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Protein

Protein arginine N-methyltransferase 7

Gene

Prmt7

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Specifically mediates the symmetric dimethylation of histone H4 'Arg-3' to form H4R3me2s. Plays a role in gene imprinting by being recruited by CTCFL at the H19 imprinted control region (ICR) and methylating histone H4 to form H4R3me2s, possibly leading to recruit DNA methyltransferases at these sites. May also play a role in embryonic stem cell (ESC) pluripotency. Also able to mediate the arginine methylation of histone H2A and myelin basic protein (MBP) in vitro; the relevance of such results is however unclear in vivo.By similarity

Catalytic activityi

S-adenosyl-L-methionine + [protein]-L-arginine = S-adenosyl-L-homocysteine + [protein]-N(omega)-methyl-L-arginine.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei144By similarity1
Active sitei153By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChromatin regulator, Methyltransferase, Transferase
Biological processDifferentiation, Transcription, Transcription regulation
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

ReactomeiR-RNO-3214858. RMTs methylate histone arginines.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein arginine N-methyltransferase 7 (EC:2.1.1.321By similarity)
Alternative name(s):
Histone-arginine N-methyltransferase PRMT7
[Myelin basic protein]-arginine N-methyltransferase PRMT7
Gene namesi
Name:Prmt7
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 19

Organism-specific databases

RGDi1304869. Prmt7.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003739021 – 693Protein arginine N-methyltransferase 7Add BLAST693

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei32Omega-N-methylarginineBy similarity1

Keywords - PTMi

Methylation

Proteomic databases

PaxDbiQ5U4E8.
PRIDEiQ5U4E8.

Expressioni

Gene expression databases

BgeeiENSRNOG00000000258.
GenevisibleiQ5U4E8. RN.

Interactioni

Subunit structurei

Homodimer and heterodimer. Interacts with CTCFL, PRMT5 and SNRPD3 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000000275.

Structurei

3D structure databases

ProteinModelPortaliQ5U4E8.
SMRiQ5U4E8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini14 – 345SAM-dependent MTase PRMT-type 1PROSITE-ProRule annotationAdd BLAST332
Domaini358 – 684SAM-dependent MTase PRMT-type 2PROSITE-ProRule annotationAdd BLAST327

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. PRMT7 subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410INRX. Eukaryota.
COG0500. LUCA.
GeneTreeiENSGT00870000136479.
HOGENOMiHOG000033951.
InParanoidiQ5U4E8.
KOiK11438.
OMAiVPWRDHW.
PhylomeDBiQ5U4E8.
TreeFamiTF315221.

Family and domain databases

InterProiView protein in InterPro
IPR025799. Arg_MeTrfase.
IPR014644. MeTrfase_PRMT7.
IPR029063. SAM-dependent_MTases.
PIRSFiPIRSF036946. Arg_N-mtase. 1 hit.
SUPFAMiSSF53335. SSF53335. 2 hits.
PROSITEiView protein in PROSITE
PS51678. SAM_MT_PRMT. 2 hits.

Sequencei

Sequence statusi: Complete.

Q5U4E8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVFCGRANP TTGSLEWLEE DEHYDYHQEI ARSSYADMLH DKDRNIKYYQ
60 70 80 90 100
GIRAAVSRVK DKGQKALVLD IGTGTGLLSM MAVTAGADFC YAVEVFKPMA
110 120 130 140 150
EAAVKIVEKN GFSDKIKVIN KHSTEVTVGP DGDLPCRANI LVTELFDTEL
160 170 180 190 200
IGEGALPSYE HAHKHLVQED CEAVPHRATV YAQLVESKRM WSWNKLFPVR
210 220 230 240 250
VQTGLGEQLI IPPSELERCP GAPSVYDIQL NQVSPADFTV LSDVLPMFSV
260 270 280 290 300
DFSKQVSSSA ACHSKQFVPL ASGQAQVVLS WWDIEMDPEG KIKCTMAPFW
310 320 330 340 350
AQTDPQELQW RDHWMQCVYF LPQEEPIMQG SPRCLAAHHD DYCVWYSLQR
360 370 380 390 400
TSPDENNSAY QVRPVCDCQA HLLWNRPRFG EINDQDRTDH YARALRTMLM
410 420 430 440 450
PGSICLCVSD GSLLSVLAHH LGAEQVFTVE SSVASYRLMK RIFKVNHLED
460 470 480 490 500
KITVINKRPE LLTSADLEGK KVSLLLGEPF FTTSLLPWHN LYFWYVRTSV
510 520 530 540 550
DQHLAPGAVV MPQAASLHAV IVEFRDLWRI RSPCGDCEGF DVHIMDDMIK
560 570 580 590 600
HSLDFRESRE AEPQPLWEYP CRSLSEPRQI LTFDFQQPIP QQPMQSRGVM
610 620 630 640 650
ELRRPGKSHG AVLWMEYQLT PDSTVSTGLM NPAEDKGDCC WNPHCKQAVY
660 670 680 690
FLSATLDPSA PLDGPQSVSY AVEFHPLTGD ITMEFRLADD TLN
Length:693
Mass (Da):78,346
Last modified:December 7, 2004 - v1
Checksum:i757BB76971EFDA48
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH473972 Genomic DNA. Translation: EDL92443.1.
BC085121 mRNA. Translation: AAH85121.1.
RefSeqiNP_001014175.1. NM_001014153.1.
UniGeneiRn.14954.

Genome annotation databases

EnsembliENSRNOT00000000275; ENSRNOP00000000275; ENSRNOG00000000258.
ENSRNOT00000081312; ENSRNOP00000075738; ENSRNOG00000000258.
GeneIDi361402.
KEGGirno:361402.
UCSCiRGD:1304869. rat.

Similar proteinsi

Entry informationi

Entry nameiANM7_RAT
AccessioniPrimary (citable) accession number: Q5U4E8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: December 7, 2004
Last modified: September 27, 2017
This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families