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Protein

Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase

Gene

B3GAT3

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

UDP-alpha-D-glucuronate + [protein]-3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-serine = UDP + [protein]-3-O-(beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-serine.UniRule annotation

Cofactori

Mn2+UniRule annotation

Pathwayi: protein glycosylation

This protein is involved in the pathway protein glycosylation, which is part of Protein modification.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

GO - Molecular functioni

Keywordsi

Molecular functionTransferaseUniRule annotation
LigandManganeseUniRule annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00378.

Names & Taxonomyi

Protein namesi
Recommended name:
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferaseUniRule annotation (EC:2.4.1.135UniRule annotation)
Gene namesi
Name:B3GAT3Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

  • Golgi apparatus membrane UniRule annotation; Single-pass type II membrane protein UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Golgi apparatusUniRule annotation

PTM / Processingi

Proteomic databases

MaxQBiQ5U676.
PaxDbiQ5U676.
PRIDEiQ5U676.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000265471.

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 43 family.UniRule annotation

Keywords - Domaini

Signal-anchorUniRule annotation, Transmembrane

Phylogenomic databases

eggNOGiKOG1476. Eukaryota.
ENOG410XP79. LUCA.
HOGENOMiHOG000261693.
HOVERGENiHBG050650.

Family and domain databases

CDDicd00218. GlcAT-I. 1 hit.
Gene3Di3.90.550.10. 1 hit.
InterProiView protein in InterPro
IPR005027. Glyco_trans_43.
IPR029044. Nucleotide-diphossugar_trans.
PANTHERiPTHR10896. PTHR10896. 1 hit.
PfamiView protein in Pfam
PF03360. Glyco_transf_43. 1 hit.
SUPFAMiSSF53448. SSF53448. 1 hit.

Sequencei

Sequence statusi: Fragment.

Q5U676-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
LLGRGRRRGH EAEAEERVSR LLPGVDRRPP LRAGQPCDCL PPLRAAAEQL
60 70 80 90 100
RQKDLRISQL QAELRRPPPA PAQPPEPEAL PTIYVVTPTY ARLVQKAELV
110 120 130 140 150
RLSQTLSLVP RLHWLLVEDA EGPTPLVSGL LAASGLLFTH LVVLTPKAQR
160 170 180 190 200
LREGEPGWVH PRGVEQRNKA LDWLRGRGGA VGGEKDPPPP GTQGVVYFAD
210 220 230 240 250
DDNTYSRELF EEMRWTRGVS VWPVGLVGGL RFEGPQVQDG RVVGFHTAWE
260 270 280 290 300
PSRPFPVDMA GFAVALPLLL DKPNAQFDST APRGHLESSL LSHLVDPKDL
310 320 330 340
EPRAANCTRV LVWHTRTEKP KMKQEEQLQR QGRGSDPAIE V
Length:341
Mass (Da):37,828
Last modified:December 7, 2004 - v1
Checksum:i130B8EDDBB67DE88
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC019832 mRNA. Translation: AAH19832.1.
RefSeqiNP_001275650.1. NM_001288721.1.
NP_001275651.1. NM_001288722.1.
NP_001275652.1. NM_001288723.1.
UniGeneiHs.502759.

Genome annotation databases

GeneIDi26229.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC019832 mRNA. Translation: AAH19832.1.
RefSeqiNP_001275650.1. NM_001288721.1.
NP_001275651.1. NM_001288722.1.
NP_001275652.1. NM_001288723.1.
UniGeneiHs.502759.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000265471.

Proteomic databases

MaxQBiQ5U676.
PaxDbiQ5U676.
PRIDEiQ5U676.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi26229.

Organism-specific databases

CTDi26229.

Phylogenomic databases

eggNOGiKOG1476. Eukaryota.
ENOG410XP79. LUCA.
HOGENOMiHOG000261693.
HOVERGENiHBG050650.

Enzyme and pathway databases

UniPathwayiUPA00378.

Miscellaneous databases

ChiTaRSiB3GAT3. human.
GenomeRNAii26229.

Family and domain databases

CDDicd00218. GlcAT-I. 1 hit.
Gene3Di3.90.550.10. 1 hit.
InterProiView protein in InterPro
IPR005027. Glyco_trans_43.
IPR029044. Nucleotide-diphossugar_trans.
PANTHERiPTHR10896. PTHR10896. 1 hit.
PfamiView protein in Pfam
PF03360. Glyco_transf_43. 1 hit.
SUPFAMiSSF53448. SSF53448. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiQ5U676_HUMAN
AccessioniPrimary (citable) accession number: Q5U676
Entry historyiIntegrated into UniProtKB/TrEMBL: December 7, 2004
Last sequence update: December 7, 2004
Last modified: February 15, 2017
This is version 63 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.