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Q5UAW9 (GP157_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 95. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable G-protein coupled receptor 157
Gene names
Name:GPR157
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length335 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Orphan receptor.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 2 family.

Sequence caution

The sequence BAB13982.1 differs from that shown. Reason: Intron retention.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 335335Probable G-protein coupled receptor 157
PRO_0000070339

Regions

Topological domain1 – 1515Extracellular Potential
Transmembrane16 – 3621Helical; Name=1; Potential
Topological domain37 – 4812Cytoplasmic Potential
Transmembrane49 – 6921Helical; Name=2; Potential
Topological domain70 – 8718Extracellular Potential
Transmembrane88 – 10821Helical; Name=3; Potential
Topological domain109 – 11911Cytoplasmic Potential
Transmembrane120 – 14021Helical; Name=4; Potential
Topological domain141 – 16626Extracellular Potential
Transmembrane167 – 18721Helical; Name=5; Potential
Topological domain188 – 22639Cytoplasmic Potential
Transmembrane227 – 24721Helical; Name=6; Potential
Topological domain248 – 25811Extracellular Potential
Transmembrane259 – 27921Helical; Name=7; Potential
Topological domain280 – 33556Cytoplasmic Potential
Compositional bias294 – 2985Poly-Cys

Experimental info

Sequence conflict711N → D in BAB13982. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Q5UAW9 [UniParc].

Last modified August 16, 2005. Version 2.
Checksum: C779B2D16C6D560C

FASTA33536,623
        10         20         30         40         50         60 
MQPSPPPTEL VPSERAVVLL SCALSALGSG LLVATHALWP DLRSRARRLL LFLSLADLLS 

        70         80         90        100        110        120 
AASYFYGVLQ NFAGPSWDCV LQGALSTFAN TSSFFWTVAI ALYLYLSIVR AARGPRTDRL 

       130        140        150        160        170        180 
LWAFHVVSWG VPLVITVAAV ALKKIGYDAS DVSVGWCWID LEAKDHVLWM LLTGKLWEML 

       190        200        210        220        230        240 
AYVLLPLLYL LVRKHINRAH TALSEYRPIL SQEHRLLRHS SMADKKLVLI PLIFIGLRVW 

       250        260        270        280        290        300 
STVRFVLTLC GSPAVQTPVL VVLHGIGNTF QGGANCIMFV LCTRAVRTRL FSLCCCCCSS 

       310        320        330 
QPPTKSPAGT PKAPAPSKPG ESQESQGTPG ELPST 

« Hide

References

« Hide 'large scale' references
[1]"Complete coding sequence of GPR157."
Bonner T.I., Kauffman D., Nagle J.W.
Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Placenta and Prostate.
[2]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-127.
Tissue: Mammary gland.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY768808 mRNA. Translation: AAV35060.1.
AL158048 Genomic DNA. Translation: CAM12842.1.
AK022194 mRNA. Translation: BAB13982.1. Sequence problems.
CCDSCCDS100.2.
RefSeqNP_079256.4. NM_024980.4.
UniGeneHs.632367.

3D structure databases

ProteinModelPortalQ5UAW9.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000366628.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteQ5UAW9.

Polymorphism databases

DMDM73621015.

Proteomic databases

PaxDbQ5UAW9.
PRIDEQ5UAW9.

Protocols and materials databases

DNASU80045.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000377411; ENSP00000366628; ENSG00000180758.
GeneID80045.
KEGGhsa:80045.
UCSCuc001apq.1. human.

Organism-specific databases

CTD80045.
GeneCardsGC01M009162.
HGNCHGNC:23687. GPR157.
HPAHPA028697.
neXtProtNX_Q5UAW9.
PharmGKBPA134876230.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG81075.
HOGENOMHOG000070448.
HOVERGENHBG055714.
InParanoidQ5UAW9.
KOK08467.
OMAVGWCWIN.
OrthoDBEOG7KH9KD.
PhylomeDBQ5UAW9.
TreeFamTF330856.

Gene expression databases

ArrayExpressQ5UAW9.
BgeeQ5UAW9.
CleanExHS_GPR157.
GenevestigatorQ5UAW9.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR022343. GCR1-cAMP_receptor.
IPR017981. GPCR_2-like.
IPR000832. GPCR_2_secretin-like.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamPF00002. 7tm_2. 1 hit.
[Graphical view]
PRINTSPR02001. GCR1CAMPR.
PROSITEPS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiGPR157.
GenomeRNAi80045.
NextBio70243.
PROQ5UAW9.

Entry information

Entry nameGP157_HUMAN
AccessionPrimary (citable) accession number: Q5UAW9
Secondary accession number(s): A2A334, Q8WWB8, Q9HA73
Entry history
Integrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: August 16, 2005
Last modified: July 9, 2014
This is version 95 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries