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Q5U777

- APR_RAT

UniProt

Q5U777 - APR_RAT

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Protein

Phorbol-12-myristate-13-acetate-induced protein 1

Gene

Pmaip1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Protein inferred from homologyi

Functioni

Promotes activation of caspases and apoptosis. Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria. Contributes to p53/TP53-dependent apoptosis after radiation exposure. Promotes proteasomal degradation of MCL1. Competes with BAK1 and with BIM/BCL2L11 for binding to MCL1; can displace BAK1 and BIM/BCL2L11 from their binding sites (By similarity).By similarity

GO - Biological processi

  1. activation of cysteine-type endopeptidase activity involved in apoptotic process Source: Ensembl
  2. apoptotic process Source: RGD
  3. cellular response to glucose starvation Source: Ensembl
  4. cellular response to hypoxia Source: Ensembl
  5. defense response to virus Source: Ensembl
  6. intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator Source: Ensembl
  7. negative regulation of fibroblast proliferation Source: Ensembl
  8. negative regulation of mitochondrial membrane potential Source: Ensembl
  9. positive regulation of apoptotic process Source: RGD
  10. positive regulation of DNA damage response, signal transduction by p53 class mediator Source: Ensembl
  11. positive regulation of extrinsic apoptotic signaling pathway via death domain receptors Source: Ensembl
  12. positive regulation of glucose metabolic process Source: Ensembl
  13. positive regulation of intrinsic apoptotic signaling pathway Source: Ensembl
  14. positive regulation of neuron apoptotic process Source: Ensembl
  15. positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway Source: Ensembl
  16. positive regulation of protein oligomerization Source: Ensembl
  17. positive regulation of release of cytochrome c from mitochondria Source: Ensembl
  18. proteasomal protein catabolic process Source: Ensembl
  19. reactive oxygen species metabolic process Source: Ensembl
  20. regulation of mitochondrial membrane permeability Source: Ensembl
  21. release of cytochrome c from mitochondria Source: Ensembl
  22. response to dsRNA Source: Ensembl
  23. response to UV Source: Ensembl
  24. response to X-ray Source: Ensembl
  25. T cell homeostasis Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Apoptosis

Enzyme and pathway databases

ReactomeiREACT_195258. Activation of NOXA and translocation to mitochondria.
REACT_234537. BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members.

Names & Taxonomyi

Protein namesi
Recommended name:
Phorbol-12-myristate-13-acetate-induced protein 1
Alternative name(s):
Protein Noxa
Gene namesi
Name:Pmaip1
Synonyms:Noxa
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 18

Organism-specific databases

RGDi1359266. Pmaip1.

Subcellular locationi

Mitochondrion By similarity

GO - Cellular componenti

  1. cytosol Source: Ensembl
  2. mitochondrion Source: RGD
  3. nucleus Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 105105Phorbol-12-myristate-13-acetate-induced protein 1PRO_0000333231Add
BLAST

PTM databases

PhosphoSiteiQ5U777.

Expressioni

Gene expression databases

GenevestigatoriQ5U777.

Interactioni

Subunit structurei

Interacts with MCL1, BCL2A1 and BAX.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000025361.

Structurei

3D structure databases

ProteinModelPortaliQ5U777.
SMRiQ5U777. Positions 17-43, 70-95.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni92 – 10110Required for mitochondrial locationBy similarity

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi27 – 359BH3 1
Motifi80 – 889BH3 2

Domaini

The BH3 motif is essential for pro-apoptotic activity.By similarity

Sequence similaritiesi

Belongs to the PMAIP1 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG119326.
GeneTreeiENSGT00530000065105.
HOGENOMiHOG000034021.
HOVERGENiHBG095669.
InParanoidiQ5U777.
KOiK10131.
OMAiLMEDADI.
OrthoDBiEOG7PP59Z.
TreeFamiTF339379.

Family and domain databases

InterProiIPR024140. Noxa.
[Graphical view]
PANTHERiPTHR14299. PTHR14299. 1 hit.
PfamiPF15150. PMAIP1. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5U777-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPGRKARRNA PLNPTRAELP PEFAAQLRKI GDKVYCTWSA PDITAVLAQM
60 70 80 90 100
PGKKSRKSTM RRSPSPTRVP ADLKDECDQL RRIGDKVNLR QKLLNFISKL

FNLIT
Length:105
Mass (Da):11,901
Last modified:December 7, 2004 - v1
Checksum:i76EF4EE17827890E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY788892 mRNA. Translation: AAV51955.1.
RefSeqiNP_001008386.1. NM_001008385.1.
UniGeneiRn.163380.

Genome annotation databases

EnsembliENSRNOT00000025362; ENSRNOP00000025361; ENSRNOG00000018770.
GeneIDi492821.
KEGGirno:492821.
UCSCiRGD:1359266. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY788892 mRNA. Translation: AAV51955.1 .
RefSeqi NP_001008386.1. NM_001008385.1.
UniGenei Rn.163380.

3D structure databases

ProteinModelPortali Q5U777.
SMRi Q5U777. Positions 17-43, 70-95.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000025361.

PTM databases

PhosphoSitei Q5U777.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000025362 ; ENSRNOP00000025361 ; ENSRNOG00000018770 .
GeneIDi 492821.
KEGGi rno:492821.
UCSCi RGD:1359266. rat.

Organism-specific databases

CTDi 5366.
RGDi 1359266. Pmaip1.

Phylogenomic databases

eggNOGi NOG119326.
GeneTreei ENSGT00530000065105.
HOGENOMi HOG000034021.
HOVERGENi HBG095669.
InParanoidi Q5U777.
KOi K10131.
OMAi LMEDADI.
OrthoDBi EOG7PP59Z.
TreeFami TF339379.

Enzyme and pathway databases

Reactomei REACT_195258. Activation of NOXA and translocation to mitochondria.
REACT_234537. BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members.

Miscellaneous databases

NextBioi 697216.
PROi Q5U777.

Gene expression databases

Genevestigatori Q5U777.

Family and domain databases

InterProi IPR024140. Noxa.
[Graphical view ]
PANTHERi PTHR14299. PTHR14299. 1 hit.
Pfami PF15150. PMAIP1. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Yakovlev A.G.
    Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Embryonic brain.

Entry informationi

Entry nameiAPR_RAT
AccessioniPrimary (citable) accession number: Q5U777
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: December 7, 2004
Last modified: November 26, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3