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Protein
Submitted name:

Exostosin-2

Gene

ext2

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity Source: ZFIN

GO - Biological processi

  • cartilage development Source: ZFIN
  • chondroitin sulfate proteoglycan biosynthetic process Source: ZFIN
  • embryonic pectoral fin morphogenesis Source: ZFIN
  • extracellular matrix organization Source: ZFIN
  • fibroblast growth factor receptor signaling pathway Source: ZFIN
  • heparan sulfate proteoglycan biosynthetic process Source: ZFIN
  • odontogenesis Source: ZFIN
  • ossification Source: ZFIN
  • osteoblast differentiation Source: ZFIN
  • pectoral fin development Source: ZFIN
  • pectoral fin morphogenesis Source: ZFIN
  • positive regulation of fibroblast growth factor receptor signaling pathway Source: ZFIN
  • proteoglycan biosynthetic process Source: ZFIN
  • regulation of axon extension Source: ZFIN
  • retinal ganglion cell axon guidance Source: ZFIN
  • sensory neuron axon guidance Source: ZFIN
  • skeletal system development Source: ZFIN
Complete GO annotation...

Protein family/group databases

CAZyiGT47. Glycosyltransferase Family 47.
GT64. Glycosyltransferase Family 64.

Names & Taxonomyi

Protein namesi
Submitted name:
Exostosin-2Imported
Gene namesi
Name:ext2Imported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

Organism-specific databases

ZFINiZDB-GENE-041124-3. ext2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei24 – 4623HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PaxDbiQ5U7A7.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000073621.

Structurei

3D structure databases

ProteinModelPortaliQ5U7A7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini457 – 702246Glyco_transf_64InterPro annotationAdd
BLAST

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG1021. Eukaryota.
ENOG410XTFH. LUCA.
HOGENOMiHOG000266990.
HOVERGENiHBG101211.
KOiK02367.
PhylomeDBiQ5U7A7.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
InterProiIPR004263. Exostosin.
IPR027673. Exostosin-2.
IPR015338. EXT_C.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PANTHERiPTHR11062:SF93. PTHR11062:SF93. 2 hits.
PfamiPF03016. Exostosin. 1 hit.
PF09258. Glyco_transf_64. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5U7A7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCASGKYGSR GPALIPRMKT KHRIYYITLF SVVLLGLIAT GMFQFWPHSI
60 70 80 90 100
ESSAEWSLDR RSVHDAPLVR ISVNSPIPGR GDLSCRMHTC FDVYRCGYNP
110 120 130 140 150
KNKIKVYIYP LQRFVDEVGV PISSTGLSRE YNDLLSAISD SDFYTDDVSR
160 170 180 190 200
ACLFVPSIDV LNQNSLRIRE TAQALAMLPR WDKGMNHLLF NMLPGGPPDY
210 220 230 240 250
NTALDVPRDR ALLAGGGFST WTYRQGYDVS IPVYSPLSAE VDLPERQPGP
260 270 280 290 300
RRYFILSSQT AIHREYRVEL ERLKDENGEA LLLLDKCSNL SQGLTSVRKR
310 320 330 340 350
CYKGQVYDYP QILQESSFCV VLRGARLGQA TLSDVLQAGC VPVIMADSYI
360 370 380 390 400
LPFSEVLDWK RASVVIPEEK LPEMYTILKS IPHRQVEEMQ RQARWFWEAY
410 420 430 440 450
FSSMKAIGMT TLQIINDRIY PYAAHTYEEW NNPPVVKWSS VNSPLFLPLI
460 470 480 490 500
PPRSPGFTAV VLTYDRIESL FRVITEISKV PSLAKLLVVW NNQNKSPPEE
510 520 530 540 550
SLWPKVAVPL KVVRTKENKL SNRFFPFDEI ETEAVLAIDD DIIMLTSDEL
560 570 580 590 600
QFGYEVWREF PDRLVGYPGR LHLWDHEMGK WKYESEWTNE VSMVLTGAAF
610 620 630 640 650
YHKYFNYLYT YKMPGDIKNW VDAHMNCEDI AMNFLVANIT GKAPIKVTPR
660 670 680 690 700
KKFKCPECTA IDGLSLDQTH MVERSECINK FASVFGTMPL KVVEHRADPV
710
LYKDDFPEKL KSFPNIGSL
Length:719
Mass (Da):82,278
Last modified:December 7, 2004 - v1
Checksum:i2010A54F8D23633B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY786508 mRNA. Translation: AAV48783.1.
RefSeqiNP_001008400.1. NM_001008400.1.
UniGeneiDr.37595.

Genome annotation databases

GeneIDi493780.
KEGGidre:493780.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY786508 mRNA. Translation: AAV48783.1.
RefSeqiNP_001008400.1. NM_001008400.1.
UniGeneiDr.37595.

3D structure databases

ProteinModelPortaliQ5U7A7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000073621.

Protein family/group databases

CAZyiGT47. Glycosyltransferase Family 47.
GT64. Glycosyltransferase Family 64.

Proteomic databases

PaxDbiQ5U7A7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi493780.
KEGGidre:493780.

Organism-specific databases

CTDi2132.
ZFINiZDB-GENE-041124-3. ext2.

Phylogenomic databases

eggNOGiKOG1021. Eukaryota.
ENOG410XTFH. LUCA.
HOGENOMiHOG000266990.
HOVERGENiHBG101211.
KOiK02367.
PhylomeDBiQ5U7A7.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
InterProiIPR004263. Exostosin.
IPR027673. Exostosin-2.
IPR015338. EXT_C.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PANTHERiPTHR11062:SF93. PTHR11062:SF93. 2 hits.
PfamiPF03016. Exostosin. 1 hit.
PF09258. Glyco_transf_64. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiQ5U7A7_DANRE
AccessioniPrimary (citable) accession number: Q5U7A7
Entry historyi
Integrated into UniProtKB/TrEMBL: December 7, 2004
Last sequence update: December 7, 2004
Last modified: June 8, 2016
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.