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Protein

Probable G-protein coupled receptor 157

Gene

GPR157

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Orphan receptor.

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Probable G-protein coupled receptor 157
Gene namesi
Name:GPR157
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:23687. GPR157.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1515ExtracellularSequence AnalysisAdd
BLAST
Transmembranei16 – 3621Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini37 – 4812CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei49 – 6921Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini70 – 8718ExtracellularSequence AnalysisAdd
BLAST
Transmembranei88 – 10821Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini109 – 11911CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei120 – 14021Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini141 – 16626ExtracellularSequence AnalysisAdd
BLAST
Transmembranei167 – 18721Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini188 – 22639CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei227 – 24721Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini248 – 25811ExtracellularSequence AnalysisAdd
BLAST
Transmembranei259 – 27921Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini280 – 33556CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134876230.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 335335Probable G-protein coupled receptor 157PRO_0000070339Add
BLAST

Proteomic databases

MaxQBiQ5UAW9.
PaxDbiQ5UAW9.
PRIDEiQ5UAW9.

PTM databases

PhosphoSiteiQ5UAW9.

Expressioni

Gene expression databases

BgeeiQ5UAW9.
CleanExiHS_GPR157.
GenevestigatoriQ5UAW9.

Organism-specific databases

HPAiHPA028697.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000366628.

Structurei

3D structure databases

ProteinModelPortaliQ5UAW9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi294 – 2985Poly-Cys

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG81075.
GeneTreeiENSGT00390000012992.
HOGENOMiHOG000070448.
HOVERGENiHBG055714.
InParanoidiQ5UAW9.
KOiK08467.
OMAiQGAANCI.
OrthoDBiEOG7KH9KD.
PhylomeDBiQ5UAW9.
TreeFamiTF330856.

Family and domain databases

InterProiIPR022343. GCR1-cAMP_receptor.
IPR017981. GPCR_2-like.
IPR000832. GPCR_2_secretin-like.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00002. 7tm_2. 1 hit.
[Graphical view]
PRINTSiPR02001. GCR1CAMPR.
PROSITEiPS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5UAW9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQPSPPPTEL VPSERAVVLL SCALSALGSG LLVATHALWP DLRSRARRLL
60 70 80 90 100
LFLSLADLLS AASYFYGVLQ NFAGPSWDCV LQGALSTFAN TSSFFWTVAI
110 120 130 140 150
ALYLYLSIVR AARGPRTDRL LWAFHVVSWG VPLVITVAAV ALKKIGYDAS
160 170 180 190 200
DVSVGWCWID LEAKDHVLWM LLTGKLWEML AYVLLPLLYL LVRKHINRAH
210 220 230 240 250
TALSEYRPIL SQEHRLLRHS SMADKKLVLI PLIFIGLRVW STVRFVLTLC
260 270 280 290 300
GSPAVQTPVL VVLHGIGNTF QGGANCIMFV LCTRAVRTRL FSLCCCCCSS
310 320 330
QPPTKSPAGT PKAPAPSKPG ESQESQGTPG ELPST
Length:335
Mass (Da):36,623
Last modified:August 16, 2005 - v2
Checksum:iC779B2D16C6D560C
GO

Sequence cautioni

The sequence BAB13982.1 differs from that shown.Intron retention.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti71 – 711N → D in BAB13982 (PubMed:14702039).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY768808 mRNA. Translation: AAV35060.1.
AL158048 Genomic DNA. Translation: CAM12842.1.
AK022194 mRNA. Translation: BAB13982.1. Sequence problems.
CCDSiCCDS100.2.
RefSeqiNP_079256.4. NM_024980.4.
UniGeneiHs.632367.

Genome annotation databases

EnsembliENST00000377411; ENSP00000366628; ENSG00000180758.
GeneIDi80045.
KEGGihsa:80045.
UCSCiuc001apq.1. human.

Polymorphism databases

DMDMi73621015.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY768808 mRNA. Translation: AAV35060.1.
AL158048 Genomic DNA. Translation: CAM12842.1.
AK022194 mRNA. Translation: BAB13982.1. Sequence problems.
CCDSiCCDS100.2.
RefSeqiNP_079256.4. NM_024980.4.
UniGeneiHs.632367.

3D structure databases

ProteinModelPortaliQ5UAW9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000366628.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiQ5UAW9.

Polymorphism databases

DMDMi73621015.

Proteomic databases

MaxQBiQ5UAW9.
PaxDbiQ5UAW9.
PRIDEiQ5UAW9.

Protocols and materials databases

DNASUi80045.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000377411; ENSP00000366628; ENSG00000180758.
GeneIDi80045.
KEGGihsa:80045.
UCSCiuc001apq.1. human.

Organism-specific databases

CTDi80045.
GeneCardsiGC01M009162.
HGNCiHGNC:23687. GPR157.
HPAiHPA028697.
neXtProtiNX_Q5UAW9.
PharmGKBiPA134876230.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG81075.
GeneTreeiENSGT00390000012992.
HOGENOMiHOG000070448.
HOVERGENiHBG055714.
InParanoidiQ5UAW9.
KOiK08467.
OMAiQGAANCI.
OrthoDBiEOG7KH9KD.
PhylomeDBiQ5UAW9.
TreeFamiTF330856.

Miscellaneous databases

ChiTaRSiGPR157. human.
GeneWikiiGPR157.
GenomeRNAii80045.
NextBioi70243.
PROiQ5UAW9.

Gene expression databases

BgeeiQ5UAW9.
CleanExiHS_GPR157.
GenevestigatoriQ5UAW9.

Family and domain databases

InterProiIPR022343. GCR1-cAMP_receptor.
IPR017981. GPCR_2-like.
IPR000832. GPCR_2_secretin-like.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00002. 7tm_2. 1 hit.
[Graphical view]
PRINTSiPR02001. GCR1CAMPR.
PROSITEiPS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete coding sequence of GPR157."
    Bonner T.I., Kauffman D., Nagle J.W.
    Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Placenta and Prostate.
  2. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-127.
    Tissue: Mammary gland.

Entry informationi

Entry nameiGP157_HUMAN
AccessioniPrimary (citable) accession number: Q5UAW9
Secondary accession number(s): A2A334, Q8WWB8, Q9HA73
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: August 16, 2005
Last modified: January 7, 2015
This is version 99 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.