Reviewed, UniProtKB/Swiss-Prot Q5U4P2 (ASPH1_HUMAN)

Names and origin

Protein names

Recommended name:
    Aspartate beta-hydroxylase domain-containing protein 1
    EC=1.14.11.-

Gene names

Name:

ASPHD1

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	390 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Subcellular location	Membrane; Single-pass type II membrane protein Potential.
Sequence similarities	Belongs to the aspartyl/asparaginyl beta-hydroxylase family.

Ontologies

Keywords
Cellular component	Membrane
Domain	Signal-anchor Transmembrane
Molecular function	Dioxygenase Oxidoreductase
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW peptidyl-amino acid modification Inferred from electronic annotation. Source: InterPro
Cellular component	integral to endoplasmic reticulum membrane Inferred from electronic annotation. Source: InterPro
Molecular function	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen Inferred from electronic annotation. Source: UniProtKB-KW peptide-aspartate beta-dioxygenase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 390	390	Aspartate beta-hydroxylase domain-containing protein 1		PRO_0000254595
Regions
	Topological domain	1 – 72	72	Cytoplasmic Potential
	Transmembrane	73 – 95	23	Potential
	Topological domain	96 – 390	295	Lumenal Potential
	Compositional bias	107 – 188	82	Gly-rich
Amino acid modifications
	Modified residue	129	1	Phosphoserine Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Q5U4P2-1 [UniParc]. Last modified November 25, 2008. Version 3. Checksum: 072163A74E3A23BF	FASTA	390	41,128
	10 20 30 40 50 60 MKEGRGSFSV ERGPRKERET AQSGMWKGNS PAGSQGAAME GTGGELGGQG NWGPEDAPGL 70 80 90 100 110 120 LARASLIMLP WPLPLASSAL TLLFGALTSL FLWYCYRLGS QDMQALGAGS RAGGVRGGPV 130 140 150 160 170 180 GCSEAGGPSP GGPGDPGEGP RTEGLVSRRL RAYARRYSWA GMGRVRRAAQ GGPGPGRGPG 190 200 210 220 230 240 VLGIQRPGLL FLPDLPSAPF VPRDAQRHDV ELLESSFPAI LRDFGAVSWD FSGTTPPPRG 250 260 270 280 290 300 WSPPLAPGCY QLLLYQAGRC QPSNCRRCPG AYRALRGLRS FMSANTFGNA GFSVLLPGAR 310 320 330 340 350 360 LEGRCGPTNA RVRCHLGLKI PPGCELVVGG EPQCWAEGHC LLVDDSFLHT VAHNGSPEDG 370 380 390 PRVVFIVDLW HPNVAGAERQ ALDFVFAPDP

References

[1]	"The sequence and analysis of duplication-rich human chromosome 16." Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J. , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A. Nature 432:988-994(2004) [PubMed: 15616553] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain, Colon and Pancreas.
[3]	"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle." Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M. Mol. Cell 31:438-448(2008) [PubMed: 18691976] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-129, MASS SPECTROMETRY.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AC120114 Genomic DNA. No translation available. BC009033 mRNA. Translation: AAH09033.1. BC029136 mRNA. Translation: AAH29136.3. BC040933 mRNA. Translation: AAH40933.3. BC085011 mRNA. Translation: AAH85011.1. BC126319 mRNA. Translation: AAI26320.1. BC126321 mRNA. Translation: AAI26322.1.
IPI	IPI00305626.
RefSeq	NP_859069.2.
UniGene	Hs.655761
3D structure databases
ModBase	Search...
PTM databases
PhosphoSite	Q5U4P2.
Proteomic databases
PRIDE	Q5U4P2.
Genome annotation databases
Ensembl	ENST00000308748; ENSP00000311447; ENSG00000174939; Homo sapiens. [Genome view] ENST00000414952; ENSP00000388036; ENSG00000174939; Homo sapiens. [Genome view]
GeneID	253982.
KEGG	hsa:253982.
UCSC	uc002dut.1. human.
Organism-specific databases
CTD	253982.
GeneCards	GC16P029820.
HGNC	HGNC:27380. ASPHD1.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	Q5U4P2.
OMA	AYARRYS
OrthoDB	EOG97M4H6
Gene expression databases
ArrayExpress	Q5U4P2.
Bgee	Q5U4P2.
CleanEx	HS_ASPHD1.
Genevestigator	Q5U4P2.
GermOnline	ENSG00000174939. Homo sapiens.
Family and domain databases
InterPro	IPR007803. Asp_Arg_b-Hydrxlase. [Graphical view]
Pfam	PF05118. Asp_Arg_Hydrox. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	92220.

Entry information

Entry name

ASPH1_HUMAN

Accession

Primary (citable) accession number: Q5U4P2
Secondary accession number(s): A0AVE3 , Q8IW63, Q8N316, Q96H00

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 31, 2006
Last sequence update:	November 25, 2008
Last modified:	November 24, 2009
This is version 44 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.