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Protein
Submitted name:

TRPA1

Gene

trpa1a

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • ligand-gated ion channel activity Source: ZFIN
  • mechanically-gated ion channel activity Source: ZFIN

GO - Biological processi

  • detection of chemical stimulus Source: ZFIN
  • detection of mechanical stimulus involved in sensory perception Source: ZFIN
  • ion transmembrane transport Source: ZFIN

Keywordsi

Molecular functionIon channelSAAS annotation
Biological processIon transport, Transport

Names & Taxonomyi

Protein namesi
Submitted name:
TRPA1Imported
Gene namesi
Name:trpa1aImported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

Organism-specific databases

ZFINiZDB-GENE-050105-6. trpa1a.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei717 – 736HelicalSequence analysisAdd BLAST20
Transmembranei801 – 819HelicalSequence analysisAdd BLAST19
Transmembranei825 – 845HelicalSequence analysisAdd BLAST21
Transmembranei865 – 887HelicalSequence analysisAdd BLAST23
Transmembranei933 – 956HelicalSequence analysisAdd BLAST24

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PaxDbiQ5UM15.

Interactioni

Protein-protein interaction databases

DIPiDIP-61525N.

Structurei

3D structure databases

ProteinModelPortaliQ5UM15.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini54 – 577ANK_REP_REGIONInterPro annotationAdd BLAST524
Repeati60 – 82ANKPROSITE-ProRule annotationAdd BLAST23
Repeati95 – 127ANKPROSITE-ProRule annotationAdd BLAST33
Repeati236 – 268ANKPROSITE-ProRule annotationAdd BLAST33
Repeati306 – 338ANKPROSITE-ProRule annotationAdd BLAST33
Repeati339 – 371ANKPROSITE-ProRule annotationAdd BLAST33
Repeati410 – 442ANKPROSITE-ProRule annotationAdd BLAST33
Repeati479 – 504ANKPROSITE-ProRule annotationAdd BLAST26
Repeati545 – 577ANKPROSITE-ProRule annotationAdd BLAST33

Sequence similaritiesi

Belongs to the transient receptor (TC 1.A.4) family. [View classification]SAAS annotation

Keywords - Domaini

ANK repeatPROSITE-ProRule annotationSAAS annotation, RepeatSAAS annotation, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG0510. Eukaryota.
COG0666. LUCA.
HOVERGENiHBG059027.

Family and domain databases

CDDicd00204. ANK. 4 hits.
Gene3Di1.25.40.20. 7 hits.
InterProiView protein in InterPro
IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR036770. Ankyrin_rpt-contain_sf.
IPR005821. Ion_trans_dom.
IPR030288. TRPA1/painless.
PANTHERiPTHR24190. PTHR24190. 1 hit.
PfamiView protein in Pfam
PF12796. Ank_2. 7 hits.
PF00520. Ion_trans. 1 hit.
PRINTSiPR01415. ANKYRIN.
SMARTiView protein in SMART
SM00248. ANK. 14 hits.
SUPFAMiSSF48403. SSF48403. 2 hits.
PROSITEiView protein in PROSITE
PS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 8 hits.

Sequencei

Sequence statusi: Complete.

Q5UM15-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKKMTHISK SEKSRQQSYD NVMDGDESNQ ISANVFEWTK QGNAAALEKN
60 70 80 90 100
SRYLDTRDNI GASPLHYASA NGHFRIIRHI VQIVGHQELN VRDEEGNTPL
110 120 130 140 150
HWAVQKDQPG SCSVLLSLGA DPNVLNNSHQ APIHMAVSLG KNFVLEQLVS
160 170 180 190 200
HKQTDVNLEG DLGNTPVILS AALDNHEALG ILYKHGAKFC RQNNLGHFPI
210 220 230 240 250
HAAAFSGAKK SMEVILLKGE EAGLSIDAHI NYVDKSCSSP LHLAVRGGNL
260 270 280 290 300
DIIKLCIGYG AKIDQQQCDK STALHFACSQ GATEVVKVML SSYPKVCDLI
310 320 330 340 350
NITDGANQTP LHKAVIFDHF ELSEYLMSQG ANIDFVDCKG HSPLLLATSC
360 370 380 390 400
GAWRTVNLLL SHGADLTKKD KSGCNFLHLA ILQPRGLKNL PTEVLQHESV
410 420 430 440 450
RELLNDEDIE GCTPLHYACR LGIPDSVKNM LGLEVSLDQK SKEKKSALHF
460 470 480 490 500
AAEFGRINTC HRLLEMVTDT RLLNEGDEKG LTPLHLASRE GHVKVVELLL
510 520 530 540 550
RKGALFHSDY RGWSGLHHAA SEGYTQTMDT LLTSNIKLLN KTDGDGNTAL
560 570 580 590 600
HLAARAGHVA AVRLLLYRGA KIILNKNDAS FLHEAVHNAR REVTNMVIES
610 620 630 640 650
DRCEEAMTTY KPNSTKRCIV MDMIEFLPES FKHLLDTCIR ESEEDVNCTN
660 670 680 690 700
YYIEYNFRWL QHPLQNLKKT GMEKDMAYKP LSALNAMVNF NRVNLLTHPV
710 720 730 740 750
CKKYLEMKWS AYGIKAHLLN MTVYALGVFP LTYLIVNLKP TLVTSRNVTS
760 770 780 790 800
VNMVCTSLYK QSYLTTSSML LVLAMNMYAV GKEILQMFQQ RLNYLRDLSN
810 820 830 840 850
YMDWAAAICA LLFVVPLLMN LKSSWHWQAG ALAALTSWLN LLLYLQRFER
860 870 880 890 900
IGIYVVMFRE ISRTLLSIIV LFFYLILGFA LSFYALMIEQ QHFGRMFLSL
910 920 930 940 950
LQTFVMMVGE MNYQDNFMKP YLQGDLPFPD LTLAIFVWFV LLVPILLMNL
960 970 980 990 1000
LIGLAVGDIA EVQTNACLKR IAMQIELHTN LEERLPYWFM KRVDQVTIRE
1010 1020 1030 1040 1050
YPNRCFSGKK RWFFGGNEVK SRTRLGPTFH QLTPLERELT KQKYRLKEIS
1060 1070 1080 1090 1100
ETMEKQHNLL KLIVQKMEIS SEADEHDGPP VFQELKEKLL TKSKWGPLLR
1110
AVTARKKGIC SFGKT
Length:1,115
Mass (Da):125,965
Last modified:December 7, 2004 - v1
Checksum:i6EAD8B69162FD993
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY677196 mRNA. Translation: AAV37177.1.
RefSeqiNP_001007066.1. NM_001007065.1.
UniGeneiDr.135281.

Genome annotation databases

GeneIDi474351.

Similar proteinsi

Entry informationi

Entry nameiQ5UM15_DANRE
AccessioniPrimary (citable) accession number: Q5UM15
Entry historyiIntegrated into UniProtKB/TrEMBL: December 7, 2004
Last sequence update: December 7, 2004
Last modified: November 22, 2017
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)