Reviewed, UniProtKB/Swiss-Prot Q5U5Z8 (CBPC2_HUMAN)

Names and origin

Protein names

Recommended name:
    Cytosolic carboxypeptidase 2
    EC=3.4.17.-
Alternative name(s):
    ATP/GTP-binding protein-like 2

Gene names

Name:	AGBL2
Synonyms:	CCP2

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	902 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	May play a role in the processing of tubulin By similarity.
Cofactor	Binds 1 zinc ion per subunit By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the peptidase M14 family.
Sequence caution	The sequence BAB15707.1 differs from that shown. Reason: Erroneous termination at position 797. Translated as Lys.

Ontologies

Keywords
Cellular component	Cytoplasm
Coding sequence diversity	Alternative splicing Polymorphism
Ligand	Metal-binding Zinc
Molecular function	Carboxypeptidase Hydrolase Metalloprotease Protease
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	proteolysis Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from direct assay. Source: HPA cytoskeleton Inferred from direct assay. Source: HPA nucleolus Inferred from direct assay. Source: HPA
Molecular function	metallocarboxypeptidase activity Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q5U5Z8-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q5U5Z8-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-471: Missing.

Isoform 3 (identifier: Q5U5Z8-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-617: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 902	902	Cytosolic carboxypeptidase 2		PRO_0000283748
Sites
	Active site	512	1	Nucleophile By similarity
	Metal binding	462	1	Zinc By similarity
	Metal binding	465	1	Zinc By similarity
	Metal binding	558	1	Zinc By similarity
Natural variations
	Alternative sequence	1 – 617	617	Missing in isoform 3.		VSP_024361
	Alternative sequence	1 – 471	471	Missing in isoform 2.		VSP_024360
	Natural variant	90	1	I → R: dbSNP rs12795414.		VAR_046637
	Natural variant	333	1	T → P: dbSNP rs35898124.		VAR_046638
	Natural variant	349	1	R → H: dbSNP rs7941404.		VAR_031572
	Natural variant	368	1	D → G: dbSNP rs1870545.		VAR_046639
	Natural variant	671	1	M → I: dbSNP rs12286721. Ref.1 Ref.2 Ref.4		VAR_046640

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified September 23, 2008. Version 2. Checksum: C9C5D8260AFBCF65	FASTA	902	104,194
	10 20 30 40 50 60 MFPALETHLK QTIPDPYEDF MYRHLQYYGY FKAQRGSLPN SATHQHVRKN NPQCLLNGSL 70 80 90 100 110 120 GEKDDLIPDT LQKEKLLWPI SLSSAVHRQI EAINRDFHSC LGWMQWRGLS SLQPPPPRFK 130 140 150 160 170 180 DSPASAFRVA GITDSHMLSL PHLRSRQLLY DELDEVNPRL REPQELFSIL STKRPLQAPR 190 200 210 220 230 240 WPIECEVIKE NIHHIEWAPP QPEYFYQPKG NEKVPEIVGE KKGTVVYQLD SVPIEGSYFT 250 260 270 280 290 300 SSRVGGKRGI VKELAVTLQG PEDNTLLFES RFESGNLQKA VRVDTYEYEL TLRTDLYTNK 310 320 330 340 350 360 HTQWFYFRVQ NTRKDATYRF TIVNLLKPKS LYTVGMKPLL YSQLDANTRN IGWRREGNEI 370 380 390 400 410 420 KYYKNNTDDG QQPFYCLTWT IQFPYDQDTC FFAHFYPYTY TDLQCYLLSV ANNPIQSQFC 430 440 450 460 470 480 KLQTLCRSLA GNTVYLLTIT NPSQTPQEAA AKKAVVLSAR VHPGESNGSW VMKGFLDFIL 490 500 510 520 530 540 SNSPDAQLLR DIFVFKVLPM LNPDGVIVGN YRCSLAGRDL NRHYKTILKE SFPCIWYTRN 550 560 570 580 590 600 MIKRLLEERE VLLYCDFHGH SRKNNIFLYG CNNNNRKYWL HERVFPLMLC KNAPDKFSFH 610 620 630 640 650 660 SCNFKVQKCK EGTGRVVMWR MGILNSYTME STFGGSTLGN KRDTHFTIED LKSLGYHVCD 670 680 690 700 710 720 TLLDFCDPDQ MKFTQCLAEL KELLRQEIHK KFHELGQDVD LEGSWSDISL SDIESSTSGS 730 740 750 760 770 780 DSSLSDGLPV HLANIADELT QKKKMFKKKK KKSLQTRKQR NEQYQKKNLM QKLKLTEDTS 790 800 810 820 830 840 EKAGFASTLQ KQPTFFKNSE NSSFLPMKNE NPRLNETNLN RRDKDTPLDP SMATLILPKN 850 860 870 880 890 900 KGRMQNKKPG FTVSCSPKRT INSSQEPAPG MKPNWPRSRY PATKRGCAAM AAYPSLHIYT YP
	Isoform 2. Checksum: 24C22924E231027A	FASTA	431	49,706
	10 20 30 40 50 60 MKGFLDFILS NSPDAQLLRD IFVFKVLPML NPDGVIVGNY RCSLAGRDLN RHYKTILKES 70 80 90 100 110 120 FPCIWYTRNM IKRLLEEREV LLYCDFHGHS RKNNIFLYGC NNNNRKYWLH ERVFPLMLCK 130 140 150 160 170 180 NAPDKFSFHS CNFKVQKCKE GTGRVVMWRM GILNSYTMES TFGGSTLGNK RDTHFTIEDL 190 200 210 220 230 240 KSLGYHVCDT LLDFCDPDQM KFTQCLAELK ELLRQEIHKK FHELGQDVDL EGSWSDISLS 250 260 270 280 290 300 DIESSTSGSD SSLSDGLPVH LANIADELTQ KKKMFKKKKK KSLQTRKQRN EQYQKKNLMQ 310 320 330 340 350 360 KLKLTEDTSE KAGFASTLQK QPTFFKNSEN SSFLPMKNEN PRLNETNLNR RDKDTPLDPS 370 380 390 400 410 420 MATLILPKNK GRMQNKKPGF TVSCSPKRTI NSSQEPAPGM KPNWPRSRYP ATKRGCAAMA 430 AYPSLHIYTY P
	Isoform 3. Checksum: C5D03FEC06B4A594	FASTA	285	32,454
	10 20 30 40 50 60 MWRMGILNSY TMESTFGGST LGNKRDTHFT IEDLKSLGYH VCDTLLDFCD PDQMKFTQCL 70 80 90 100 110 120 AELKELLRQE IHKKFHELGQ DVDLEGSWSD ISLSDIESST SGSDSSLSDG LPVHLANIAD 130 140 150 160 170 180 ELTQKKKMFK KKKKKSLQTR KQRNEQYQKK NLMQKLKLTE DTSEKAGFAS TLQKQPTFFK 190 200 210 220 230 240 NSENSSFLPM KNENPRLNET NLNRRDKDTP LDPSMATLIL PKNKGRMQNK KPGFTVSCSP 250 260 270 280 KRTINSSQEP APGMKPNWPR SRYPATKRGC AAMAAYPSLH IYTYP

References

[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT ILE-671. Tissue: Lung.
[2]	Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S. Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT ILE-671. Tissue: Lung.
[3]	"Human chromosome 11 DNA sequence and analysis including novel gene identification." Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. , Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y. Nature 440:497-500(2006) [PubMed: 16554811] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3), VARIANT ILE-671. Tissue: Lung and Testis.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AK027251 mRNA. Translation: BAB15707.1. Sequence problems. AK223171 mRNA. Translation: BAD96891.1. Different initiation. AK223176 mRNA. Translation: BAD96896.1. Different initiation. AC021443 Genomic DNA. No translation available. BC028200 mRNA. Translation: AAH28200.1. BC036234 mRNA. Translation: AAH36234.1.
IPI	IPI00478928. IPI00844012. IPI00844064.
RefSeq	NP_079059.2.
UniGene	Hs.147377
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q5U5Z8.
Protein family/group databases
MEROPS	M14.029.
Proteomic databases
PRIDE	Q5U5Z8.
Genome annotation databases
Ensembl	ENST00000298861; ENSP00000298861; ENSG00000165923; Homo sapiens. [Genome view]
GeneID	79841.
KEGG	hsa:79841.
UCSC	uc001ngg.1. human.
Organism-specific databases
CTD	79841.
GeneCards	GC11M047638.
HGNC	HGNC:26296. AGBL2.
HPA	HPA007718.
PharmGKB	PA142672634.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	Q5U5Z8.
Gene expression databases
ArrayExpress	Q5U5Z8.
Bgee	Q5U5Z8.
CleanEx	HS_AGBL2.
Genevestigator	Q5U5Z8.
Family and domain databases
InterPro	IPR000834. Peptidase_M14. [Graphical view]
Pfam	PF00246. Peptidase_M14. 1 hit. [Graphical view]
PROSITE	PS00132. CARBOXYPEPT_ZN_1. False negative. PS00133. CARBOXYPEPT_ZN_2. False negative. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	69520.

Entry information

Entry name

CBPC2_HUMAN

Accession

Primary (citable) accession number: Q5U5Z8
Secondary accession number(s): A8MPX2 , Q53FV5, Q8IV57, Q9H5C0

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 3, 2007
Last sequence update:	September 23, 2008
Last modified:	November 24, 2009
This is version 44 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.