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Q5U4V2

- HNMTA_XENLA

UniProt

Q5U4V2 - HNMTA_XENLA

Protein

Histamine N-methyltransferase A

Gene

hnmt-a

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 46 (01 Oct 2014)
      Sequence version 1 (07 Dec 2004)
      Previous versions | rss
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    Functioni

    Inactivates histamine by N-methylation. Plays an important role in degrading histamine and in regulating the airway response to histamine By similarity.By similarity

    Catalytic activityi

    S-adenosyl-L-methionine + histamine = S-adenosyl-L-homocysteine + N(tau)-methylhistamine.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei28 – 281SubstratePROSITE-ProRule annotation
    Binding sitei60 – 601S-adenosyl-L-methionine; via carbonyl oxygenPROSITE-ProRule annotation
    Binding sitei89 – 891S-adenosyl-L-methioninePROSITE-ProRule annotation
    Binding sitei94 – 941S-adenosyl-L-methioninePROSITE-ProRule annotation
    Binding sitei120 – 1201S-adenosyl-L-methionine; via amide nitrogenPROSITE-ProRule annotation
    Binding sitei142 – 1421S-adenosyl-L-methionine; via carbonyl oxygenPROSITE-ProRule annotation
    Binding sitei283 – 2831SubstratePROSITE-ProRule annotation

    GO - Molecular functioni

    1. histamine N-methyltransferase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histamine N-methyltransferase A (EC:2.1.1.8)
    Short name:
    HMT A
    Gene namesi
    Name:hnmt-a
    OrganismiXenopus laevis (African clawed frog)
    Taxonomic identifieri8355 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

    Organism-specific databases

    XenbaseiXB-GENE-6253847. hnmt.

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 293293Histamine N-methyltransferase APRO_0000271426Add
    BLAST

    Interactioni

    Subunit structurei

    Monomer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ5U4V2.
    SMRiQ5U4V2. Positions 5-292.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the class I-like SAM-binding methyltransferase superfamily. HNMT family.PROSITE-ProRule annotation

    Phylogenomic databases

    HOVERGENiHBG051914.
    KOiK00546.

    Family and domain databases

    Gene3Di3.40.50.150. 1 hit.
    InterProiIPR016673. Histamine_N-methyltransferase.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view]
    PIRSFiPIRSF016616. HHMT. 1 hit.
    SUPFAMiSSF53335. SSF53335. 1 hit.
    PROSITEiPS51597. SAM_HNMT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5U4V2-1 [UniParc]FASTAAdd to Basket

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    MDSKLRSLLS DHSRYVESFR LFLQNSTEHQ CMQHFIESKL PNIISSIGND    50
    KPVIDVLGVG SGSGEIDLQM IAKIQARWPG VPINNQIVEP SAEQIFGYKE 100
    RVAKAPNLEN VTFSWHRQTS SEFESQVNED KQMRKFDFIH MIQMLYYVKD 150
    VLGTLKFFKS CLAPSGKLLI ILVSGNSGWA TLWKKYGQRL PLNDLCLYIT 200
    AGDIAEMLSS MGARFQSHEL QSDMDITECF IEGDRDGELL LDFLTETCDF 250
    KRNAPADLRD QIICDLKSPG CSTTKDGKVI FNNNLSVIVV EAD 293
    Length:293
    Mass (Da):33,086
    Last modified:December 7, 2004 - v1
    Checksum:i8C798F3E19A8DDF9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC084942 mRNA. Translation: AAH84942.1.
    RefSeqiNP_001088552.1. NM_001095083.1.
    UniGeneiXl.8875.

    Genome annotation databases

    GeneIDi495426.
    KEGGixla:495426.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC084942 mRNA. Translation: AAH84942.1 .
    RefSeqi NP_001088552.1. NM_001095083.1.
    UniGenei Xl.8875.

    3D structure databases

    ProteinModelPortali Q5U4V2.
    SMRi Q5U4V2. Positions 5-292.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 495426.
    KEGGi xla:495426.

    Organism-specific databases

    CTDi 495426.
    Xenbasei XB-GENE-6253847. hnmt.

    Phylogenomic databases

    HOVERGENi HBG051914.
    KOi K00546.

    Family and domain databases

    Gene3Di 3.40.50.150. 1 hit.
    InterProi IPR016673. Histamine_N-methyltransferase.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view ]
    PIRSFi PIRSF016616. HHMT. 1 hit.
    SUPFAMi SSF53335. SSF53335. 1 hit.
    PROSITEi PS51597. SAM_HNMT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Xenopus Gene Collection (XGC) project
      Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Kidney.

    Entry informationi

    Entry nameiHNMTA_XENLA
    AccessioniPrimary (citable) accession number: Q5U4V2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 9, 2007
    Last sequence update: December 7, 2004
    Last modified: October 1, 2014
    This is version 46 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3