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Protein

Cytosolic carboxypeptidase 2

Gene

AGBL2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Metallocarboxypeptidase that mediates deglutamylation of target proteins. Catalyzes the deglutamylation of polyglutamate side chains generated by post-translational polyglutamylation in proteins such as tubulins. Also removes gene-encoded polyglutamates from the carboxy-terminus of target proteins such as MYLK. Does not show detyrosinase or deglycylase activities from the carboxy-terminus of tubulin.By similarity1 Publication

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Enzyme regulationi

Inhibited by RARRES1.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi462ZincBy similarity1
Metal bindingi465ZincBy similarity1
Active sitei512NucleophileBy similarity1
Metal bindingi558ZincBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Metal-binding, Zinc

Protein family/group databases

MEROPSiM14.029.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytosolic carboxypeptidase 2 (EC:3.4.17.-)
Alternative name(s):
ATP/GTP-binding protein-like 2
Gene namesi
Name:AGBL2
Synonyms:CCP2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:26296. AGBL2.

Subcellular locationi

GO - Cellular componenti

  • centriole Source: UniProtKB
  • ciliary basal body Source: UniProtKB
  • cytosol Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

DisGeNETi79841.
OpenTargetsiENSG00000165923.
PharmGKBiPA142672634.

Polymorphism and mutation databases

BioMutaiAGBL2.
DMDMi206729855.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002837481 – 902Cytosolic carboxypeptidase 2Add BLAST902

Proteomic databases

PaxDbiQ5U5Z8.
PRIDEiQ5U5Z8.

PTM databases

iPTMnetiQ5U5Z8.
PhosphoSitePlusiQ5U5Z8.

Expressioni

Gene expression databases

BgeeiENSG00000165923.
CleanExiHS_AGBL2.
ExpressionAtlasiQ5U5Z8. baseline and differential.
GenevisibleiQ5U5Z8. HS.

Organism-specific databases

HPAiHPA007718.

Interactioni

Protein-protein interaction databases

BioGridi122932. 4 interactors.
IntActiQ5U5Z8. 1 interactor.
STRINGi9606.ENSP00000298861.

Structurei

3D structure databases

ProteinModelPortaliQ5U5Z8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M14 family.Curated

Phylogenomic databases

eggNOGiKOG3641. Eukaryota.
COG2866. LUCA.
GeneTreeiENSGT00550000074405.
HOGENOMiHOG000111052.
HOVERGENiHBG070840.
InParanoidiQ5U5Z8.
PhylomeDBiQ5U5Z8.
TreeFamiTF313794.

Family and domain databases

InterProiIPR000834. Peptidase_M14.
[Graphical view]
PfamiPF00246. Peptidase_M14. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5U5Z8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFPALETHLK QTIPDPYEDF MYRHLQYYGY FKAQRGSLPN SATHQHVRKN
60 70 80 90 100
NPQCLLNGSL GEKDDLIPDT LQKEKLLWPI SLSSAVHRQI EAINRDFHSC
110 120 130 140 150
LGWMQWRGLS SLQPPPPRFK DSPASAFRVA GITDSHMLSL PHLRSRQLLY
160 170 180 190 200
DELDEVNPRL REPQELFSIL STKRPLQAPR WPIECEVIKE NIHHIEWAPP
210 220 230 240 250
QPEYFYQPKG NEKVPEIVGE KKGTVVYQLD SVPIEGSYFT SSRVGGKRGI
260 270 280 290 300
VKELAVTLQG PEDNTLLFES RFESGNLQKA VRVDTYEYEL TLRTDLYTNK
310 320 330 340 350
HTQWFYFRVQ NTRKDATYRF TIVNLLKPKS LYTVGMKPLL YSQLDANTRN
360 370 380 390 400
IGWRREGNEI KYYKNNTDDG QQPFYCLTWT IQFPYDQDTC FFAHFYPYTY
410 420 430 440 450
TDLQCYLLSV ANNPIQSQFC KLQTLCRSLA GNTVYLLTIT NPSQTPQEAA
460 470 480 490 500
AKKAVVLSAR VHPGESNGSW VMKGFLDFIL SNSPDAQLLR DIFVFKVLPM
510 520 530 540 550
LNPDGVIVGN YRCSLAGRDL NRHYKTILKE SFPCIWYTRN MIKRLLEERE
560 570 580 590 600
VLLYCDFHGH SRKNNIFLYG CNNNNRKYWL HERVFPLMLC KNAPDKFSFH
610 620 630 640 650
SCNFKVQKCK EGTGRVVMWR MGILNSYTME STFGGSTLGN KRDTHFTIED
660 670 680 690 700
LKSLGYHVCD TLLDFCDPDQ MKFTQCLAEL KELLRQEIHK KFHELGQDVD
710 720 730 740 750
LEGSWSDISL SDIESSTSGS DSSLSDGLPV HLANIADELT QKKKMFKKKK
760 770 780 790 800
KKSLQTRKQR NEQYQKKNLM QKLKLTEDTS EKAGFASTLQ KQPTFFKNSE
810 820 830 840 850
NSSFLPMKNE NPRLNETNLN RRDKDTPLDP SMATLILPKN KGRMQNKKPG
860 870 880 890 900
FTVSCSPKRT INSSQEPAPG MKPNWPRSRY PATKRGCAAM AAYPSLHIYT

YP
Length:902
Mass (Da):104,194
Last modified:September 23, 2008 - v2
Checksum:iC9C5D8260AFBCF65
GO
Isoform 2 (identifier: Q5U5Z8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-471: Missing.

Show »
Length:431
Mass (Da):49,706
Checksum:i24C22924E231027A
GO
Isoform 3 (identifier: Q5U5Z8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-617: Missing.

Show »
Length:285
Mass (Da):32,454
Checksum:iC5D03FEC06B4A594
GO

Sequence cautioni

The sequence BAB15707 differs from that shown. Reason: Erroneous termination at position 797. Translated as Lys.Curated
The sequence BAD96891 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAD96896 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04663790I → R.Corresponds to variant rs12795414dbSNPEnsembl.1
Natural variantiVAR_046638333T → P.Corresponds to variant rs35898124dbSNPEnsembl.1
Natural variantiVAR_031572349R → H.Corresponds to variant rs7941404dbSNPEnsembl.1
Natural variantiVAR_046639368D → G.Corresponds to variant rs1870545dbSNPEnsembl.1
Natural variantiVAR_046640671M → I.3 PublicationsCorresponds to variant rs12286721dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0243611 – 617Missing in isoform 3. 1 PublicationAdd BLAST617
Alternative sequenceiVSP_0243601 – 471Missing in isoform 2. 2 PublicationsAdd BLAST471

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK027251 mRNA. Translation: BAB15707.1. Sequence problems.
AK223171 mRNA. Translation: BAD96891.1. Different initiation.
AK223176 mRNA. Translation: BAD96896.1. Different initiation.
AC021443 Genomic DNA. No translation available.
BC028200 mRNA. Translation: AAH28200.1.
BC036234 mRNA. Translation: AAH36234.1.
CCDSiCCDS7944.1. [Q5U5Z8-1]
RefSeqiNP_079059.2. NM_024783.3. [Q5U5Z8-1]
UniGeneiHs.147377.

Genome annotation databases

EnsembliENST00000525123; ENSP00000435582; ENSG00000165923. [Q5U5Z8-1]
GeneIDi79841.
KEGGihsa:79841.
UCSCiuc001ngg.4. human. [Q5U5Z8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK027251 mRNA. Translation: BAB15707.1. Sequence problems.
AK223171 mRNA. Translation: BAD96891.1. Different initiation.
AK223176 mRNA. Translation: BAD96896.1. Different initiation.
AC021443 Genomic DNA. No translation available.
BC028200 mRNA. Translation: AAH28200.1.
BC036234 mRNA. Translation: AAH36234.1.
CCDSiCCDS7944.1. [Q5U5Z8-1]
RefSeqiNP_079059.2. NM_024783.3. [Q5U5Z8-1]
UniGeneiHs.147377.

3D structure databases

ProteinModelPortaliQ5U5Z8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122932. 4 interactors.
IntActiQ5U5Z8. 1 interactor.
STRINGi9606.ENSP00000298861.

Protein family/group databases

MEROPSiM14.029.

PTM databases

iPTMnetiQ5U5Z8.
PhosphoSitePlusiQ5U5Z8.

Polymorphism and mutation databases

BioMutaiAGBL2.
DMDMi206729855.

Proteomic databases

PaxDbiQ5U5Z8.
PRIDEiQ5U5Z8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000525123; ENSP00000435582; ENSG00000165923. [Q5U5Z8-1]
GeneIDi79841.
KEGGihsa:79841.
UCSCiuc001ngg.4. human. [Q5U5Z8-1]

Organism-specific databases

CTDi79841.
DisGeNETi79841.
GeneCardsiAGBL2.
HGNCiHGNC:26296. AGBL2.
HPAiHPA007718.
neXtProtiNX_Q5U5Z8.
OpenTargetsiENSG00000165923.
PharmGKBiPA142672634.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3641. Eukaryota.
COG2866. LUCA.
GeneTreeiENSGT00550000074405.
HOGENOMiHOG000111052.
HOVERGENiHBG070840.
InParanoidiQ5U5Z8.
PhylomeDBiQ5U5Z8.
TreeFamiTF313794.

Miscellaneous databases

ChiTaRSiAGBL2. human.
GenomeRNAii79841.
PROiQ5U5Z8.

Gene expression databases

BgeeiENSG00000165923.
CleanExiHS_AGBL2.
ExpressionAtlasiQ5U5Z8. baseline and differential.
GenevisibleiQ5U5Z8. HS.

Family and domain databases

InterProiIPR000834. Peptidase_M14.
[Graphical view]
PfamiPF00246. Peptidase_M14. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCBPC2_HUMAN
AccessioniPrimary (citable) accession number: Q5U5Z8
Secondary accession number(s): A8MPX2
, Q53FV5, Q8IV57, Q9H5C0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: September 23, 2008
Last modified: November 30, 2016
This is version 100 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Was originally thought to have detyrosinating activity from C-terminal positions on tubulin.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Peptidase families
    Classification of peptidase families and list of entries
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.