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Protein
Submitted name:

Exostosin-2

Gene

ext2

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity Source: ZFIN

GO - Biological processi

  • cartilage development Source: ZFIN
  • chondroitin sulfate proteoglycan biosynthetic process Source: ZFIN
  • embryonic pectoral fin morphogenesis Source: ZFIN
  • extracellular matrix organization Source: ZFIN
  • fibroblast growth factor receptor signaling pathway Source: ZFIN
  • glycosaminoglycan biosynthetic process Source: InterPro
  • heparan sulfate proteoglycan biosynthetic process Source: ZFIN
  • odontogenesis Source: ZFIN
  • ossification Source: ZFIN
  • osteoblast differentiation Source: ZFIN
  • pectoral fin development Source: ZFIN
  • pectoral fin morphogenesis Source: ZFIN
  • positive regulation of fibroblast growth factor receptor signaling pathway Source: ZFIN
  • posterior lateral line neuromast primordium migration Source: ZFIN
  • protein glycosylation Source: InterPro
  • proteoglycan biosynthetic process Source: ZFIN
  • regulation of axon extension Source: ZFIN
  • retinal ganglion cell axon guidance Source: ZFIN
  • sensory neuron axon guidance Source: ZFIN
  • skeletal system development Source: ZFIN
  • thymus development Source: ZFIN

Protein family/group databases

CAZyiGT47 Glycosyltransferase Family 47
GT64 Glycosyltransferase Family 64

Names & Taxonomyi

Protein namesi
Submitted name:
Exostosin-2Imported
Gene namesi
Name:ext2Imported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

Organism-specific databases

ZFINiZDB-GENE-041124-3 ext2

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei24 – 46HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Membrane

Structurei

3D structure databases

ProteinModelPortaliQ5U7A7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini457 – 702Glyco_transf_64InterPro annotationAdd BLAST246

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili256 – 276Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG1021 Eukaryota
ENOG410XTFH LUCA
HOGENOMiHOG000266990
HOVERGENiHBG101211
KOiK02367
PhylomeDBiQ5U7A7

Family and domain databases

Gene3Di3.90.550.10, 1 hit
InterProiView protein in InterPro
IPR004263 Exostosin
IPR027673 Exostosin-2
IPR015338 EXT_C
IPR029044 Nucleotide-diphossugar_trans
PANTHERiPTHR11062:SF128 PTHR11062:SF128, 1 hit
PfamiView protein in Pfam
PF03016 Exostosin, 1 hit
PF09258 Glyco_transf_64, 1 hit
SUPFAMiSSF53448 SSF53448, 1 hit

Sequencei

Sequence statusi: Complete.

Q5U7A7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCASGKYGSR GPALIPRMKT KHRIYYITLF SVVLLGLIAT GMFQFWPHSI
60 70 80 90 100
ESSAEWSLDR RSVHDAPLVR ISVNSPIPGR GDLSCRMHTC FDVYRCGYNP
110 120 130 140 150
KNKIKVYIYP LQRFVDEVGV PISSTGLSRE YNDLLSAISD SDFYTDDVSR
160 170 180 190 200
ACLFVPSIDV LNQNSLRIRE TAQALAMLPR WDKGMNHLLF NMLPGGPPDY
210 220 230 240 250
NTALDVPRDR ALLAGGGFST WTYRQGYDVS IPVYSPLSAE VDLPERQPGP
260 270 280 290 300
RRYFILSSQT AIHREYRVEL ERLKDENGEA LLLLDKCSNL SQGLTSVRKR
310 320 330 340 350
CYKGQVYDYP QILQESSFCV VLRGARLGQA TLSDVLQAGC VPVIMADSYI
360 370 380 390 400
LPFSEVLDWK RASVVIPEEK LPEMYTILKS IPHRQVEEMQ RQARWFWEAY
410 420 430 440 450
FSSMKAIGMT TLQIINDRIY PYAAHTYEEW NNPPVVKWSS VNSPLFLPLI
460 470 480 490 500
PPRSPGFTAV VLTYDRIESL FRVITEISKV PSLAKLLVVW NNQNKSPPEE
510 520 530 540 550
SLWPKVAVPL KVVRTKENKL SNRFFPFDEI ETEAVLAIDD DIIMLTSDEL
560 570 580 590 600
QFGYEVWREF PDRLVGYPGR LHLWDHEMGK WKYESEWTNE VSMVLTGAAF
610 620 630 640 650
YHKYFNYLYT YKMPGDIKNW VDAHMNCEDI AMNFLVANIT GKAPIKVTPR
660 670 680 690 700
KKFKCPECTA IDGLSLDQTH MVERSECINK FASVFGTMPL KVVEHRADPV
710
LYKDDFPEKL KSFPNIGSL
Length:719
Mass (Da):82,278
Last modified:December 7, 2004 - v1
Checksum:i2010A54F8D23633B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY786508 mRNA Translation: AAV48783.1
RefSeqiNP_001008400.1, NM_001008400.1
UniGeneiDr.37595

Genome annotation databases

GeneIDi493780
KEGGidre:493780

Similar proteinsi

Entry informationi

Entry nameiQ5U7A7_DANRE
AccessioniPrimary (citable) accession number: Q5U7A7
Entry historyiIntegrated into UniProtKB/TrEMBL: December 7, 2004
Last sequence update: December 7, 2004
Last modified: March 28, 2018
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health