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Protein

Cyclic AMP-responsive element-binding protein 3-like protein 4

Gene

Creb3l4

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Transcriptional activator that may play a role in the unfolded protein response. Binds to the UPR element (UPRE) but not to CRE element. Preferentially binds DNA with to the consensus sequence 5'-T[GT]ACGT[GA][GT]-3' and has transcriptional activation activity from UPRE. Binds to NF-kappa-B site and has transcriptional activation activity from NF-kappa-B-containing regulatory elements. Increases the binding of CREM isoform Delta with CRE. The CREM isoform Delta-CREB3L4 heterodimer functions through CRE but not through UPRE and may recruit HIRA to CRE to regulate histone exchange (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation, Unfolded protein response

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclic AMP-responsive element-binding protein 3-like protein 4
Short name:
cAMP-responsive element-binding protein 3-like protein 4
Alternative name(s):
Androgen-induced basic leucine zipper protein
Short name:
AIbZIP
Cleaved into the following chain:
Gene namesi
Name:Creb3l4
Synonyms:Aibzip
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi1359278. Creb3l4.

Subcellular locationi

Processed cyclic AMP-responsive element-binding protein 3-like protein 4 :
  • Nucleus PROSITE-ProRule annotation

  • Note: Under ER stress the cleaved N-terminal cytoplasmic domain translocates into the nucleus.By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 267267CytoplasmicSequence analysisAdd
BLAST
Transmembranei268 – 28821Helical; Signal-anchor for type II membrane proteinSequence analysisAdd
BLAST
Topological domaini289 – 36779LumenalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 367367Cyclic AMP-responsive element-binding protein 3-like protein 4PRO_0000288082Add
BLAST
Chaini1 – ?Processed cyclic AMP-responsive element-binding protein 3-like protein 4PRO_0000296222

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi338 – 3381N-linked (GlcNAc...)Sequence analysis

Post-translational modificationi

Controlled by regulated intramembrane proteolysis (RIP). Following ER stress a fragment containing the cytoplasmic transcription factor domain is released by proteolysis. The cleavage seems to be performed sequentially by site-1 and site-2 proteases (PS1 and PS2). PS1 cleavage may be suppressed by a determinant in the C-terminal region (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei310 – 3112Cleavage; by PS1By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ5UEM7.
PRIDEiQ5UEM7.

PTM databases

iPTMnetiQ5UEM7.
PhosphoSiteiQ5UEM7.

Expressioni

Gene expression databases

GenevisibleiQ5UEM7. RN.

Interactioni

Subunit structurei

Binds DNA as a dimer. Forms a heterodimer with CREM isoform Delta (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000033353.

Structurei

3D structure databases

ProteinModelPortaliQ5UEM7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini189 – 25264bZIPPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 5252Required for transcriptional activationBy similarityAdd
BLAST
Regioni191 – 23040Basic motifPROSITE-ProRule annotationAdd
BLAST
Regioni231 – 25222Leucine-zipperPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the bZIP family. ATF subfamily.Curated
Contains 1 bZIP (basic-leucine zipper) domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0709. Eukaryota.
ENOG410ZZQM. LUCA.
GeneTreeiENSGT00520000055538.
HOGENOMiHOG000059566.
HOVERGENiHBG058316.
InParanoidiQ5UEM7.
KOiK09048.
OMAiEDYQPHG.
OrthoDBiEOG7KM5SZ.
PhylomeDBiQ5UEM7.

Family and domain databases

InterProiIPR004827. bZIP.
IPR029807. CREB4.
[Graphical view]
PANTHERiPTHR22952:SF105. PTHR22952:SF105. 1 hit.
PfamiPF00170. bZIP_1. 1 hit.
[Graphical view]
SMARTiSM00338. BRLZ. 1 hit.
[Graphical view]
PROSITEiPS50217. BZIP. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5UEM7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MELGCPELLE PPEDIFSTGS FLELGFNGPP SKVPGLQKSE SDDFLNLFID
60 70 80 90 100
PNMIRCSETS PGSDSGVSED PGSPAPQAPS SPALYEVVYE AGALQGTQRE
110 120 130 140 150
AGPTFGLISI QIDQWSPAFM VPGACTVSDL PSEAHRHILP RVSTIAPPPP
160 170 180 190 200
AALLSCQRLF LTDEEKHLLG QEGVTLPSHL PLTKAEERIL KKIRRKIRNK
210 220 230 240 250
QSAQDSRRRK KEYIDGLESR VAACSEQNQK LQRKVQELER QNISLVAQVH
260 270 280 290 300
QLQKFTAQTS SRAAQTSTCV LILLFSLALI ILPSFSPFQS QPEARSEGYQ
310 320 330 340 350
LHGVISRNIL THEDMTESPE SPVLKANLEE LPQVPATNGS TKMAHLKMRV
360
KARPTGPIRG MVHADEM
Length:367
Mass (Da):40,281
Last modified:December 7, 2004 - v1
Checksum:i5670035EC3F9C37E
GO
Isoform 2 (identifier: Q5UEM7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     33-34: Missing.

Show »
Length:365
Mass (Da):40,085
Checksum:iE3632145EEB5BA81
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei33 – 342Missing in isoform 2. 1 PublicationVSP_025640

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY750875 mRNA. Translation: AAV29942.1.
AY750876 mRNA. Translation: AAV29943.1.
RefSeqiNP_001007094.1. NM_001007093.1. [Q5UEM7-1]
XP_006232689.1. XM_006232627.2. [Q5UEM7-1]
XP_008759369.1. XM_008761147.1. [Q5UEM7-2]
UniGeneiRn.19624.

Genome annotation databases

EnsembliENSRNOT00000032062; ENSRNOP00000033353; ENSRNOG00000023493. [Q5UEM7-2]
GeneIDi310616.
KEGGirno:310616.
UCSCiRGD:1359278. rat. [Q5UEM7-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY750875 mRNA. Translation: AAV29942.1.
AY750876 mRNA. Translation: AAV29943.1.
RefSeqiNP_001007094.1. NM_001007093.1. [Q5UEM7-1]
XP_006232689.1. XM_006232627.2. [Q5UEM7-1]
XP_008759369.1. XM_008761147.1. [Q5UEM7-2]
UniGeneiRn.19624.

3D structure databases

ProteinModelPortaliQ5UEM7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000033353.

PTM databases

iPTMnetiQ5UEM7.
PhosphoSiteiQ5UEM7.

Proteomic databases

PaxDbiQ5UEM7.
PRIDEiQ5UEM7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000032062; ENSRNOP00000033353; ENSRNOG00000023493. [Q5UEM7-2]
GeneIDi310616.
KEGGirno:310616.
UCSCiRGD:1359278. rat. [Q5UEM7-1]

Organism-specific databases

CTDi148327.
RGDi1359278. Creb3l4.

Phylogenomic databases

eggNOGiKOG0709. Eukaryota.
ENOG410ZZQM. LUCA.
GeneTreeiENSGT00520000055538.
HOGENOMiHOG000059566.
HOVERGENiHBG058316.
InParanoidiQ5UEM7.
KOiK09048.
OMAiEDYQPHG.
OrthoDBiEOG7KM5SZ.
PhylomeDBiQ5UEM7.

Miscellaneous databases

PROiQ5UEM7.

Gene expression databases

GenevisibleiQ5UEM7. RN.

Family and domain databases

InterProiIPR004827. bZIP.
IPR029807. CREB4.
[Graphical view]
PANTHERiPTHR22952:SF105. PTHR22952:SF105. 1 hit.
PfamiPF00170. bZIP_1. 1 hit.
[Graphical view]
SMARTiSM00338. BRLZ. 1 hit.
[Graphical view]
PROSITEiPS50217. BZIP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Characterization of the transcriptional properties of mammalian AIbZIP proteins."
    Savard M.-P., Pelletier M., Leveille N., Grenier J., Qi H., Labrie C.
    Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
    Strain: Sprague-Dawley.
    Tissue: Prostate.

Entry informationi

Entry nameiCR3L4_RAT
AccessioniPrimary (citable) accession number: Q5UEM7
Secondary accession number(s): Q5UEM6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: December 7, 2004
Last modified: June 8, 2016
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.