Reviewed, UniProtKB/Swiss-Prot Q5U4U6 (T23O_XENLA)

Names and origin

Protein names

Recommended name:
    Tryptophan 2,3-dioxygenase
      Short name=TDO
    EC=1.13.11.11
Alternative name(s):
    Tryptophan pyrrolase
      Short name=Tryptophanase
    Tryptophan oxygenase
      Short name=TRPO
      Short name=TO
    Tryptamin 2,3-dioxygenase

Gene names

Name:

tdo2

Organism

Xenopus laevis (African clawed frog)

Taxonomic identifier

8355 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Mesobatrachia › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus

Protein attributes

Sequence length	406 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring By similarity.
Catalytic activity	L-tryptophan + O2 = N-formyl-L-kynurenine.
Cofactor	Binds 2 heme groups per tetramer By similarity.
Pathway	Amino-acid degradation; L-tryptophan degradation via kynurenine pathway; L-kynurenine from L-tryptophan: step 1/2.
Subunit structure	Homotetramer By similarity.
Sequence similarities	Belongs to the tryptophan 2,3-dioxygenase family.

Ontologies

Keywords
Biological process	Tryptophan catabolism
Ligand	Heme Iron Metal-binding
Molecular function	Dioxygenase Oxidoreductase
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW tryptophan catabolic process to kynurenine Inferred from electronic annotation. Source: InterPro
Molecular function	iron ion binding Inferred from electronic annotation. Source: UniProtKB-KW tryptophan 2,3-dioxygenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 406	406	Tryptophan 2,3-dioxygenase		PRO_0000247476
Regions
	Region	42 – 46	5	Substrate binding By similarity
	Region	72 – 76	5	Substrate binding By similarity
Sites
	Metal binding	328	1	Iron (heme axial ligand) By similarity
	Binding site	144	1	Substrate By similarity
	Binding site	151	1	Heme By similarity
	Binding site	342	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5U4U6-1 [UniParc]. Last modified December 7, 2004. Version 1. Checksum: 54C81EAE30A944AE	FASTA	406	47,677
	10 20 30 40 50 60 MSGCPFMAKK HHFTFSELSL EDKHEDNSQE GLNKASKGGL IYGDYLQLDK VLNAQELQSE 70 80 90 100 110 120 KKGNKIHDEH LFIVTHQAYE LWFKQILWEL DSVREIFQNG HVRDERNMLK VVARIHRISM 130 140 150 160 170 180 ILKLLVEQFS VLETMTAMDF FDFRDYLSPA SGFQSLQFRL LENKIGVPEI LRVPYNRRHY 190 200 210 220 230 240 RDNFKGETNE LLLRSEQEPT LLGLVEAWLE RTPGLEEEGF HFWGKLEVNI FRALEEELQA 250 260 270 280 290 300 AKTKPDSEDK EEHLAELQKQ KELFGALFDE RRHEHLLSKG ERRLSYKALK GALMINFYRE 310 320 330 340 350 360 EPRFQVPFQL LTSLMEIDTL MTKWRYNHVC MVHRMIGSKA GTGGSSGYQY LRSTVSDRYK 370 380 390 400 VFVDLFNLST YLVPRHWVPR LNPSIHKFLY TAECCDSSYF SSDDSD

References

[1]	NIH - Xenopus Gene Collection (XGC) project Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Liver.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BC084948 mRNA. Translation: AAH84948.1.
RefSeq	NP_001088604.1.
UniGene	Xl.14845
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	495495.
KEGG	xla:495495.
Organism-specific databases
Xenbase	XB-FEAT-976711. tdo2.
Phylogenomic databases
HOVERGEN	Q5U4U6.
Enzyme and pathway databases
BRENDA	1.13.11.11. 648.
Family and domain databases
InterPro	IPR004981. Trp_2_3_dOase. [Graphical view]
PANTHER	PTHR10138. Trp_2_3_dOase. 1 hit.
Pfam	PF03301. Trp_dioxygenase. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

T23O_XENLA

Accession

Primary (citable) accession number: Q5U4U6

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 25, 2006
Last sequence update:	December 7, 2004
Last modified:	June 16, 2009
This is version 28 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Xenopus annotation project