Q5U7A7 (Q5U7A7_DANRE) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Exostosin-2 EMBL AAV48783.1

Gene names

Name:

ext2 ZFIN ZDB-GENE-041124-3

Organism

Danio rerio (Zebrafish) (Brachydanio rerio) EMBL AAV48783.1

Taxonomic identifier

7955 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Actinopterygii › Actinopteri › Neopterygii › Teleostei › Elopocephala › Clupeocephala › Otocephala › Ostariophysi › Otophysi › Cypriniphysi › Cypriniformes › Cyprinoidea › Cyprinidae › Danio

Protein attributes

Sequence length	719 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

Ontologies

Gene Ontology (GO)
Biological_process	cartilage development Inferred from mutant phenotype PubMed 18654627PubMed 21294126. Source: ZFIN chondroitin sulfate proteoglycan biosynthetic process Inferred from genetic interaction PubMed 22869369. Source: ZFIN embryonic pectoral fin morphogenesis Inferred from mutant phenotype PubMed 16221725. Source: ZFIN extracellular matrix organization Inferred from mutant phenotype PubMed 21506131. Source: ZFIN fibroblast growth factor receptor signaling pathway Inferred from genetic interaction PubMed 10976049. Source: ZFIN heparan sulfate proteoglycan biosynthetic process Inferred from mutant phenotype Ref.1PubMed 22869369. Source: ZFIN odontogenesis Inferred from mutant phenotype PubMed 22253766. Source: ZFIN osteoblast differentiation Inferred from mutant phenotype PubMed 18654627. Source: ZFIN positive regulation of fibroblast growth factor receptor signaling pathway Inferred from mutant phenotype PubMed 16221725. Source: ZFIN regulation of axon extension Inferred from mutant phenotype Ref.1. Source: ZFIN retinal ganglion cell axon guidance Inferred from mutant phenotype PubMed 9007260. Source: ZFIN
Cellular_component	intrinsic to endoplasmic reticulum membrane Inferred from electronic annotation. Source: InterPro
Molecular_function	N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity Inferred from sequence or structural similarity Ref.1. Source: ZFIN
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q5U7A7 [UniParc]. Last modified December 7, 2004. Version 1. Checksum: 2010A54F8D23633B	FASTA	719	82,278
	10 20 30 40 50 60 MCASGKYGSR GPALIPRMKT KHRIYYITLF SVVLLGLIAT GMFQFWPHSI ESSAEWSLDR 70 80 90 100 110 120 RSVHDAPLVR ISVNSPIPGR GDLSCRMHTC FDVYRCGYNP KNKIKVYIYP LQRFVDEVGV 130 140 150 160 170 180 PISSTGLSRE YNDLLSAISD SDFYTDDVSR ACLFVPSIDV LNQNSLRIRE TAQALAMLPR 190 200 210 220 230 240 WDKGMNHLLF NMLPGGPPDY NTALDVPRDR ALLAGGGFST WTYRQGYDVS IPVYSPLSAE 250 260 270 280 290 300 VDLPERQPGP RRYFILSSQT AIHREYRVEL ERLKDENGEA LLLLDKCSNL SQGLTSVRKR 310 320 330 340 350 360 CYKGQVYDYP QILQESSFCV VLRGARLGQA TLSDVLQAGC VPVIMADSYI LPFSEVLDWK 370 380 390 400 410 420 RASVVIPEEK LPEMYTILKS IPHRQVEEMQ RQARWFWEAY FSSMKAIGMT TLQIINDRIY 430 440 450 460 470 480 PYAAHTYEEW NNPPVVKWSS VNSPLFLPLI PPRSPGFTAV VLTYDRIESL FRVITEISKV 490 500 510 520 530 540 PSLAKLLVVW NNQNKSPPEE SLWPKVAVPL KVVRTKENKL SNRFFPFDEI ETEAVLAIDD 550 560 570 580 590 600 DIIMLTSDEL QFGYEVWREF PDRLVGYPGR LHLWDHEMGK WKYESEWTNE VSMVLTGAAF 610 620 630 640 650 660 YHKYFNYLYT YKMPGDIKNW VDAHMNCEDI AMNFLVANIT GKAPIKVTPR KKFKCPECTA 670 680 690 700 710 IDGLSLDQTH MVERSECINK FASVFGTMPL KVVEHRADPV LYKDDFPEKL KSFPNIGSL

References

[1]	"Axon sorting in the optic tract requires HSPG synthesis by ext2 (dackel) and extl3 (boxer)." Lee J.-S., von der Hardt S., Rusch M.A., Stringer S.E., Stickney H.L., Talbot W.S., Geisler R., Nuesslein-Volhard C., Selleck S.B., Chien C.-B., Roehl H.H. Neuron 44:947-960(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY786508 mRNA. Translation: AAV48783.1.
IPI	IPI00486949.
RefSeq	NP_001008400.1. NM_001008400.1.
UniGene	Dr.37595.
3D structure databases
ProteinModelPortal	Q5U7A7.
ModBase	Search...
Protein-protein interaction databases
STRING	7955.ENSDARP00000073621.
Protein family/group databases
CAZy	GT47. Glycosyltransferase Family 47. GT64. Glycosyltransferase Family 64.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	493780.
KEGG	dre:493780.
Organism-specific databases
CTD	2132.
ZFIN	ZDB-GENE-041124-3. ext2.
Phylogenomic databases
eggNOG	NOG272619.
HOGENOM	HOG000266990.
HOVERGEN	HBG101211.
InParanoid	Q5U7A7.
KO	K02367.
OrthoDB	EOG41VK2B.
Family and domain databases
InterPro	IPR004263. Exostosin. IPR015338. HexNAc_Trfase_a. [Graphical view]
Pfam	PF03016. Exostosin. 1 hit. PF09258. Glyco_transf_64. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	20865484.

Entry information

Entry name

Q5U7A7_DANRE

Accession

Primary (citable) accession number: Q5U7A7

Entry history

Integrated into UniProtKB/TrEMBL:	December 7, 2004
Last sequence update:	December 7, 2004
Last modified:	April 3, 2013
This is version 51 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)