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Q5UIP0 (RIF1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 97. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Telomere-associated protein RIF1
Alternative name(s):
Rap1-interacting factor 1 homolog
Gene names
Name:RIF1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length2472 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Required for checkpoint mediated arrest of cell cycle progression in response to DNA damage during S-phase (the intra-S-phase checkpoint). This checkpoint requires activation of at least 2 parallel pathways by the ATM kinase: one involves the MRN (MRE11A-RAD50-NBS1) complex, while the second requires CHEK2. RIF1 seems to act independently of both these pathways. Seems to play no role in either the G1/S or G2/M DNA damage checkpoints. Ref.1

Subcellular location

Nucleus. Chromosometelomere. Cytoplasmcytoskeletonspindle. Note: Exhibits ATM- and TP53BP1-dependent localization to uncapped or aberrant telomeres and to DNA double strand breaks (DSBs). Does not associate with normal telomere structures. Localizes to microtubules of the midzone of the mitotic spindle during anaphase, and to condensed chromosomes in telophase. Ref.1 Ref.3

Tissue specificity

Highly expressed in testis. Ref.3

Developmental stage

Expression peaks in late G2/S phase of the cell cycle. Ref.3

Sequence caution

The sequence BAA91705.1 differs from that shown. Reason: Erroneous initiation.

The sequence BAB14313.1 differs from that shown. Reason: Erroneous initiation.

The sequence BAB14792.1 differs from that shown. Reason: Erroneous initiation.

The sequence BAB85058.1 differs from that shown. Reason: Erroneous initiation.

The sequence CAI45961.1 differs from that shown. Reason: Frameshift at position 470.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q5UIP0-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q5UIP0-2)

The sequence of this isoform differs from the canonical sequence as follows:
     2250-2275: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 24722472Telomere-associated protein RIF1
PRO_0000097333

Regions

Region1924 – 2472549Interaction with condensed chromosomes in telophase

Amino acid modifications

Modified residue4021Phosphoserine Ref.11
Modified residue4091Phosphothreonine Ref.9 Ref.11
Modified residue7821Phosphoserine Ref.16
Modified residue9791Phosphoserine Ref.13
Modified residue10471Phosphothreonine Ref.13
Modified residue11621Phosphoserine Ref.11
Modified residue12361Phosphoserine Ref.11
Modified residue12381Phosphoserine Ref.11 Ref.14
Modified residue14221Phosphoserine Ref.11 Ref.16
Modified residue14541Phosphoserine Ref.8 Ref.14 Ref.16
Modified residue15131Phosphoserine Ref.10
Modified residue15181Phosphothreonine Ref.10
Modified residue15421Phosphoserine Ref.10 Ref.16
Modified residue15521Phosphoserine Ref.13
Modified residue15541Phosphoserine Ref.11 Ref.13 Ref.16
Modified residue15761Phosphoserine Ref.16
Modified residue15791Phosphoserine Ref.9 Ref.13 Ref.14 Ref.16
Modified residue16161Phosphoserine Ref.11
Modified residue16881Phosphoserine Ref.8 Ref.11 Ref.13 Ref.14 Ref.16
Modified residue16931Phosphoserine Ref.11
Modified residue18061Phosphothreonine Ref.13
Modified residue18101Phosphoserine Ref.11 Ref.14
Modified residue18731Phosphoserine Ref.14 Ref.16
Modified residue18761Phosphoserine Ref.14
Modified residue19711Phosphoserine Ref.13
Modified residue21441Phosphoserine Ref.11 Ref.16
Modified residue21611Phosphoserine Ref.14 Ref.16
Modified residue21671Phosphothreonine Ref.16
Modified residue21721Phosphoserine Ref.11 Ref.14
Modified residue21761Phosphoserine Ref.14
Modified residue21961Phosphoserine Ref.11 Ref.13 Ref.14
Modified residue22051Phosphoserine Ref.11 Ref.14
Modified residue22601Phosphoserine Ref.11
Modified residue23391Phosphoserine Ref.11
Modified residue23911Phosphoserine Ref.11
Modified residue23931Phosphoserine Ref.11 Ref.14 Ref.16
Modified residue24651Phosphoserine Ref.11
Modified residue24711Phosphoserine Ref.11

Natural variations

Alternative sequence2250 – 227526Missing in isoform 2.
VSP_014431
Natural variant8361G → S. Ref.3 Ref.6
Corresponds to variant rs2444263 [ dbSNP | Ensembl ].
VAR_022788
Natural variant13621V → M. Ref.3 Ref.6
Corresponds to variant rs2123465 [ dbSNP | Ensembl ].
VAR_022789
Natural variant16861R → G.
Corresponds to variant rs3732305 [ dbSNP | Ensembl ].
VAR_022790
Natural variant17841E → K in a breast cancer sample; somatic mutation. Ref.18
VAR_035983
Natural variant18621V → I.
Corresponds to variant rs2444258 [ dbSNP | Ensembl ].
VAR_022791
Natural variant19551D → H in a breast cancer sample; somatic mutation. Ref.18
VAR_035984
Natural variant20211N → Y. Ref.1 Ref.3 Ref.5
Corresponds to variant rs2444257 [ dbSNP | Ensembl ].
VAR_022792
Natural variant21651M → R.
Corresponds to variant rs16830057 [ dbSNP | Ensembl ].
VAR_022793
Natural variant24181L → V. Ref.1 Ref.3 Ref.5 Ref.6 Ref.7
Corresponds to variant rs1065177 [ dbSNP | Ensembl ].
VAR_022794

Experimental info

Sequence conflict961N → D in AAT40745. Ref.1
Sequence conflict6991A → P in BAA91705. Ref.6
Sequence conflict12561M → V in BAA91705. Ref.6
Sequence conflict23161R → G in BAB85058. Ref.6
Sequence conflict23921L → F in BAB85058. Ref.6
Sequence conflict2445 – 24462HE → RV in BAB85058. Ref.6
Sequence conflict24641R → G in BAB85058. Ref.6

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified July 5, 2005. Version 2.
Checksum: A45DCE3C5F9E052D

FASTA2,472274,466
        10         20         30         40         50         60 
MTARGQSPLA PLLETLEDPS ASHGGQTDAY LTLTSRMTGE EGKEVITEIE KKLPRLYKVL 

        70         80         90        100        110        120 
KTHISSQNSE LSSAALQALG FCLYNPKITS ELSEANALEL LSKLNDTIKN SDKNVRTRAL 

       130        140        150        160        170        180 
WVISKQTFPS EVVGKMVSSI IDSLEILFNK GETHSAVVDF EALNVIVRLI EQAPIQMGEE 

       190        200        210        220        230        240 
AVRWAKLVIP LVVHSAQKVH LRGATALEMG MPLLLQKQQE IASITEQLMT TKLISELQKL 

       250        260        270        280        290        300 
FMSKNETYVL KLWPLFVKLL GRTLHRSGSF INSLLQLEEL GFRSGAPMIK KIAFIAWKSL 

       310        320        330        340        350        360 
IDNFALNPDI LCSAKRLKLL MQPLSSIHVR TETLALTKLE VWWYLLMRLG PHLPANFEQV 

       370        380        390        400        410        420 
CVPLIQSTIS IDSNASPQGN SCHVATSPGL NPMTPVHKGA SSPYGAPGTP RMNLSSNLGG 

       430        440        450        460        470        480 
MATIPSIQLL GLEMLLHFLL GPEALSFAKQ NKLVLSLEPL EHPLISSPSF FSKHANTLIT 

       490        500        510        520        530        540 
AVHDSFVAVG KDAPDVVVSA IWKELISLVK SVTESGNKKE KPGSEVLTLL LKSLESIVKS 

       550        560        570        580        590        600 
EVFPVSKTLV LMEITIKGLP QKVLGSPAYQ VANMDILNGT PALFLIQLIF NNFLECGVSD 

       610        620        630        640        650        660 
ERFFLSLESL VGCVLSGPTS PLAFSDSVLN VINQNAKQLE NKEHLWKMWS VIVTPLTELI 

       670        680        690        700        710        720 
NQTNEVNQGD ALEHNFSAIY GALTLPVNHI FSEQRFPVAT MKTLLRTWSE LYRAFARCAA 

       730        740        750        760        770        780 
LVATAEENLC CEELSSKIMS SLEDEGFSNL LFVDRIIYII TVMVDCIDFS PYNIKYQPKV 

       790        800        810        820        830        840 
KSPQRPSDWS KKKNEPLGKL TSLFKLIVKV IYSFHTLSFK EAHSDTLFTI GNSITGIISS 

       850        860        870        880        890        900 
VLGHISLPSM IRKIFATLTR PLALFYENSK LDEVPKVYSC LNNKLEKLLG EIIACLQFSY 

       910        920        930        940        950        960 
TGTYDSELLE QLSPLLCIIF LHKNKQIRKQ SAQFWNATFA KVMMLVYPEE LKPVLTQAKQ 

       970        980        990       1000       1010       1020 
KFLLLLPGLE TVEMMEESSG PYSDGTENSQ LNVKISGMER KSNGKRDSFL AQTKNKKENM 

      1030       1040       1050       1060       1070       1080 
KPAAKLKLES SSLKVKGEIL LEEEKSTDFV FIPPEGKDAK ERILTDHQKE VLKTKRCDIP 

      1090       1100       1110       1120       1130       1140 
AMYNNLDVSQ DTLFTQYSQE EPMEIPTLTR KPKEDSKMMI TEEQMDSDIV IPQDVTEDCG 

      1150       1160       1170       1180       1190       1200 
MAEHLEKSSL SNNECGSLDK TSPEMSNSNN DERKKALISS RKTSTECASS TENSFVVSSS 

      1210       1220       1230       1240       1250       1260 
SVSNTTVAGT PPYPTSRRQT FITLEKFDGS ENRPFSPSPL NNISSTVTVK NNQETMIKTD 

      1270       1280       1290       1300       1310       1320 
FLPKAKQREG TFSKSDSEKI VNGTKRSSRR AGKAEQTGNK RSKPLMRSEP EKNTEESVEG 

      1330       1340       1350       1360       1370       1380 
IVVLENNPPG LLNQTECVSD NQVHLSESTM EHDNTKLKAA TVENAVLLET NTVEEKNVEI 

      1390       1400       1410       1420       1430       1440 
NLESKENTPP VVISADQMVN EDSQVQITPN QKTLRRSSRR RSEVVESTTE SQDKENSHQK 

      1450       1460       1470       1480       1490       1500 
KERRKEEEKP LQKSPLHIKD DVLPKQKLIA EQTLQENLIE KGSNLHEKTL GETSANAETE 

      1510       1520       1530       1540       1550       1560 
QNKKKADPEN IKSEGDGTQD IVDKSSEKLV RGRTRYQTRR ASQGLLSSIE NSESDSSEAK 

      1570       1580       1590       1600       1610       1620 
EEGSRKKRSG KWKNKSNESV DIQDQEEKVV KQECIKAENQ SHDYKATSEE DVSIKSPICE 

      1630       1640       1650       1660       1670       1680 
KQDESNTVIC QDSTVTSDLL QVPDDLPNVC EEKNETSKYA EYSFTSLPVP ESNLRTRNAI 

      1690       1700       1710       1720       1730       1740 
KRLHKRDSFD NCSLGESSKI GISDISSLSE KTFQTLECQH KRSRRVRRSK GCDCCGEKSQ 

      1750       1760       1770       1780       1790       1800 
PQEKSLIGLK NTENNDVEIS ETKKADVQAP VSPSETSQAN PYSEGQFLDE HHSVNFHLGL 

      1810       1820       1830       1840       1850       1860 
KEDNDTINDS LIVSETKSKE NTMQESLPSG IVNFREEICD MDSSEAMSLE SQESPNENFK 

      1870       1880       1890       1900       1910       1920 
TVGPCLGDSK NVSQESLETK EEKPEETPKM ELSLENVTVE GNACKVTESN LEKAKTMELN 

      1930       1940       1950       1960       1970       1980 
VGNEASFHGQ ERTKTGISEE AAIEENKRND DSEADTAKLN AKEVATEEFN SDISLSDNTT 

      1990       2000       2010       2020       2030       2040 
PVKLNAQTEI SEQTAAGELD GGNDVSDLHS SEETNTKMKN NEEMMIGEAM AETGHDGETE 

      2050       2060       2070       2080       2090       2100 
NEGITTKTSK PDEAETNMLT AEMDNFVCDT VEMSTEEGII DANKTETNTE YSKSEEKLDN 

      2110       2120       2130       2140       2150       2160 
NQMVMESDIL QEDHHTSQKV EEPSQCLASG TAISELIIED NNASPQKLRE LDPSLVSAND 

      2170       2180       2190       2200       2210       2220 
SPSGMQTRCV WSPLASPSTS ILKRGLKRSQ EDEISSPVNK VRRVSFADPI YQAGLADDID 

      2230       2240       2250       2260       2270       2280 
RRCSIVRSHS SNSSPIGKSV KTSPTTQSKH NTTSAKGFLS PGSRSPKFKS SKKCLISEMA 

      2290       2300       2310       2320       2330       2340 
KESIPCPTES VYPPLVNCVA PVDIILPQIT SNMWARGLGQ LIRAKNIKTI GDLSTLTASE 

      2350       2360       2370       2380       2390       2400 
IKTLPIRSPK VSNVKKALRI YHEQQVKTRG LEEIPVFDIS EKTVNGIENK SLSPDEERLV 

      2410       2420       2430       2440       2450       2460 
SDIIDPVALE IPLSKNLLAQ ISALALQLDS EDLHNYSGSQ LFEMHEKLSC MANSVIKNLQ 

      2470 
SRWRSPSHEN SI 

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Isoform 2 [UniParc].

Checksum: 44D755C85EF23042
Show »

FASTA2,446271,689

References

« Hide 'large scale' references
[1]"Human Rif1, ortholog of a yeast telomeric protein, is regulated by ATM and 53BP1 and functions in the S-phase checkpoint."
Silverman J., Takai H., Buonomo S.B.C., Eisenhaber F., De Lange T.
Genes Dev. 18:2108-2119(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, SUBCELLULAR LOCATION, VARIANTS TYR-2021 AND VAL-2418.
[2]"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. expand/collapse author list , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"Human Rif1 protein binds aberrant telomeres and aligns along anaphase midzone microtubules."
Xu L., Blackburn E.H.
J. Cell Biol. 167:819-830(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, VARIANTS SER-836; MET-1362; TYR-2021 AND VAL-2418.
[4]"Identification and characterization of human Rif1."
Simonsson T.
Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[5]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 35-853 AND 1728-2472 (ISOFORM 1), VARIANTS TYR-2021 AND VAL-2418.
Tissue: Testis and Testis carcinoma.
[6]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 161-1499 AND 2217-2472 (ISOFORM 1), VARIANTS SER-836; MET-1362 AND VAL-2418.
[7]"Large-scale concatenation cDNA sequencing."
Yu W., Andersson B., Worley K.C., Muzny D.M., Ding Y., Liu W., Ricafrente J.Y., Wentland M.A., Lennon G., Gibbs R.A.
Genome Res. 7:353-358(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2108-2472 (ISOFORM 2), VARIANT VAL-2418.
Tissue: Brain.
[8]"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1454 AND SER-1688, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[9]"A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.
Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-409 AND SER-1579, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[10]"ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."
Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III, Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N., Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.
Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1513; THR-1518 AND SER-1542, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Embryonic kidney.
[11]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-402; THR-409; SER-1162; SER-1236; SER-1238; SER-1422; SER-1554; SER-1616; SER-1688; SER-1693; SER-1810; SER-2144; SER-2172; SER-2196; SER-2205; SER-2260; SER-2339; SER-2391; SER-2393; SER-2465 AND SER-2471, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[12]"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[13]"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-979; THR-1047; SER-1552; SER-1554; SER-1579; SER-1688; THR-1806; SER-1971 AND SER-2196, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Leukemic T-cell.
[14]"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1238; SER-1454; SER-1579; SER-1688; SER-1810; SER-1873; SER-1876; SER-2161; SER-2172; SER-2176; SER-2196; SER-2205 AND SER-2393, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[15]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[16]"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-782; SER-1422; SER-1454; SER-1542; SER-1554; SER-1576; SER-1579; SER-1688; SER-1873; SER-2144; SER-2161; THR-2167 AND SER-2393, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[17]"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A., Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[18]"The consensus coding sequences of human breast and colorectal cancers."
Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. expand/collapse author list , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E.
Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANTS [LARGE SCALE ANALYSIS] LYS-1784 AND HIS-1955.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY585745 mRNA. Translation: AAT40745.1.
AY727910 mRNA. Translation: AAV51401.1.
AY727911 mRNA. Translation: AAV51402.1.
AY727912 mRNA. Translation: AAV51403.1.
AY727913 mRNA. Translation: AAV51404.1.
AY584066 mRNA. Translation: AAS94233.1.
AC009311 Genomic DNA. No translation available.
AC009497 Genomic DNA. No translation available.
AL080129 mRNA. Translation: CAB45727.1.
CR933663 mRNA. Translation: CAI45961.1. Sequence problems.
AK001461 mRNA. Translation: BAA91705.1. Different initiation.
AK022932 mRNA. Translation: BAB14313.1. Different initiation.
AK024033 mRNA. Translation: BAB14792.1. Different initiation.
AK074349 mRNA. Translation: BAB85058.1. Different initiation.
U79263 mRNA. Translation: AAB50209.1.
PIRT12518.
RefSeqNP_001171134.1. NM_001177663.1.
NP_001171135.1. NM_001177664.1.
NP_001171136.1. NM_001177665.1.
NP_060621.3. NM_018151.4.
XP_005246722.1. XM_005246665.1.
UniGeneHs.655671.
Hs.735592.

3D structure databases

ProteinModelPortalQ5UIP0.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid120482. 25 interactions.
IntActQ5UIP0. 118 interactions.
MINTMINT-3974483.

PTM databases

PhosphoSiteQ5UIP0.

Polymorphism databases

DMDM68565701.

Proteomic databases

PaxDbQ5UIP0.
PRIDEQ5UIP0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000243326; ENSP00000243326; ENSG00000080345. [Q5UIP0-1]
ENST00000428287; ENSP00000415691; ENSG00000080345. [Q5UIP0-2]
ENST00000430328; ENSP00000416123; ENSG00000080345. [Q5UIP0-2]
ENST00000444746; ENSP00000390181; ENSG00000080345. [Q5UIP0-1]
ENST00000453091; ENSP00000414615; ENSG00000080345. [Q5UIP0-2]
GeneID55183.
KEGGhsa:55183.
UCSCuc002txl.3. human. [Q5UIP0-2]
uc002txm.3. human. [Q5UIP0-1]

Organism-specific databases

CTD55183.
GeneCardsGC02P152266.
HGNCHGNC:23207. RIF1.
HPAHPA036887.
HPA036888.
MIM608952. gene.
neXtProtNX_Q5UIP0.
PharmGKBPA134933858.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG87885.
HOVERGENHBG080431.
InParanoidQ5UIP0.
KOK11138.
OMAPTESVYP.
OrthoDBEOG70GMDW.
PhylomeDBQ5UIP0.
TreeFamTF323789.

Gene expression databases

ArrayExpressQ5UIP0.
BgeeQ5UIP0.
CleanExHS_RIF1.
GenevestigatorQ5UIP0.

Family and domain databases

Gene3D1.25.10.10. 3 hits.
InterProIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR028566. Rif1.
IPR028567. Rif1_metazoan.
IPR022031. Rif1_N.
[Graphical view]
PANTHERPTHR22928. PTHR22928. 1 hit.
PTHR22928:SF0. PTHR22928:SF0. 1 hit.
PfamPF12231. Rif1_N. 1 hit.
[Graphical view]
SUPFAMSSF48371. SSF48371. 4 hits.
ProtoNetSearch...

Other

ChiTaRSRIF1. human.
GeneWikiRIF1.
GenomeRNAi55183.
NextBio59015.
PROQ5UIP0.
SOURCESearch...

Entry information

Entry nameRIF1_HUMAN
AccessionPrimary (citable) accession number: Q5UIP0
Secondary accession number(s): A6NC27 expand/collapse secondary AC list , C9JBR1, Q5H9R3, Q5UIP2, Q66YK6, Q6PRU2, Q8TE94, Q99772, Q9H830, Q9H9B9, Q9NVP5, Q9Y4R4
Entry history
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: July 5, 2005
Last modified: April 16, 2014
This is version 97 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 2

Human chromosome 2: entries, gene names and cross-references to MIM