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Protein

Hepcidin

Gene

HAMP

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Seems to act as a signaling molecule involved in the maintenance of iron homeostasis. Seems to be required in conjunction with HFE to regulate both intestinal iron absorption and iron storage in macrophages. May also have antimicrobial activity (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Antibiotic, Antimicrobial, Hormone

Names & Taxonomyi

Protein namesi
Recommended name:
Hepcidin
Gene namesi
Name:HAMP
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence analysisAdd
BLAST
Propeptidei23 – 5432Sequence analysisPRO_0000013376Add
BLAST
Peptidei61 – 8525HepcidinPRO_0000013377Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi67 ↔ 83By similarity
Disulfide bondi70 ↔ 73By similarity
Disulfide bondi71 ↔ 79By similarity
Disulfide bondi74 ↔ 82By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PaxDbiQ5U9D2.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000010474.

Family & Domainsi

Sequence similaritiesi

Belongs to the hepcidin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J3JD. Eukaryota.
ENOG4111C2J. LUCA.
HOGENOMiHOG000008666.
HOVERGENiHBG003716.
InParanoidiQ5U9D2.

Family and domain databases

InterProiIPR010500. Hepcidin.
[Graphical view]
PfamiPF06446. Hepcidin. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5U9D2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALSTRIQAA CLLLLLLASV ASVSVLPHQT GQLTDLRAQD TAGAEAGLQP
60 70 80
TLQLRRLRRR DTHFPICIFC CGCCKTPKCG LCCKT
Length:85
Mass (Da):9,172
Last modified:December 7, 2004 - v1
Checksum:i39C3114830CED31B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti81 – 811L → F in AAW82336 (Ref. 2) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY772532 mRNA. Translation: AAV40979.1.
AY899807 mRNA. Translation: AAW82336.1.
RefSeqiNP_001007141.1. NM_001007140.1.
UniGeneiCfa.14486.

Genome annotation databases

GeneIDi492281.
KEGGicfa:492281.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY772532 mRNA. Translation: AAV40979.1.
AY899807 mRNA. Translation: AAW82336.1.
RefSeqiNP_001007141.1. NM_001007140.1.
UniGeneiCfa.14486.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000010474.

Proteomic databases

PaxDbiQ5U9D2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi492281.
KEGGicfa:492281.

Organism-specific databases

CTDi57817.

Phylogenomic databases

eggNOGiENOG410J3JD. Eukaryota.
ENOG4111C2J. LUCA.
HOGENOMiHOG000008666.
HOVERGENiHBG003716.
InParanoidiQ5U9D2.

Family and domain databases

InterProiIPR010500. Hepcidin.
[Graphical view]
PfamiPF06446. Hepcidin. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Identification of dog hepcidin."
    Shi J., Wei Y., Boothe D.
    Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.
  2. "Identification of dog hepcidin in China."
    Li X.D., Zhao T.Z., Sun M., Tian K.G., Chen X.Z.
    Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiHEPC_CANLF
AccessioniPrimary (citable) accession number: Q5U9D2
Secondary accession number(s): Q5EES0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: December 7, 2004
Last modified: June 8, 2016
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.