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Protein

S-adenosylmethionine mitochondrial carrier protein

Gene

Slc25a26

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Mitochondrial solute carriers shuttle metabolites, nucleotides, and cofactors through the mitochondrial inner membrane. Specifically mediates the transport of S-adenosylmethionine (SAM) into the mitochondria (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

ReactomeiR-MMU-425393. Transport of inorganic cations/anions and amino acids/oligopeptides.

Names & Taxonomyi

Protein namesi
Recommended name:
S-adenosylmethionine mitochondrial carrier protein
Alternative name(s):
Mitochondrial S-adenosylmethionine transporter
Solute carrier family 25 member 26
Gene namesi
Name:Slc25a26
Synonyms:Samc
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1914832. Slc25a26.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei5 – 2521Helical; Name=1Sequence analysisAdd
BLAST
Transmembranei49 – 6921Helical; Name=2Sequence analysisAdd
BLAST
Transmembranei85 – 10521Helical; Name=3Sequence analysisAdd
BLAST
Transmembranei142 – 16221Helical; Name=4Sequence analysisAdd
BLAST
Transmembranei182 – 20221Helical; Name=5Sequence analysisAdd
BLAST
Transmembranei238 – 25821Helical; Name=6Sequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • mitochondrial inner membrane Source: UniProtKB
  • mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 274274S-adenosylmethionine mitochondrial carrier proteinPRO_0000317588Add
BLAST

Proteomic databases

EPDiQ5U680.
MaxQBiQ5U680.
PaxDbiQ5U680.
PRIDEiQ5U680.

Expressioni

Gene expression databases

BgeeiQ5U680.
ExpressionAtlasiQ5U680. baseline and differential.
GenevisibleiQ5U680. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000058028.

Structurei

3D structure databases

ProteinModelPortaliQ5U680.
SMRiQ5U680. Positions 6-274.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati4 – 7774Solcar 1Add
BLAST
Repeati86 – 16883Solcar 2Add
BLAST
Repeati177 – 26589Solcar 3Add
BLAST

Sequence similaritiesi

Contains 3 Solcar repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0768. Eukaryota.
ENOG4110BII. LUCA.
GeneTreeiENSGT00550000074950.
HOGENOMiHOG000038810.
HOVERGENiHBG108456.
InParanoidiQ5U680.
KOiK15111.
OMAiGAYDRTH.
OrthoDBiEOG773XGT.
PhylomeDBiQ5U680.
TreeFamiTF313186.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00926. MITOCARRIER.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5U680-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDAPGFTASL VAGGVAGVSV DLILFPLDTI KTRLQSPQGF NKAGGFRGIY
60 70 80 90 100
AGVPSAAVGS FPNAAAFFLT YEYVKSLLHT DSTSHFKPVK HMLAASTGEV
110 120 130 140 150
VACLIRVPSE VVKQRAQVSA SSKTLQIFLT ILSEEGIQGL YRGYKSTVLR
160 170 180 190 200
EIPFSLVQFP LWESLKALWA WRRGHVVDSW QSAVCGAFAG GFAAAVTTPL
210 220 230 240 250
DVAKTRIMLA KAGSSTAVGN VLSAMHGVWR SQGLAGLFAG VLPRMAAISM
260 270
GGFIFLGAYD QARSLLLEVG RKSP
Length:274
Mass (Da):29,027
Last modified:February 5, 2008 - v2
Checksum:i35C2828A51D793CB
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti262 – 2621A → T in AAH19156 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC019156 mRNA. Translation: AAH19156.1.
BC019170 mRNA. Translation: AAH19170.1.
BC037142 mRNA. Translation: AAH37142.1.
CCDSiCCDS20379.1.
RefSeqiNP_080531.2. NM_026255.5.
UniGeneiMm.280725.

Genome annotation databases

EnsembliENSMUST00000061118; ENSMUSP00000058028; ENSMUSG00000045100.
GeneIDi67582.
KEGGimmu:67582.
UCSCiuc009czr.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC019156 mRNA. Translation: AAH19156.1.
BC019170 mRNA. Translation: AAH19170.1.
BC037142 mRNA. Translation: AAH37142.1.
CCDSiCCDS20379.1.
RefSeqiNP_080531.2. NM_026255.5.
UniGeneiMm.280725.

3D structure databases

ProteinModelPortaliQ5U680.
SMRiQ5U680. Positions 6-274.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000058028.

Proteomic databases

EPDiQ5U680.
MaxQBiQ5U680.
PaxDbiQ5U680.
PRIDEiQ5U680.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000061118; ENSMUSP00000058028; ENSMUSG00000045100.
GeneIDi67582.
KEGGimmu:67582.
UCSCiuc009czr.2. mouse.

Organism-specific databases

CTDi115286.
MGIiMGI:1914832. Slc25a26.

Phylogenomic databases

eggNOGiKOG0768. Eukaryota.
ENOG4110BII. LUCA.
GeneTreeiENSGT00550000074950.
HOGENOMiHOG000038810.
HOVERGENiHBG108456.
InParanoidiQ5U680.
KOiK15111.
OMAiGAYDRTH.
OrthoDBiEOG773XGT.
PhylomeDBiQ5U680.
TreeFamiTF313186.

Enzyme and pathway databases

ReactomeiR-MMU-425393. Transport of inorganic cations/anions and amino acids/oligopeptides.

Miscellaneous databases

PROiQ5U680.
SOURCEiSearch...

Gene expression databases

BgeeiQ5U680.
ExpressionAtlasiQ5U680. baseline and differential.
GenevisibleiQ5U680. MM.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00926. MITOCARRIER.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Czech II, FVB/N and FVB/N-3.
    Tissue: Mammary tumor.
  2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brown adipose tissue.

Entry informationi

Entry nameiSAMC_MOUSE
AccessioniPrimary (citable) accession number: Q5U680
Secondary accession number(s): Q8JZT2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 5, 2008
Last modified: June 8, 2016
This is version 85 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.