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Q5U777

- APR_RAT

UniProt

Q5U777 - APR_RAT

Protein

Phorbol-12-myristate-13-acetate-induced protein 1

Gene

Pmaip1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Protein inferred from homologyi
  1. Functioni

    Promotes activation of caspases and apoptosis. Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria. Contributes to p53/TP53-dependent apoptosis after radiation exposure. Promotes proteasomal degradation of MCL1. Competes with BAK1 and with BIM/BCL2L11 for binding to MCL1; can displace BAK1 and BIM/BCL2L11 from their binding sites By similarity.By similarity

    GO - Biological processi

    1. activation of cysteine-type endopeptidase activity involved in apoptotic process Source: Ensembl
    2. apoptotic process Source: RGD
    3. cellular response to glucose starvation Source: Ensembl
    4. cellular response to hypoxia Source: Ensembl
    5. defense response to virus Source: Ensembl
    6. intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator Source: Ensembl
    7. negative regulation of fibroblast proliferation Source: Ensembl
    8. negative regulation of mitochondrial membrane potential Source: Ensembl
    9. positive regulation of apoptotic process Source: RGD
    10. positive regulation of DNA damage response, signal transduction by p53 class mediator Source: Ensembl
    11. positive regulation of extrinsic apoptotic signaling pathway via death domain receptors Source: Ensembl
    12. positive regulation of glucose metabolic process Source: Ensembl
    13. positive regulation of intrinsic apoptotic signaling pathway Source: Ensembl
    14. positive regulation of neuron apoptotic process Source: Ensembl
    15. positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway Source: Ensembl
    16. positive regulation of protein oligomerization Source: Ensembl
    17. positive regulation of release of cytochrome c from mitochondria Source: Ensembl
    18. proteasomal protein catabolic process Source: Ensembl
    19. reactive oxygen species metabolic process Source: Ensembl
    20. regulation of mitochondrial membrane permeability Source: Ensembl
    21. release of cytochrome c from mitochondria Source: Ensembl
    22. response to dsRNA Source: Ensembl
    23. response to UV Source: Ensembl
    24. response to X-ray Source: Ensembl
    25. T cell homeostasis Source: Ensembl

    Keywords - Biological processi

    Apoptosis

    Enzyme and pathway databases

    ReactomeiREACT_195258. Activation of NOXA and translocation to mitochondria.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phorbol-12-myristate-13-acetate-induced protein 1
    Alternative name(s):
    Protein Noxa
    Gene namesi
    Name:Pmaip1
    Synonyms:Noxa
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 18

    Organism-specific databases

    RGDi1359266. Pmaip1.

    Subcellular locationi

    Mitochondrion By similarity

    GO - Cellular componenti

    1. cytosol Source: Ensembl
    2. mitochondrion Source: RGD
    3. nucleus Source: Ensembl

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 105105Phorbol-12-myristate-13-acetate-induced protein 1PRO_0000333231Add
    BLAST

    PTM databases

    PhosphoSiteiQ5U777.

    Expressioni

    Gene expression databases

    GenevestigatoriQ5U777.

    Interactioni

    Subunit structurei

    Interacts with MCL1, BCL2A1 and BAX.By similarity

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000025361.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5U777.
    SMRiQ5U777. Positions 17-43, 70-95.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni92 – 10110Required for mitochondrial locationBy similarity

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi27 – 359BH3 1
    Motifi80 – 889BH3 2

    Domaini

    The BH3 motif is essential for pro-apoptotic activity.By similarity

    Sequence similaritiesi

    Belongs to the PMAIP1 family.Curated

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG119326.
    GeneTreeiENSGT00530000065105.
    HOGENOMiHOG000034021.
    HOVERGENiHBG095669.
    InParanoidiQ5U777.
    KOiK10131.
    OMAiLMEDADI.
    OrthoDBiEOG7PP59Z.
    TreeFamiTF339379.

    Family and domain databases

    InterProiIPR024140. Noxa.
    [Graphical view]
    PANTHERiPTHR14299. PTHR14299. 1 hit.
    PfamiPF15150. PMAIP1. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5U777-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPGRKARRNA PLNPTRAELP PEFAAQLRKI GDKVYCTWSA PDITAVLAQM    50
    PGKKSRKSTM RRSPSPTRVP ADLKDECDQL RRIGDKVNLR QKLLNFISKL 100
    FNLIT 105
    Length:105
    Mass (Da):11,901
    Last modified:December 7, 2004 - v1
    Checksum:i76EF4EE17827890E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY788892 mRNA. Translation: AAV51955.1.
    RefSeqiNP_001008386.1. NM_001008385.1.
    UniGeneiRn.163380.

    Genome annotation databases

    EnsembliENSRNOT00000025362; ENSRNOP00000025361; ENSRNOG00000018770.
    GeneIDi492821.
    KEGGirno:492821.
    UCSCiRGD:1359266. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY788892 mRNA. Translation: AAV51955.1 .
    RefSeqi NP_001008386.1. NM_001008385.1.
    UniGenei Rn.163380.

    3D structure databases

    ProteinModelPortali Q5U777.
    SMRi Q5U777. Positions 17-43, 70-95.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000025361.

    PTM databases

    PhosphoSitei Q5U777.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000025362 ; ENSRNOP00000025361 ; ENSRNOG00000018770 .
    GeneIDi 492821.
    KEGGi rno:492821.
    UCSCi RGD:1359266. rat.

    Organism-specific databases

    CTDi 5366.
    RGDi 1359266. Pmaip1.

    Phylogenomic databases

    eggNOGi NOG119326.
    GeneTreei ENSGT00530000065105.
    HOGENOMi HOG000034021.
    HOVERGENi HBG095669.
    InParanoidi Q5U777.
    KOi K10131.
    OMAi LMEDADI.
    OrthoDBi EOG7PP59Z.
    TreeFami TF339379.

    Enzyme and pathway databases

    Reactomei REACT_195258. Activation of NOXA and translocation to mitochondria.

    Miscellaneous databases

    NextBioi 697216.
    PROi Q5U777.

    Gene expression databases

    Genevestigatori Q5U777.

    Family and domain databases

    InterProi IPR024140. Noxa.
    [Graphical view ]
    PANTHERi PTHR14299. PTHR14299. 1 hit.
    Pfami PF15150. PMAIP1. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Yakovlev A.G.
      Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Sprague-Dawley.
      Tissue: Embryonic brain.

    Entry informationi

    Entry nameiAPR_RAT
    AccessioniPrimary (citable) accession number: Q5U777
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: December 7, 2004
    Last modified: October 1, 2014
    This is version 59 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3