Q5U583 (GPX8B_XENLA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable glutathione peroxidase 8-B
Short name=GPx-8-B
Short name=GSHPx-8-B
EC=1.11.1.9

Gene names

Name:

gpx8-b

Organism

Xenopus laevis (African clawed frog)

Taxonomic identifier

8355 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Mesobatrachia › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus

Protein attributes

Sequence length	209 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	2 glutathione + H2O2 = glutathione disulfide + 2 H2O.
Subcellular location	Membrane; Single-pass membrane protein Potential.
Sequence similarities	Belongs to the glutathione peroxidase family.

Ontologies

Keywords
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Oxidoreductase Peroxidase
Gene Ontology (GO)
Biological process	response to oxidative stress Inferred from electronic annotation. Source: InterPro
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	glutathione peroxidase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 209	209	Probable glutathione peroxidase 8-B		PRO_0000317760
Regions
	Transmembrane	18 – 40	23	Helical; Potential
Sites
	Active site	79	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5U583 [UniParc]. Last modified December 7, 2004. Version 1. Checksum: B4D575C7F5888041	FASTA	209	23,730
	10 20 30 40 50 60 MEPLSPYPLK CSSPKAKVFL VFFSMVLCTG ILCVLQLKFL RAKGGDFYSY EVTDAKGRTV 70 80 90 100 110 120 ALSKYRGKAS LVVNVASGCP HTEANYRSLQ ELHREFGPSH FTVLAFPCNQ FGESEPGTNK 130 140 150 160 170 180 EIEAMAKRNY GVTFPVFSKI KILGSEAEPA YRFLVDSTKK EPRWNFWKYL VDPQGQVVKY 190 200 WRPDETAESI RPEVASLVRQ IIMKKKEDL

References

[1]	NIH - Xenopus Gene Collection (XGC) project Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC084801 mRNA. Translation: AAH84801.1.
RefSeq	NP_001088474.1. NM_001095005.1.
UniGene	Xl.49093.
3D structure databases
HSSP	HSSP built from PDB template 2F8A based on UniProtKB P07203.
ProteinModelPortal	Q5U583.
SMR	Q5U583. Positions 47-209.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	495339.
KEGG	xla:495339.
Organism-specific databases
CTD	495339.
Xenbase	XB-GENE-6253966. gpx8.
Phylogenomic databases
HOVERGEN	HBG004333.
Family and domain databases
InterPro	IPR013376. Glut_perox_Gpx7. IPR000889. Glutathione_peroxidase. IPR012336. Thioredoxin-like_fold. [Graphical view]
Gene3D	G3DSA:3.40.30.10. Thioredoxin_fold. 1 hit.
KO	K00432.
PANTHER	PTHR11592. Glut_peroxidase. 1 hit.
Pfam	PF00255. GSHPx. 1 hit. [Graphical view]
PIRSF	PIRSF000303. Glutathion_perox. 1 hit.
PRINTS	PR01011. GLUTPROXDASE.
SUPFAM	SSF52833. Thiordxn-like_fd. 1 hit.
TIGRFAMs	TIGR02540. Gpx7. 1 hit.
PROSITE	PS00460. GLUTATHIONE_PEROXID_1. False negative. PS00763. GLUTATHIONE_PEROXID_2. 1 hit. PS51355. GLUTATHIONE_PEROXID_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GPX8B_XENLA

Accession

Primary (citable) accession number: Q5U583

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	December 7, 2004
Last modified:	November 16, 2011
This is version 49 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program