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Q5U5Z8

- CBPC2_HUMAN

UniProt

Q5U5Z8 - CBPC2_HUMAN

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Protein

Cytosolic carboxypeptidase 2

Gene

AGBL2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Metallocarboxypeptidase involved in the detyrosination of alpha-tubulin C-terminus.1 Publication

Cofactori

Binds 1 zinc ion per subunit.By similarity

Enzyme regulationi

Inhibited by RARRES1.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi462 – 4621ZincBy similarity
Metal bindingi465 – 4651ZincBy similarity
Active sitei512 – 5121NucleophileBy similarity
Metal bindingi558 – 5581ZincBy similarity

GO - Molecular functioni

  1. metallocarboxypeptidase activity Source: InterPro
  2. zinc ion binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Metal-binding, Zinc

Protein family/group databases

MEROPSiM14.029.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytosolic carboxypeptidase 2 (EC:3.4.17.-)
Alternative name(s):
ATP/GTP-binding protein-like 2
Gene namesi
Name:AGBL2
Synonyms:CCP2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:26296. AGBL2.

Subcellular locationi

Cytoplasmcytosol By similarity

GO - Cellular componenti

  1. cytosol Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142672634.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 902902Cytosolic carboxypeptidase 2PRO_0000283748Add
BLAST

Proteomic databases

PaxDbiQ5U5Z8.
PRIDEiQ5U5Z8.

PTM databases

PhosphoSiteiQ5U5Z8.

Expressioni

Gene expression databases

BgeeiQ5U5Z8.
CleanExiHS_AGBL2.
ExpressionAtlasiQ5U5Z8. baseline and differential.
GenevestigatoriQ5U5Z8.

Organism-specific databases

HPAiHPA007718.

Interactioni

Protein-protein interaction databases

BioGridi122932. 3 interactions.
STRINGi9606.ENSP00000298861.

Structurei

3D structure databases

ProteinModelPortaliQ5U5Z8.
SMRiQ5U5Z8. Positions 265-570.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M14 family.Curated

Phylogenomic databases

eggNOGiCOG2866.
GeneTreeiENSGT00550000074405.
HOGENOMiHOG000111052.
HOVERGENiHBG070840.
InParanoidiQ5U5Z8.
OrthoDBiEOG78H3SB.
PhylomeDBiQ5U5Z8.
TreeFamiTF313794.

Family and domain databases

InterProiIPR000834. Peptidase_M14.
[Graphical view]
PfamiPF00246. Peptidase_M14. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q5U5Z8-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFPALETHLK QTIPDPYEDF MYRHLQYYGY FKAQRGSLPN SATHQHVRKN
60 70 80 90 100
NPQCLLNGSL GEKDDLIPDT LQKEKLLWPI SLSSAVHRQI EAINRDFHSC
110 120 130 140 150
LGWMQWRGLS SLQPPPPRFK DSPASAFRVA GITDSHMLSL PHLRSRQLLY
160 170 180 190 200
DELDEVNPRL REPQELFSIL STKRPLQAPR WPIECEVIKE NIHHIEWAPP
210 220 230 240 250
QPEYFYQPKG NEKVPEIVGE KKGTVVYQLD SVPIEGSYFT SSRVGGKRGI
260 270 280 290 300
VKELAVTLQG PEDNTLLFES RFESGNLQKA VRVDTYEYEL TLRTDLYTNK
310 320 330 340 350
HTQWFYFRVQ NTRKDATYRF TIVNLLKPKS LYTVGMKPLL YSQLDANTRN
360 370 380 390 400
IGWRREGNEI KYYKNNTDDG QQPFYCLTWT IQFPYDQDTC FFAHFYPYTY
410 420 430 440 450
TDLQCYLLSV ANNPIQSQFC KLQTLCRSLA GNTVYLLTIT NPSQTPQEAA
460 470 480 490 500
AKKAVVLSAR VHPGESNGSW VMKGFLDFIL SNSPDAQLLR DIFVFKVLPM
510 520 530 540 550
LNPDGVIVGN YRCSLAGRDL NRHYKTILKE SFPCIWYTRN MIKRLLEERE
560 570 580 590 600
VLLYCDFHGH SRKNNIFLYG CNNNNRKYWL HERVFPLMLC KNAPDKFSFH
610 620 630 640 650
SCNFKVQKCK EGTGRVVMWR MGILNSYTME STFGGSTLGN KRDTHFTIED
660 670 680 690 700
LKSLGYHVCD TLLDFCDPDQ MKFTQCLAEL KELLRQEIHK KFHELGQDVD
710 720 730 740 750
LEGSWSDISL SDIESSTSGS DSSLSDGLPV HLANIADELT QKKKMFKKKK
760 770 780 790 800
KKSLQTRKQR NEQYQKKNLM QKLKLTEDTS EKAGFASTLQ KQPTFFKNSE
810 820 830 840 850
NSSFLPMKNE NPRLNETNLN RRDKDTPLDP SMATLILPKN KGRMQNKKPG
860 870 880 890 900
FTVSCSPKRT INSSQEPAPG MKPNWPRSRY PATKRGCAAM AAYPSLHIYT

YP
Length:902
Mass (Da):104,194
Last modified:September 23, 2008 - v2
Checksum:iC9C5D8260AFBCF65
GO
Isoform 2 (identifier: Q5U5Z8-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-471: Missing.

Show »
Length:431
Mass (Da):49,706
Checksum:i24C22924E231027A
GO
Isoform 3 (identifier: Q5U5Z8-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-617: Missing.

Show »
Length:285
Mass (Da):32,454
Checksum:iC5D03FEC06B4A594
GO

Sequence cautioni

The sequence BAD96891.1 differs from that shown. Reason: Erroneous initiation.
The sequence BAD96896.1 differs from that shown. Reason: Erroneous initiation.
The sequence BAB15707.1 differs from that shown. Reason: Erroneous termination at position 797. Translated as Lys.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti90 – 901I → R.
Corresponds to variant rs12795414 [ dbSNP | Ensembl ].
VAR_046637
Natural varianti333 – 3331T → P.
Corresponds to variant rs35898124 [ dbSNP | Ensembl ].
VAR_046638
Natural varianti349 – 3491R → H.
Corresponds to variant rs7941404 [ dbSNP | Ensembl ].
VAR_031572
Natural varianti368 – 3681D → G.
Corresponds to variant rs1870545 [ dbSNP | Ensembl ].
VAR_046639
Natural varianti671 – 6711M → I.3 Publications
Corresponds to variant rs12286721 [ dbSNP | Ensembl ].
VAR_046640

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 617617Missing in isoform 3. 1 PublicationVSP_024361Add
BLAST
Alternative sequencei1 – 471471Missing in isoform 2. 2 PublicationsVSP_024360Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK027251 mRNA. Translation: BAB15707.1. Sequence problems.
AK223171 mRNA. Translation: BAD96891.1. Different initiation.
AK223176 mRNA. Translation: BAD96896.1. Different initiation.
AC021443 Genomic DNA. No translation available.
BC028200 mRNA. Translation: AAH28200.1.
BC036234 mRNA. Translation: AAH36234.1.
CCDSiCCDS7944.1. [Q5U5Z8-1]
RefSeqiNP_079059.2. NM_024783.3. [Q5U5Z8-1]
UniGeneiHs.147377.

Genome annotation databases

EnsembliENST00000525123; ENSP00000435582; ENSG00000165923. [Q5U5Z8-1]
GeneIDi79841.
KEGGihsa:79841.
UCSCiuc001ngg.3. human. [Q5U5Z8-1]

Polymorphism databases

DMDMi206729855.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK027251 mRNA. Translation: BAB15707.1 . Sequence problems.
AK223171 mRNA. Translation: BAD96891.1 . Different initiation.
AK223176 mRNA. Translation: BAD96896.1 . Different initiation.
AC021443 Genomic DNA. No translation available.
BC028200 mRNA. Translation: AAH28200.1 .
BC036234 mRNA. Translation: AAH36234.1 .
CCDSi CCDS7944.1. [Q5U5Z8-1 ]
RefSeqi NP_079059.2. NM_024783.3. [Q5U5Z8-1 ]
UniGenei Hs.147377.

3D structure databases

ProteinModelPortali Q5U5Z8.
SMRi Q5U5Z8. Positions 265-570.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 122932. 3 interactions.
STRINGi 9606.ENSP00000298861.

Protein family/group databases

MEROPSi M14.029.

PTM databases

PhosphoSitei Q5U5Z8.

Polymorphism databases

DMDMi 206729855.

Proteomic databases

PaxDbi Q5U5Z8.
PRIDEi Q5U5Z8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000525123 ; ENSP00000435582 ; ENSG00000165923 . [Q5U5Z8-1 ]
GeneIDi 79841.
KEGGi hsa:79841.
UCSCi uc001ngg.3. human. [Q5U5Z8-1 ]

Organism-specific databases

CTDi 79841.
GeneCardsi GC11M047681.
HGNCi HGNC:26296. AGBL2.
HPAi HPA007718.
neXtProti NX_Q5U5Z8.
PharmGKBi PA142672634.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG2866.
GeneTreei ENSGT00550000074405.
HOGENOMi HOG000111052.
HOVERGENi HBG070840.
InParanoidi Q5U5Z8.
OrthoDBi EOG78H3SB.
PhylomeDBi Q5U5Z8.
TreeFami TF313794.

Miscellaneous databases

GenomeRNAii 79841.
NextBioi 69520.
PROi Q5U5Z8.

Gene expression databases

Bgeei Q5U5Z8.
CleanExi HS_AGBL2.
ExpressionAtlasi Q5U5Z8. baseline and differential.
Genevestigatori Q5U5Z8.

Family and domain databases

InterProi IPR000834. Peptidase_M14.
[Graphical view ]
Pfami PF00246. Peptidase_M14. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT ILE-671.
    Tissue: Lung.
  2. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
    Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT ILE-671.
    Tissue: Lung.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3), VARIANT ILE-671.
    Tissue: Lung and Testis.
  5. "Tumor suppressor RARRES1 interacts with cytoplasmic carboxypeptidase AGBL2 to regulate the alpha-tubulin tyrosination cycle."
    Sahab Z.J., Hall M.D., Me Sung Y., Dakshanamurthy S., Ji Y., Kumar D., Byers S.W.
    Cancer Res. 71:1219-1228(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, 3D-STRUCTURE MODELING, ENZYME REGULATION, INTERACTION WITH RARRES1.

Entry informationi

Entry nameiCBPC2_HUMAN
AccessioniPrimary (citable) accession number: Q5U5Z8
Secondary accession number(s): A8MPX2
, Q53FV5, Q8IV57, Q9H5C0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: September 23, 2008
Last modified: October 29, 2014
This is version 84 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Peptidase families
    Classification of peptidase families and list of entries
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3