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Q5U581

- MTRAA_XENLA

UniProt

Q5U581 - MTRAA_XENLA

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Protein
Myotubularin-related protein 10-A
Gene
mtmr10-a
Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

Probable pseudophosphatase. Contains a Glu residue instead of a conserved Cys residue in the dsPTPase catalytic loop which renders it catalytically inactive as a phosphatase Reviewed prediction.

GO - Molecular functioni

  1. phosphatase activity Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Myotubularin-related protein 10-A
Gene namesi
Name:mtmr10-a
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-1002521. mtmr10.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 765765Myotubularin-related protein 10-A
PRO_0000284363Add
BLAST

Proteomic databases

PRIDEiQ5U581.

Structurei

3D structure databases

ProteinModelPortaliQ5U581.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini209 – 650442Myotubularin phosphatase
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi197 – 2004Poly-Gly

Sequence similaritiesi

Phylogenomic databases

HOVERGENiHBG108154.
KOiK18085.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR010569. Myotubularin-like_Pase_dom.
IPR022587. Myotubularin_assoc.
IPR011993. PH_like_dom.
IPR029021. Prot-tyrosine_phosphatase-like.
[Graphical view]
PfamiPF12578. 3-PAP. 1 hit.
PF06602. Myotub-related. 2 hits.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 2 hits.
PROSITEiPS51339. PPASE_MYOTUBULARIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5U581-1 [UniParc]FASTAAdd to Basket

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MFSLKQPKPS FRSYLLPPQQ EDKLNPETKI KKLKAVLLPG EIVVNEVNFV    50
RKCIASDTSQ YDLWGKLICT NFKISFITEN SVPFQRFHYK NLLLGEHDVP 100
LTCIEQIVVV NDTKRKQKIL SHNQKLKFNP TELIIYCKDF RILRFRFDEA 150
GPESAKKVCL ALAHYSQPTD LQLLFAFEYV AQMYHKPEYK VNGIDPGGGG 200
DFCQRTPLFE TYSDWDREIK RTGASDWRVC SVNEGYMIST CLPEYFVVPS 250
SLADQDLKQY SHAFVGRRMP LWCWNHSNGS ALVRMASIKD LLQQRKIGQR 300
VCSGITRSHP LRSDVYKCDL DHNVPSIQDI QAAFSKLRQL CVNEPFDETE 350
EKWLSSLENA QWLEFVRTFL KQAAELAYVL DFSRRSVVLQ EEEGRDVSCL 400
VASLVQLMLD PYFRTIVGFQ SLIQKEWVMS AYPFLDRCNH LKRSEKESPL 450
FVLFLDCVWQ LLQQYPAAFQ FTETYLTVLH DSTRISLFGT FLFNSPHQRV 500
QQSTEFAIAR NIQLGEEKGL KFPSVWDWSL QFSAKDRALF NNPLYIGKSV 550
PCVQNGAVKS FKRTKNYSST MRGMPPSVKN GMAIQQDFMP RRNSLILKLK 600
PEILQQVPVI IPSSGFEQYL RDWFTKPADL HGVILPCLHG THIKLWKLCY 650
LRWTPEAQIN HGGFITAFHK ISLLASEIEL LQSRLRQYRA YPLSTVTSPV 700
GEQNRMFFRP DELHSSNGSL DILTSSFPFS PIGNLCRRSI LGTPLSKFIN 750
GAKIWLSTET LANED 765
Length:765
Mass (Da):88,113
Last modified:December 7, 2004 - v1
Checksum:i89E4B64712513599
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC084803 mRNA. Translation: AAH84803.1.
RefSeqiNP_001088476.1. NM_001095007.1.
UniGeneiXl.49502.

Genome annotation databases

GeneIDi495341.
KEGGixla:495341.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC084803 mRNA. Translation: AAH84803.1 .
RefSeqi NP_001088476.1. NM_001095007.1.
UniGenei Xl.49502.

3D structure databases

ProteinModelPortali Q5U581.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q5U581.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 495341.
KEGGi xla:495341.

Organism-specific databases

CTDi 495341.
Xenbasei XB-GENE-1002521. mtmr10.

Phylogenomic databases

HOVERGENi HBG108154.
KOi K18085.

Family and domain databases

Gene3Di 2.30.29.30. 1 hit.
InterProi IPR010569. Myotubularin-like_Pase_dom.
IPR022587. Myotubularin_assoc.
IPR011993. PH_like_dom.
IPR029021. Prot-tyrosine_phosphatase-like.
[Graphical view ]
Pfami PF12578. 3-PAP. 1 hit.
PF06602. Myotub-related. 2 hits.
[Graphical view ]
SUPFAMi SSF52799. SSF52799. 2 hits.
PROSITEi PS51339. PPASE_MYOTUBULARIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Xenopus Gene Collection (XGC) project
    Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Eye.

Entry informationi

Entry nameiMTRAA_XENLA
AccessioniPrimary (citable) accession number: Q5U581
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: December 7, 2004
Last modified: June 11, 2014
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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