Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q5UBV8

- TNF15_MOUSE

UniProt

Q5UBV8 - TNF15_MOUSE

Protein

Tumor necrosis factor ligand superfamily member 15

Gene

Tnfsf15

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 54 (01 Oct 2014)
      Sequence version 2 (20 May 2008)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Receptor for TNFRSF25 and TNFRSF6B. Mediates activation of NF-kappa-B. Inhibits vascular endothelial growth and angiogenesis (in vitro). Promotes activation of caspases and apoptosis By similarity. Promotes splenocyte alloactivation.By similarity1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei188 – 1881Important for binding TNFRSF6BBy similarity
    Sitei191 – 1911Important for binding TNFRSF6BBy similarity

    GO - Biological processi

    1. activation of cysteine-type endopeptidase activity involved in apoptotic process Source: MGI
    2. activation of NF-kappaB-inducing kinase activity Source: MGI
    3. cytokine metabolic process Source: MGI
    4. immune response Source: InterPro

    Keywords - Molecular functioni

    Cytokine

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tumor necrosis factor ligand superfamily member 15
    Alternative name(s):
    TNF ligand-related molecule 1
    Vascular endothelial cell growth inhibitor
    Gene namesi
    Name:Tnfsf15
    Synonyms:Tl1, Vegi
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Unplaced

    Organism-specific databases

    MGIiMGI:2180140. Tnfsf15.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: UniProtKB-KW
    2. integral component of membrane Source: UniProtKB-KW
    3. plasma membrane Source: MGI

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 252252Tumor necrosis factor ligand superfamily member 15PRO_0000333232Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi137 – 1371N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi163 ↔ 203By similarity
    Glycosylationi230 – 2301N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiQ5UBV8.

    Expressioni

    Inductioni

    Up-regulated by TNF-alpha.1 Publication

    Gene expression databases

    GenevestigatoriQ5UBV8.

    Interactioni

    Subunit structurei

    Homotrimer.By similarity

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000050144.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5UBV8.
    SMRiQ5UBV8. Positions 95-252.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3939CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini61 – 252192ExtracellularSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei40 – 6021Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the tumor necrosis factor family.Curated

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG40368.
    HOGENOMiHOG000060140.
    HOVERGENiHBG067254.
    InParanoidiQ5UBV8.
    KOiK05478.
    PhylomeDBiQ5UBV8.

    Family and domain databases

    Gene3Di2.60.120.40. 1 hit.
    InterProiIPR006053. TNF.
    IPR006052. TNF_dom.
    IPR008064. TNFSF15.
    IPR008983. Tumour_necrosis_fac-like_dom.
    [Graphical view]
    PANTHERiPTHR11471:SF24. PTHR11471:SF24. 1 hit.
    PfamiPF00229. TNF. 1 hit.
    [Graphical view]
    PRINTSiPR01234. TNECROSISFCT.
    SMARTiSM00207. TNF. 1 hit.
    [Graphical view]
    SUPFAMiSSF49842. SSF49842. 1 hit.
    PROSITEiPS50049. TNF_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5UBV8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAEELGLGFG EGVPVEVLPE GCRHRPEARA GLAARSKACL ALTCCLLSFP    50
    ILAGLSTLLM AGQLRVPGKD CMLRAITEER SEPSPQQVYS PPRGKPRAHL 100
    TIKKQTPAPH LKNQLSALHW EHDLGMAFTK NGMKYINKSL VIPESGDYFI 150
    YSQITFRGTT SVCGDISRGR RPNKPDSITV VITKVADSYP EPARLLTGSK 200
    SVCEISNNWF QSLYLGAMFS LEEGDRLMVN VSDISLVDYT KEDKTFFGAF 250
    LL 252
    Length:252
    Mass (Da):27,723
    Last modified:May 20, 2008 - v2
    Checksum:iBB901C9350119E0F
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti180 – 1801V → M in AAV33431. (PubMed:15702971)Curated
    Sequence conflicti180 – 1801V → M in AAH96494. (PubMed:15489334)Curated
    Sequence conflicti218 – 2181M → T in AAV33431. (PubMed:15702971)Curated
    Sequence conflicti218 – 2181M → T in AAH96494. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF520786 mRNA. Translation: AAM77367.1.
    AY764130 mRNA. Translation: AAV33431.1.
    BC096494 mRNA. Translation: AAH96494.1.
    RefSeqiNP_796345.3. NM_177371.3.
    UniGeneiMm.208152.

    Genome annotation databases

    GeneIDi326623.
    KEGGimmu:326623.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF520786 mRNA. Translation: AAM77367.1 .
    AY764130 mRNA. Translation: AAV33431.1 .
    BC096494 mRNA. Translation: AAH96494.1 .
    RefSeqi NP_796345.3. NM_177371.3.
    UniGenei Mm.208152.

    3D structure databases

    ProteinModelPortali Q5UBV8.
    SMRi Q5UBV8. Positions 95-252.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000050144.

    Proteomic databases

    PRIDEi Q5UBV8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 326623.
    KEGGi mmu:326623.

    Organism-specific databases

    CTDi 9966.
    MGIi MGI:2180140. Tnfsf15.

    Phylogenomic databases

    eggNOGi NOG40368.
    HOGENOMi HOG000060140.
    HOVERGENi HBG067254.
    InParanoidi Q5UBV8.
    KOi K05478.
    PhylomeDBi Q5UBV8.

    Miscellaneous databases

    NextBioi 397918.
    PROi Q5UBV8.
    SOURCEi Search...

    Gene expression databases

    Genevestigatori Q5UBV8.

    Family and domain databases

    Gene3Di 2.60.120.40. 1 hit.
    InterProi IPR006053. TNF.
    IPR006052. TNF_dom.
    IPR008064. TNFSF15.
    IPR008983. Tumour_necrosis_fac-like_dom.
    [Graphical view ]
    PANTHERi PTHR11471:SF24. PTHR11471:SF24. 1 hit.
    Pfami PF00229. TNF. 1 hit.
    [Graphical view ]
    PRINTSi PR01234. TNECROSISFCT.
    SMARTi SM00207. TNF. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49842. SSF49842. 1 hit.
    PROSITEi PS50049. TNF_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
      Strain: BALB/c.
      Tissue: Kidney.
    2. "Characterization of cis-regulatory elements of the vascular endothelial growth inhibitor gene promoter."
      Xiao Q., Hsu C.Y., Chen H., Ma X., Xu J., Lee J.-M.
      Biochem. J. 388:913-920(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], INDUCTION.
      Strain: C57BL/6.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C3H/He.
      Tissue: Osteoblast.

    Entry informationi

    Entry nameiTNF15_MOUSE
    AccessioniPrimary (citable) accession number: Q5UBV8
    Secondary accession number(s): Q8K3Y8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: May 20, 2008
    Last modified: October 1, 2014
    This is version 54 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3