Q5UAW9 (GP157_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable G-protein coupled receptor 157

Gene names

Name:

GPR157

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	335 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Orphan receptor.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the G-protein coupled receptor 2 family.
Sequence caution	The sequence BAB13982.1 differs from that shown. Reason: Intron retention.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	G-protein coupled receptor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 335	335	Probable G-protein coupled receptor 157		PRO_0000070339
Regions
	Topological domain	1 – 15	15	Extracellular Potential
	Transmembrane	16 – 36	21	Helical; Name=1; Potential
	Topological domain	37 – 48	12	Cytoplasmic Potential
	Transmembrane	49 – 69	21	Helical; Name=2; Potential
	Topological domain	70 – 87	18	Extracellular Potential
	Transmembrane	88 – 108	21	Helical; Name=3; Potential
	Topological domain	109 – 119	11	Cytoplasmic Potential
	Transmembrane	120 – 140	21	Helical; Name=4; Potential
	Topological domain	141 – 166	26	Extracellular Potential
	Transmembrane	167 – 187	21	Helical; Name=5; Potential
	Topological domain	188 – 226	39	Cytoplasmic Potential
	Transmembrane	227 – 247	21	Helical; Name=6; Potential
	Topological domain	248 – 258	11	Extracellular Potential
	Transmembrane	259 – 279	21	Helical; Name=7; Potential
	Topological domain	280 – 335	56	Cytoplasmic Potential
	Compositional bias	294 – 298	5	Poly-Cys
Experimental info
	Sequence conflict	71	1	N → D in BAB13982. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Q5UAW9 [UniParc]. Last modified August 16, 2005. Version 2. Checksum: C779B2D16C6D560C	FASTA	335	36,623
	10 20 30 40 50 60 MQPSPPPTEL VPSERAVVLL SCALSALGSG LLVATHALWP DLRSRARRLL LFLSLADLLS 70 80 90 100 110 120 AASYFYGVLQ NFAGPSWDCV LQGALSTFAN TSSFFWTVAI ALYLYLSIVR AARGPRTDRL 130 140 150 160 170 180 LWAFHVVSWG VPLVITVAAV ALKKIGYDAS DVSVGWCWID LEAKDHVLWM LLTGKLWEML 190 200 210 220 230 240 AYVLLPLLYL LVRKHINRAH TALSEYRPIL SQEHRLLRHS SMADKKLVLI PLIFIGLRVW 250 260 270 280 290 300 STVRFVLTLC GSPAVQTPVL VVLHGIGNTF QGGANCIMFV LCTRAVRTRL FSLCCCCCSS 310 320 330 QPPTKSPAGT PKAPAPSKPG ESQESQGTPG ELPST

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete coding sequence of GPR157." Bonner T.I., Kauffman D., Nagle J.W. Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Placenta and Prostate.
[2]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-127. Tissue: Mammary gland.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY768808 mRNA. Translation: AAV35060.1. AL158048 Genomic DNA. Translation: CAM12842.1. AK022194 mRNA. Translation: BAB13982.1. Sequence problems.
IPI	IPI00478934.
RefSeq	NP_079256.4. NM_024980.4.
UniGene	Hs.632367.
3D structure databases
ProteinModelPortal	Q5UAW9.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000366628.
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	Q5UAW9.
Polymorphism databases
DMDM	73621015.
Proteomic databases
PaxDb	Q5UAW9.
PRIDE	Q5UAW9.
Protocols and materials databases
DNASU	80045.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000377411; ENSP00000366628; ENSG00000180758.
GeneID	80045.
KEGG	hsa:80045.
UCSC	uc001apq.1. human.
Organism-specific databases
CTD	80045.
GeneCards	GC01M009162.
HGNC	HGNC:23687. GPR157.
HPA	HPA028697.
neXtProt	NX_Q5UAW9.
PharmGKB	PA134876230.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG81075.
HOGENOM	HOG000070448.
HOVERGEN	HBG055714.
InParanoid	Q5UAW9.
KO	K08467.
OMA	QGAANCI.
OrthoDB	EOG4KPTBK.
Gene expression databases
ArrayExpress	Q5UAW9.
Bgee	Q5UAW9.
CleanEx	HS_GPR157.
Genevestigator	Q5UAW9.
GermOnline	ENSG00000180758. Homo sapiens.
Family and domain databases
InterPro	IPR022343. GCR1-cAMP_receptor. IPR017981. GPCR_2-like. IPR000832. GPCR_2_secretin-like. IPR017452. GPCR_Rhodpsn_7TM. [Graphical view]
Pfam	PF00002. 7tm_2. 1 hit. [Graphical view]
PRINTS	PR02001. GCR1CAMPR.
PROSITE	PS00649. G_PROTEIN_RECEP_F2_1. False negative. PS00650. G_PROTEIN_RECEP_F2_2. False negative. PS50227. G_PROTEIN_RECEP_F2_3. False negative. PS50261. G_PROTEIN_RECEP_F2_4. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	80045.
NextBio	70243.

Entry information

Entry name

GP157_HUMAN

Accession

Primary (citable) accession number: Q5UAW9
Secondary accession number(s): A2A334, Q8WWB8, Q9HA73

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 16, 2005
Last sequence update:	August 16, 2005
Last modified:	May 1, 2013
This is version 85 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.