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Q5U4D8 (SC5A6_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 81. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Sodium-dependent multivitamin transporter

Short name=Na(+)-dependent multivitamin transporter
Alternative name(s):
Solute carrier family 5 member 6
Gene names
Name:Slc5a6
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length634 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Transports pantothenate, biotin and lipoate in the presence of sodium.

Subcellular location

Membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. [View classification]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 634634Sodium-dependent multivitamin transporter
PRO_0000105387

Regions

Transmembrane23 – 4321Helical; Potential
Transmembrane65 – 8521Helical; Potential
Transmembrane100 – 12021Helical; Potential
Transmembrane142 – 16221Helical; Potential
Transmembrane175 – 19521Helical; Potential
Transmembrane207 – 22721Helical; Potential
Transmembrane255 – 27521Helical; Potential
Transmembrane295 – 31521Helical; Potential
Transmembrane350 – 37021Helical; Potential
Transmembrane403 – 42321Helical; Potential
Transmembrane427 – 44721Helical; Potential
Transmembrane455 – 47521Helical; Potential
Transmembrane526 – 54621Helical; Potential

Amino acid modifications

Glycosylation4881N-linked (GlcNAc...) Potential
Glycosylation4971N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict251V → D in AAH85132. Ref.4

Sequences

Sequence LengthMass (Da)Tools
Q5U4D8 [UniParc].

Last modified July 27, 2011. Version 2.
Checksum: 5C43F53C19F3F38E

FASTA63468,511
        10         20         30         40         50         60 
MSVASTAAPF HTTSGSSGAI STFSVVDYVV FGLLLVLSLV IGLYHACRGW GHHTVGELLM 

        70         80         90        100        110        120 
ADRKMGCLPV ALSLLATFQS AVAILGAPAE IFRFGTQYWF LGCSYFLGLL IPAHIFIPVF 

       130        140        150        160        170        180 
YRLHLTSAYE YLELRFNKAV RICGTVTFIF QMVIYMGVAL YAPSLALNAV TGFDLWLSVL 

       190        200        210        220        230        240 
ALGIVCNIYT ALGGLKAVIW TDVFQTLVMF LGQLVVIIVG AARVGGLGHV WNVTSQHGLI 

       250        260        270        280        290        300 
SGINLDPDPF VRHTFWTLAF GGVFMMLSLY GVNQAQVQRY LSSHSERAAV LSCYAVFPCQ 

       310        320        330        340        350        360 
QVALCMSCLI GLVMFAYYNM YSMSPELKQA APDQLVLYFV MDLLKDMPGL PGLFVACLFS 

       370        380        390        400        410        420 
GSLSTISSAF NSLATVTMED LIQPWFPQLT ETRAIMLSRG LAFAYGLVCL GMAYISSHLG 

       430        440        450        460        470        480 
SVLQAALSIF GMVGGPLLGL FCLGLFFPCA NPLGAIVGLL TGLTMAFWIG IGSIVSRMSS 

       490        500        510        520        530        540 
AVAPPPLNGS SSFLPANVTV AAVTTVMPST LSKPTGLQHF YSLSYLWYSA HNSTTVIVVG 

       550        560        570        580        590        600 
LIVSLLTGGM RGRSLNPGTI YPVLPKLLAL LPLSCQKRLC WRSHSQDIPV IPNLFPEKMR 

       610        620        630 
NGVLQDSTDK ERMAEDGLVH QPCSPTYVVQ ETSL 

« Hide

References

« Hide 'large scale' references
[1]"Mus musculus small intestine sodium dependent multivitamin transporter."
Balamurugan K., Said H.M.
Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: BALB/cJ x C57BL/6J.
Tissue: Small intestine.
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J and NOD.
Tissue: Embryo and Thymus.
[3]Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6.
[5]"The phagosomal proteome in interferon-gamma-activated macrophages."
Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY572835 mRNA. Translation: AAS79366.1.
AK088682 mRNA. Translation: BAC40502.1.
AK161633 mRNA. Translation: BAE36503.1.
CH466524 Genomic DNA. Translation: EDL37322.1.
BC085132 mRNA. Translation: AAH85132.1.
BC117852 mRNA. Translation: AAI17853.1.
BC117853 mRNA. Translation: AAI17854.1.
CCDSCCDS19169.1.
RefSeqNP_001171092.1. NM_001177621.1.
NP_001171093.1. NM_001177622.1.
NP_808538.1. NM_177870.5.
UniGeneMm.205463.

3D structure databases

ProteinModelPortalQ5U4D8.
SMRQ5U4D8. Positions 70-469.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ5U4D8.

Proteomic databases

PaxDbQ5U4D8.
PRIDEQ5U4D8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000006817; ENSMUSP00000006817; ENSMUSG00000006641.
ENSMUST00000080431; ENSMUSP00000079291; ENSMUSG00000006641.
ENSMUST00000114665; ENSMUSP00000110313; ENSMUSG00000006641.
ENSMUST00000114668; ENSMUSP00000110316; ENSMUSG00000006641.
GeneID330064.
KEGGmmu:330064.
UCSCuc008wwt.2. mouse.

Organism-specific databases

CTD8884.
MGIMGI:2660847. Slc5a6.

Phylogenomic databases

eggNOGCOG0591.
GeneTreeENSGT00550000074437.
HOGENOMHOG000261662.
HOVERGENHBG057280.
InParanoidQ8BTU3.
KOK14386.
OMAPWFPQFS.
OrthoDBEOG70PBX7.
TreeFamTF316728.

Gene expression databases

BgeeQ5U4D8.
GenevestigatorQ5U4D8.

Family and domain databases

InterProIPR001734. Na/solute_symporter.
IPR018212. Na/solute_symporter_CS.
IPR019900. Na/solute_symporter_subgr.
[Graphical view]
PANTHERPTHR11819. PTHR11819. 1 hit.
PfamPF00474. SSF. 1 hit.
[Graphical view]
TIGRFAMsTIGR00813. sss. 1 hit.
PROSITEPS00456. NA_SOLUT_SYMP_1. 1 hit.
PS50283. NA_SOLUT_SYMP_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSSLC5A6. mouse.
NextBio399132.
PROQ5U4D8.
SOURCESearch...

Entry information

Entry nameSC5A6_MOUSE
AccessionPrimary (citable) accession number: Q5U4D8
Secondary accession number(s): Q8BTU3
Entry history
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: July 27, 2011
Last modified: July 9, 2014
This is version 81 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot