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Protein
Submitted name:

Insulin-like growth factor 1 (Somatomedin C)

Gene

IGF1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

  • positive regulation of glycoprotein biosynthetic process Source: AgBase
  • positive regulation of protein secretion Source: AgBase
  • protein stabilization Source: AgBase
  • proteoglycan biosynthetic process Source: AgBase
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Insulin-like growth factor 1 (Somatomedin C)Imported
Submitted name:
Insulin-like growth factor 1 (Somatomedin C), isoform CRA_dImported
Gene namesi
Name:IGF1Imported
ORF Names:hCG_21873Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

  • Secreted UniRule annotationSAAS annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

SecretedUniRule annotationSAAS annotation

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29697.

Protein family/group databases

Allergomei11751. Hom s IGF-1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 4848Sequence analysisAdd
BLAST
Chaini49 – 153105Sequence analysisPRO_5007706773Add
BLAST

Keywords - PTMi

Disulfide bondSAAS annotation

Expressioni

Gene expression databases

BgeeiENSG00000017427.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000302665.

Structurei

3D structure databases

SMRiQ5U743. Positions 49-118.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini51 – 10959IlGFInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the insulin family.UniRule annotationSAAS annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiENOG410IJ2T. Eukaryota.
ENOG4111MIV. LUCA.
HOVERGENiHBG006137.
KOiK05459.
OMAiHTVSYIH.

Family and domain databases

Gene3Di1.10.100.10. 1 hit.
InterProiIPR022341. IGF-I.
IPR016179. Insulin-like.
IPR022350. Insulin-like_growth_factor.
IPR022353. Insulin_CS.
IPR022352. Insulin_family.
[Graphical view]
PfamiPF00049. Insulin. 1 hit.
[Graphical view]
PRINTSiPR02002. INSLNLIKEGF.
PR02005. INSLNLIKEGF1.
PR00276. INSULINFAMLY.
SMARTiSM00078. IlGF. 1 hit.
[Graphical view]
SUPFAMiSSF56994. SSF56994. 1 hit.
PROSITEiPS00262. INSULIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5U743-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKISSLPTQ LFKCCFCDFL KVKMHTMSSS HLFYLALCLL TFTSSATAGP
60 70 80 90 100
ETLCGAELVD ALQFVCGDRG FYFNKPTGYG SSSRRAPQTG IVDECCFRSC
110 120 130 140 150
DLRRLEMYCA PLKPAKSARS VRAQRHTDMP KTQKEVHLKN ASRGSAGNKN

YRM
Length:153
Mass (Da):17,026
Last modified:May 10, 2005 - v1
Checksum:iC6ECD92DCA9B37BC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC152321 mRNA. Translation: AAI52322.1.
AY790940 Genomic DNA. Translation: AAV40833.1.
CH471054 Genomic DNA. Translation: EAW97698.1.
RefSeqiNP_000609.1. NM_000618.4.
UniGeneiHs.160562.

Genome annotation databases

GeneIDi3479.
KEGGihsa:3479.
UCSCiuc001tjo.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC152321 mRNA. Translation: AAI52322.1.
AY790940 Genomic DNA. Translation: AAV40833.1.
CH471054 Genomic DNA. Translation: EAW97698.1.
RefSeqiNP_000609.1. NM_000618.4.
UniGeneiHs.160562.

3D structure databases

SMRiQ5U743. Positions 49-118.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000302665.

Protein family/group databases

Allergomei11751. Hom s IGF-1.

Protocols and materials databases

DNASUi3479.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi3479.
KEGGihsa:3479.
UCSCiuc001tjo.3. human.

Organism-specific databases

CTDi3479.
PharmGKBiPA29697.

Phylogenomic databases

eggNOGiENOG410IJ2T. Eukaryota.
ENOG4111MIV. LUCA.
HOVERGENiHBG006137.
KOiK05459.
OMAiHTVSYIH.

Miscellaneous databases

ChiTaRSiIGF1. human.
GenomeRNAii3479.

Gene expression databases

BgeeiENSG00000017427.

Family and domain databases

Gene3Di1.10.100.10. 1 hit.
InterProiIPR022341. IGF-I.
IPR016179. Insulin-like.
IPR022350. Insulin-like_growth_factor.
IPR022353. Insulin_CS.
IPR022352. Insulin_family.
[Graphical view]
PfamiPF00049. Insulin. 1 hit.
[Graphical view]
PRINTSiPR02002. INSLNLIKEGF.
PR02005. INSLNLIKEGF1.
PR00276. INSULINFAMLY.
SMARTiSM00078. IlGF. 1 hit.
[Graphical view]
SUPFAMiSSF56994. SSF56994. 1 hit.
PROSITEiPS00262. INSULIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ5U743_HUMAN
AccessioniPrimary (citable) accession number: Q5U743
Entry historyi
Integrated into UniProtKB/TrEMBL: May 10, 2005
Last sequence update: May 10, 2005
Last modified: September 7, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.