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Q5U4V2

- HNMTA_XENLA

UniProt

Q5U4V2 - HNMTA_XENLA

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Protein

Histamine N-methyltransferase A

Gene

hnmt-a

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

Inactivates histamine by N-methylation. Plays an important role in degrading histamine and in regulating the airway response to histamine By similarity.By similarity

Catalytic activityi

S-adenosyl-L-methionine + histamine = S-adenosyl-L-homocysteine + N(tau)-methylhistamine.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei28 – 281SubstratePROSITE-ProRule annotation
Binding sitei60 – 601S-adenosyl-L-methionine; via carbonyl oxygenPROSITE-ProRule annotation
Binding sitei89 – 891S-adenosyl-L-methioninePROSITE-ProRule annotation
Binding sitei94 – 941S-adenosyl-L-methioninePROSITE-ProRule annotation
Binding sitei120 – 1201S-adenosyl-L-methionine; via amide nitrogenPROSITE-ProRule annotation
Binding sitei142 – 1421S-adenosyl-L-methionine; via carbonyl oxygenPROSITE-ProRule annotation
Binding sitei283 – 2831SubstratePROSITE-ProRule annotation

GO - Molecular functioni

  1. histamine N-methyltransferase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Ligandi

S-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Histamine N-methyltransferase A (EC:2.1.1.8)
Short name:
HMT A
Gene namesi
Name:hnmt-a
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-6253847. hnmt.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 293293Histamine N-methyltransferase APRO_0000271426Add
BLAST

Interactioni

Subunit structurei

Monomer.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ5U4V2.
SMRiQ5U4V2. Positions 5-292.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. HNMT family.PROSITE-ProRule annotation

Phylogenomic databases

HOVERGENiHBG051914.
KOiK00546.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR016673. Histamine_N-methyltransferase.
IPR029063. SAM-dependent_MTases-like.
[Graphical view]
PIRSFiPIRSF016616. HHMT. 1 hit.
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiPS51597. SAM_HNMT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5U4V2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDSKLRSLLS DHSRYVESFR LFLQNSTEHQ CMQHFIESKL PNIISSIGND
60 70 80 90 100
KPVIDVLGVG SGSGEIDLQM IAKIQARWPG VPINNQIVEP SAEQIFGYKE
110 120 130 140 150
RVAKAPNLEN VTFSWHRQTS SEFESQVNED KQMRKFDFIH MIQMLYYVKD
160 170 180 190 200
VLGTLKFFKS CLAPSGKLLI ILVSGNSGWA TLWKKYGQRL PLNDLCLYIT
210 220 230 240 250
AGDIAEMLSS MGARFQSHEL QSDMDITECF IEGDRDGELL LDFLTETCDF
260 270 280 290
KRNAPADLRD QIICDLKSPG CSTTKDGKVI FNNNLSVIVV EAD
Length:293
Mass (Da):33,086
Last modified:December 7, 2004 - v1
Checksum:i8C798F3E19A8DDF9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC084942 mRNA. Translation: AAH84942.1.
RefSeqiNP_001088552.1. NM_001095083.1.
UniGeneiXl.8875.

Genome annotation databases

GeneIDi495426.
KEGGixla:495426.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC084942 mRNA. Translation: AAH84942.1 .
RefSeqi NP_001088552.1. NM_001095083.1.
UniGenei Xl.8875.

3D structure databases

ProteinModelPortali Q5U4V2.
SMRi Q5U4V2. Positions 5-292.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 495426.
KEGGi xla:495426.

Organism-specific databases

CTDi 495426.
Xenbasei XB-GENE-6253847. hnmt.

Phylogenomic databases

HOVERGENi HBG051914.
KOi K00546.

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
InterProi IPR016673. Histamine_N-methyltransferase.
IPR029063. SAM-dependent_MTases-like.
[Graphical view ]
PIRSFi PIRSF016616. HHMT. 1 hit.
SUPFAMi SSF53335. SSF53335. 1 hit.
PROSITEi PS51597. SAM_HNMT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Xenopus Gene Collection (XGC) project
    Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.

Entry informationi

Entry nameiHNMTA_XENLA
AccessioniPrimary (citable) accession number: Q5U4V2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: December 7, 2004
Last modified: October 29, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3