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Protein

Lipoma HMGIC fusion partner-like 4 protein

Gene

Lhfpl4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Lipoma HMGIC fusion partner-like 4 protein
Gene namesi
Name:Lhfpl4
Synonyms:Kiaa4027
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:3057108. Lhfpl4.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei22 – 42HelicalSequence analysisAdd BLAST21
Transmembranei97 – 117HelicalSequence analysisAdd BLAST21
Transmembranei127 – 147HelicalSequence analysisAdd BLAST21
Transmembranei178 – 198HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002859621 – 247Lipoma HMGIC fusion partner-like 4 proteinAdd BLAST247

Proteomic databases

EPDiQ5U4E0.
PaxDbiQ5U4E0.
PRIDEiQ5U4E0.

PTM databases

iPTMnetiQ5U4E0.
PhosphoSitePlusiQ5U4E0.

Expressioni

Gene expression databases

BgeeiENSMUSG00000042873.
CleanExiMM_LHFPL4.
ExpressionAtlasiQ5U4E0. baseline and differential.
GenevisibleiQ5U4E0. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000124470.

Structurei

3D structure databases

ProteinModelPortaliQ5U4E0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LHFP family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4026. Eukaryota.
ENOG410XSUB. LUCA.
GeneTreeiENSGT00550000074479.
HOGENOMiHOG000294163.
HOVERGENiHBG056723.
InParanoidiQ5U4E0.
OMAiDLQTDNK.
OrthoDBiEOG091G0H85.
PhylomeDBiQ5U4E0.
TreeFamiTF321143.

Family and domain databases

InterProiIPR019372. Lipome_HGMIC_fus_partner-like.
[Graphical view]
PfamiPF10242. L_HMGIC_fpl. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5U4E0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLPSQEASKL YHEHYMRNSR AIGVLWAIFT ICFAIINVVV FIQPYWVGDS
60 70 80 90 100
VSTPKPGYFG LFHYCVGSGL AGRELTCRGS FTDFSTIPSS AFKAAAFFVL
110 120 130 140 150
LSMVLILGCI TCFALFFFCN TATVYKICAW MQLLAALCLV LGCMIFPDGW
160 170 180 190 200
DAETIRDMCG AKTGKYSLGD CSVRWAYILA IIGILNALIL SFLAFVLGNR
210 220 230 240
QTDLLQEELK QENKDFVGTT VSSVLRPGGD VSGWGVLPCP VAHTQGP
Length:247
Mass (Da):27,050
Last modified:December 7, 2004 - v1
Checksum:iCB1F73E45A0E32BD
GO

Sequence cautioni

The sequence BAD90276 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti155I → V in BAC32729 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK046437 mRNA. Translation: BAC32729.1.
AK220449 mRNA. Translation: BAD90276.1. Different initiation.
BC085130 mRNA. Translation: AAH85130.1.
CCDSiCCDS39591.1.
RefSeqiNP_808431.2. NM_177763.3.
XP_017177089.1. XM_017321600.1.
UniGeneiMm.37943.

Genome annotation databases

EnsembliENSMUST00000162280; ENSMUSP00000124470; ENSMUSG00000042873.
GeneIDi269788.
KEGGimmu:269788.
UCSCiuc009dev.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK046437 mRNA. Translation: BAC32729.1.
AK220449 mRNA. Translation: BAD90276.1. Different initiation.
BC085130 mRNA. Translation: AAH85130.1.
CCDSiCCDS39591.1.
RefSeqiNP_808431.2. NM_177763.3.
XP_017177089.1. XM_017321600.1.
UniGeneiMm.37943.

3D structure databases

ProteinModelPortaliQ5U4E0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000124470.

PTM databases

iPTMnetiQ5U4E0.
PhosphoSitePlusiQ5U4E0.

Proteomic databases

EPDiQ5U4E0.
PaxDbiQ5U4E0.
PRIDEiQ5U4E0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000162280; ENSMUSP00000124470; ENSMUSG00000042873.
GeneIDi269788.
KEGGimmu:269788.
UCSCiuc009dev.1. mouse.

Organism-specific databases

CTDi375323.
MGIiMGI:3057108. Lhfpl4.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG4026. Eukaryota.
ENOG410XSUB. LUCA.
GeneTreeiENSGT00550000074479.
HOGENOMiHOG000294163.
HOVERGENiHBG056723.
InParanoidiQ5U4E0.
OMAiDLQTDNK.
OrthoDBiEOG091G0H85.
PhylomeDBiQ5U4E0.
TreeFamiTF321143.

Miscellaneous databases

ChiTaRSiLhfpl4. mouse.
PROiQ5U4E0.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000042873.
CleanExiMM_LHFPL4.
ExpressionAtlasiQ5U4E0. baseline and differential.
GenevisibleiQ5U4E0. MM.

Family and domain databases

InterProiIPR019372. Lipome_HGMIC_fus_partner-like.
[Graphical view]
PfamiPF10242. L_HMGIC_fpl. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLHPL4_MOUSE
AccessioniPrimary (citable) accession number: Q5U4E0
Secondary accession number(s): Q5DTS1, Q8BQU2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: December 7, 2004
Last modified: November 2, 2016
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.