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Q5U4D8

- SC5A6_MOUSE

UniProt

Q5U4D8 - SC5A6_MOUSE

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Protein

Sodium-dependent multivitamin transporter

Gene

Slc5a6

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Transports pantothenate, biotin and lipoate in the presence of sodium.

GO - Molecular functioni

  1. sodium-dependent multivitamin transmembrane transporter activity Source: Ensembl

GO - Biological processi

  1. biotin transport Source: Ensembl
  2. pantothenate transmembrane transport Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Ion transport, Sodium transport, Symport, Transport

Keywords - Ligandi

Biotin, Sodium

Enzyme and pathway databases

ReactomeiREACT_206176. Biotin transport and metabolism.
REACT_221573. Vitamin B5 (pantothenate) metabolism.

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium-dependent multivitamin transporter
Short name:
Na(+)-dependent multivitamin transporter
Alternative name(s):
Solute carrier family 5 member 6
Gene namesi
Name:Slc5a6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 5

Organism-specific databases

MGIiMGI:2660847. Slc5a6.

Subcellular locationi

GO - Cellular componenti

  1. brush border membrane Source: Ensembl
  2. integral component of membrane Source: UniProtKB-KW
  3. vesicle membrane Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 634634Sodium-dependent multivitamin transporterPRO_0000105387Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi488 – 4881N-linked (GlcNAc...)Sequence Analysis
Glycosylationi497 – 4971N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ5U4D8.
PRIDEiQ5U4D8.

PTM databases

PhosphoSiteiQ5U4D8.

Expressioni

Gene expression databases

BgeeiQ5U4D8.
ExpressionAtlasiQ5U4D8. baseline and differential.
GenevestigatoriQ5U4D8.

Structurei

3D structure databases

ProteinModelPortaliQ5U4D8.
SMRiQ5U4D8. Positions 70-469.
ModBaseiSearch...
MobiDBiSearch...

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei23 – 4321HelicalSequence AnalysisAdd
BLAST
Transmembranei65 – 8521HelicalSequence AnalysisAdd
BLAST
Transmembranei100 – 12021HelicalSequence AnalysisAdd
BLAST
Transmembranei142 – 16221HelicalSequence AnalysisAdd
BLAST
Transmembranei175 – 19521HelicalSequence AnalysisAdd
BLAST
Transmembranei207 – 22721HelicalSequence AnalysisAdd
BLAST
Transmembranei255 – 27521HelicalSequence AnalysisAdd
BLAST
Transmembranei295 – 31521HelicalSequence AnalysisAdd
BLAST
Transmembranei350 – 37021HelicalSequence AnalysisAdd
BLAST
Transmembranei403 – 42321HelicalSequence AnalysisAdd
BLAST
Transmembranei427 – 44721HelicalSequence AnalysisAdd
BLAST
Transmembranei455 – 47521HelicalSequence AnalysisAdd
BLAST
Transmembranei526 – 54621HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0591.
GeneTreeiENSGT00760000118955.
HOGENOMiHOG000261662.
HOVERGENiHBG057280.
InParanoidiQ5U4D8.
KOiK14386.
OMAiPWFPQFS.
OrthoDBiEOG70PBX7.
TreeFamiTF316728.

Family and domain databases

InterProiIPR001734. Na/solute_symporter.
IPR018212. Na/solute_symporter_CS.
IPR019900. Na/solute_symporter_subgr.
[Graphical view]
PANTHERiPTHR11819. PTHR11819. 1 hit.
PfamiPF00474. SSF. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00813. sss. 1 hit.
PROSITEiPS00456. NA_SOLUT_SYMP_1. 1 hit.
PS50283. NA_SOLUT_SYMP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5U4D8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSVASTAAPF HTTSGSSGAI STFSVVDYVV FGLLLVLSLV IGLYHACRGW
60 70 80 90 100
GHHTVGELLM ADRKMGCLPV ALSLLATFQS AVAILGAPAE IFRFGTQYWF
110 120 130 140 150
LGCSYFLGLL IPAHIFIPVF YRLHLTSAYE YLELRFNKAV RICGTVTFIF
160 170 180 190 200
QMVIYMGVAL YAPSLALNAV TGFDLWLSVL ALGIVCNIYT ALGGLKAVIW
210 220 230 240 250
TDVFQTLVMF LGQLVVIIVG AARVGGLGHV WNVTSQHGLI SGINLDPDPF
260 270 280 290 300
VRHTFWTLAF GGVFMMLSLY GVNQAQVQRY LSSHSERAAV LSCYAVFPCQ
310 320 330 340 350
QVALCMSCLI GLVMFAYYNM YSMSPELKQA APDQLVLYFV MDLLKDMPGL
360 370 380 390 400
PGLFVACLFS GSLSTISSAF NSLATVTMED LIQPWFPQLT ETRAIMLSRG
410 420 430 440 450
LAFAYGLVCL GMAYISSHLG SVLQAALSIF GMVGGPLLGL FCLGLFFPCA
460 470 480 490 500
NPLGAIVGLL TGLTMAFWIG IGSIVSRMSS AVAPPPLNGS SSFLPANVTV
510 520 530 540 550
AAVTTVMPST LSKPTGLQHF YSLSYLWYSA HNSTTVIVVG LIVSLLTGGM
560 570 580 590 600
RGRSLNPGTI YPVLPKLLAL LPLSCQKRLC WRSHSQDIPV IPNLFPEKMR
610 620 630
NGVLQDSTDK ERMAEDGLVH QPCSPTYVVQ ETSL
Length:634
Mass (Da):68,511
Last modified:July 27, 2011 - v2
Checksum:i5C43F53C19F3F38E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti25 – 251V → D in AAH85132. (PubMed:15489334)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY572835 mRNA. Translation: AAS79366.1.
AK088682 mRNA. Translation: BAC40502.1.
AK161633 mRNA. Translation: BAE36503.1.
CH466524 Genomic DNA. Translation: EDL37322.1.
BC085132 mRNA. Translation: AAH85132.1.
BC117852 mRNA. Translation: AAI17853.1.
BC117853 mRNA. Translation: AAI17854.1.
CCDSiCCDS19169.1.
RefSeqiNP_001171092.1. NM_001177621.1.
NP_001171093.1. NM_001177622.1.
NP_808538.1. NM_177870.5.
UniGeneiMm.205463.

Genome annotation databases

EnsembliENSMUST00000006817; ENSMUSP00000006817; ENSMUSG00000006641.
ENSMUST00000080431; ENSMUSP00000079291; ENSMUSG00000006641.
ENSMUST00000114665; ENSMUSP00000110313; ENSMUSG00000006641.
ENSMUST00000114668; ENSMUSP00000110316; ENSMUSG00000006641.
GeneIDi330064.
KEGGimmu:330064.
UCSCiuc008wwt.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY572835 mRNA. Translation: AAS79366.1 .
AK088682 mRNA. Translation: BAC40502.1 .
AK161633 mRNA. Translation: BAE36503.1 .
CH466524 Genomic DNA. Translation: EDL37322.1 .
BC085132 mRNA. Translation: AAH85132.1 .
BC117852 mRNA. Translation: AAI17853.1 .
BC117853 mRNA. Translation: AAI17854.1 .
CCDSi CCDS19169.1.
RefSeqi NP_001171092.1. NM_001177621.1.
NP_001171093.1. NM_001177622.1.
NP_808538.1. NM_177870.5.
UniGenei Mm.205463.

3D structure databases

ProteinModelPortali Q5U4D8.
SMRi Q5U4D8. Positions 70-469.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q5U4D8.

Proteomic databases

PaxDbi Q5U4D8.
PRIDEi Q5U4D8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000006817 ; ENSMUSP00000006817 ; ENSMUSG00000006641 .
ENSMUST00000080431 ; ENSMUSP00000079291 ; ENSMUSG00000006641 .
ENSMUST00000114665 ; ENSMUSP00000110313 ; ENSMUSG00000006641 .
ENSMUST00000114668 ; ENSMUSP00000110316 ; ENSMUSG00000006641 .
GeneIDi 330064.
KEGGi mmu:330064.
UCSCi uc008wwt.2. mouse.

Organism-specific databases

CTDi 8884.
MGIi MGI:2660847. Slc5a6.

Phylogenomic databases

eggNOGi COG0591.
GeneTreei ENSGT00760000118955.
HOGENOMi HOG000261662.
HOVERGENi HBG057280.
InParanoidi Q5U4D8.
KOi K14386.
OMAi PWFPQFS.
OrthoDBi EOG70PBX7.
TreeFami TF316728.

Enzyme and pathway databases

Reactomei REACT_206176. Biotin transport and metabolism.
REACT_221573. Vitamin B5 (pantothenate) metabolism.

Miscellaneous databases

ChiTaRSi SLC5A6. mouse.
NextBioi 399132.
PROi Q5U4D8.
SOURCEi Search...

Gene expression databases

Bgeei Q5U4D8.
ExpressionAtlasi Q5U4D8. baseline and differential.
Genevestigatori Q5U4D8.

Family and domain databases

InterProi IPR001734. Na/solute_symporter.
IPR018212. Na/solute_symporter_CS.
IPR019900. Na/solute_symporter_subgr.
[Graphical view ]
PANTHERi PTHR11819. PTHR11819. 1 hit.
Pfami PF00474. SSF. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00813. sss. 1 hit.
PROSITEi PS00456. NA_SOLUT_SYMP_1. 1 hit.
PS50283. NA_SOLUT_SYMP_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Mus musculus small intestine sodium dependent multivitamin transporter."
    Balamurugan K., Said H.M.
    Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/cJ x C57BL/6J.
    Tissue: Small intestine.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and NOD.
    Tissue: Embryo and Thymus.
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
  5. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSC5A6_MOUSE
AccessioniPrimary (citable) accession number: Q5U4D8
Secondary accession number(s): Q8BTU3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: July 27, 2011
Last modified: October 29, 2014
This is version 84 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3