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Protein

Tumor necrosis factor ligand superfamily member 15

Gene

Tnfsf15

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for TNFRSF25 and TNFRSF6B. Mediates activation of NF-kappa-B. Inhibits vascular endothelial growth and angiogenesis (in vitro). Promotes activation of caspases and apoptosis (By similarity). Promotes splenocyte alloactivation.By similarity1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei188Important for binding TNFRSF6BBy similarity1
Sitei191Important for binding TNFRSF6BBy similarity1

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor necrosis factor ligand superfamily member 15
Alternative name(s):
TNF ligand-related molecule 1
Vascular endothelial cell growth inhibitor
Gene namesi
Name:Tnfsf15
Synonyms:Tl1, Vegi
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:2180140. Tnfsf15.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 39CytoplasmicSequence analysisAdd BLAST39
Transmembranei40 – 60Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini61 – 252ExtracellularSequence analysisAdd BLAST192

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003332321 – 252Tumor necrosis factor ligand superfamily member 15Add BLAST252

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi137N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi163 ↔ 203By similarity
Glycosylationi230N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ5UBV8.
PRIDEiQ5UBV8.

Expressioni

Inductioni

Up-regulated by TNF-alpha.1 Publication

Interactioni

Subunit structurei

Homotrimer.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000050144.

Structurei

3D structure databases

ProteinModelPortaliQ5UBV8.
SMRiQ5UBV8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tumor necrosis factor family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFSK. Eukaryota.
ENOG4111Y6F. LUCA.
HOGENOMiHOG000060140.
HOVERGENiHBG067254.
InParanoidiQ5UBV8.
KOiK05478.
PhylomeDBiQ5UBV8.

Family and domain databases

Gene3Di2.60.120.40. 1 hit.
InterProiIPR006053. TNF.
IPR006052. TNF_dom.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view]
PfamiPF00229. TNF. 1 hit.
[Graphical view]
PRINTSiPR01234. TNECROSISFCT.
SMARTiSM00207. TNF. 1 hit.
[Graphical view]
SUPFAMiSSF49842. SSF49842. 1 hit.
PROSITEiPS50049. TNF_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5UBV8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEELGLGFG EGVPVEVLPE GCRHRPEARA GLAARSKACL ALTCCLLSFP
60 70 80 90 100
ILAGLSTLLM AGQLRVPGKD CMLRAITEER SEPSPQQVYS PPRGKPRAHL
110 120 130 140 150
TIKKQTPAPH LKNQLSALHW EHDLGMAFTK NGMKYINKSL VIPESGDYFI
160 170 180 190 200
YSQITFRGTT SVCGDISRGR RPNKPDSITV VITKVADSYP EPARLLTGSK
210 220 230 240 250
SVCEISNNWF QSLYLGAMFS LEEGDRLMVN VSDISLVDYT KEDKTFFGAF

LL
Length:252
Mass (Da):27,723
Last modified:May 20, 2008 - v2
Checksum:iBB901C9350119E0F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti180V → M in AAV33431 (PubMed:15702971).Curated1
Sequence conflicti180V → M in AAH96494 (PubMed:15489334).Curated1
Sequence conflicti218M → T in AAV33431 (PubMed:15702971).Curated1
Sequence conflicti218M → T in AAH96494 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF520786 mRNA. Translation: AAM77367.1.
AY764130 mRNA. Translation: AAV33431.1.
BC096494 mRNA. Translation: AAH96494.1.
RefSeqiNP_796345.3. NM_177371.3.
UniGeneiMm.208152.

Genome annotation databases

GeneIDi326623.
KEGGimmu:326623.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF520786 mRNA. Translation: AAM77367.1.
AY764130 mRNA. Translation: AAV33431.1.
BC096494 mRNA. Translation: AAH96494.1.
RefSeqiNP_796345.3. NM_177371.3.
UniGeneiMm.208152.

3D structure databases

ProteinModelPortaliQ5UBV8.
SMRiQ5UBV8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000050144.

Proteomic databases

PaxDbiQ5UBV8.
PRIDEiQ5UBV8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi326623.
KEGGimmu:326623.

Organism-specific databases

CTDi9966.
MGIiMGI:2180140. Tnfsf15.

Phylogenomic databases

eggNOGiENOG410IFSK. Eukaryota.
ENOG4111Y6F. LUCA.
HOGENOMiHOG000060140.
HOVERGENiHBG067254.
InParanoidiQ5UBV8.
KOiK05478.
PhylomeDBiQ5UBV8.

Miscellaneous databases

PROiQ5UBV8.
SOURCEiSearch...

Family and domain databases

Gene3Di2.60.120.40. 1 hit.
InterProiIPR006053. TNF.
IPR006052. TNF_dom.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view]
PfamiPF00229. TNF. 1 hit.
[Graphical view]
PRINTSiPR01234. TNECROSISFCT.
SMARTiSM00207. TNF. 1 hit.
[Graphical view]
SUPFAMiSSF49842. SSF49842. 1 hit.
PROSITEiPS50049. TNF_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTNF15_MOUSE
AccessioniPrimary (citable) accession number: Q5UBV8
Secondary accession number(s): Q8K3Y8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 20, 2008
Last modified: November 2, 2016
This is version 62 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.