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Q5U4D8

- SC5A6_MOUSE

UniProt

Q5U4D8 - SC5A6_MOUSE

Protein

Sodium-dependent multivitamin transporter

Gene

Slc5a6

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 83 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Transports pantothenate, biotin and lipoate in the presence of sodium.

    GO - Molecular functioni

    1. sodium-dependent multivitamin transmembrane transporter activity Source: Ensembl

    GO - Biological processi

    1. biotin transport Source: Ensembl
    2. pantothenate transmembrane transport Source: Ensembl

    Keywords - Biological processi

    Ion transport, Sodium transport, Symport, Transport

    Keywords - Ligandi

    Biotin, Sodium

    Enzyme and pathway databases

    ReactomeiREACT_206176. Biotin transport and metabolism.
    REACT_221573. Vitamin B5 (pantothenate) metabolism.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sodium-dependent multivitamin transporter
    Short name:
    Na(+)-dependent multivitamin transporter
    Alternative name(s):
    Solute carrier family 5 member 6
    Gene namesi
    Name:Slc5a6
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 5

    Organism-specific databases

    MGIiMGI:2660847. Slc5a6.

    Subcellular locationi

    GO - Cellular componenti

    1. brush border membrane Source: Ensembl
    2. integral component of membrane Source: UniProtKB-KW
    3. vesicle membrane Source: Ensembl

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 634634Sodium-dependent multivitamin transporterPRO_0000105387Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi488 – 4881N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi497 – 4971N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ5U4D8.
    PRIDEiQ5U4D8.

    PTM databases

    PhosphoSiteiQ5U4D8.

    Expressioni

    Gene expression databases

    BgeeiQ5U4D8.
    GenevestigatoriQ5U4D8.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5U4D8.
    SMRiQ5U4D8. Positions 70-469.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei23 – 4321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei65 – 8521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei100 – 12021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei142 – 16221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei175 – 19521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei207 – 22721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei255 – 27521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei295 – 31521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei350 – 37021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei403 – 42321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei427 – 44721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei455 – 47521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei526 – 54621HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0591.
    GeneTreeiENSGT00550000074437.
    HOGENOMiHOG000261662.
    HOVERGENiHBG057280.
    InParanoidiQ8BTU3.
    KOiK14386.
    OMAiPWFPQFS.
    OrthoDBiEOG70PBX7.
    TreeFamiTF316728.

    Family and domain databases

    InterProiIPR001734. Na/solute_symporter.
    IPR018212. Na/solute_symporter_CS.
    IPR019900. Na/solute_symporter_subgr.
    [Graphical view]
    PANTHERiPTHR11819. PTHR11819. 1 hit.
    PfamiPF00474. SSF. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00813. sss. 1 hit.
    PROSITEiPS00456. NA_SOLUT_SYMP_1. 1 hit.
    PS50283. NA_SOLUT_SYMP_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5U4D8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSVASTAAPF HTTSGSSGAI STFSVVDYVV FGLLLVLSLV IGLYHACRGW    50
    GHHTVGELLM ADRKMGCLPV ALSLLATFQS AVAILGAPAE IFRFGTQYWF 100
    LGCSYFLGLL IPAHIFIPVF YRLHLTSAYE YLELRFNKAV RICGTVTFIF 150
    QMVIYMGVAL YAPSLALNAV TGFDLWLSVL ALGIVCNIYT ALGGLKAVIW 200
    TDVFQTLVMF LGQLVVIIVG AARVGGLGHV WNVTSQHGLI SGINLDPDPF 250
    VRHTFWTLAF GGVFMMLSLY GVNQAQVQRY LSSHSERAAV LSCYAVFPCQ 300
    QVALCMSCLI GLVMFAYYNM YSMSPELKQA APDQLVLYFV MDLLKDMPGL 350
    PGLFVACLFS GSLSTISSAF NSLATVTMED LIQPWFPQLT ETRAIMLSRG 400
    LAFAYGLVCL GMAYISSHLG SVLQAALSIF GMVGGPLLGL FCLGLFFPCA 450
    NPLGAIVGLL TGLTMAFWIG IGSIVSRMSS AVAPPPLNGS SSFLPANVTV 500
    AAVTTVMPST LSKPTGLQHF YSLSYLWYSA HNSTTVIVVG LIVSLLTGGM 550
    RGRSLNPGTI YPVLPKLLAL LPLSCQKRLC WRSHSQDIPV IPNLFPEKMR 600
    NGVLQDSTDK ERMAEDGLVH QPCSPTYVVQ ETSL 634
    Length:634
    Mass (Da):68,511
    Last modified:July 27, 2011 - v2
    Checksum:i5C43F53C19F3F38E
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti25 – 251V → D in AAH85132. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY572835 mRNA. Translation: AAS79366.1.
    AK088682 mRNA. Translation: BAC40502.1.
    AK161633 mRNA. Translation: BAE36503.1.
    CH466524 Genomic DNA. Translation: EDL37322.1.
    BC085132 mRNA. Translation: AAH85132.1.
    BC117852 mRNA. Translation: AAI17853.1.
    BC117853 mRNA. Translation: AAI17854.1.
    CCDSiCCDS19169.1.
    RefSeqiNP_001171092.1. NM_001177621.1.
    NP_001171093.1. NM_001177622.1.
    NP_808538.1. NM_177870.5.
    UniGeneiMm.205463.

    Genome annotation databases

    EnsembliENSMUST00000006817; ENSMUSP00000006817; ENSMUSG00000006641.
    ENSMUST00000080431; ENSMUSP00000079291; ENSMUSG00000006641.
    ENSMUST00000114665; ENSMUSP00000110313; ENSMUSG00000006641.
    ENSMUST00000114668; ENSMUSP00000110316; ENSMUSG00000006641.
    GeneIDi330064.
    KEGGimmu:330064.
    UCSCiuc008wwt.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY572835 mRNA. Translation: AAS79366.1 .
    AK088682 mRNA. Translation: BAC40502.1 .
    AK161633 mRNA. Translation: BAE36503.1 .
    CH466524 Genomic DNA. Translation: EDL37322.1 .
    BC085132 mRNA. Translation: AAH85132.1 .
    BC117852 mRNA. Translation: AAI17853.1 .
    BC117853 mRNA. Translation: AAI17854.1 .
    CCDSi CCDS19169.1.
    RefSeqi NP_001171092.1. NM_001177621.1.
    NP_001171093.1. NM_001177622.1.
    NP_808538.1. NM_177870.5.
    UniGenei Mm.205463.

    3D structure databases

    ProteinModelPortali Q5U4D8.
    SMRi Q5U4D8. Positions 70-469.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q5U4D8.

    Proteomic databases

    PaxDbi Q5U4D8.
    PRIDEi Q5U4D8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000006817 ; ENSMUSP00000006817 ; ENSMUSG00000006641 .
    ENSMUST00000080431 ; ENSMUSP00000079291 ; ENSMUSG00000006641 .
    ENSMUST00000114665 ; ENSMUSP00000110313 ; ENSMUSG00000006641 .
    ENSMUST00000114668 ; ENSMUSP00000110316 ; ENSMUSG00000006641 .
    GeneIDi 330064.
    KEGGi mmu:330064.
    UCSCi uc008wwt.2. mouse.

    Organism-specific databases

    CTDi 8884.
    MGIi MGI:2660847. Slc5a6.

    Phylogenomic databases

    eggNOGi COG0591.
    GeneTreei ENSGT00550000074437.
    HOGENOMi HOG000261662.
    HOVERGENi HBG057280.
    InParanoidi Q8BTU3.
    KOi K14386.
    OMAi PWFPQFS.
    OrthoDBi EOG70PBX7.
    TreeFami TF316728.

    Enzyme and pathway databases

    Reactomei REACT_206176. Biotin transport and metabolism.
    REACT_221573. Vitamin B5 (pantothenate) metabolism.

    Miscellaneous databases

    ChiTaRSi SLC5A6. mouse.
    NextBioi 399132.
    PROi Q5U4D8.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q5U4D8.
    Genevestigatori Q5U4D8.

    Family and domain databases

    InterProi IPR001734. Na/solute_symporter.
    IPR018212. Na/solute_symporter_CS.
    IPR019900. Na/solute_symporter_subgr.
    [Graphical view ]
    PANTHERi PTHR11819. PTHR11819. 1 hit.
    Pfami PF00474. SSF. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00813. sss. 1 hit.
    PROSITEi PS00456. NA_SOLUT_SYMP_1. 1 hit.
    PS50283. NA_SOLUT_SYMP_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Mus musculus small intestine sodium dependent multivitamin transporter."
      Balamurugan K., Said H.M.
      Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: BALB/cJ x C57BL/6J.
      Tissue: Small intestine.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J and NOD.
      Tissue: Embryo and Thymus.
    3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6.
    5. "The phagosomal proteome in interferon-gamma-activated macrophages."
      Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
      Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiSC5A6_MOUSE
    AccessioniPrimary (citable) accession number: Q5U4D8
    Secondary accession number(s): Q8BTU3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 15, 2005
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 83 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3