationAdd BLAST107

Sequence similaritiesi

Contains 1 ERV/ALR sulfhydryl oxidase domain.PROSITE-ProRule annotation

Phylogenomic databases

KOiK17783.

Family and domain databases

Gene3Di1.20.120.310. 1 hit.
InterProiIPR017905. ERV/ALR_sulphydryl_oxidase.
[Graphical view]
PfamiPF04777. Evr1_Alr. 1 hit.
[Graphical view]
SUPFAMiSSF69000. SSF69000. 1 hit.
PROSITEiPS51324. ERV_ALR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5UP54-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLSKQVVPT HRVEIAPNSE STCKMDHSNY QHNGLITKIW GTAGWTFNHA
60 70 80 90 100
VTFGYPLNPT SDDKRRYKNY FISLGDVLPC RLCRESYKKF ITTGKTALTN
110 120 130 140 150
EVLRNRHTLT KWFYDVHNAV NNKLEVDYGL SYEDVVNKYE SFRAKCGKPV
160 170 180 190 200
PTVKGCVTPL DHKAFSFKKL YYMDAPIVSL DKVENFVRIA RMRGISDKYF
210 220 230 240 250
CFLELATVLN GDFNELKKQS SWEYRNKYCQ KKIRHMRENA IPSIEEQGYW
260 270 280 290
KGTPTIDELK LLLFLCSNLN RTEVNDAINN VERLESTHYI EN
Length:292
Mass (Da):33,998
Last modified:December 7, 2004 - v1
Checksum:i5FEBA7FD1B7F526B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY653733 Genomic DNA. Translation: AAV50859.1.
RefSeqiYP_003987112.1. NC_014649.1.

Genome annotation databases

GeneIDi9925233.
KEGGivg:9925233.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY653733 Genomic DNA. Translation: AAV50859.1.
RefSeqiYP_003987112.1. NC_014649.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3GWNX-ray1.78A/B33-145[»]
3TD7X-ray2.21A1-292[»]
ProteinModelPortaliQ5UP54.
SMRiQ5UP54.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi9925233.
KEGGivg:9925233.

Phylogenomic databases

KOiK17783.

Miscellaneous databases

EvolutionaryTraceiQ5UP54.

Family and domain databases

Gene3Di1.20.120.310. 1 hit.
InterProiIPR017905. ERV/ALR_sulphydryl_oxidase.
[Graphical view]
PfamiPF04777. Evr1_Alr. 1 hit.
[Graphical view]
SUPFAMiSSF69000. SSF69000. 1 hit.
PROSITEiPS51324. ERV_ALR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiYR596_MIMIV
AccessioniPrimary (citable) accession number: Q5UP54
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: December 7, 2004
Last modified: November 2, 2016
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.