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Q5UAW9

- GP157_HUMAN

UniProt

Q5UAW9 - GP157_HUMAN

Protein

Probable G-protein coupled receptor 157

Gene

GPR157

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 2 (16 Aug 2005)
      Previous versions | rss
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    Functioni

    Orphan receptor.

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable G-protein coupled receptor 157
    Gene namesi
    Name:GPR157
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:23687. GPR157.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134876230.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 335335Probable G-protein coupled receptor 157PRO_0000070339Add
    BLAST

    Proteomic databases

    PaxDbiQ5UAW9.
    PRIDEiQ5UAW9.

    PTM databases

    PhosphoSiteiQ5UAW9.

    Expressioni

    Gene expression databases

    ArrayExpressiQ5UAW9.
    BgeeiQ5UAW9.
    CleanExiHS_GPR157.
    GenevestigatoriQ5UAW9.

    Organism-specific databases

    HPAiHPA028697.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000366628.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5UAW9.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 1515ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini37 – 4812CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini70 – 8718ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini109 – 11911CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini141 – 16626ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini188 – 22639CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini248 – 25811ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini280 – 33556CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei16 – 3621Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei49 – 6921Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei88 – 10821Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei120 – 14021Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei167 – 18721Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei227 – 24721Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei259 – 27921Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi294 – 2985Poly-Cys

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG81075.
    HOGENOMiHOG000070448.
    HOVERGENiHBG055714.
    InParanoidiQ5UAW9.
    KOiK08467.
    OMAiVGWCWIN.
    OrthoDBiEOG7KH9KD.
    PhylomeDBiQ5UAW9.
    TreeFamiTF330856.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR022343. GCR1-cAMP_receptor.
    IPR017981. GPCR_2-like.
    IPR000832. GPCR_2_secretin-like.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PfamiPF00002. 7tm_2. 1 hit.
    [Graphical view]
    PRINTSiPR02001. GCR1CAMPR.
    PROSITEiPS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5UAW9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQPSPPPTEL VPSERAVVLL SCALSALGSG LLVATHALWP DLRSRARRLL    50
    LFLSLADLLS AASYFYGVLQ NFAGPSWDCV LQGALSTFAN TSSFFWTVAI 100
    ALYLYLSIVR AARGPRTDRL LWAFHVVSWG VPLVITVAAV ALKKIGYDAS 150
    DVSVGWCWID LEAKDHVLWM LLTGKLWEML AYVLLPLLYL LVRKHINRAH 200
    TALSEYRPIL SQEHRLLRHS SMADKKLVLI PLIFIGLRVW STVRFVLTLC 250
    GSPAVQTPVL VVLHGIGNTF QGGANCIMFV LCTRAVRTRL FSLCCCCCSS 300
    QPPTKSPAGT PKAPAPSKPG ESQESQGTPG ELPST 335
    Length:335
    Mass (Da):36,623
    Last modified:August 16, 2005 - v2
    Checksum:iC779B2D16C6D560C
    GO

    Sequence cautioni

    The sequence BAB13982.1 differs from that shown. Reason: Intron retention.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti71 – 711N → D in BAB13982. (PubMed:14702039)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY768808 mRNA. Translation: AAV35060.1.
    AL158048 Genomic DNA. Translation: CAM12842.1.
    AK022194 mRNA. Translation: BAB13982.1. Sequence problems.
    CCDSiCCDS100.2.
    RefSeqiNP_079256.4. NM_024980.4.
    UniGeneiHs.632367.

    Genome annotation databases

    EnsembliENST00000377411; ENSP00000366628; ENSG00000180758.
    GeneIDi80045.
    KEGGihsa:80045.
    UCSCiuc001apq.1. human.

    Polymorphism databases

    DMDMi73621015.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY768808 mRNA. Translation: AAV35060.1 .
    AL158048 Genomic DNA. Translation: CAM12842.1 .
    AK022194 mRNA. Translation: BAB13982.1 . Sequence problems.
    CCDSi CCDS100.2.
    RefSeqi NP_079256.4. NM_024980.4.
    UniGenei Hs.632367.

    3D structure databases

    ProteinModelPortali Q5UAW9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000366628.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q5UAW9.

    Polymorphism databases

    DMDMi 73621015.

    Proteomic databases

    PaxDbi Q5UAW9.
    PRIDEi Q5UAW9.

    Protocols and materials databases

    DNASUi 80045.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000377411 ; ENSP00000366628 ; ENSG00000180758 .
    GeneIDi 80045.
    KEGGi hsa:80045.
    UCSCi uc001apq.1. human.

    Organism-specific databases

    CTDi 80045.
    GeneCardsi GC01M009162.
    HGNCi HGNC:23687. GPR157.
    HPAi HPA028697.
    neXtProti NX_Q5UAW9.
    PharmGKBi PA134876230.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG81075.
    HOGENOMi HOG000070448.
    HOVERGENi HBG055714.
    InParanoidi Q5UAW9.
    KOi K08467.
    OMAi VGWCWIN.
    OrthoDBi EOG7KH9KD.
    PhylomeDBi Q5UAW9.
    TreeFami TF330856.

    Miscellaneous databases

    GeneWikii GPR157.
    GenomeRNAii 80045.
    NextBioi 70243.
    PROi Q5UAW9.

    Gene expression databases

    ArrayExpressi Q5UAW9.
    Bgeei Q5UAW9.
    CleanExi HS_GPR157.
    Genevestigatori Q5UAW9.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR022343. GCR1-cAMP_receptor.
    IPR017981. GPCR_2-like.
    IPR000832. GPCR_2_secretin-like.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    Pfami PF00002. 7tm_2. 1 hit.
    [Graphical view ]
    PRINTSi PR02001. GCR1CAMPR.
    PROSITEi PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete coding sequence of GPR157."
      Bonner T.I., Kauffman D., Nagle J.W.
      Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Placenta and Prostate.
    2. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-127.
      Tissue: Mammary gland.

    Entry informationi

    Entry nameiGP157_HUMAN
    AccessioniPrimary (citable) accession number: Q5UAW9
    Secondary accession number(s): A2A334, Q8WWB8, Q9HA73
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 16, 2005
    Last sequence update: August 16, 2005
    Last modified: October 1, 2014
    This is version 96 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3