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Q5U4V2 (HNMTA_XENLA) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 45. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Histamine N-methyltransferase A

Short name=HMT A
EC=2.1.1.8
Gene names
Name:hnmt-a
OrganismXenopus laevis (African clawed frog)
Taxonomic identifier8355 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Protein attributes

Sequence length293 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Inactivates histamine by N-methylation. Plays an important role in degrading histamine and in regulating the airway response to histamine By similarity.

Catalytic activity

S-adenosyl-L-methionine + histamine = S-adenosyl-L-homocysteine + N(tau)-methylhistamine.

Subunit structure

Monomer By similarity.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the class I-like SAM-binding methyltransferase superfamily. HNMT family.

Ontologies

Keywords
   Cellular componentCytoplasm
   LigandS-adenosyl-L-methionine
   Molecular functionMethyltransferase
Transferase
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionhistamine N-methyltransferase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 293293Histamine N-methyltransferase A
PRO_0000271426

Sites

Binding site281Substrate By similarity
Binding site601S-adenosyl-L-methionine; via carbonyl oxygen By similarity
Binding site891S-adenosyl-L-methionine By similarity
Binding site941S-adenosyl-L-methionine By similarity
Binding site1201S-adenosyl-L-methionine; via amide nitrogen By similarity
Binding site1421S-adenosyl-L-methionine; via carbonyl oxygen By similarity
Binding site2831Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5U4V2 [UniParc].

Last modified December 7, 2004. Version 1.
Checksum: 8C798F3E19A8DDF9

FASTA29333,086
        10         20         30         40         50         60 
MDSKLRSLLS DHSRYVESFR LFLQNSTEHQ CMQHFIESKL PNIISSIGND KPVIDVLGVG 

        70         80         90        100        110        120 
SGSGEIDLQM IAKIQARWPG VPINNQIVEP SAEQIFGYKE RVAKAPNLEN VTFSWHRQTS 

       130        140        150        160        170        180 
SEFESQVNED KQMRKFDFIH MIQMLYYVKD VLGTLKFFKS CLAPSGKLLI ILVSGNSGWA 

       190        200        210        220        230        240 
TLWKKYGQRL PLNDLCLYIT AGDIAEMLSS MGARFQSHEL QSDMDITECF IEGDRDGELL 

       250        260        270        280        290 
LDFLTETCDF KRNAPADLRD QIICDLKSPG CSTTKDGKVI FNNNLSVIVV EAD 

« Hide

References

[1]NIH - Xenopus Gene Collection (XGC) project
Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Kidney.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC084942 mRNA. Translation: AAH84942.1.
RefSeqNP_001088552.1. NM_001095083.1.
UniGeneXl.8875.

3D structure databases

ProteinModelPortalQ5U4V2.
SMRQ5U4V2. Positions 5-292.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID495426.
KEGGxla:495426.

Organism-specific databases

CTD495426.
XenbaseXB-GENE-6253847. hnmt.

Phylogenomic databases

HOVERGENHBG051914.
KOK00546.

Family and domain databases

Gene3D3.40.50.150. 1 hit.
InterProIPR016673. Histamine_N-methyltransferase.
IPR029063. SAM-dependent_MTases-like.
[Graphical view]
PIRSFPIRSF016616. HHMT. 1 hit.
SUPFAMSSF53335. SSF53335. 1 hit.
PROSITEPS51597. SAM_HNMT. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHNMTA_XENLA
AccessionPrimary (citable) accession number: Q5U4V2
Entry history
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: December 7, 2004
Last modified: June 11, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families