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Protein

Mitochondrial amidoxime-reducing component 1

Gene

marc1

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

As a component of an N-hydroxylated prodrug-converting complex required to reduce N-hydroxylated prodrugs, such as benzamidoxime. Also able to reduce N(omega)-hydroxy-L-arginine (NOHA) and N(omega)-hydroxy-N(delta)-methyl-L-arginine (NHAM) into L-arginine and N(delta)-methyl-L-arginine, respectively (By similarity).By similarity

Cofactori

Mo-molybdopterinBy similarityNote: Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.By similarity

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
LigandMolybdenum

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial amidoxime-reducing component 1 (EC:1.-.-.-)
Short name:
mARC1
Gene namesi
Name:marc1
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-5823412. marc1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 25Mitochondrial matrixBy similarityAdd BLAST25
Transmembranei26 – 44Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST19
Topological domaini45 – 343CytoplasmicBy similarityAdd BLAST299

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002733381 – 343Mitochondrial amidoxime-reducing component 1Add BLAST343

Structurei

3D structure databases

ProteinModelPortaliQ5U534.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini181 – 339MOSCPROSITE-ProRule annotationAdd BLAST159

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG081982.

Family and domain databases

InterProiView protein in InterPro
IPR005302. MoCF_Sase_C.
IPR005303. MOSC_N.
IPR011037. Pyrv_Knase-like_insert_dom_sf.
PfamiView protein in Pfam
PF03473. MOSC. 1 hit.
PF03476. MOSC_N. 1 hit.
SUPFAMiSSF50800. SSF50800. 2 hits.
PROSITEiView protein in PROSITE
PS51340. MOSC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5U534-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNTVFSGAV GPLRAAALSI SRHRLPLLCA AGLGLTAVAS WMWWRKRQGE
60 70 80 90 100
AEDLQQVGIV SQLLIYPVKS CRAVPVQEAE CSALGLKSGH LEDRHWLVVT
110 120 130 140 150
EEGNMVTARQ EPRMVLISAT FCGNTLCLNG PEMQEVQIPL PLPKSNRVLD
160 170 180 190 200
CRVFGQDIQG RDSGEQASEW LATYFQSSQP YRLVHFEADV MRPRQSKKKE
210 220 230 240 250
KLFRDKDVIA YPDASPIMLL SETSMEALNS RLEQPVSLAN FRPCIVASGC
260 270 280 290 300
EAFAEDDWDD VRLGATRLKR VMACGRCVLT TVNPNSGVIT RKEPLDTLRT
310 320 330 340
FRQSDSSLKE VYKNAPLFGQ YYGVEQTGII RVGDPVYRVT RKG
Length:343
Mass (Da):38,221
Last modified:December 7, 2004 - v1
Checksum:i7BBEBF378A392AEB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC084850 mRNA. Translation: AAH84850.1.
RefSeqiNP_001088512.1. NM_001095043.2.
UniGeneiXl.49111.

Genome annotation databases

GeneIDi495382.
KEGGixla:495382.

Similar proteinsi

Entry informationi

Entry nameiMARC1_XENLA
AccessioniPrimary (citable) accession number: Q5U534
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: December 7, 2004
Last modified: November 22, 2017
This is version 51 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program