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Protein

WW domain-containing adapter protein with coiled-coil

Gene

wac

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Acts as a linker between gene transcription and histone H2B monoubiquitination at 'Lys-120' (H2BK120ub1). Positive regulator of amino acid starvation-induced autophagy. May negatively regulate the ubiquitin proteasome pathway.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
WW domain-containing adapter protein with coiled-coil
Gene namesi
Name:wac
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
Proteomesi
  • UP000008143 Componenti: Unassembled WGS sequence

Organism-specific databases

XenbaseiXB-GENE-6258902. wac.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004069821 – 628WW domain-containing adapter protein with coiled-coilAdd BLAST628

Proteomic databases

PaxDbiQ5U4Q0.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi8364.ENSXETP00000059493.

Structurei

3D structure databases

ProteinModelPortaliQ5U4Q0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini123 – 156WWPROSITE-ProRule annotationAdd BLAST34

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili599 – 625Sequence analysisAdd BLAST27

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi416 – 535Ser-richAdd BLAST120

Sequence similaritiesi

Contains 1 WW domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0152. Eukaryota.
ENOG4111EBW. LUCA.
HOGENOMiHOG000013038.
HOVERGENiHBG057585.
InParanoidiQ5U4Q0.

Family and domain databases

InterProiIPR001202. WW_dom.
[Graphical view]
PfamiPF00397. WW. 1 hit.
[Graphical view]
SMARTiSM00456. WW. 1 hit.
[Graphical view]
SUPFAMiSSF51045. SSF51045. 1 hit.
PROSITEiPS01159. WW_DOMAIN_1. 1 hit.
PS50020. WW_DOMAIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5U4Q0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVMYARKQAR LSDGCHDRRD SQPYQTLKYS SKSHPSSSDH RHDKMRDSTD
60 70 80 90 100
PSPPNKMRRS NSPENKYIDS AGHGKAKSMH LHRVRERDGG TSFSPQENSH
110 120 130 140 150
NHSAIHSSNS HSSTPSKTSD SAYDPADDWS EHISSSGKKY YYNCRTEVSQ
160 170 180 190 200
WEKPKEWLER EQRQKETSKV AVNSFPKDRD YRREAMQAAA AVEEKHSSDT
210 220 230 240 250
STMLPQNILS QTSRHNDRDY RLPRTDSHSS AAPVQQPVKA AVHPAAAPST
260 270 280 290 300
VPSSPFTVQP DHPPPKKSYD ANGAALSKLP TPTSSIPVPK SERKETASSD
310 320 330 340 350
KSSCTTPSTS SAPGLNLSAA PPSSSSSTVP VSPVPQSPIP PILQDPNLLR
360 370 380 390 400
QLLPALQATL QLNNSNVDIS KINEAAVTQA SLQSILHKIL TAGPSAFNIT
410 420 430 440 450
SLISQVAQLS AQAAQSNQSP MSLTSDASSP RSYVSPRIST PQTNTVPHKP
460 470 480 490 500
LLSTPPVTSQ PKVGTPGSKQ GSSAQTASQQ SSAADKSQGH EPTSPRNLQR
510 520 530 540 550
SSSQRSPSPG PNHNSSTCAS STSAPQNSSA RSSCSLTPTL AAYFNENLVK
560 570 580 590 600
HVQGWPADHA EKQASRLREE AHNMGSIHMS EVCTELKNLR SLVRVCEIQA
610 620
TLREQRILFL RQQIKELEKL KNQNSFMV
Length:628
Mass (Da):68,404
Last modified:December 7, 2004 - v1
Checksum:i4CD0455341394880
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC084997 mRNA. Translation: AAH84997.1.
RefSeqiNP_001011171.1. NM_001011171.1.
UniGeneiStr.2721.

Genome annotation databases

GeneIDi496589.
KEGGixtr:496589.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC084997 mRNA. Translation: AAH84997.1.
RefSeqiNP_001011171.1. NM_001011171.1.
UniGeneiStr.2721.

3D structure databases

ProteinModelPortaliQ5U4Q0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi8364.ENSXETP00000059493.

Proteomic databases

PaxDbiQ5U4Q0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi496589.
KEGGixtr:496589.

Organism-specific databases

CTDi51322.
XenbaseiXB-GENE-6258902. wac.

Phylogenomic databases

eggNOGiKOG0152. Eukaryota.
ENOG4111EBW. LUCA.
HOGENOMiHOG000013038.
HOVERGENiHBG057585.
InParanoidiQ5U4Q0.

Family and domain databases

InterProiIPR001202. WW_dom.
[Graphical view]
PfamiPF00397. WW. 1 hit.
[Graphical view]
SMARTiSM00456. WW. 1 hit.
[Graphical view]
SUPFAMiSSF51045. SSF51045. 1 hit.
PROSITEiPS01159. WW_DOMAIN_1. 1 hit.
PS50020. WW_DOMAIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiWAC_XENTR
AccessioniPrimary (citable) accession number: Q5U4Q0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 5, 2011
Last sequence update: December 7, 2004
Last modified: November 11, 2015
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.