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Q5UBV8

- TNF15_MOUSE

UniProt

Q5UBV8 - TNF15_MOUSE

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Protein
Tumor necrosis factor ligand superfamily member 15
Gene
Tnfsf15, Tl1, Vegi
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Receptor for TNFRSF25 and TNFRSF6B. Mediates activation of NF-kappa-B. Inhibits vascular endothelial growth and angiogenesis (in vitro). Promotes activation of caspases and apoptosis By similarity. Promotes splenocyte alloactivation.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei188 – 1881Important for binding TNFRSF6B By similarity
Sitei191 – 1911Important for binding TNFRSF6B By similarity

GO - Biological processi

  1. activation of NF-kappaB-inducing kinase activity Source: MGI
  2. activation of cysteine-type endopeptidase activity involved in apoptotic process Source: MGI
  3. cytokine metabolic process Source: MGI
  4. immune response Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor necrosis factor ligand superfamily member 15
Alternative name(s):
TNF ligand-related molecule 1
Vascular endothelial cell growth inhibitor
Gene namesi
Name:Tnfsf15
Synonyms:Tl1, Vegi
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:2180140. Tnfsf15.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3939Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei40 – 6021Helical; Signal-anchor for type II membrane protein; Reviewed prediction
Add
BLAST
Topological domaini61 – 252192Extracellular Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. extracellular space Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
  3. plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 252252Tumor necrosis factor ligand superfamily member 15
PRO_0000333232Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi137 – 1371N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi163 ↔ 203 By similarity
Glycosylationi230 – 2301N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ5UBV8.

Expressioni

Inductioni

Up-regulated by TNF-alpha.1 Publication

Gene expression databases

GenevestigatoriQ5UBV8.

Interactioni

Subunit structurei

Homotrimer By similarity.

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000050144.

Structurei

3D structure databases

ProteinModelPortaliQ5UBV8.
SMRiQ5UBV8. Positions 95-252.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG40368.
HOGENOMiHOG000060140.
HOVERGENiHBG067254.
InParanoidiQ5UBV8.
KOiK05478.
PhylomeDBiQ5UBV8.

Family and domain databases

Gene3Di2.60.120.40. 1 hit.
InterProiIPR006053. TNF.
IPR006052. TNF_dom.
IPR008064. TNFSF15.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view]
PANTHERiPTHR11471:SF24. PTHR11471:SF24. 1 hit.
PfamiPF00229. TNF. 1 hit.
[Graphical view]
PRINTSiPR01234. TNECROSISFCT.
SMARTiSM00207. TNF. 1 hit.
[Graphical view]
SUPFAMiSSF49842. SSF49842. 1 hit.
PROSITEiPS50049. TNF_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5UBV8-1 [UniParc]FASTAAdd to Basket

« Hide

MAEELGLGFG EGVPVEVLPE GCRHRPEARA GLAARSKACL ALTCCLLSFP    50
ILAGLSTLLM AGQLRVPGKD CMLRAITEER SEPSPQQVYS PPRGKPRAHL 100
TIKKQTPAPH LKNQLSALHW EHDLGMAFTK NGMKYINKSL VIPESGDYFI 150
YSQITFRGTT SVCGDISRGR RPNKPDSITV VITKVADSYP EPARLLTGSK 200
SVCEISNNWF QSLYLGAMFS LEEGDRLMVN VSDISLVDYT KEDKTFFGAF 250
LL 252
Length:252
Mass (Da):27,723
Last modified:May 20, 2008 - v2
Checksum:iBB901C9350119E0F
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti180 – 1801V → M in AAV33431. 1 Publication
Sequence conflicti180 – 1801V → M in AAH96494. 1 Publication
Sequence conflicti218 – 2181M → T in AAV33431. 1 Publication
Sequence conflicti218 – 2181M → T in AAH96494. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF520786 mRNA. Translation: AAM77367.1.
AY764130 mRNA. Translation: AAV33431.1.
BC096494 mRNA. Translation: AAH96494.1.
RefSeqiNP_796345.3. NM_177371.3.
UniGeneiMm.208152.

Genome annotation databases

GeneIDi326623.
KEGGimmu:326623.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF520786 mRNA. Translation: AAM77367.1 .
AY764130 mRNA. Translation: AAV33431.1 .
BC096494 mRNA. Translation: AAH96494.1 .
RefSeqi NP_796345.3. NM_177371.3.
UniGenei Mm.208152.

3D structure databases

ProteinModelPortali Q5UBV8.
SMRi Q5UBV8. Positions 95-252.
ModBasei Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000050144.

Proteomic databases

PRIDEi Q5UBV8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 326623.
KEGGi mmu:326623.

Organism-specific databases

CTDi 9966.
MGIi MGI:2180140. Tnfsf15.

Phylogenomic databases

eggNOGi NOG40368.
HOGENOMi HOG000060140.
HOVERGENi HBG067254.
InParanoidi Q5UBV8.
KOi K05478.
PhylomeDBi Q5UBV8.

Miscellaneous databases

NextBioi 397918.
PROi Q5UBV8.
SOURCEi Search...

Gene expression databases

Genevestigatori Q5UBV8.

Family and domain databases

Gene3Di 2.60.120.40. 1 hit.
InterProi IPR006053. TNF.
IPR006052. TNF_dom.
IPR008064. TNFSF15.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view ]
PANTHERi PTHR11471:SF24. PTHR11471:SF24. 1 hit.
Pfami PF00229. TNF. 1 hit.
[Graphical view ]
PRINTSi PR01234. TNECROSISFCT.
SMARTi SM00207. TNF. 1 hit.
[Graphical view ]
SUPFAMi SSF49842. SSF49842. 1 hit.
PROSITEi PS50049. TNF_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
    Strain: BALB/c.
    Tissue: Kidney.
  2. "Characterization of cis-regulatory elements of the vascular endothelial growth inhibitor gene promoter."
    Xiao Q., Hsu C.Y., Chen H., Ma X., Xu J., Lee J.-M.
    Biochem. J. 388:913-920(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], INDUCTION.
    Strain: C57BL/6.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C3H/He.
    Tissue: Osteoblast.

Entry informationi

Entry nameiTNF15_MOUSE
AccessioniPrimary (citable) accession number: Q5UBV8
Secondary accession number(s): Q8K3Y8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 20, 2008
Last modified: June 11, 2014
This is version 53 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi