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Protein

Phorbol-12-myristate-13-acetate-induced protein 1

Gene

Pmaip1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Protein inferred from homologyi

Functioni

Promotes activation of caspases and apoptosis. Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria. Contributes to p53/TP53-dependent apoptosis after radiation exposure. Promotes proteasomal degradation of MCL1. Competes with BAK1 and with BIM/BCL2L11 for binding to MCL1; can displace BAK1 and BIM/BCL2L11 from their binding sites (By similarity).By similarity

GO - Biological processi

  1. activation of cysteine-type endopeptidase activity involved in apoptotic process Source: Ensembl
  2. apoptotic process Source: RGD
  3. cellular response to glucose starvation Source: Ensembl
  4. cellular response to hypoxia Source: Ensembl
  5. defense response to virus Source: Ensembl
  6. intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator Source: Ensembl
  7. negative regulation of fibroblast proliferation Source: Ensembl
  8. negative regulation of mitochondrial membrane potential Source: Ensembl
  9. positive regulation of apoptotic process Source: RGD
  10. positive regulation of DNA damage response, signal transduction by p53 class mediator Source: Ensembl
  11. positive regulation of extrinsic apoptotic signaling pathway via death domain receptors Source: Ensembl
  12. positive regulation of glucose metabolic process Source: Ensembl
  13. positive regulation of intrinsic apoptotic signaling pathway Source: Ensembl
  14. positive regulation of neuron apoptotic process Source: Ensembl
  15. positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway Source: Ensembl
  16. positive regulation of protein oligomerization Source: Ensembl
  17. positive regulation of release of cytochrome c from mitochondria Source: Ensembl
  18. proteasomal protein catabolic process Source: Ensembl
  19. reactive oxygen species metabolic process Source: Ensembl
  20. regulation of mitochondrial membrane permeability Source: Ensembl
  21. release of cytochrome c from mitochondria Source: Ensembl
  22. response to dsRNA Source: Ensembl
  23. response to UV Source: Ensembl
  24. response to X-ray Source: Ensembl
  25. T cell homeostasis Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Apoptosis

Enzyme and pathway databases

ReactomeiREACT_195258. Activation of NOXA and translocation to mitochondria.
REACT_234537. BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members.

Names & Taxonomyi

Protein namesi
Recommended name:
Phorbol-12-myristate-13-acetate-induced protein 1
Alternative name(s):
Protein Noxa
Gene namesi
Name:Pmaip1
Synonyms:Noxa
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 18

Organism-specific databases

RGDi1359266. Pmaip1.

Subcellular locationi

Mitochondrion By similarity

GO - Cellular componenti

  1. cytosol Source: Ensembl
  2. mitochondrion Source: RGD
  3. nucleus Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 105105Phorbol-12-myristate-13-acetate-induced protein 1PRO_0000333231Add
BLAST

PTM databases

PhosphoSiteiQ5U777.

Expressioni

Gene expression databases

GenevestigatoriQ5U777.

Interactioni

Subunit structurei

Interacts with MCL1, BCL2A1 and BAX.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000025361.

Structurei

3D structure databases

ProteinModelPortaliQ5U777.
SMRiQ5U777. Positions 17-43, 70-95.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni92 – 10110Required for mitochondrial locationBy similarity

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi27 – 359BH3 1
Motifi80 – 889BH3 2

Domaini

The BH3 motif is essential for pro-apoptotic activity.By similarity

Sequence similaritiesi

Belongs to the PMAIP1 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG119326.
GeneTreeiENSGT00530000065105.
HOGENOMiHOG000034021.
HOVERGENiHBG095669.
InParanoidiQ5U777.
KOiK10131.
OMAiADLKDEC.
OrthoDBiEOG7PP59Z.
TreeFamiTF339379.

Family and domain databases

InterProiIPR024140. Noxa.
[Graphical view]
PANTHERiPTHR14299. PTHR14299. 1 hit.
PfamiPF15150. PMAIP1. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5U777-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPGRKARRNA PLNPTRAELP PEFAAQLRKI GDKVYCTWSA PDITAVLAQM
60 70 80 90 100
PGKKSRKSTM RRSPSPTRVP ADLKDECDQL RRIGDKVNLR QKLLNFISKL

FNLIT
Length:105
Mass (Da):11,901
Last modified:December 7, 2004 - v1
Checksum:i76EF4EE17827890E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY788892 mRNA. Translation: AAV51955.1.
RefSeqiNP_001008386.1. NM_001008385.1.
UniGeneiRn.163380.

Genome annotation databases

EnsembliENSRNOT00000025362; ENSRNOP00000025361; ENSRNOG00000018770.
GeneIDi492821.
KEGGirno:492821.
UCSCiRGD:1359266. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY788892 mRNA. Translation: AAV51955.1.
RefSeqiNP_001008386.1. NM_001008385.1.
UniGeneiRn.163380.

3D structure databases

ProteinModelPortaliQ5U777.
SMRiQ5U777. Positions 17-43, 70-95.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000025361.

PTM databases

PhosphoSiteiQ5U777.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000025362; ENSRNOP00000025361; ENSRNOG00000018770.
GeneIDi492821.
KEGGirno:492821.
UCSCiRGD:1359266. rat.

Organism-specific databases

CTDi5366.
RGDi1359266. Pmaip1.

Phylogenomic databases

eggNOGiNOG119326.
GeneTreeiENSGT00530000065105.
HOGENOMiHOG000034021.
HOVERGENiHBG095669.
InParanoidiQ5U777.
KOiK10131.
OMAiADLKDEC.
OrthoDBiEOG7PP59Z.
TreeFamiTF339379.

Enzyme and pathway databases

ReactomeiREACT_195258. Activation of NOXA and translocation to mitochondria.
REACT_234537. BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members.

Miscellaneous databases

NextBioi697216.
PROiQ5U777.

Gene expression databases

GenevestigatoriQ5U777.

Family and domain databases

InterProiIPR024140. Noxa.
[Graphical view]
PANTHERiPTHR14299. PTHR14299. 1 hit.
PfamiPF15150. PMAIP1. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Yakovlev A.G.
    Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Embryonic brain.

Entry informationi

Entry nameiAPR_RAT
AccessioniPrimary (citable) accession number: Q5U777
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: December 7, 2004
Last modified: January 7, 2015
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.