Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Phosphoinositide 3-kinase regulatory subunit 6

Gene

PIK3R6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Regulatory subunit of the PI3K gamma complex. Acts as an adapter to drive activation of PIK3CG by beta-gamma G protein dimers. The PIK3CG:PIK3R6 heterodimer is much less sensitive to beta-gamma G protein dimers than PIK3CG:PIK3R5 and its membrane recruitment and beta-gamma G protein dimer-dependent activation requires HRAS bound to PIK3CG. Recruits of the PI3K gamma complex to a PDE3B:RAPGEF3 signaling complex involved in angiogenesis; signaling seems to involve RRAS.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Angiogenesis

Enzyme and pathway databases

BioCyciMetaCyc:ENSG00000174083-MONOMER.
ReactomeiR-HSA-114604. GPVI-mediated activation cascade.
R-HSA-1660499. Synthesis of PIPs at the plasma membrane.
R-HSA-392451. G beta:gamma signalling through PI3Kgamma.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoinositide 3-kinase regulatory subunit 6
Alternative name(s):
Phosphoinositide 3-kinase gamma adapter protein of 87 kDa
p84 PI3K adapter protein
Short name:
p84 PIKAP
p87 PI3K adapter protein
Short name:
p87PIKAP
Gene namesi
Name:PIK3R6
Synonyms:C17orf38
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:27101. PIK3R6.

Subcellular locationi

  • Cytoplasm By similarity
  • Cell membrane By similarity; Peripheral membrane protein By similarity

  • Note: Translocated to the plasma membrane in a Ras-dependent manner.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162399570.

Polymorphism and mutation databases

BioMutaiPIK3R6.
DMDMi74746772.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 754754Phosphoinositide 3-kinase regulatory subunit 6PRO_0000234338Add
BLAST

Proteomic databases

EPDiQ5UE93.
PeptideAtlasiQ5UE93.
PRIDEiQ5UE93.

PTM databases

iPTMnetiQ5UE93.
PhosphoSiteiQ5UE93.

Expressioni

Gene expression databases

BgeeiENSG00000174083.
CleanExiHS_PIK3R6.
ExpressionAtlasiQ5UE93. baseline and differential.
GenevisibleiQ5UE93. HS.

Organism-specific databases

HPAiHPA023077.

Interactioni

Subunit structurei

Heterodimer of a catalytic subunit (PIK3CG) and a regulatory (PIK3R6) subunit. The binding of PIK3R6 to PIK3CG may exclude the binding of PIK3R5 to PIK3CG. Interacts with beta-gamma G protein dimers. Interacts with PDE3B; the interaction allows recruitment of the PI3K gamma complex to a PDE3B:RAPGEF3 complex.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
PDE3BQ133703EBI-6172907,EBI-6172856

Protein-protein interaction databases

IntActiQ5UE93. 2 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ5UE93.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00530000063753.
HOVERGENiHBG080761.
InParanoidiQ5UE93.
OMAiIQDSKFP.
OrthoDBiEOG091G0339.
PhylomeDBiQ5UE93.

Family and domain databases

InterProiIPR019522. PIK3R5/6.
[Graphical view]
PfamiPF10486. PI3K_1B_p101. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5UE93-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESSDVELDL QRSVQAVLRE LSTQAPALQS NQGMWRWSLH KKVERDPGKS
60 70 80 90 100
PVLVRILLRE LEKAESQDLR HVIIPLLHTV MYVLTKATGI TEELYQRIYA
110 120 130 140 150
FCTRLLTLPT PYCTVALDCA IRLKTEMAVP GTLYQRMVIA EQNLTNELYP
160 170 180 190 200
YQERVFLFVD PELVSASVCS ALLLEIEAAQ AQQTPETCMR HVVSHALQAA
210 220 230 240 250
LGEACHAGAL HRKLQASPRR TLEHYFHAVV AALEQMASEA SPSREGHVER
260 270 280 290 300
LEEIYCSLLG PAAGRCGGDL VQERPPSIPL PSPYITFHLW TGEEQLWKEL
310 320 330 340 350
VLFLRPRSQL RLSADLEVLD LQGLRPDREL ARVSVLSTDS GIERDLPTGA
360 370 380 390 400
DELPAPGSPE MERAGLQRKG GIKKRAWPLD FLMPGSWDGP PGLHRRTGRP
410 420 430 440 450
SGDGEMLPGV SRLHTARVLV LGDDRMLGRL AQAYHRLRKR ETQKFCLTPR
460 470 480 490 500
LSLQLYYIPV LAPEKPAASR QPELGELATF LGRVDPWYQS NVNTLCPAIH
510 520 530 540 550
KLAEMPPSLD TSRTVDPFIL DVITYYIRMG TQPIYFQIYT VKIFFSDLSQ
560 570 580 590 600
DPTEDIFLIE LKVKIQDSKF PKDGFSPRRR GVAEGPGAEL SLCYQKALLS
610 620 630 640 650
HRPREVTVSL RATGLILKAI PASDTEVSGS SHCPLPAAPV TDHTCLNVNV
660 670 680 690 700
TEVVKSSNLA GKSFSTVTNT FRTNNIQIQS RDQRLLTLSL DKDDQRTFRD
710 720 730 740 750
VVRFEVAPCP EPCSGAQKSK APWLNLHGQQ EVEAIKAKPK PLLMPINTFS

GIVQ
Length:754
Mass (Da):84,258
Last modified:December 7, 2004 - v1
Checksum:iB7E3F1C2D422E2E6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY753192 mRNA. Translation: AAV30085.1.
AC003695 Genomic DNA. No translation available.
AC009451 Genomic DNA. No translation available.
AL833037 mRNA. Translation: CAH56340.1.
CCDSiCCDS73985.1.
RefSeqiNP_001010855.1. NM_001010855.3.
UniGeneiHs.255809.

Genome annotation databases

EnsembliENST00000614407; ENSP00000482341; ENSG00000276231.
ENST00000619866; ENSP00000480157; ENSG00000276231.
GeneIDi146850.
KEGGihsa:146850.
UCSCiuc032etf.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY753192 mRNA. Translation: AAV30085.1.
AC003695 Genomic DNA. No translation available.
AC009451 Genomic DNA. No translation available.
AL833037 mRNA. Translation: CAH56340.1.
CCDSiCCDS73985.1.
RefSeqiNP_001010855.1. NM_001010855.3.
UniGeneiHs.255809.

3D structure databases

ProteinModelPortaliQ5UE93.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ5UE93. 2 interactions.

PTM databases

iPTMnetiQ5UE93.
PhosphoSiteiQ5UE93.

Polymorphism and mutation databases

BioMutaiPIK3R6.
DMDMi74746772.

Proteomic databases

EPDiQ5UE93.
PeptideAtlasiQ5UE93.
PRIDEiQ5UE93.

Protocols and materials databases

DNASUi146850.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000614407; ENSP00000482341; ENSG00000276231.
ENST00000619866; ENSP00000480157; ENSG00000276231.
GeneIDi146850.
KEGGihsa:146850.
UCSCiuc032etf.1. human.

Organism-specific databases

CTDi146850.
GeneCardsiPIK3R6.
HGNCiHGNC:27101. PIK3R6.
HPAiHPA023077.
MIMi611462. gene.
neXtProtiNX_Q5UE93.
PharmGKBiPA162399570.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00530000063753.
HOVERGENiHBG080761.
InParanoidiQ5UE93.
OMAiIQDSKFP.
OrthoDBiEOG091G0339.
PhylomeDBiQ5UE93.

Enzyme and pathway databases

BioCyciMetaCyc:ENSG00000174083-MONOMER.
ReactomeiR-HSA-114604. GPVI-mediated activation cascade.
R-HSA-1660499. Synthesis of PIPs at the plasma membrane.
R-HSA-392451. G beta:gamma signalling through PI3Kgamma.

Miscellaneous databases

GenomeRNAii146850.
PROiQ5UE93.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000174083.
CleanExiHS_PIK3R6.
ExpressionAtlasiQ5UE93. baseline and differential.
GenevisibleiQ5UE93. HS.

Family and domain databases

InterProiIPR019522. PIK3R5/6.
[Graphical view]
PfamiPF10486. PI3K_1B_p101. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPI3R6_HUMAN
AccessioniPrimary (citable) accession number: Q5UE93
Secondary accession number(s): Q658R3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: December 7, 2004
Last modified: September 7, 2016
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.