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Q5UE59

- Q5UE59_MOUSE

UniProt

Q5UE59 - Q5UE59_MOUSE

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Protein
Submitted name: Kinesin light chain 1
Gene
Klc1, Kns2
Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. microtubule motor activity Source: InterPro
  2. protein binding Source: MGI

GO - Biological processi

  1. axon cargo transport Source: MGI
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_196550. MHC class II antigen presentation.
REACT_199117. Kinesins.

Names & Taxonomyi

Protein namesi
Submitted name:
Kinesin light chain 1Imported
Submitted name:
Kinesin light chain-1Imported
Gene namesi
Name:Klc1Imported
Synonyms:Kns2Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 12

Organism-specific databases

MGIiMGI:107978. Klc1.

Subcellular locationi

GO - Cellular componenti

  1. axon Source: MGI
  2. ciliary rootlet Source: MGI
  3. cytoplasm Source: MGI
  4. cytoplasmic vesicle Source: MGI
  5. kinesin complex Source: InterPro
  6. membrane-bounded organelle Source: MGI
  7. neuron projection Source: MGI
Complete GO annotation...

Expressioni

Gene expression databases

GenevestigatoriQ5UE59.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000021717.

Family & Domainsi

Keywords - Domaini

RepeatUniRule annotation, TPR repeatUniRule annotationSAAS annotations

Phylogenomic databases

GeneTreeiENSGT00390000006393.
HOGENOMiHOG000261663.
HOVERGENiHBG006217.
KOiK10407.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
InterProiIPR002151. Kinesin_light.
IPR015792. Kinesin_light_repeat.
IPR015390. Rabaptin_Rab5-bd_dom.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical.
IPR001440. TPR_1.
IPR013105. TPR_2.
IPR019734. TPR_repeat.
[Graphical view]
PfamiPF09311. Rab5-bind. 1 hit.
PF00515. TPR_1. 1 hit.
PF07719. TPR_2. 1 hit.
[Graphical view]
PRINTSiPR00381. KINESINLIGHT.
SMARTiSM00028. TPR. 5 hits.
[Graphical view]
PROSITEiPS01160. KINESIN_LIGHT. 4 hits.
PS50005. TPR. 6 hits.
PS50293. TPR_REGION. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5UE59-1 [UniParc]FASTAAdd to Basket

« Hide

MYDNMSTMVY IKEEKLEKLT QDEIISKTKQ VIQGLEALKN EHNSILQSLL    50
ETLKCLKKDD ESNLVEEKSS MIRKSLEMLE LGLSEAQVMM ALSNHLNAVE 100
SEKQKLRAQV RRLCQENQWL RDELANTQQK LQKSEQSVAQ LEEEKKHLEF 150
MNQLKKYDDD ISPSEDKDSD SSKEPLDDLF PNDEDEPGQG IQQQHSSAAA 200
AAQQGGYEIP ARLRTLHNLV IQYASQGRYE VAVPLCKQAL EDLEKTSGHD 250
HPDVATMLNI LALVYRDQNK YKDAANLLND ALAIREKTLG RDHPAVAATL 300
NNLAVLYGKR GKYKEAEPLC KRALEIREKV LGKDHPDVAK QLNNLALLCQ 350
NQGKYEEVEY YYQRALGIYQ TKLGPDDPNV AKTKNNLASC YLKQGKFKQA 400
ETLYKEILTR AHEREFGSVD DENKPIWMHA EEREECKGKQ KDGSAFGEYG 450
GWYKACKVDS PTVTTTLKNL GALYRRQGKF EAAETLEEAA MRSRKQGLDN 500
VHKQRVAEVL NDPESMEKRR SRESLNMDVV KYESGPDGGE EA 542
Length:542
Mass (Da):61,629
Last modified:December 7, 2004 - v1
Checksum:i5A44688CEA0AB123
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC152065 Genomic DNA. No translation available.
AY753300 mRNA. Translation: AAV30550.1.
RefSeqiNP_032476.2. NM_008450.2.
UniGeneiMm.278357.

Genome annotation databases

EnsembliENSMUST00000118471; ENSMUSP00000113171; ENSMUSG00000021288.
GeneIDi16593.
KEGGimmu:16593.
UCSCiuc007pdv.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC152065 Genomic DNA. No translation available.
AY753300 mRNA. Translation: AAV30550.1 .
RefSeqi NP_032476.2. NM_008450.2.
UniGenei Mm.278357.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000021717.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000118471 ; ENSMUSP00000113171 ; ENSMUSG00000021288 .
GeneIDi 16593.
KEGGi mmu:16593.
UCSCi uc007pdv.1. mouse.

Organism-specific databases

CTDi 3831.
MGIi MGI:107978. Klc1.

Phylogenomic databases

GeneTreei ENSGT00390000006393.
HOGENOMi HOG000261663.
HOVERGENi HBG006217.
KOi K10407.

Enzyme and pathway databases

Reactomei REACT_196550. MHC class II antigen presentation.
REACT_199117. Kinesins.

Miscellaneous databases

ChiTaRSi KLC1. mouse.
NextBioi 290149.
SOURCEi Search...

Gene expression databases

Genevestigatori Q5UE59.

Family and domain databases

Gene3Di 1.25.40.10. 1 hit.
InterProi IPR002151. Kinesin_light.
IPR015792. Kinesin_light_repeat.
IPR015390. Rabaptin_Rab5-bd_dom.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical.
IPR001440. TPR_1.
IPR013105. TPR_2.
IPR019734. TPR_repeat.
[Graphical view ]
Pfami PF09311. Rab5-bind. 1 hit.
PF00515. TPR_1. 1 hit.
PF07719. TPR_2. 1 hit.
[Graphical view ]
PRINTSi PR00381. KINESINLIGHT.
SMARTi SM00028. TPR. 5 hits.
[Graphical view ]
PROSITEi PS01160. KINESIN_LIGHT. 4 hits.
PS50005. TPR. 6 hits.
PS50293. TPR_REGION. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The novel cargo Alcadein induces vesicle association of kinesin-1 motor components and activates axonal transport."
    Araki Y., Kawano T., Taru H., Saito Y., Wada S., Miyamoto K., Kobayashi H., Ishikawa H.O., Ohsugi Y., Yamamoto T., Matsuno K., Kinjo M., Suzuki T.
    EMBO J. 26:1475-1486(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6Imported.
  2. "Quantitative time-resolved phosphoproteomic analysis of mast cell signaling."
    Cao L., Yu K., Banh C., Nguyen V., Ritz A., Raphael B.J., Kawakami Y., Kawakami T., Salomon A.R.
    J. Immunol. 179:5864-5876(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  4. Ensembl
    Submitted (JUN-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiQ5UE59_MOUSE
AccessioniPrimary (citable) accession number: Q5UE59
Entry historyi
Integrated into UniProtKB/TrEMBL: December 7, 2004
Last sequence update: December 7, 2004
Last modified: September 3, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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