Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

ER membrane protein complex subunit 10

Gene

EMC10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
ER membrane protein complex subunit 10
Alternative name(s):
Hematopoietic signal peptide-containing membrane domain-containing protein 1
Gene namesi
Name:EMC10
Synonyms:C19orf63, HSM1, INM02
ORF Names:UNQ764/PRO1556
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:27609. EMC10.

Subcellular locationi

Isoform 1 :
Isoform 2 :

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini28 – 221194ExtracellularSequence analysisAdd
BLAST
Transmembranei222 – 24221HelicalSequence analysisAdd
BLAST
Topological domaini243 – 26220CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • ER membrane protein complex Source: UniProtKB
  • extracellular region Source: UniProtKB-SubCell
  • integral component of membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162378790.

Polymorphism and mutation databases

DMDMi74708213.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2727Sequence analysisAdd
BLAST
Chaini28 – 262235ER membrane protein complex subunit 10PRO_0000315048Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi182 – 1821N-linked (GlcNAc...)1 Publication

Post-translational modificationi

Glycosylated.2 Publications

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ5UCC4.
MaxQBiQ5UCC4.
PaxDbiQ5UCC4.
PRIDEiQ5UCC4.
TopDownProteomicsiQ5UCC4-1. [Q5UCC4-1]

PTM databases

iPTMnetiQ5UCC4.
PhosphoSiteiQ5UCC4.

Expressioni

Tissue specificityi

Present in serum (at protein level). Expressed in the pituitary gland; very low levels in other brain regions.2 Publications

Gene expression databases

BgeeiQ5UCC4.
CleanExiHS_C19orf63.
ExpressionAtlasiQ5UCC4. baseline and differential.
GenevisibleiQ5UCC4. HS.

Organism-specific databases

HPAiHPA053905.
HPA062723.

Interactioni

Subunit structurei

Component of the ER membrane protein complex (EMC).1 Publication

Protein-protein interaction databases

BioGridi129844. 17 interactions.
IntActiQ5UCC4. 6 interactions.
STRINGi9606.ENSP00000334037.

Structurei

3D structure databases

ProteinModelPortaliQ5UCC4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the EMC10 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4827. Eukaryota.
ENOG4111PEN. LUCA.
GeneTreeiENSGT00390000004520.
HOGENOMiHOG000111998.
InParanoidiQ5UCC4.
OMAiCALAKSQ.
PhylomeDBiQ5UCC4.
TreeFamiTF314052.

Family and domain databases

InterProiIPR029615. Emc10.
[Graphical view]
PANTHERiPTHR21397:SF4. PTHR21397:SF4. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5UCC4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAASAGATR LLLLLLMAVA APSRARGSGC RAGTGARGAG AEGREGEACG
60 70 80 90 100
TVGLLLEHSF EIDDSANFRK RGSLLWNQQD GTLSLSQRQL SEEERGRLRD
110 120 130 140 150
VAALNGLYRV RIPRRPGALD GLEAGGYVSS FVPACSLVES HLSDQLTLHV
160 170 180 190 200
DVAGNVVGVS VVTHPGGCRG HEVEDVDLEL FNTSVQLQPP TTAPGPETAA
210 220 230 240 250
FIERLEMEQA QKAKNPQEQK SFFAKYWMYI IPVVLFLMMS GAPDTGGQGG
260
GGGGGGGGGS GR
Length:262
Mass (Da):27,347
Last modified:December 7, 2004 - v1
Checksum:i816940C105B95AA1
GO
Isoform 2 (identifier: Q5UCC4-2) [UniParc]FASTAAdd to basket

Also known as: Hematopoietic signal peptide-containing secreted protein 1, HSS1

The sequence of this isoform differs from the canonical sequence as follows:
     228-262: MYIIPVVLFLMMSGAPDTGGQGGGGGGGGGGGSGR → HIILGGAVLLTALRPAAPGPAPPPQEA

Show »
Length:254
Mass (Da):26,806
Checksum:i8D5D4A2AD42344BA
GO

Sequence cautioni

The sequence AAQ89073.1 differs from that shown.Intron retention at the C-terminus.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti63 – 631D → G in AAO23975 (PubMed:15163304).Curated
Sequence conflicti245 – 2451T → A in AAH32948 (PubMed:15489334).Curated
Sequence conflicti245 – 2451T → A in AAH35001 (PubMed:15489334).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei228 – 26235MYIIP…GGSGR → HIILGGAVLLTALRPAAPGP APPPQEA in isoform 2. 3 PublicationsVSP_030473Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY194293 mRNA. Translation: AAO23975.2.
AY761095 mRNA. Translation: AAV30543.1.
AY761097 mRNA. Translation: AAV30545.1.
CH471135 Genomic DNA. Translation: EAW71871.1.
BC032948 mRNA. Translation: AAH32948.1.
BC035001 mRNA. Translation: AAH35001.1.
AY358710 mRNA. Translation: AAQ89073.1. Sequence problems.
AL512761 mRNA. Translation: CAH10658.1.
CCDSiCCDS12796.1. [Q5UCC4-1]
CCDS42594.1. [Q5UCC4-2]
RefSeqiNP_778233.4. NM_175063.5. [Q5UCC4-2]
NP_996261.1. NM_206538.3. [Q5UCC4-1]
UniGeneiHs.448941.
Hs.515550.

Genome annotation databases

EnsembliENST00000334976; ENSP00000334037; ENSG00000161671. [Q5UCC4-1]
ENST00000376918; ENSP00000366117; ENSG00000161671. [Q5UCC4-2]
GeneIDi284361.
KEGGihsa:284361.
UCSCiuc002psk.5. human. [Q5UCC4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY194293 mRNA. Translation: AAO23975.2.
AY761095 mRNA. Translation: AAV30543.1.
AY761097 mRNA. Translation: AAV30545.1.
CH471135 Genomic DNA. Translation: EAW71871.1.
BC032948 mRNA. Translation: AAH32948.1.
BC035001 mRNA. Translation: AAH35001.1.
AY358710 mRNA. Translation: AAQ89073.1. Sequence problems.
AL512761 mRNA. Translation: CAH10658.1.
CCDSiCCDS12796.1. [Q5UCC4-1]
CCDS42594.1. [Q5UCC4-2]
RefSeqiNP_778233.4. NM_175063.5. [Q5UCC4-2]
NP_996261.1. NM_206538.3. [Q5UCC4-1]
UniGeneiHs.448941.
Hs.515550.

3D structure databases

ProteinModelPortaliQ5UCC4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129844. 17 interactions.
IntActiQ5UCC4. 6 interactions.
STRINGi9606.ENSP00000334037.

PTM databases

iPTMnetiQ5UCC4.
PhosphoSiteiQ5UCC4.

Polymorphism and mutation databases

DMDMi74708213.

Proteomic databases

EPDiQ5UCC4.
MaxQBiQ5UCC4.
PaxDbiQ5UCC4.
PRIDEiQ5UCC4.
TopDownProteomicsiQ5UCC4-1. [Q5UCC4-1]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000334976; ENSP00000334037; ENSG00000161671. [Q5UCC4-1]
ENST00000376918; ENSP00000366117; ENSG00000161671. [Q5UCC4-2]
GeneIDi284361.
KEGGihsa:284361.
UCSCiuc002psk.5. human. [Q5UCC4-1]

Organism-specific databases

CTDi284361.
GeneCardsiEMC10.
HGNCiHGNC:27609. EMC10.
HPAiHPA053905.
HPA062723.
MIMi614545. gene.
neXtProtiNX_Q5UCC4.
PharmGKBiPA162378790.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4827. Eukaryota.
ENOG4111PEN. LUCA.
GeneTreeiENSGT00390000004520.
HOGENOMiHOG000111998.
InParanoidiQ5UCC4.
OMAiCALAKSQ.
PhylomeDBiQ5UCC4.
TreeFamiTF314052.

Miscellaneous databases

GenomeRNAii284361.
NextBioi94781.
PROiQ5UCC4.
SOURCEiSearch...

Gene expression databases

BgeeiQ5UCC4.
CleanExiHS_C19orf63.
ExpressionAtlasiQ5UCC4. baseline and differential.
GenevisibleiQ5UCC4. HS.

Family and domain databases

InterProiIPR029615. Emc10.
[Graphical view]
PANTHERiPTHR21397:SF4. PTHR21397:SF4. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Gene expression profiling in human insulinoma tissue: genes involved in the insulin secretion pathway and cloning of novel full-length cDNAs."
    Wang X.-C., Xu S.-Y., Wu X.-Y., Song H.-D., Mao Y.-F., Fan H.-Y., Yu F., Mou B., Gu Y.-Y., Xu L.-Q., Zhou X.-O., Chen Z., Chen J.-L., Hu R.-M.
    Endocr. Relat. Cancer 11:295-303(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    Tissue: Insulinoma.
  2. "hHSS1: a novel secreted factor and suppressor of glioma growth located at chromosome 19q13.33."
    Junes-Gill K.S., Gallaher T.K., Gluzman-Poltorak Z., Miller J.D., Wheeler C.J., Fan X., Basile L.A.
    J. Neurooncol. 102:197-211(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), GLYCOSYLATION, SUBCELLULAR LOCATION (ISOFORM 1), TISSUE SPECIFICITY.
    Tissue: Testis.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-261 (ISOFORM 1).
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 140-262 (ISOFORM 2).
    Tissue: Testis.
  7. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
    Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
    J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-182.
    Tissue: Liver.
  8. "Molecular cloning of a novel secreted peptide, INM02, and regulation of its expression by glucose."
    Wang X., Gong W., Liu Y., Yang Z., Zhou W., Wang M., Yang Z., Wen J., Hu R.
    J. Endocrinol. 202:355-364(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, SUBCELLULAR LOCATION (ISOFORM 2).
  9. Cited for: IDENTIFICATION IN THE EMC COMPLEX, SUBCELLULAR LOCATION (ISOFORM 1).
  10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiEMC10_HUMAN
AccessioniPrimary (citable) accession number: Q5UCC4
Secondary accession number(s): Q5UCC6
, Q69YT5, Q6UWP3, Q86YL4, Q8N541
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: December 7, 2004
Last modified: April 13, 2016
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
  4. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.