Q5UBV8 (TNF15_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Tumor necrosis factor ligand superfamily member 15

Alternative name(s):
TNF ligand-related molecule 1
Vascular endothelial cell growth inhibitor

Gene names

Name:	Tnfsf15
Synonyms:	Tl1, Vegi

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	252 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Receptor for TNFRSF25 and TNFRSF6B. Mediates activation of NF-kappa-B. Inhibits vascular endothelial growth and angiogenesis (in vitro). Promotes activation of caspases and apoptosis By similarity. Promotes splenocyte alloactivation. Ref.1
Subunit structure	Homotrimer By similarity.
Subcellular location	Membrane; Single-pass type II membrane protein Probable.
Induction	Up-regulated by TNF-alpha. Ref.2
Sequence similarities	Belongs to the tumor necrosis factor family.

Ontologies

Keywords
Cellular component	Membrane
Domain	Signal-anchor Transmembrane Transmembrane helix
Molecular function	Cytokine
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	activation of NF-kappaB-inducing kinase activity Inferred from sequence orthology Ref.1. Source: MGI activation of cysteine-type endopeptidase activity involved in apoptotic process Inferred from sequence orthology Ref.1. Source: MGI cytokine metabolic process Inferred from sequence orthology Ref.1. Source: MGI immune response Inferred from electronic annotation. Source: InterPro
Cellular_component	extracellular space Inferred from electronic annotation. Source: UniProtKB-KW integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from sequence orthology Ref.1. Source: MGI
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 252	252	Tumor necrosis factor ligand superfamily member 15		PRO_0000333232
Regions
	Topological domain	1 – 39	39	Cytoplasmic Potential
	Transmembrane	40 – 60	21	Helical; Signal-anchor for type II membrane protein; Potential
	Topological domain	61 – 252	192	Extracellular Potential
Sites
	Site	188	1	Important for binding TNFRSF6B By similarity
	Site	191	1	Important for binding TNFRSF6B By similarity
Amino acid modifications
	Glycosylation	137	1	N-linked (GlcNAc...) Potential
	Glycosylation	230	1	N-linked (GlcNAc...) Potential
	Disulfide bond	163 ↔ 203		By similarity
Experimental info
	Sequence conflict	180	1	V → M in AAV33431. Ref.2
	Sequence conflict	180	1	V → M in AAH96494. Ref.3
	Sequence conflict	218	1	M → T in AAV33431. Ref.2
	Sequence conflict	218	1	M → T in AAH96494. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Q5UBV8 [UniParc]. Last modified May 20, 2008. Version 2. Checksum: BB901C9350119E0F	FASTA	252	27,723
	10 20 30 40 50 60 MAEELGLGFG EGVPVEVLPE GCRHRPEARA GLAARSKACL ALTCCLLSFP ILAGLSTLLM 70 80 90 100 110 120 AGQLRVPGKD CMLRAITEER SEPSPQQVYS PPRGKPRAHL TIKKQTPAPH LKNQLSALHW 130 140 150 160 170 180 EHDLGMAFTK NGMKYINKSL VIPESGDYFI YSQITFRGTT SVCGDISRGR RPNKPDSITV 190 200 210 220 230 240 VITKVADSYP EPARLLTGSK SVCEISNNWF QSLYLGAMFS LEEGDRLMVN VSDISLVDYT 250 KEDKTFFGAF LL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"TL1A is a TNF-like ligand for DR3 and TR6/DcR3 and functions as a T cell costimulator." Migone T.-S., Zhang J., Luo X., Zhuang L., Chen C., Hu B., Hong J.S., Perry J.W., Chen S.-F., Zhou J.X.H., Cho Y.H., Ullrich S., Kanakaraj P., Carrell J., Boyd E., Olsen H.S., Hu G., Pukac L. , Liu D., Ni J., Kim S., Gentz R., Feng P., Moore P.A., Ruben S.M., Wei P. Immunity 16:479-492(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION. Strain: BALB/c. Tissue: Kidney.
[2]	"Characterization of cis-regulatory elements of the vascular endothelial growth inhibitor gene promoter." Xiao Q., Hsu C.Y., Chen H., Ma X., Xu J., Lee J.-M. Biochem. J. 388:913-920(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], INDUCTION. Strain: C57BL/6.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C3H/He. Tissue: Osteoblast.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF520786 mRNA. Translation: AAM77367.1. AY764130 mRNA. Translation: AAV33431.1. BC096494 mRNA. Translation: AAH96494.1.
IPI	IPI00990091.
RefSeq	NP_796345.3. NM_177371.3.
UniGene	Mm.208152.
3D structure databases
ProteinModelPortal	Q5UBV8.
SMR	Q5UBV8. Positions 95-252.
ModBase	Search...
Proteomic databases
PRIDE	Q5UBV8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	326623.
KEGG	mmu:326623.
Organism-specific databases
CTD	9966.
MGI	MGI:2180140. Tnfsf15.
Phylogenomic databases
eggNOG	NOG40368.
HOGENOM	HOG000060140.
HOVERGEN	HBG067254.
InParanoid	Q5UBV8.
KO	K05478.
OrthoDB	EOG4P5K9X.
Gene expression databases
Genevestigator	Q5UBV8.
Family and domain databases
Gene3D	2.60.120.40. 1 hit.
InterPro	IPR006052. TNF. IPR006053. TNF_a/b/c. IPR008983. Tumour_necrosis_fac-like_dom. [Graphical view]
Pfam	PF00229. TNF. 1 hit. [Graphical view]
PRINTS	PR01234. TNECROSISFCT.
SMART	SM00207. TNF. 1 hit. [Graphical view]
SUPFAM	SSF49842. TNF_like. 1 hit.
PROSITE	PS50049. TNF_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	397918.
SOURCE	Search...

Entry information

Entry name

TNF15_MOUSE

Accession

Primary (citable) accession number: Q5UBV8
Secondary accession number(s): Q8K3Y8

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	May 20, 2008
Last modified:	April 3, 2013
This is version 45 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program