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Protein

Telomere-associated protein RIF1

Gene

RIF1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Required for checkpoint mediated arrest of cell cycle progression in response to DNA damage during S-phase (the intra-S-phase checkpoint). This checkpoint requires activation of at least 2 parallel pathways by the ATM kinase: one involves the MRN (MRE11A-RAD50-NBS1) complex, while the second requires CHEK2. RIF1 seems to act independently of both these pathways. Seems to play no role in either the G1/S or G2/M DNA damage checkpoints.1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle, DNA damage

Enzyme and pathway databases

ReactomeiR-HSA-5693571. Nonhomologous End-Joining (NHEJ).

Names & Taxonomyi

Protein namesi
Recommended name:
Telomere-associated protein RIF1
Alternative name(s):
Rap1-interacting factor 1 homolog
Gene namesi
Name:RIF1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:23207. RIF1.

Subcellular locationi

  • Nucleus
  • Chromosometelomere
  • Cytoplasmcytoskeletonspindle

  • Note: Exhibits ATM- and TP53BP1-dependent localization to uncapped or aberrant telomeres and to DNA double strand breaks (DSBs). Does not associate with normal telomere structures. Localizes to microtubules of the midzone of the mitotic spindle during anaphase, and to condensed chromosomes in telophase.

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Cytoplasm, Cytoskeleton, Nucleus, Telomere

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134933858.

Polymorphism and mutation databases

BioMutaiRIF1.
DMDMi68565701.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 24722472Telomere-associated protein RIF1PRO_0000097333Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei402 – 4021PhosphoserineCombined sources
Modified residuei409 – 4091PhosphothreonineCombined sources
Modified residuei782 – 7821PhosphoserineCombined sources
Modified residuei979 – 9791PhosphoserineCombined sources
Modified residuei1008 – 10081PhosphoserineCombined sources
Modified residuei1047 – 10471PhosphothreonineCombined sources
Modified residuei1162 – 11621PhosphoserineCombined sources
Modified residuei1220 – 12201PhosphothreonineCombined sources
Modified residuei1236 – 12361PhosphoserineCombined sources
Modified residuei1238 – 12381PhosphoserineCombined sources
Modified residuei1422 – 14221PhosphoserineCombined sources
Modified residuei1454 – 14541PhosphoserineCombined sources
Modified residuei1513 – 15131PhosphoserineCombined sources
Modified residuei1518 – 15181PhosphothreonineCombined sources
Modified residuei1542 – 15421PhosphoserineCombined sources
Modified residuei1552 – 15521PhosphoserineCombined sources
Modified residuei1554 – 15541PhosphoserineCombined sources
Modified residuei1556 – 15561PhosphoserineCombined sources
Modified residuei1564 – 15641PhosphoserineBy similarity
Modified residuei1576 – 15761PhosphoserineCombined sources
Modified residuei1579 – 15791PhosphoserineCombined sources
Modified residuei1613 – 16131PhosphoserineCombined sources
Modified residuei1616 – 16161PhosphoserineCombined sources
Modified residuei1688 – 16881PhosphoserineCombined sources
Modified residuei1693 – 16931PhosphoserineCombined sources
Modified residuei1706 – 17061PhosphoserineCombined sources
Modified residuei1709 – 17091PhosphoserineCombined sources
Modified residuei1806 – 18061PhosphothreonineCombined sources
Modified residuei1810 – 18101PhosphoserineCombined sources
Modified residuei1873 – 18731PhosphoserineCombined sources
Modified residuei1876 – 18761PhosphoserineCombined sources
Modified residuei1926 – 19261PhosphoserineCombined sources
Modified residuei1971 – 19711PhosphoserineCombined sources
Modified residuei2144 – 21441PhosphoserineCombined sources
Modified residuei2161 – 21611PhosphoserineCombined sources
Modified residuei2167 – 21671PhosphothreonineCombined sources
Modified residuei2172 – 21721PhosphoserineCombined sources
Modified residuei2176 – 21761PhosphoserineCombined sources
Modified residuei2195 – 21951PhosphoserineBy similarity
Modified residuei2196 – 21961PhosphoserineCombined sources
Modified residuei2205 – 22051PhosphoserineCombined sources
Modified residuei2260 – 22601PhosphoserineCombined sources
Modified residuei2339 – 23391PhosphoserineCombined sources
Modified residuei2391 – 23911PhosphoserineCombined sources
Modified residuei2393 – 23931PhosphoserineCombined sources
Modified residuei2465 – 24651PhosphoserineCombined sources
Modified residuei2471 – 24711PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ5UIP0.
MaxQBiQ5UIP0.
PaxDbiQ5UIP0.
PeptideAtlasiQ5UIP0.
PRIDEiQ5UIP0.

PTM databases

iPTMnetiQ5UIP0.
PhosphoSiteiQ5UIP0.

Expressioni

Tissue specificityi

Highly expressed in testis.1 Publication

Developmental stagei

Expression peaks in late G2/S phase of the cell cycle.1 Publication

Gene expression databases

BgeeiENSG00000080345.
CleanExiHS_RIF1.
ExpressionAtlasiQ5UIP0. baseline and differential.
GenevisibleiQ5UIP0. HS.

Organism-specific databases

HPAiHPA036887.
HPA036888.

Interactioni

Protein-protein interaction databases

BioGridi120482. 56 interactions.
IntActiQ5UIP0. 132 interactions.
MINTiMINT-3974483.
STRINGi9606.ENSP00000243326.

Structurei

3D structure databases

ProteinModelPortaliQ5UIP0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1924 – 2472549Interaction with condensed chromosomes in telophaseAdd
BLAST

Phylogenomic databases

eggNOGiENOG410IJ7R. Eukaryota.
ENOG410YNMC. LUCA.
GeneTreeiENSGT00390000012204.
HOVERGENiHBG080431.
InParanoidiQ5UIP0.
KOiK11138.
OMAiPTESVYP.
OrthoDBiEOG091G01D4.
PhylomeDBiQ5UIP0.
TreeFamiTF323789.

Family and domain databases

Gene3Di1.25.10.10. 3 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR028566. Rif1.
IPR022031. Rif1_N.
[Graphical view]
PANTHERiPTHR22928. PTHR22928. 3 hits.
PfamiPF12231. Rif1_N. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 4 hits.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5UIP0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTARGQSPLA PLLETLEDPS ASHGGQTDAY LTLTSRMTGE EGKEVITEIE
60 70 80 90 100
KKLPRLYKVL KTHISSQNSE LSSAALQALG FCLYNPKITS ELSEANALEL
110 120 130 140 150
LSKLNDTIKN SDKNVRTRAL WVISKQTFPS EVVGKMVSSI IDSLEILFNK
160 170 180 190 200
GETHSAVVDF EALNVIVRLI EQAPIQMGEE AVRWAKLVIP LVVHSAQKVH
210 220 230 240 250
LRGATALEMG MPLLLQKQQE IASITEQLMT TKLISELQKL FMSKNETYVL
260 270 280 290 300
KLWPLFVKLL GRTLHRSGSF INSLLQLEEL GFRSGAPMIK KIAFIAWKSL
310 320 330 340 350
IDNFALNPDI LCSAKRLKLL MQPLSSIHVR TETLALTKLE VWWYLLMRLG
360 370 380 390 400
PHLPANFEQV CVPLIQSTIS IDSNASPQGN SCHVATSPGL NPMTPVHKGA
410 420 430 440 450
SSPYGAPGTP RMNLSSNLGG MATIPSIQLL GLEMLLHFLL GPEALSFAKQ
460 470 480 490 500
NKLVLSLEPL EHPLISSPSF FSKHANTLIT AVHDSFVAVG KDAPDVVVSA
510 520 530 540 550
IWKELISLVK SVTESGNKKE KPGSEVLTLL LKSLESIVKS EVFPVSKTLV
560 570 580 590 600
LMEITIKGLP QKVLGSPAYQ VANMDILNGT PALFLIQLIF NNFLECGVSD
610 620 630 640 650
ERFFLSLESL VGCVLSGPTS PLAFSDSVLN VINQNAKQLE NKEHLWKMWS
660 670 680 690 700
VIVTPLTELI NQTNEVNQGD ALEHNFSAIY GALTLPVNHI FSEQRFPVAT
710 720 730 740 750
MKTLLRTWSE LYRAFARCAA LVATAEENLC CEELSSKIMS SLEDEGFSNL
760 770 780 790 800
LFVDRIIYII TVMVDCIDFS PYNIKYQPKV KSPQRPSDWS KKKNEPLGKL
810 820 830 840 850
TSLFKLIVKV IYSFHTLSFK EAHSDTLFTI GNSITGIISS VLGHISLPSM
860 870 880 890 900
IRKIFATLTR PLALFYENSK LDEVPKVYSC LNNKLEKLLG EIIACLQFSY
910 920 930 940 950
TGTYDSELLE QLSPLLCIIF LHKNKQIRKQ SAQFWNATFA KVMMLVYPEE
960 970 980 990 1000
LKPVLTQAKQ KFLLLLPGLE TVEMMEESSG PYSDGTENSQ LNVKISGMER
1010 1020 1030 1040 1050
KSNGKRDSFL AQTKNKKENM KPAAKLKLES SSLKVKGEIL LEEEKSTDFV
1060 1070 1080 1090 1100
FIPPEGKDAK ERILTDHQKE VLKTKRCDIP AMYNNLDVSQ DTLFTQYSQE
1110 1120 1130 1140 1150
EPMEIPTLTR KPKEDSKMMI TEEQMDSDIV IPQDVTEDCG MAEHLEKSSL
1160 1170 1180 1190 1200
SNNECGSLDK TSPEMSNSNN DERKKALISS RKTSTECASS TENSFVVSSS
1210 1220 1230 1240 1250
SVSNTTVAGT PPYPTSRRQT FITLEKFDGS ENRPFSPSPL NNISSTVTVK
1260 1270 1280 1290 1300
NNQETMIKTD FLPKAKQREG TFSKSDSEKI VNGTKRSSRR AGKAEQTGNK
1310 1320 1330 1340 1350
RSKPLMRSEP EKNTEESVEG IVVLENNPPG LLNQTECVSD NQVHLSESTM
1360 1370 1380 1390 1400
EHDNTKLKAA TVENAVLLET NTVEEKNVEI NLESKENTPP VVISADQMVN
1410 1420 1430 1440 1450
EDSQVQITPN QKTLRRSSRR RSEVVESTTE SQDKENSHQK KERRKEEEKP
1460 1470 1480 1490 1500
LQKSPLHIKD DVLPKQKLIA EQTLQENLIE KGSNLHEKTL GETSANAETE
1510 1520 1530 1540 1550
QNKKKADPEN IKSEGDGTQD IVDKSSEKLV RGRTRYQTRR ASQGLLSSIE
1560 1570 1580 1590 1600
NSESDSSEAK EEGSRKKRSG KWKNKSNESV DIQDQEEKVV KQECIKAENQ
1610 1620 1630 1640 1650
SHDYKATSEE DVSIKSPICE KQDESNTVIC QDSTVTSDLL QVPDDLPNVC
1660 1670 1680 1690 1700
EEKNETSKYA EYSFTSLPVP ESNLRTRNAI KRLHKRDSFD NCSLGESSKI
1710 1720 1730 1740 1750
GISDISSLSE KTFQTLECQH KRSRRVRRSK GCDCCGEKSQ PQEKSLIGLK
1760 1770 1780 1790 1800
NTENNDVEIS ETKKADVQAP VSPSETSQAN PYSEGQFLDE HHSVNFHLGL
1810 1820 1830 1840 1850
KEDNDTINDS LIVSETKSKE NTMQESLPSG IVNFREEICD MDSSEAMSLE
1860 1870 1880 1890 1900
SQESPNENFK TVGPCLGDSK NVSQESLETK EEKPEETPKM ELSLENVTVE
1910 1920 1930 1940 1950
GNACKVTESN LEKAKTMELN VGNEASFHGQ ERTKTGISEE AAIEENKRND
1960 1970 1980 1990 2000
DSEADTAKLN AKEVATEEFN SDISLSDNTT PVKLNAQTEI SEQTAAGELD
2010 2020 2030 2040 2050
GGNDVSDLHS SEETNTKMKN NEEMMIGEAM AETGHDGETE NEGITTKTSK
2060 2070 2080 2090 2100
PDEAETNMLT AEMDNFVCDT VEMSTEEGII DANKTETNTE YSKSEEKLDN
2110 2120 2130 2140 2150
NQMVMESDIL QEDHHTSQKV EEPSQCLASG TAISELIIED NNASPQKLRE
2160 2170 2180 2190 2200
LDPSLVSAND SPSGMQTRCV WSPLASPSTS ILKRGLKRSQ EDEISSPVNK
2210 2220 2230 2240 2250
VRRVSFADPI YQAGLADDID RRCSIVRSHS SNSSPIGKSV KTSPTTQSKH
2260 2270 2280 2290 2300
NTTSAKGFLS PGSRSPKFKS SKKCLISEMA KESIPCPTES VYPPLVNCVA
2310 2320 2330 2340 2350
PVDIILPQIT SNMWARGLGQ LIRAKNIKTI GDLSTLTASE IKTLPIRSPK
2360 2370 2380 2390 2400
VSNVKKALRI YHEQQVKTRG LEEIPVFDIS EKTVNGIENK SLSPDEERLV
2410 2420 2430 2440 2450
SDIIDPVALE IPLSKNLLAQ ISALALQLDS EDLHNYSGSQ LFEMHEKLSC
2460 2470
MANSVIKNLQ SRWRSPSHEN SI
Length:2,472
Mass (Da):274,466
Last modified:July 5, 2005 - v2
Checksum:iA45DCE3C5F9E052D
GO
Isoform 2 (identifier: Q5UIP0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     2250-2275: Missing.

Show »
Length:2,446
Mass (Da):271,689
Checksum:i44D755C85EF23042
GO

Sequence cautioni

The sequence BAA91705 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAB14313 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAB14792 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAB85058 differs from that shown. Reason: Erroneous initiation. Curated
The sequence CAI45961 differs from that shown. Reason: Frameshift at position 470. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti96 – 961N → D in AAT40745 (PubMed:15342490).Curated
Sequence conflicti699 – 6991A → P in BAA91705 (PubMed:14702039).Curated
Sequence conflicti1256 – 12561M → V in BAA91705 (PubMed:14702039).Curated
Sequence conflicti2316 – 23161R → G in BAB85058 (PubMed:14702039).Curated
Sequence conflicti2392 – 23921L → F in BAB85058 (PubMed:14702039).Curated
Sequence conflicti2445 – 24462HE → RV in BAB85058 (PubMed:14702039).Curated
Sequence conflicti2464 – 24641R → G in BAB85058 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti836 – 8361G → S.2 Publications
Corresponds to variant rs2444263 [ dbSNP | Ensembl ].
VAR_022788
Natural varianti1362 – 13621V → M.2 Publications
Corresponds to variant rs2123465 [ dbSNP | Ensembl ].
VAR_022789
Natural varianti1686 – 16861R → G.
Corresponds to variant rs3732305 [ dbSNP | Ensembl ].
VAR_022790
Natural varianti1784 – 17841E → K in a breast cancer sample; somatic mutation. 1 Publication
VAR_035983
Natural varianti1862 – 18621V → I.
Corresponds to variant rs2444258 [ dbSNP | Ensembl ].
VAR_022791
Natural varianti1955 – 19551D → H in a breast cancer sample; somatic mutation. 1 Publication
VAR_035984
Natural varianti2021 – 20211N → Y.3 Publications
Corresponds to variant rs2444257 [ dbSNP | Ensembl ].
VAR_022792
Natural varianti2165 – 21651M → R.
Corresponds to variant rs16830057 [ dbSNP | Ensembl ].
VAR_022793
Natural varianti2418 – 24181L → V.5 Publications
Corresponds to variant rs1065177 [ dbSNP | Ensembl ].
VAR_022794

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei2250 – 227526Missing in isoform 2. 2 PublicationsVSP_014431Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY585745 mRNA. Translation: AAT40745.1.
AY727910 mRNA. Translation: AAV51401.1.
AY727911 mRNA. Translation: AAV51402.1.
AY727912 mRNA. Translation: AAV51403.1.
AY727913 mRNA. Translation: AAV51404.1.
AY584066 mRNA. Translation: AAS94233.1.
AC009311 Genomic DNA. No translation available.
AC009497 Genomic DNA. No translation available.
AL080129 mRNA. Translation: CAB45727.1.
CR933663 mRNA. Translation: CAI45961.1. Sequence problems.
AK001461 mRNA. Translation: BAA91705.1. Different initiation.
AK022932 mRNA. Translation: BAB14313.1. Different initiation.
AK024033 mRNA. Translation: BAB14792.1. Different initiation.
AK074349 mRNA. Translation: BAB85058.1. Different initiation.
U79263 mRNA. Translation: AAB50209.1.
CCDSiCCDS2194.1. [Q5UIP0-1]
CCDS54406.1. [Q5UIP0-2]
PIRiT12518.
RefSeqiNP_001171134.1. NM_001177663.1. [Q5UIP0-2]
NP_001171135.1. NM_001177664.1. [Q5UIP0-2]
NP_001171136.1. NM_001177665.1. [Q5UIP0-2]
NP_060621.3. NM_018151.4. [Q5UIP0-1]
XP_005246722.1. XM_005246665.3. [Q5UIP0-1]
UniGeneiHs.655671.
Hs.735592.

Genome annotation databases

EnsembliENST00000243326; ENSP00000243326; ENSG00000080345. [Q5UIP0-1]
ENST00000428287; ENSP00000415691; ENSG00000080345. [Q5UIP0-2]
ENST00000430328; ENSP00000416123; ENSG00000080345. [Q5UIP0-2]
ENST00000444746; ENSP00000390181; ENSG00000080345. [Q5UIP0-1]
ENST00000453091; ENSP00000414615; ENSG00000080345. [Q5UIP0-2]
GeneIDi55183.
KEGGihsa:55183.
UCSCiuc002txl.4. human. [Q5UIP0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY585745 mRNA. Translation: AAT40745.1.
AY727910 mRNA. Translation: AAV51401.1.
AY727911 mRNA. Translation: AAV51402.1.
AY727912 mRNA. Translation: AAV51403.1.
AY727913 mRNA. Translation: AAV51404.1.
AY584066 mRNA. Translation: AAS94233.1.
AC009311 Genomic DNA. No translation available.
AC009497 Genomic DNA. No translation available.
AL080129 mRNA. Translation: CAB45727.1.
CR933663 mRNA. Translation: CAI45961.1. Sequence problems.
AK001461 mRNA. Translation: BAA91705.1. Different initiation.
AK022932 mRNA. Translation: BAB14313.1. Different initiation.
AK024033 mRNA. Translation: BAB14792.1. Different initiation.
AK074349 mRNA. Translation: BAB85058.1. Different initiation.
U79263 mRNA. Translation: AAB50209.1.
CCDSiCCDS2194.1. [Q5UIP0-1]
CCDS54406.1. [Q5UIP0-2]
PIRiT12518.
RefSeqiNP_001171134.1. NM_001177663.1. [Q5UIP0-2]
NP_001171135.1. NM_001177664.1. [Q5UIP0-2]
NP_001171136.1. NM_001177665.1. [Q5UIP0-2]
NP_060621.3. NM_018151.4. [Q5UIP0-1]
XP_005246722.1. XM_005246665.3. [Q5UIP0-1]
UniGeneiHs.655671.
Hs.735592.

3D structure databases

ProteinModelPortaliQ5UIP0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120482. 56 interactions.
IntActiQ5UIP0. 132 interactions.
MINTiMINT-3974483.
STRINGi9606.ENSP00000243326.

PTM databases

iPTMnetiQ5UIP0.
PhosphoSiteiQ5UIP0.

Polymorphism and mutation databases

BioMutaiRIF1.
DMDMi68565701.

Proteomic databases

EPDiQ5UIP0.
MaxQBiQ5UIP0.
PaxDbiQ5UIP0.
PeptideAtlasiQ5UIP0.
PRIDEiQ5UIP0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000243326; ENSP00000243326; ENSG00000080345. [Q5UIP0-1]
ENST00000428287; ENSP00000415691; ENSG00000080345. [Q5UIP0-2]
ENST00000430328; ENSP00000416123; ENSG00000080345. [Q5UIP0-2]
ENST00000444746; ENSP00000390181; ENSG00000080345. [Q5UIP0-1]
ENST00000453091; ENSP00000414615; ENSG00000080345. [Q5UIP0-2]
GeneIDi55183.
KEGGihsa:55183.
UCSCiuc002txl.4. human. [Q5UIP0-1]

Organism-specific databases

CTDi55183.
GeneCardsiRIF1.
HGNCiHGNC:23207. RIF1.
HPAiHPA036887.
HPA036888.
MIMi608952. gene.
neXtProtiNX_Q5UIP0.
PharmGKBiPA134933858.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJ7R. Eukaryota.
ENOG410YNMC. LUCA.
GeneTreeiENSGT00390000012204.
HOVERGENiHBG080431.
InParanoidiQ5UIP0.
KOiK11138.
OMAiPTESVYP.
OrthoDBiEOG091G01D4.
PhylomeDBiQ5UIP0.
TreeFamiTF323789.

Enzyme and pathway databases

ReactomeiR-HSA-5693571. Nonhomologous End-Joining (NHEJ).

Miscellaneous databases

ChiTaRSiRIF1. human.
GeneWikiiRIF1.
GenomeRNAii55183.
PROiQ5UIP0.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000080345.
CleanExiHS_RIF1.
ExpressionAtlasiQ5UIP0. baseline and differential.
GenevisibleiQ5UIP0. HS.

Family and domain databases

Gene3Di1.25.10.10. 3 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR028566. Rif1.
IPR022031. Rif1_N.
[Graphical view]
PANTHERiPTHR22928. PTHR22928. 3 hits.
PfamiPF12231. Rif1_N. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 4 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiRIF1_HUMAN
AccessioniPrimary (citable) accession number: Q5UIP0
Secondary accession number(s): A6NC27
, C9JBR1, Q5H9R3, Q5UIP2, Q66YK6, Q6PRU2, Q8TE94, Q99772, Q9H830, Q9H9B9, Q9NVP5, Q9Y4R4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: July 5, 2005
Last modified: September 7, 2016
This is version 121 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.