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Q5U581

- MTRAA_XENLA

UniProt

Q5U581 - MTRAA_XENLA

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Protein

Myotubularin-related protein 10-A

Gene

mtmr10-a

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

Probable pseudophosphatase. Contains a Glu residue instead of a conserved Cys residue in the dsPTPase catalytic loop which renders it catalytically inactive as a phosphatase Potential.Curated

GO - Molecular functioni

  1. phosphatase activity Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Myotubularin-related protein 10-A
Gene namesi
Name:mtmr10-a
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-1002521. mtmr10.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 765765Myotubularin-related protein 10-APRO_0000284363Add
BLAST

Proteomic databases

PRIDEiQ5U581.

Structurei

3D structure databases

ProteinModelPortaliQ5U581.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini209 – 650442Myotubularin phosphatasePROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi197 – 2004Poly-Gly

Sequence similaritiesi

Contains 1 myotubularin phosphatase domain.PROSITE-ProRule annotation

Phylogenomic databases

HOVERGENiHBG108154.
KOiK18085.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR010569. Myotubularin-like_Pase_dom.
IPR022587. Myotubularin_assoc.
IPR011993. PH_like_dom.
IPR029021. Prot-tyrosine_phosphatase-like.
[Graphical view]
PfamiPF12578. 3-PAP. 1 hit.
PF06602. Myotub-related. 2 hits.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 2 hits.
PROSITEiPS51339. PPASE_MYOTUBULARIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5U581-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MFSLKQPKPS FRSYLLPPQQ EDKLNPETKI KKLKAVLLPG EIVVNEVNFV
60 70 80 90 100
RKCIASDTSQ YDLWGKLICT NFKISFITEN SVPFQRFHYK NLLLGEHDVP
110 120 130 140 150
LTCIEQIVVV NDTKRKQKIL SHNQKLKFNP TELIIYCKDF RILRFRFDEA
160 170 180 190 200
GPESAKKVCL ALAHYSQPTD LQLLFAFEYV AQMYHKPEYK VNGIDPGGGG
210 220 230 240 250
DFCQRTPLFE TYSDWDREIK RTGASDWRVC SVNEGYMIST CLPEYFVVPS
260 270 280 290 300
SLADQDLKQY SHAFVGRRMP LWCWNHSNGS ALVRMASIKD LLQQRKIGQR
310 320 330 340 350
VCSGITRSHP LRSDVYKCDL DHNVPSIQDI QAAFSKLRQL CVNEPFDETE
360 370 380 390 400
EKWLSSLENA QWLEFVRTFL KQAAELAYVL DFSRRSVVLQ EEEGRDVSCL
410 420 430 440 450
VASLVQLMLD PYFRTIVGFQ SLIQKEWVMS AYPFLDRCNH LKRSEKESPL
460 470 480 490 500
FVLFLDCVWQ LLQQYPAAFQ FTETYLTVLH DSTRISLFGT FLFNSPHQRV
510 520 530 540 550
QQSTEFAIAR NIQLGEEKGL KFPSVWDWSL QFSAKDRALF NNPLYIGKSV
560 570 580 590 600
PCVQNGAVKS FKRTKNYSST MRGMPPSVKN GMAIQQDFMP RRNSLILKLK
610 620 630 640 650
PEILQQVPVI IPSSGFEQYL RDWFTKPADL HGVILPCLHG THIKLWKLCY
660 670 680 690 700
LRWTPEAQIN HGGFITAFHK ISLLASEIEL LQSRLRQYRA YPLSTVTSPV
710 720 730 740 750
GEQNRMFFRP DELHSSNGSL DILTSSFPFS PIGNLCRRSI LGTPLSKFIN
760
GAKIWLSTET LANED
Length:765
Mass (Da):88,113
Last modified:December 7, 2004 - v1
Checksum:i89E4B64712513599
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC084803 mRNA. Translation: AAH84803.1.
RefSeqiNP_001088476.1. NM_001095007.1.
UniGeneiXl.49502.

Genome annotation databases

GeneIDi495341.
KEGGixla:495341.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC084803 mRNA. Translation: AAH84803.1 .
RefSeqi NP_001088476.1. NM_001095007.1.
UniGenei Xl.49502.

3D structure databases

ProteinModelPortali Q5U581.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q5U581.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 495341.
KEGGi xla:495341.

Organism-specific databases

CTDi 495341.
Xenbasei XB-GENE-1002521. mtmr10.

Phylogenomic databases

HOVERGENi HBG108154.
KOi K18085.

Family and domain databases

Gene3Di 2.30.29.30. 1 hit.
InterProi IPR010569. Myotubularin-like_Pase_dom.
IPR022587. Myotubularin_assoc.
IPR011993. PH_like_dom.
IPR029021. Prot-tyrosine_phosphatase-like.
[Graphical view ]
Pfami PF12578. 3-PAP. 1 hit.
PF06602. Myotub-related. 2 hits.
[Graphical view ]
SUPFAMi SSF52799. SSF52799. 2 hits.
PROSITEi PS51339. PPASE_MYOTUBULARIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Xenopus Gene Collection (XGC) project
    Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Eye.

Entry informationi

Entry nameiMTRAA_XENLA
AccessioniPrimary (citable) accession number: Q5U581
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: December 7, 2004
Last modified: October 1, 2014
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3