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Q5UBV8 (TNF15_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 53. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tumor necrosis factor ligand superfamily member 15
Alternative name(s):
TNF ligand-related molecule 1
Vascular endothelial cell growth inhibitor
Gene names
Name:Tnfsf15
Synonyms:Tl1, Vegi
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length252 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Receptor for TNFRSF25 and TNFRSF6B. Mediates activation of NF-kappa-B. Inhibits vascular endothelial growth and angiogenesis (in vitro). Promotes activation of caspases and apoptosis By similarity. Promotes splenocyte alloactivation. Ref.1

Subunit structure

Homotrimer By similarity.

Subcellular location

Membrane; Single-pass type II membrane protein Probable.

Induction

Up-regulated by TNF-alpha. Ref.2

Sequence similarities

Belongs to the tumor necrosis factor family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 252252Tumor necrosis factor ligand superfamily member 15
PRO_0000333232

Regions

Topological domain1 – 3939Cytoplasmic Potential
Transmembrane40 – 6021Helical; Signal-anchor for type II membrane protein; Potential
Topological domain61 – 252192Extracellular Potential

Sites

Site1881Important for binding TNFRSF6B By similarity
Site1911Important for binding TNFRSF6B By similarity

Amino acid modifications

Glycosylation1371N-linked (GlcNAc...) Potential
Glycosylation2301N-linked (GlcNAc...) Potential
Disulfide bond163 ↔ 203 By similarity

Experimental info

Sequence conflict1801V → M in AAV33431. Ref.2
Sequence conflict1801V → M in AAH96494. Ref.3
Sequence conflict2181M → T in AAV33431. Ref.2
Sequence conflict2181M → T in AAH96494. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Q5UBV8 [UniParc].

Last modified May 20, 2008. Version 2.
Checksum: BB901C9350119E0F

FASTA25227,723
        10         20         30         40         50         60 
MAEELGLGFG EGVPVEVLPE GCRHRPEARA GLAARSKACL ALTCCLLSFP ILAGLSTLLM 

        70         80         90        100        110        120 
AGQLRVPGKD CMLRAITEER SEPSPQQVYS PPRGKPRAHL TIKKQTPAPH LKNQLSALHW 

       130        140        150        160        170        180 
EHDLGMAFTK NGMKYINKSL VIPESGDYFI YSQITFRGTT SVCGDISRGR RPNKPDSITV 

       190        200        210        220        230        240 
VITKVADSYP EPARLLTGSK SVCEISNNWF QSLYLGAMFS LEEGDRLMVN VSDISLVDYT 

       250 
KEDKTFFGAF LL 

« Hide

References

« Hide 'large scale' references
[1]"TL1A is a TNF-like ligand for DR3 and TR6/DcR3 and functions as a T cell costimulator."
Migone T.-S., Zhang J., Luo X., Zhuang L., Chen C., Hu B., Hong J.S., Perry J.W., Chen S.-F., Zhou J.X.H., Cho Y.H., Ullrich S., Kanakaraj P., Carrell J., Boyd E., Olsen H.S., Hu G., Pukac L. expand/collapse author list , Liu D., Ni J., Kim S., Gentz R., Feng P., Moore P.A., Ruben S.M., Wei P.
Immunity 16:479-492(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
Strain: BALB/c.
Tissue: Kidney.
[2]"Characterization of cis-regulatory elements of the vascular endothelial growth inhibitor gene promoter."
Xiao Q., Hsu C.Y., Chen H., Ma X., Xu J., Lee J.-M.
Biochem. J. 388:913-920(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], INDUCTION.
Strain: C57BL/6.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C3H/He.
Tissue: Osteoblast.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF520786 mRNA. Translation: AAM77367.1.
AY764130 mRNA. Translation: AAV33431.1.
BC096494 mRNA. Translation: AAH96494.1.
RefSeqNP_796345.3. NM_177371.3.
UniGeneMm.208152.

3D structure databases

ProteinModelPortalQ5UBV8.
SMRQ5UBV8. Positions 95-252.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000050144.

Proteomic databases

PRIDEQ5UBV8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID326623.
KEGGmmu:326623.

Organism-specific databases

CTD9966.
MGIMGI:2180140. Tnfsf15.

Phylogenomic databases

eggNOGNOG40368.
HOGENOMHOG000060140.
HOVERGENHBG067254.
InParanoidQ5UBV8.
KOK05478.
PhylomeDBQ5UBV8.

Gene expression databases

GenevestigatorQ5UBV8.

Family and domain databases

Gene3D2.60.120.40. 1 hit.
InterProIPR006053. TNF.
IPR006052. TNF_dom.
IPR008064. TNFSF15.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view]
PANTHERPTHR11471:SF24. PTHR11471:SF24. 1 hit.
PfamPF00229. TNF. 1 hit.
[Graphical view]
PRINTSPR01234. TNECROSISFCT.
SMARTSM00207. TNF. 1 hit.
[Graphical view]
SUPFAMSSF49842. SSF49842. 1 hit.
PROSITEPS50049. TNF_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio397918.
PROQ5UBV8.
SOURCESearch...

Entry information

Entry nameTNF15_MOUSE
AccessionPrimary (citable) accession number: Q5UBV8
Secondary accession number(s): Q8K3Y8
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 20, 2008
Last modified: June 11, 2014
This is version 53 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot