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Q5U4S8 (CEGTB_XENLA) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 41. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ceramide glucosyltransferase-B

EC=2.4.1.80
Alternative name(s):
UDP-glucose ceramide glucosyltransferase
Gene names
Name:ugcg-b
Synonyms:ugcg
OrganismXenopus laevis (African clawed frog)
Taxonomic identifier8355 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Protein attributes

Sequence length394 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Catalyzes the first glycosylation step in glycosphingolipid biosynthesis, the transfer of glucose to ceramide. Glycosphingolipids are required for convergence extension movements during early development By similarity. UniProtKB Q8AY29

Catalytic activity

UDP-glucose + N-acylsphingosine = UDP + D-glucosyl-N-acylsphingosine. UniProtKB Q8AY29

Pathway

Lipid metabolism; sphingolipid metabolism. UniProtKB Q8AY29

Subcellular location

Golgi apparatus membrane; Multi-pass membrane protein By similarity UniProtKB Q8AY29.

Sequence similarities

Belongs to the glycosyltransferase 2 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 394394Ceramide glucosyltransferase-B
PRO_0000376855

Regions

Topological domain1 – 1010Lumenal Potential
Transmembrane11 – 3222Helical; Potential
Topological domain33 – 195163Cytoplasmic Potential
Transmembrane196 – 21520Helical; Potential
Topological domain216 – 28772Lumenal Potential
Transmembrane288 – 30417Helical; Potential
Topological domain305 – 3095Cytoplasmic Potential
Transmembrane310 – 32819Helical; Potential
Topological domain329 – 34820Lumenal Potential
Transmembrane349 – 36921Helical; Potential
Topological domain370 – 39425Cytoplasmic Potential

Sequences

Sequence LengthMass (Da)Tools
Q5U4S8 [UniParc].

Last modified December 7, 2004. Version 1.
Checksum: FDA06E33F49749B3

FASTA39444,607
        10         20         30         40         50         60 
MAVLDLALQG LAIFGCILFF VLWFMHFLSI VYTRLHLNKK VSDKQPYSKL PGVSLLKPLK 

        70         80         90        100        110        120 
GVDSNLINNL ETFFELDYPK FEILLCVQDL DDPAVDVCKK LLGKYPSVDA KLFIGGKKVG 

       130        140        150        160        170        180 
INPKINNLMP GYEVAKYDLI WICDSGIKVK PDTLTDMANQ MTEKVGLVHG LPYVADRQGF 

       190        200        210        220        230        240 
AATLEQVYFG TSHPRSYISA NVTGIKCVTG MSCLMRKEVL DQAGGLIAFA QYIAEDYFMA 

       250        260        270        280        290        300 
KAIADRGWKF SMATQVAMQN SGCYSISQFQ SRMIRWAKLR INMLPATIIC EPISECFVAS 

       310        320        330        340        350        360 
LIIGWAAHHI FRWDIMVFFM CHCLAWFIFD YIQLRGVQGG PLNFSKLDYA VAWFIRESMT 

       370        380        390 
IYIFLSALWD PTISWRTGRY RLRCGGTAEE ILDV 

« Hide

References

[1]NIH - Xenopus Gene Collection (XGC) project
Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC084966 mRNA. Translation: AAH84966.1.
RefSeqNP_001088566.1. NM_001095097.1.
UniGeneXl.21133.

3D structure databases

ProteinModelPortalQ5U4S8.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID495444.
KEGGxla:495444.

Organism-specific databases

CTD495444.
XenbaseXB-GENE-944700. ugcg.

Phylogenomic databases

KOK00720.

Enzyme and pathway databases

UniPathwayUPA00222.

Family and domain databases

InterProIPR025993. Ceramide_glucosylTrfase.
[Graphical view]
PfamPF13506. Glyco_transf_21. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCEGTB_XENLA
AccessionPrimary (citable) accession number: Q5U4S8
Entry history
Integrated into UniProtKB/Swiss-Prot: June 16, 2009
Last sequence update: December 7, 2004
Last modified: February 19, 2014
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways