Cyclic AMP-responsive element-binding protein 3-like protein 4 - Macaca fascicularis (Crab-eating macaque)

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Q5UEM8 (CR3L4_MACFA) Reviewed, UniProtKB/Swiss-Prot

Last modified November 28, 2012. Version 48. History...

Clusters with 100%, 90%, 50% identity |

Documents (1) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Cyclic AMP-responsive element-binding protein 3-like protein 4
Short name=cAMP-responsive element-binding protein 3-like protein 4

Alternative name(s):
Androgen-induced basic leucine zipper protein
Short name=AIbZIP

Cleaved into the following chain:

Processed cyclic AMP-responsive element-binding protein 3-like protein 4

Gene names

Name:	CREB3L4
Synonyms:	AIBZIP

Organism

Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)

Taxonomic identifier

9541 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Cercopithecidae › Cercopithecinae › Macaca

Protein attributes

Sequence length	395 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Transcriptional activator that may play a role in the unfolded protein response. Binds to the UPR element (UPRE) but not to CRE element. Preferentially binds DNA with to the consensus sequence 5'-T[GT]ACGT[GA][GT]-3' and has transcriptional activation activity from UPRE. Binds to NF-kappa-B site and has transcriptional activation activity from NF-kappa-B-containing regulatory elements By similarity.
Subunit structure	Binds DNA as a dimer By similarity.
Subcellular location	Endoplasmic reticulum membrane; Single-pass type II membrane protein By similarity. Processed cyclic AMP-responsive element-binding protein 3-like protein 4: Nucleus By similarity. Note: Under ER stress the cleaved N-terminal cytoplasmic domain translocates into the nucleus By similarity.
Post-translational modification	Controlled by regulated intramembrane proteolysis (RIP). Following ER stress a fragment containing the cytoplasmic transcription factor domain is released by proteolysis. The cleavage seems to be performed sequentially by site-1 and site-2 proteases (PS1 and PS2). PS1 cleavage may be suppressed by a determinant in the C-terminal region By similarity.
Sequence similarities	Belongs to the bZIP family. ATF subfamily. Contains 1 bZIP (basic-leucine zipper) domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation Unfolded protein response
Cellular component	Endoplasmic reticulum Membrane Nucleus
Domain	Signal-anchor Transmembrane Transmembrane helix
Ligand	DNA-binding
Molecular function	Activator
PTM	Glycoprotein
Gene Ontology (GO)
Biological_process	response to unfolded protein Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 395

395

Cyclic AMP-responsive element-binding protein 3-like protein 4

PRO_0000288080

Chain

1 – ?

Processed cyclic AMP-responsive element-binding protein 3-like protein 4

PRO_0000296220

Regions

Topological domain

1 – 295

295

Cytoplasmic Potential

Transmembrane

296 – 316

Helical; Signal-anchor for type II membrane protein; Potential

Topological domain

317 – 395

Lumenal Potential

Domain

217 – 280

bZIP

Region

219 – 248

Basic motif By similarity

Region

259 – 280

Leucine-zipper By similarity

Sites

Site

338 – 339

Cleavage; by PS1 By similarity

Amino acid modifications

Glycosylation

366

N-linked (GlcNAc...) Potential

Sequences

Sequence

Length

Mass (Da)

Tools

Q5UEM8 [UniParc].

Last modified December 7, 2004. Version 1.
Checksum: 5586B84CBF7DC6C1
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FASTA

395

43,510

        10         20         30         40         50         60 
MDLGIPDLLD AWLEPPEDIF STGSVLELGL HCPPPEVPVT RLQEQGLQGW KSGGDHGCGL 

        70         80         90        100        110        120 
QESEPEDFLK LFIDPNEVYR SEASPGNDSG TSEDPCRPDS PPAPRATSSP TLYEVVYEAG 

       130        140        150        160        170        180 
ALERMQGETG PTVGLISIQL DQWSPAFMVP DSCMVSELPF DAHAHILPRA GTLAPVPCTT 

       190        200        210        220        230        240 
LLPCQTLFLT DEEKRLLGQE GVSLPSHLPL TKAEERVLKK VRRKIRNKQS AQDSRRRKKE 

       250        260        270        280        290        300 
YIDGLESRVA ACSAQNQELQ KKVQELERHN ISLVAQLRQL QTLIAQTSNK AAQTSTCVLI 

       310        320        330        340        350        360 
LLFSLALIIL PSFSPFQGRP EAGPEDYQPH GVTSRNILTH KDITENLETQ VVESRLREPP 

       370        380        390 
EAKDANDSTR TLLEKMGGKP RPSGRIGTVL HADEM

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References

[1]	"Characterization of the transcriptional properties of mammalian AIbZIP proteins." Savard M.-P., Pelletier M., Leveille N., Grenier J., Qi H., Labrie C. Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Prostate.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY750874 mRNA. Translation: AAV29941.1.
3D structure databases
HSSP	HSSP built from PDB template 1JNM based on UniProtKB P05412.
ProteinModelPortal	Q5UEM8.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
HOVERGEN	HBG058316.
OrthoDB	EOG4M91RN.
Family and domain databases
InterPro	IPR004827. bZIP. IPR008917. Euk_TF_DNA-bd. [Graphical view]
Pfam	PF00170. bZIP_1. 1 hit. [Graphical view]
SMART	SM00338. BRLZ. 1 hit. [Graphical view]
SUPFAM	SSF47454. Euk_transcr_DNA. 1 hit.
PROSITE	PS50217. BZIP. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CR3L4_MACFA

Accession

Primary (citable) accession number: Q5UEM8

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 29, 2007
Last sequence update:	December 7, 2004
Last modified:	November 28, 2012
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

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