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Q5U4S8

- CEGTB_XENLA

UniProt

Q5U4S8 - CEGTB_XENLA

Protein

Ceramide glucosyltransferase-B

Gene

ugcg-b

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 43 (01 Oct 2014)
      Sequence version 1 (07 Dec 2004)
      Previous versions | rss
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    Functioni

    Catalyzes the first glycosylation step in glycosphingolipid biosynthesis, the transfer of glucose to ceramide. Glycosphingolipids are required for convergence extension movements during early development By similarity.By similarity

    Catalytic activityi

    UDP-glucose + N-acylsphingosine = UDP + D-glucosyl-N-acylsphingosine.By similarity

    Pathwayi

    GO - Molecular functioni

    1. ceramide glucosyltransferase activity Source: UniProtKB

    GO - Biological processi

    1. glycosphingolipid catabolic process Source: UniProtKB
    2. multicellular organismal development Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein, Glycosyltransferase, Transferase

    Keywords - Biological processi

    Lipid biosynthesis, Lipid metabolism, Sphingolipid metabolism

    Enzyme and pathway databases

    UniPathwayiUPA00222.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ceramide glucosyltransferase-B (EC:2.4.1.80)
    Alternative name(s):
    UDP-glucose ceramide glucosyltransferaseBy similarity
    Gene namesi
    Name:ugcg-b
    Synonyms:ugcg
    OrganismiXenopus laevis (African clawed frog)
    Taxonomic identifieri8355 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

    Organism-specific databases

    XenbaseiXB-GENE-944700. ugcg.

    Subcellular locationi

    Golgi apparatus membrane By similaritySequence Analysis; Multi-pass membrane protein By similaritySequence Analysis

    GO - Cellular componenti

    1. Golgi apparatus Source: UniProtKB
    2. Golgi membrane Source: UniProtKB-SubCell
    3. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Golgi apparatus, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 394394Ceramide glucosyltransferase-BPRO_0000376855Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ5U4S8.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 1010LumenalSequence Analysis
    Topological domaini33 – 195163CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini216 – 28772LumenalSequence AnalysisAdd
    BLAST
    Topological domaini305 – 3095CytoplasmicSequence Analysis
    Topological domaini329 – 34820LumenalSequence AnalysisAdd
    BLAST
    Topological domaini370 – 39425CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei11 – 3222HelicalSequence AnalysisAdd
    BLAST
    Transmembranei196 – 21520HelicalSequence AnalysisAdd
    BLAST
    Transmembranei288 – 30417HelicalSequence AnalysisAdd
    BLAST
    Transmembranei310 – 32819HelicalSequence AnalysisAdd
    BLAST
    Transmembranei349 – 36921HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glycosyltransferase 2 family.Sequence Analysis

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    KOiK00720.

    Family and domain databases

    Gene3Di3.90.550.10. 1 hit.
    InterProiIPR025993. Ceramide_glucosylTrfase.
    IPR029044. Nucleotide-diphossugar_trans.
    [Graphical view]
    PfamiPF13506. Glyco_transf_21. 1 hit.
    [Graphical view]
    SUPFAMiSSF53448. SSF53448. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q5U4S8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAVLDLALQG LAIFGCILFF VLWFMHFLSI VYTRLHLNKK VSDKQPYSKL    50
    PGVSLLKPLK GVDSNLINNL ETFFELDYPK FEILLCVQDL DDPAVDVCKK 100
    LLGKYPSVDA KLFIGGKKVG INPKINNLMP GYEVAKYDLI WICDSGIKVK 150
    PDTLTDMANQ MTEKVGLVHG LPYVADRQGF AATLEQVYFG TSHPRSYISA 200
    NVTGIKCVTG MSCLMRKEVL DQAGGLIAFA QYIAEDYFMA KAIADRGWKF 250
    SMATQVAMQN SGCYSISQFQ SRMIRWAKLR INMLPATIIC EPISECFVAS 300
    LIIGWAAHHI FRWDIMVFFM CHCLAWFIFD YIQLRGVQGG PLNFSKLDYA 350
    VAWFIRESMT IYIFLSALWD PTISWRTGRY RLRCGGTAEE ILDV 394
    Length:394
    Mass (Da):44,607
    Last modified:December 7, 2004 - v1
    Checksum:iFDA06E33F49749B3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC084966 mRNA. Translation: AAH84966.1.
    RefSeqiNP_001088566.1. NM_001095097.1.
    UniGeneiXl.21133.

    Genome annotation databases

    GeneIDi495444.
    KEGGixla:495444.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC084966 mRNA. Translation: AAH84966.1 .
    RefSeqi NP_001088566.1. NM_001095097.1.
    UniGenei Xl.21133.

    3D structure databases

    ProteinModelPortali Q5U4S8.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 495444.
    KEGGi xla:495444.

    Organism-specific databases

    CTDi 495444.
    Xenbasei XB-GENE-944700. ugcg.

    Phylogenomic databases

    KOi K00720.

    Enzyme and pathway databases

    UniPathwayi UPA00222 .

    Family and domain databases

    Gene3Di 3.90.550.10. 1 hit.
    InterProi IPR025993. Ceramide_glucosylTrfase.
    IPR029044. Nucleotide-diphossugar_trans.
    [Graphical view ]
    Pfami PF13506. Glyco_transf_21. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53448. SSF53448. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. NIH - Xenopus Gene Collection (XGC) project
      Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: BrainImported.

    Entry informationi

    Entry nameiCEGTB_XENLA
    AccessioniPrimary (citable) accession number: Q5U4S8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 16, 2009
    Last sequence update: December 7, 2004
    Last modified: October 1, 2014
    This is version 43 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3