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Q5UAW9

- GP157_HUMAN

UniProt

Q5UAW9 - GP157_HUMAN

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Protein

Probable G-protein coupled receptor 157

Gene

GPR157

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Orphan receptor.

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Probable G-protein coupled receptor 157
Gene namesi
Name:GPR157
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:23687. GPR157.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1515ExtracellularSequence AnalysisAdd
BLAST
Transmembranei16 – 3621Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini37 – 4812CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei49 – 6921Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini70 – 8718ExtracellularSequence AnalysisAdd
BLAST
Transmembranei88 – 10821Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini109 – 11911CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei120 – 14021Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini141 – 16626ExtracellularSequence AnalysisAdd
BLAST
Transmembranei167 – 18721Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini188 – 22639CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei227 – 24721Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini248 – 25811ExtracellularSequence AnalysisAdd
BLAST
Transmembranei259 – 27921Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini280 – 33556CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134876230.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 335335Probable G-protein coupled receptor 157PRO_0000070339Add
BLAST

Proteomic databases

MaxQBiQ5UAW9.
PaxDbiQ5UAW9.
PRIDEiQ5UAW9.

PTM databases

PhosphoSiteiQ5UAW9.

Expressioni

Gene expression databases

BgeeiQ5UAW9.
CleanExiHS_GPR157.
GenevestigatoriQ5UAW9.

Organism-specific databases

HPAiHPA028697.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000366628.

Structurei

3D structure databases

ProteinModelPortaliQ5UAW9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi294 – 2985Poly-Cys

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG81075.
GeneTreeiENSGT00390000012992.
HOGENOMiHOG000070448.
HOVERGENiHBG055714.
InParanoidiQ5UAW9.
KOiK08467.
OMAiVGWCWIN.
OrthoDBiEOG7KH9KD.
PhylomeDBiQ5UAW9.
TreeFamiTF330856.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR022343. GCR1-cAMP_receptor.
IPR017981. GPCR_2-like.
IPR000832. GPCR_2_secretin-like.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00002. 7tm_2. 1 hit.
[Graphical view]
PRINTSiPR02001. GCR1CAMPR.
PROSITEiPS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5UAW9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQPSPPPTEL VPSERAVVLL SCALSALGSG LLVATHALWP DLRSRARRLL
60 70 80 90 100
LFLSLADLLS AASYFYGVLQ NFAGPSWDCV LQGALSTFAN TSSFFWTVAI
110 120 130 140 150
ALYLYLSIVR AARGPRTDRL LWAFHVVSWG VPLVITVAAV ALKKIGYDAS
160 170 180 190 200
DVSVGWCWID LEAKDHVLWM LLTGKLWEML AYVLLPLLYL LVRKHINRAH
210 220 230 240 250
TALSEYRPIL SQEHRLLRHS SMADKKLVLI PLIFIGLRVW STVRFVLTLC
260 270 280 290 300
GSPAVQTPVL VVLHGIGNTF QGGANCIMFV LCTRAVRTRL FSLCCCCCSS
310 320 330
QPPTKSPAGT PKAPAPSKPG ESQESQGTPG ELPST
Length:335
Mass (Da):36,623
Last modified:August 16, 2005 - v2
Checksum:iC779B2D16C6D560C
GO

Sequence cautioni

The sequence BAB13982.1 differs from that shown. Reason: Intron retention.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti71 – 711N → D in BAB13982. (PubMed:14702039)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY768808 mRNA. Translation: AAV35060.1.
AL158048 Genomic DNA. Translation: CAM12842.1.
AK022194 mRNA. Translation: BAB13982.1. Sequence problems.
CCDSiCCDS100.2.
RefSeqiNP_079256.4. NM_024980.4.
UniGeneiHs.632367.

Genome annotation databases

EnsembliENST00000377411; ENSP00000366628; ENSG00000180758.
GeneIDi80045.
KEGGihsa:80045.
UCSCiuc001apq.1. human.

Polymorphism databases

DMDMi73621015.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY768808 mRNA. Translation: AAV35060.1 .
AL158048 Genomic DNA. Translation: CAM12842.1 .
AK022194 mRNA. Translation: BAB13982.1 . Sequence problems.
CCDSi CCDS100.2.
RefSeqi NP_079256.4. NM_024980.4.
UniGenei Hs.632367.

3D structure databases

ProteinModelPortali Q5UAW9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000366628.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei Q5UAW9.

Polymorphism databases

DMDMi 73621015.

Proteomic databases

MaxQBi Q5UAW9.
PaxDbi Q5UAW9.
PRIDEi Q5UAW9.

Protocols and materials databases

DNASUi 80045.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000377411 ; ENSP00000366628 ; ENSG00000180758 .
GeneIDi 80045.
KEGGi hsa:80045.
UCSCi uc001apq.1. human.

Organism-specific databases

CTDi 80045.
GeneCardsi GC01M009162.
HGNCi HGNC:23687. GPR157.
HPAi HPA028697.
neXtProti NX_Q5UAW9.
PharmGKBi PA134876230.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG81075.
GeneTreei ENSGT00390000012992.
HOGENOMi HOG000070448.
HOVERGENi HBG055714.
InParanoidi Q5UAW9.
KOi K08467.
OMAi VGWCWIN.
OrthoDBi EOG7KH9KD.
PhylomeDBi Q5UAW9.
TreeFami TF330856.

Miscellaneous databases

ChiTaRSi GPR157. human.
GeneWikii GPR157.
GenomeRNAii 80045.
NextBioi 70243.
PROi Q5UAW9.

Gene expression databases

Bgeei Q5UAW9.
CleanExi HS_GPR157.
Genevestigatori Q5UAW9.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR022343. GCR1-cAMP_receptor.
IPR017981. GPCR_2-like.
IPR000832. GPCR_2_secretin-like.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view ]
Pfami PF00002. 7tm_2. 1 hit.
[Graphical view ]
PRINTSi PR02001. GCR1CAMPR.
PROSITEi PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete coding sequence of GPR157."
    Bonner T.I., Kauffman D., Nagle J.W.
    Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Placenta and Prostate.
  2. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-127.
    Tissue: Mammary gland.

Entry informationi

Entry nameiGP157_HUMAN
AccessioniPrimary (citable) accession number: Q5UAW9
Secondary accession number(s): A2A334, Q8WWB8, Q9HA73
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: August 16, 2005
Last modified: November 26, 2014
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3