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Q5UIP0

- RIF1_HUMAN

UniProt

Q5UIP0 - RIF1_HUMAN

Protein

Telomere-associated protein RIF1

Gene

RIF1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 2 (05 Jul 2005)
      Previous versions | rss
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    Functioni

    Required for checkpoint mediated arrest of cell cycle progression in response to DNA damage during S-phase (the intra-S-phase checkpoint). This checkpoint requires activation of at least 2 parallel pathways by the ATM kinase: one involves the MRN (MRE11A-RAD50-NBS1) complex, while the second requires CHEK2. RIF1 seems to act independently of both these pathways. Seems to play no role in either the G1/S or G2/M DNA damage checkpoints.1 Publication

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. cellular response to DNA damage stimulus Source: UniProtKB-KW
    3. stem cell maintenance Source: Ensembl

    Keywords - Biological processi

    Cell cycle, DNA damage

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Telomere-associated protein RIF1
    Alternative name(s):
    Rap1-interacting factor 1 homolog
    Gene namesi
    Name:RIF1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:23207. RIF1.

    Subcellular locationi

    Nucleus. Chromosometelomere. Cytoplasmcytoskeletonspindle
    Note: Exhibits ATM- and TP53BP1-dependent localization to uncapped or aberrant telomeres and to DNA double strand breaks (DSBs). Does not associate with normal telomere structures. Localizes to microtubules of the midzone of the mitotic spindle during anaphase, and to condensed chromosomes in telophase.

    GO - Cellular componenti

    1. chromosome, telomeric region Source: UniProtKB-SubCell
    2. cytoplasm Source: UniProtKB-KW
    3. female pronucleus Source: Ensembl
    4. male pronucleus Source: Ensembl
    5. nucleolus Source: HPA
    6. nucleus Source: HPA
    7. plasma membrane Source: HPA
    8. spindle Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Chromosome, Cytoplasm, Cytoskeleton, Nucleus, Telomere

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134933858.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 24722472Telomere-associated protein RIF1PRO_0000097333Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei402 – 4021Phosphoserine1 Publication
    Modified residuei409 – 4091Phosphothreonine2 Publications
    Modified residuei782 – 7821Phosphoserine1 Publication
    Modified residuei979 – 9791Phosphoserine1 Publication
    Modified residuei1047 – 10471Phosphothreonine1 Publication
    Modified residuei1162 – 11621Phosphoserine1 Publication
    Modified residuei1236 – 12361Phosphoserine1 Publication
    Modified residuei1238 – 12381Phosphoserine2 Publications
    Modified residuei1422 – 14221Phosphoserine2 Publications
    Modified residuei1454 – 14541Phosphoserine3 Publications
    Modified residuei1513 – 15131Phosphoserine1 Publication
    Modified residuei1518 – 15181Phosphothreonine1 Publication
    Modified residuei1542 – 15421Phosphoserine2 Publications
    Modified residuei1552 – 15521Phosphoserine1 Publication
    Modified residuei1554 – 15541Phosphoserine3 Publications
    Modified residuei1576 – 15761Phosphoserine1 Publication
    Modified residuei1579 – 15791Phosphoserine4 Publications
    Modified residuei1616 – 16161Phosphoserine1 Publication
    Modified residuei1688 – 16881Phosphoserine5 Publications
    Modified residuei1693 – 16931Phosphoserine1 Publication
    Modified residuei1806 – 18061Phosphothreonine1 Publication
    Modified residuei1810 – 18101Phosphoserine2 Publications
    Modified residuei1873 – 18731Phosphoserine2 Publications
    Modified residuei1876 – 18761Phosphoserine1 Publication
    Modified residuei1971 – 19711Phosphoserine1 Publication
    Modified residuei2144 – 21441Phosphoserine2 Publications
    Modified residuei2161 – 21611Phosphoserine2 Publications
    Modified residuei2167 – 21671Phosphothreonine1 Publication
    Modified residuei2172 – 21721Phosphoserine2 Publications
    Modified residuei2176 – 21761Phosphoserine1 Publication
    Modified residuei2196 – 21961Phosphoserine3 Publications
    Modified residuei2205 – 22051Phosphoserine2 Publications
    Modified residuei2260 – 22601Phosphoserine1 Publication
    Modified residuei2339 – 23391Phosphoserine1 Publication
    Modified residuei2391 – 23911Phosphoserine1 Publication
    Modified residuei2393 – 23931Phosphoserine3 Publications
    Modified residuei2465 – 24651Phosphoserine1 Publication
    Modified residuei2471 – 24711Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ5UIP0.
    PaxDbiQ5UIP0.
    PRIDEiQ5UIP0.

    PTM databases

    PhosphoSiteiQ5UIP0.

    Expressioni

    Tissue specificityi

    Highly expressed in testis.1 Publication

    Developmental stagei

    Expression peaks in late G2/S phase of the cell cycle.1 Publication

    Gene expression databases

    ArrayExpressiQ5UIP0.
    BgeeiQ5UIP0.
    CleanExiHS_RIF1.
    GenevestigatoriQ5UIP0.

    Organism-specific databases

    HPAiHPA036887.
    HPA036888.

    Interactioni

    Protein-protein interaction databases

    BioGridi120482. 25 interactions.
    IntActiQ5UIP0. 118 interactions.
    MINTiMINT-3974483.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5UIP0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1924 – 2472549Interaction with condensed chromosomes in telophaseAdd
    BLAST

    Phylogenomic databases

    eggNOGiNOG87885.
    HOVERGENiHBG080431.
    InParanoidiQ5UIP0.
    KOiK11138.
    OMAiPTESVYP.
    OrthoDBiEOG70GMDW.
    PhylomeDBiQ5UIP0.
    TreeFamiTF323789.

    Family and domain databases

    Gene3Di1.25.10.10. 3 hits.
    InterProiIPR011989. ARM-like.
    IPR016024. ARM-type_fold.
    IPR028566. Rif1.
    IPR022031. Rif1_N.
    [Graphical view]
    PANTHERiPTHR22928. PTHR22928. 1 hit.
    PfamiPF12231. Rif1_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF48371. SSF48371. 4 hits.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q5UIP0-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MTARGQSPLA PLLETLEDPS ASHGGQTDAY LTLTSRMTGE EGKEVITEIE     50
    KKLPRLYKVL KTHISSQNSE LSSAALQALG FCLYNPKITS ELSEANALEL 100
    LSKLNDTIKN SDKNVRTRAL WVISKQTFPS EVVGKMVSSI IDSLEILFNK 150
    GETHSAVVDF EALNVIVRLI EQAPIQMGEE AVRWAKLVIP LVVHSAQKVH 200
    LRGATALEMG MPLLLQKQQE IASITEQLMT TKLISELQKL FMSKNETYVL 250
    KLWPLFVKLL GRTLHRSGSF INSLLQLEEL GFRSGAPMIK KIAFIAWKSL 300
    IDNFALNPDI LCSAKRLKLL MQPLSSIHVR TETLALTKLE VWWYLLMRLG 350
    PHLPANFEQV CVPLIQSTIS IDSNASPQGN SCHVATSPGL NPMTPVHKGA 400
    SSPYGAPGTP RMNLSSNLGG MATIPSIQLL GLEMLLHFLL GPEALSFAKQ 450
    NKLVLSLEPL EHPLISSPSF FSKHANTLIT AVHDSFVAVG KDAPDVVVSA 500
    IWKELISLVK SVTESGNKKE KPGSEVLTLL LKSLESIVKS EVFPVSKTLV 550
    LMEITIKGLP QKVLGSPAYQ VANMDILNGT PALFLIQLIF NNFLECGVSD 600
    ERFFLSLESL VGCVLSGPTS PLAFSDSVLN VINQNAKQLE NKEHLWKMWS 650
    VIVTPLTELI NQTNEVNQGD ALEHNFSAIY GALTLPVNHI FSEQRFPVAT 700
    MKTLLRTWSE LYRAFARCAA LVATAEENLC CEELSSKIMS SLEDEGFSNL 750
    LFVDRIIYII TVMVDCIDFS PYNIKYQPKV KSPQRPSDWS KKKNEPLGKL 800
    TSLFKLIVKV IYSFHTLSFK EAHSDTLFTI GNSITGIISS VLGHISLPSM 850
    IRKIFATLTR PLALFYENSK LDEVPKVYSC LNNKLEKLLG EIIACLQFSY 900
    TGTYDSELLE QLSPLLCIIF LHKNKQIRKQ SAQFWNATFA KVMMLVYPEE 950
    LKPVLTQAKQ KFLLLLPGLE TVEMMEESSG PYSDGTENSQ LNVKISGMER 1000
    KSNGKRDSFL AQTKNKKENM KPAAKLKLES SSLKVKGEIL LEEEKSTDFV 1050
    FIPPEGKDAK ERILTDHQKE VLKTKRCDIP AMYNNLDVSQ DTLFTQYSQE 1100
    EPMEIPTLTR KPKEDSKMMI TEEQMDSDIV IPQDVTEDCG MAEHLEKSSL 1150
    SNNECGSLDK TSPEMSNSNN DERKKALISS RKTSTECASS TENSFVVSSS 1200
    SVSNTTVAGT PPYPTSRRQT FITLEKFDGS ENRPFSPSPL NNISSTVTVK 1250
    NNQETMIKTD FLPKAKQREG TFSKSDSEKI VNGTKRSSRR AGKAEQTGNK 1300
    RSKPLMRSEP EKNTEESVEG IVVLENNPPG LLNQTECVSD NQVHLSESTM 1350
    EHDNTKLKAA TVENAVLLET NTVEEKNVEI NLESKENTPP VVISADQMVN 1400
    EDSQVQITPN QKTLRRSSRR RSEVVESTTE SQDKENSHQK KERRKEEEKP 1450
    LQKSPLHIKD DVLPKQKLIA EQTLQENLIE KGSNLHEKTL GETSANAETE 1500
    QNKKKADPEN IKSEGDGTQD IVDKSSEKLV RGRTRYQTRR ASQGLLSSIE 1550
    NSESDSSEAK EEGSRKKRSG KWKNKSNESV DIQDQEEKVV KQECIKAENQ 1600
    SHDYKATSEE DVSIKSPICE KQDESNTVIC QDSTVTSDLL QVPDDLPNVC 1650
    EEKNETSKYA EYSFTSLPVP ESNLRTRNAI KRLHKRDSFD NCSLGESSKI 1700
    GISDISSLSE KTFQTLECQH KRSRRVRRSK GCDCCGEKSQ PQEKSLIGLK 1750
    NTENNDVEIS ETKKADVQAP VSPSETSQAN PYSEGQFLDE HHSVNFHLGL 1800
    KEDNDTINDS LIVSETKSKE NTMQESLPSG IVNFREEICD MDSSEAMSLE 1850
    SQESPNENFK TVGPCLGDSK NVSQESLETK EEKPEETPKM ELSLENVTVE 1900
    GNACKVTESN LEKAKTMELN VGNEASFHGQ ERTKTGISEE AAIEENKRND 1950
    DSEADTAKLN AKEVATEEFN SDISLSDNTT PVKLNAQTEI SEQTAAGELD 2000
    GGNDVSDLHS SEETNTKMKN NEEMMIGEAM AETGHDGETE NEGITTKTSK 2050
    PDEAETNMLT AEMDNFVCDT VEMSTEEGII DANKTETNTE YSKSEEKLDN 2100
    NQMVMESDIL QEDHHTSQKV EEPSQCLASG TAISELIIED NNASPQKLRE 2150
    LDPSLVSAND SPSGMQTRCV WSPLASPSTS ILKRGLKRSQ EDEISSPVNK 2200
    VRRVSFADPI YQAGLADDID RRCSIVRSHS SNSSPIGKSV KTSPTTQSKH 2250
    NTTSAKGFLS PGSRSPKFKS SKKCLISEMA KESIPCPTES VYPPLVNCVA 2300
    PVDIILPQIT SNMWARGLGQ LIRAKNIKTI GDLSTLTASE IKTLPIRSPK 2350
    VSNVKKALRI YHEQQVKTRG LEEIPVFDIS EKTVNGIENK SLSPDEERLV 2400
    SDIIDPVALE IPLSKNLLAQ ISALALQLDS EDLHNYSGSQ LFEMHEKLSC 2450
    MANSVIKNLQ SRWRSPSHEN SI 2472
    Length:2,472
    Mass (Da):274,466
    Last modified:July 5, 2005 - v2
    Checksum:iA45DCE3C5F9E052D
    GO
    Isoform 2 (identifier: Q5UIP0-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         2250-2275: Missing.

    Show »
    Length:2,446
    Mass (Da):271,689
    Checksum:i44D755C85EF23042
    GO

    Sequence cautioni

    The sequence CAI45961.1 differs from that shown. Reason: Frameshift at position 470.
    The sequence BAA91705.1 differs from that shown. Reason: Erroneous initiation.
    The sequence BAB14313.1 differs from that shown. Reason: Erroneous initiation.
    The sequence BAB14792.1 differs from that shown. Reason: Erroneous initiation.
    The sequence BAB85058.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti96 – 961N → D in AAT40745. (PubMed:15342490)Curated
    Sequence conflicti699 – 6991A → P in BAA91705. (PubMed:14702039)Curated
    Sequence conflicti1256 – 12561M → V in BAA91705. (PubMed:14702039)Curated
    Sequence conflicti2316 – 23161R → G in BAB85058. (PubMed:14702039)Curated
    Sequence conflicti2392 – 23921L → F in BAB85058. (PubMed:14702039)Curated
    Sequence conflicti2445 – 24462HE → RV in BAB85058. (PubMed:14702039)Curated
    Sequence conflicti2464 – 24641R → G in BAB85058. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti836 – 8361G → S.2 Publications
    Corresponds to variant rs2444263 [ dbSNP | Ensembl ].
    VAR_022788
    Natural varianti1362 – 13621V → M.2 Publications
    Corresponds to variant rs2123465 [ dbSNP | Ensembl ].
    VAR_022789
    Natural varianti1686 – 16861R → G.
    Corresponds to variant rs3732305 [ dbSNP | Ensembl ].
    VAR_022790
    Natural varianti1784 – 17841E → K in a breast cancer sample; somatic mutation. 1 Publication
    VAR_035983
    Natural varianti1862 – 18621V → I.
    Corresponds to variant rs2444258 [ dbSNP | Ensembl ].
    VAR_022791
    Natural varianti1955 – 19551D → H in a breast cancer sample; somatic mutation. 1 Publication
    VAR_035984
    Natural varianti2021 – 20211N → Y.3 Publications
    Corresponds to variant rs2444257 [ dbSNP | Ensembl ].
    VAR_022792
    Natural varianti2165 – 21651M → R.
    Corresponds to variant rs16830057 [ dbSNP | Ensembl ].
    VAR_022793
    Natural varianti2418 – 24181L → V.5 Publications
    Corresponds to variant rs1065177 [ dbSNP | Ensembl ].
    VAR_022794

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei2250 – 227526Missing in isoform 2. 2 PublicationsVSP_014431Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY585745 mRNA. Translation: AAT40745.1.
    AY727910 mRNA. Translation: AAV51401.1.
    AY727911 mRNA. Translation: AAV51402.1.
    AY727912 mRNA. Translation: AAV51403.1.
    AY727913 mRNA. Translation: AAV51404.1.
    AY584066 mRNA. Translation: AAS94233.1.
    AC009311 Genomic DNA. No translation available.
    AC009497 Genomic DNA. No translation available.
    AL080129 mRNA. Translation: CAB45727.1.
    CR933663 mRNA. Translation: CAI45961.1. Sequence problems.
    AK001461 mRNA. Translation: BAA91705.1. Different initiation.
    AK022932 mRNA. Translation: BAB14313.1. Different initiation.
    AK024033 mRNA. Translation: BAB14792.1. Different initiation.
    AK074349 mRNA. Translation: BAB85058.1. Different initiation.
    U79263 mRNA. Translation: AAB50209.1.
    CCDSiCCDS2194.1. [Q5UIP0-1]
    CCDS54406.1. [Q5UIP0-2]
    PIRiT12518.
    RefSeqiNP_001171134.1. NM_001177663.1. [Q5UIP0-2]
    NP_001171135.1. NM_001177664.1. [Q5UIP0-2]
    NP_001171136.1. NM_001177665.1. [Q5UIP0-2]
    NP_060621.3. NM_018151.4. [Q5UIP0-1]
    XP_005246722.1. XM_005246665.1. [Q5UIP0-1]
    UniGeneiHs.655671.
    Hs.735592.

    Genome annotation databases

    EnsembliENST00000243326; ENSP00000243326; ENSG00000080345. [Q5UIP0-1]
    ENST00000428287; ENSP00000415691; ENSG00000080345. [Q5UIP0-2]
    ENST00000430328; ENSP00000416123; ENSG00000080345. [Q5UIP0-2]
    ENST00000444746; ENSP00000390181; ENSG00000080345. [Q5UIP0-1]
    ENST00000453091; ENSP00000414615; ENSG00000080345. [Q5UIP0-2]
    GeneIDi55183.
    KEGGihsa:55183.
    UCSCiuc002txl.3. human. [Q5UIP0-2]
    uc002txm.3. human. [Q5UIP0-1]

    Polymorphism databases

    DMDMi68565701.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY585745 mRNA. Translation: AAT40745.1 .
    AY727910 mRNA. Translation: AAV51401.1 .
    AY727911 mRNA. Translation: AAV51402.1 .
    AY727912 mRNA. Translation: AAV51403.1 .
    AY727913 mRNA. Translation: AAV51404.1 .
    AY584066 mRNA. Translation: AAS94233.1 .
    AC009311 Genomic DNA. No translation available.
    AC009497 Genomic DNA. No translation available.
    AL080129 mRNA. Translation: CAB45727.1 .
    CR933663 mRNA. Translation: CAI45961.1 . Sequence problems.
    AK001461 mRNA. Translation: BAA91705.1 . Different initiation.
    AK022932 mRNA. Translation: BAB14313.1 . Different initiation.
    AK024033 mRNA. Translation: BAB14792.1 . Different initiation.
    AK074349 mRNA. Translation: BAB85058.1 . Different initiation.
    U79263 mRNA. Translation: AAB50209.1 .
    CCDSi CCDS2194.1. [Q5UIP0-1 ]
    CCDS54406.1. [Q5UIP0-2 ]
    PIRi T12518.
    RefSeqi NP_001171134.1. NM_001177663.1. [Q5UIP0-2 ]
    NP_001171135.1. NM_001177664.1. [Q5UIP0-2 ]
    NP_001171136.1. NM_001177665.1. [Q5UIP0-2 ]
    NP_060621.3. NM_018151.4. [Q5UIP0-1 ]
    XP_005246722.1. XM_005246665.1. [Q5UIP0-1 ]
    UniGenei Hs.655671.
    Hs.735592.

    3D structure databases

    ProteinModelPortali Q5UIP0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 120482. 25 interactions.
    IntActi Q5UIP0. 118 interactions.
    MINTi MINT-3974483.

    PTM databases

    PhosphoSitei Q5UIP0.

    Polymorphism databases

    DMDMi 68565701.

    Proteomic databases

    MaxQBi Q5UIP0.
    PaxDbi Q5UIP0.
    PRIDEi Q5UIP0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000243326 ; ENSP00000243326 ; ENSG00000080345 . [Q5UIP0-1 ]
    ENST00000428287 ; ENSP00000415691 ; ENSG00000080345 . [Q5UIP0-2 ]
    ENST00000430328 ; ENSP00000416123 ; ENSG00000080345 . [Q5UIP0-2 ]
    ENST00000444746 ; ENSP00000390181 ; ENSG00000080345 . [Q5UIP0-1 ]
    ENST00000453091 ; ENSP00000414615 ; ENSG00000080345 . [Q5UIP0-2 ]
    GeneIDi 55183.
    KEGGi hsa:55183.
    UCSCi uc002txl.3. human. [Q5UIP0-2 ]
    uc002txm.3. human. [Q5UIP0-1 ]

    Organism-specific databases

    CTDi 55183.
    GeneCardsi GC02P152266.
    HGNCi HGNC:23207. RIF1.
    HPAi HPA036887.
    HPA036888.
    MIMi 608952. gene.
    neXtProti NX_Q5UIP0.
    PharmGKBi PA134933858.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG87885.
    HOVERGENi HBG080431.
    InParanoidi Q5UIP0.
    KOi K11138.
    OMAi PTESVYP.
    OrthoDBi EOG70GMDW.
    PhylomeDBi Q5UIP0.
    TreeFami TF323789.

    Miscellaneous databases

    ChiTaRSi RIF1. human.
    GeneWikii RIF1.
    GenomeRNAii 55183.
    NextBioi 59015.
    PROi Q5UIP0.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q5UIP0.
    Bgeei Q5UIP0.
    CleanExi HS_RIF1.
    Genevestigatori Q5UIP0.

    Family and domain databases

    Gene3Di 1.25.10.10. 3 hits.
    InterProi IPR011989. ARM-like.
    IPR016024. ARM-type_fold.
    IPR028566. Rif1.
    IPR022031. Rif1_N.
    [Graphical view ]
    PANTHERi PTHR22928. PTHR22928. 1 hit.
    Pfami PF12231. Rif1_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48371. SSF48371. 4 hits.
    ProtoNeti Search...

    Publicationsi

    1. "Human Rif1, ortholog of a yeast telomeric protein, is regulated by ATM and 53BP1 and functions in the S-phase checkpoint."
      Silverman J., Takai H., Buonomo S.B.C., Eisenhaber F., De Lange T.
      Genes Dev. 18:2108-2119(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, SUBCELLULAR LOCATION, VARIANTS TYR-2021 AND VAL-2418.
    2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "Human Rif1 protein binds aberrant telomeres and aligns along anaphase midzone microtubules."
      Xu L., Blackburn E.H.
      J. Cell Biol. 167:819-830(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, VARIANTS SER-836; MET-1362; TYR-2021 AND VAL-2418.
    4. "Identification and characterization of human Rif1."
      Simonsson T.
      Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 35-853 AND 1728-2472 (ISOFORM 1), VARIANTS TYR-2021 AND VAL-2418.
      Tissue: Testis and Testis carcinoma.
    6. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 161-1499 AND 2217-2472 (ISOFORM 1), VARIANTS SER-836; MET-1362 AND VAL-2418.
    7. "Large-scale concatenation cDNA sequencing."
      Yu W., Andersson B., Worley K.C., Muzny D.M., Ding Y., Liu W., Ricafrente J.Y., Wentland M.A., Lennon G., Gibbs R.A.
      Genome Res. 7:353-358(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2108-2472 (ISOFORM 2), VARIANT VAL-2418.
      Tissue: Brain.
    8. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
      Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1454 AND SER-1688, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    9. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
      Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.
      Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-409 AND SER-1579, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    10. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1513; THR-1518 AND SER-1542, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic kidney.
    11. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-402; THR-409; SER-1162; SER-1236; SER-1238; SER-1422; SER-1554; SER-1616; SER-1688; SER-1693; SER-1810; SER-2144; SER-2172; SER-2196; SER-2205; SER-2260; SER-2339; SER-2391; SER-2393; SER-2465 AND SER-2471, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    12. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    13. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-979; THR-1047; SER-1552; SER-1554; SER-1579; SER-1688; THR-1806; SER-1971 AND SER-2196, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    14. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1238; SER-1454; SER-1579; SER-1688; SER-1810; SER-1873; SER-1876; SER-2161; SER-2172; SER-2176; SER-2196; SER-2205 AND SER-2393, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    15. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    16. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-782; SER-1422; SER-1454; SER-1542; SER-1554; SER-1576; SER-1579; SER-1688; SER-1873; SER-2144; SER-2161; THR-2167 AND SER-2393, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    17. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    18. Cited for: VARIANTS [LARGE SCALE ANALYSIS] LYS-1784 AND HIS-1955.

    Entry informationi

    Entry nameiRIF1_HUMAN
    AccessioniPrimary (citable) accession number: Q5UIP0
    Secondary accession number(s): A6NC27
    , C9JBR1, Q5H9R3, Q5UIP2, Q66YK6, Q6PRU2, Q8TE94, Q99772, Q9H830, Q9H9B9, Q9NVP5, Q9Y4R4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 5, 2005
    Last sequence update: July 5, 2005
    Last modified: October 1, 2014
    This is version 102 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

    External Data

    Dasty 3