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Q5U4S8

- CEGTB_XENLA

UniProt

Q5U4S8 - CEGTB_XENLA

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Protein

Ceramide glucosyltransferase-B

Gene
ugcg-b, ugcg
Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalyzes the first glycosylation step in glycosphingolipid biosynthesis, the transfer of glucose to ceramide. Glycosphingolipids are required for convergence extension movements during early development By similarity.By similarity

Catalytic activityi

UDP-glucose + N-acylsphingosine = UDP + D-glucosyl-N-acylsphingosine.By similarity

Pathwayi

GO - Molecular functioni

  1. ceramide glucosyltransferase activity Source: UniProtKB

GO - Biological processi

  1. glycosphingolipid catabolic process Source: UniProtKB
  2. multicellular organismal development Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Glycosyltransferase, Transferase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Sphingolipid metabolism

Enzyme and pathway databases

UniPathwayiUPA00222.

Names & Taxonomyi

Protein namesi
Recommended name:
Ceramide glucosyltransferase-B (EC:2.4.1.80)
Alternative name(s):
UDP-glucose ceramide glucosyltransferase
Gene namesi
Name:ugcg-b
Synonyms:ugcg
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-944700. ugcg.

Subcellular locationi

Golgi apparatus membrane; Multi-pass membrane protein By similarity By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1010Lumenal Reviewed prediction
Transmembranei11 – 3222Helical; Reviewed predictionAdd
BLAST
Topological domaini33 – 195163Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei196 – 21520Helical; Reviewed predictionAdd
BLAST
Topological domaini216 – 28772Lumenal Reviewed predictionAdd
BLAST
Transmembranei288 – 30417Helical; Reviewed predictionAdd
BLAST
Topological domaini305 – 3095Cytoplasmic Reviewed prediction
Transmembranei310 – 32819Helical; Reviewed predictionAdd
BLAST
Topological domaini329 – 34820Lumenal Reviewed predictionAdd
BLAST
Transmembranei349 – 36921Helical; Reviewed predictionAdd
BLAST
Topological domaini370 – 39425Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. Golgi apparatus Source: UniProtKB
  2. Golgi membrane Source: UniProtKB-SubCell
  3. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 394394Ceramide glucosyltransferase-BPRO_0000376855Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ5U4S8.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

KOiK00720.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
InterProiIPR025993. Ceramide_glucosylTrfase.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PfamiPF13506. Glyco_transf_21. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5U4S8-1 [UniParc]FASTAAdd to Basket

« Hide

MAVLDLALQG LAIFGCILFF VLWFMHFLSI VYTRLHLNKK VSDKQPYSKL    50
PGVSLLKPLK GVDSNLINNL ETFFELDYPK FEILLCVQDL DDPAVDVCKK 100
LLGKYPSVDA KLFIGGKKVG INPKINNLMP GYEVAKYDLI WICDSGIKVK 150
PDTLTDMANQ MTEKVGLVHG LPYVADRQGF AATLEQVYFG TSHPRSYISA 200
NVTGIKCVTG MSCLMRKEVL DQAGGLIAFA QYIAEDYFMA KAIADRGWKF 250
SMATQVAMQN SGCYSISQFQ SRMIRWAKLR INMLPATIIC EPISECFVAS 300
LIIGWAAHHI FRWDIMVFFM CHCLAWFIFD YIQLRGVQGG PLNFSKLDYA 350
VAWFIRESMT IYIFLSALWD PTISWRTGRY RLRCGGTAEE ILDV 394
Length:394
Mass (Da):44,607
Last modified:December 7, 2004 - v1
Checksum:iFDA06E33F49749B3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC084966 mRNA. Translation: AAH84966.1.
RefSeqiNP_001088566.1. NM_001095097.1.
UniGeneiXl.21133.

Genome annotation databases

GeneIDi495444.
KEGGixla:495444.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC084966 mRNA. Translation: AAH84966.1 .
RefSeqi NP_001088566.1. NM_001095097.1.
UniGenei Xl.21133.

3D structure databases

ProteinModelPortali Q5U4S8.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 495444.
KEGGi xla:495444.

Organism-specific databases

CTDi 495444.
Xenbasei XB-GENE-944700. ugcg.

Phylogenomic databases

KOi K00720.

Enzyme and pathway databases

UniPathwayi UPA00222 .

Family and domain databases

Gene3Di 3.90.550.10. 1 hit.
InterProi IPR025993. Ceramide_glucosylTrfase.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view ]
Pfami PF13506. Glyco_transf_21. 1 hit.
[Graphical view ]
SUPFAMi SSF53448. SSF53448. 1 hit.
ProtoNeti Search...

Publicationsi

  1. NIH - Xenopus Gene Collection (XGC) project
    Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiCEGTB_XENLA
AccessioniPrimary (citable) accession number: Q5U4S8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 16, 2009
Last sequence update: December 7, 2004
Last modified: June 11, 2014
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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