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Q5U777 (APR_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Phorbol-12-myristate-13-acetate-induced protein 1
Alternative name(s):
Protein Noxa
Gene names
Name:Pmaip1
Synonyms:Noxa
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length105 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Promotes activation of caspases and apoptosis. Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria. Contributes to p53/TP53-dependent apoptosis after radiation exposure. Promotes proteasomal degradation of MCL1. Competes with BAK1 and with BIM/BCL2L11 for binding to MCL1; can displace BAK1 and BIM/BCL2L11 from their binding sites By similarity.

Subunit structure

Interacts with MCL1, BCL2A1 and BAX By similarity.

Subcellular location

Mitochondrion By similarity.

Domain

The BH3 motif is essential for pro-apoptotic activity By similarity.

Sequence similarities

Belongs to the PMAIP1 family.

Ontologies

Keywords
   Biological processApoptosis
   Cellular componentMitochondrion
   DomainRepeat
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processT cell homeostasis

Inferred from electronic annotation. Source: Ensembl

activation of cysteine-type endopeptidase activity involved in apoptotic process

Inferred from electronic annotation. Source: Ensembl

apoptotic process

Inferred from expression pattern PubMed 18959742. Source: RGD

cellular response to glucose starvation

Inferred from electronic annotation. Source: Ensembl

cellular response to hypoxia

Inferred from electronic annotation. Source: Ensembl

intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

Inferred from electronic annotation. Source: Ensembl

negative regulation of fibroblast proliferation

Inferred from electronic annotation. Source: Ensembl

negative regulation of mitochondrial membrane potential

Inferred from electronic annotation. Source: Ensembl

positive regulation of DNA damage response, signal transduction by p53 class mediator

Inferred from electronic annotation. Source: Ensembl

positive regulation of apoptotic process

Inferred from mutant phenotype PubMed 18614532. Source: RGD

positive regulation of extrinsic apoptotic signaling pathway via death domain receptors

Inferred from electronic annotation. Source: Ensembl

positive regulation of glucose metabolic process

Inferred from electronic annotation. Source: Ensembl

positive regulation of intrinsic apoptotic signaling pathway

Inferred from electronic annotation. Source: Ensembl

positive regulation of neuron apoptotic process

Inferred from electronic annotation. Source: Ensembl

positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway

Inferred from electronic annotation. Source: Ensembl

positive regulation of protein oligomerization

Inferred from electronic annotation. Source: Ensembl

positive regulation of release of cytochrome c from mitochondria

Inferred from electronic annotation. Source: Ensembl

proteasomal protein catabolic process

Inferred from electronic annotation. Source: Ensembl

reactive oxygen species metabolic process

Inferred from electronic annotation. Source: Ensembl

regulation of mitochondrial membrane permeability

Inferred from electronic annotation. Source: Ensembl

release of cytochrome c from mitochondria

Inferred from electronic annotation. Source: Ensembl

response to UV

Inferred from electronic annotation. Source: Ensembl

response to X-ray

Inferred from electronic annotation. Source: Ensembl

response to dsRNA

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentcytosol

Inferred from electronic annotation. Source: Ensembl

mitochondrion

Inferred from direct assay PubMed 17127418. Source: RGD

nucleus

Inferred from electronic annotation. Source: Ensembl

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 105105Phorbol-12-myristate-13-acetate-induced protein 1
PRO_0000333231

Regions

Region92 – 10110Required for mitochondrial location By similarity
Motif27 – 359BH3 1
Motif80 – 889BH3 2

Sequences

Sequence LengthMass (Da)Tools
Q5U777 [UniParc].

Last modified December 7, 2004. Version 1.
Checksum: 76EF4EE17827890E

FASTA10511,901
        10         20         30         40         50         60 
MPGRKARRNA PLNPTRAELP PEFAAQLRKI GDKVYCTWSA PDITAVLAQM PGKKSRKSTM 

        70         80         90        100 
RRSPSPTRVP ADLKDECDQL RRIGDKVNLR QKLLNFISKL FNLIT 

« Hide

References

[1]Yakovlev A.G.
Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Sprague-Dawley.
Tissue: Embryonic brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY788892 mRNA. Translation: AAV51955.1.
RefSeqNP_001008386.1. NM_001008385.1.
UniGeneRn.163380.

3D structure databases

ProteinModelPortalQ5U777.
SMRQ5U777. Positions 17-43, 70-95.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000025361.

PTM databases

PhosphoSiteQ5U777.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000025362; ENSRNOP00000025361; ENSRNOG00000018770.
GeneID492821.
KEGGrno:492821.
UCSCRGD:1359266. rat.

Organism-specific databases

CTD5366.
RGD1359266. Pmaip1.

Phylogenomic databases

eggNOGNOG119326.
GeneTreeENSGT00530000065105.
HOGENOMHOG000034021.
HOVERGENHBG095669.
InParanoidQ5U777.
KOK10131.
OMAADLKDEC.
OrthoDBEOG7PP59Z.
TreeFamTF339379.

Gene expression databases

GenevestigatorQ5U777.

Family and domain databases

InterProIPR024140. Noxa.
[Graphical view]
PANTHERPTHR14299. PTHR14299. 1 hit.
PfamPF15150. PMAIP1. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio697216.
PROQ5U777.

Entry information

Entry nameAPR_RAT
AccessionPrimary (citable) accession number: Q5U777
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: December 7, 2004
Last modified: February 19, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families